Navigation Links
The internal clock and feeding rhythm set the pace of the liver
Date:1/15/2014

Living organisms have adapted to the day-night cycle and, in most cases, they have evolved a "circadian clock". Its effects are not completely known yet but its functioning has been shown to have important metabolic consequences for the body. Disruption of normal circadian rhythms can have deleterious effects on health; for example lack of sleep is linked with obesity, and the time of feeding was shown to affect the ability to control body weight.

Scientists from the Nestl Institute of Health Sciences (NIHS) and the cole polytechnique fdrale de Lausanne (EPFL), supported by a 2012 grant from the Swiss Leenaards Foundation originally awarded to the Universit de Lausanne, have found that in the case of the liver, the rhythm of protein production and release is dictated by both the organisms' feeding behaviors and their internal clock. The current study was published last week in the journal Proceedings of the National Academy of Science of the USA (PNAS).

The researchers, under the direction of Frdric Gachon (NIHS) and Felix Naef (EPFL), analyzed liver proteins with mass spectrometry, one of the new analytical tools currently available that allow a closer inspection of the real impact of this clock on some biological processes, in particular at a level of temporal protein abundance. They measured the concentration of more than 5000 different proteins whereas previous techniques only allowed the identification a few hundreds at best.

The results suggest that the circadian clock does not only influence the production of proteins by the genes, but also the way the liver regulated the storage and release of proteins into the body. "Our experiments seem to prove that the pace set by feeding patterns takes precedence over the circadian rhythm. However, it appears that the strongest effect takes place when these two rhythms overlap", said Frdric Gachon.

As a next step, this research will attempt to translate some of these results to humans. "Our work will help develop strategies focused on diet to help treat patients suffering from disorders associated to circadian dysfunctions" said Felix Naef.


'/>"/>

Contact: Sarah Perrin
sarah.perrin@epfl.ch
41-216-932-107
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Related biology news :

1. Our internal clocks can become ticking time bombs for diabetes and obesity
2. Internal relations
3. Annals of Internal Medicine tip sheet for Sept. 4, 2012
4. Nanoparticles added to platelets double internal injury survival rate
5. In protein folding, internal friction may play a more significant role than previously thought
6. Synthetic genetic clock checks the thermometer
7. Stomach clock tells us how much to eat
8. Broken cellular clock linked to brain damage
9. UT Southwestern researchers identify how body clock affects inflammation
10. The molecular clock of the common buzzard
11. Coastal animals have their own tidal timer -- separate from the 24-hour body clock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2020)... (PRWEB) , ... June 18, ... ... three-part webinar series, “Automate Your Lab with Software for Data Decisions,” for ... will learn how to integrate and automate cutting-edge scientific instruments and laboratory ...
(Date:6/13/2020)... ... 2020 , ... Bode Technology (Bode), a leading ... team. Bode’s Forensic Genealogy Service (FGS) continues to deliver investigative leads ... The team has added experienced genealogists, each having over a decade of field ...
(Date:6/11/2020)... ... June 09, 2020 , ... Superior Controls, Inc. , an ... IT solutions for the life sciences industry, is pleased to announce the recent hiring ... of the company’s Seabrook, New Hampshire office. In his new role, Boudreau will ...
Breaking Biology News(10 mins):
(Date:5/30/2020)... FRANCISCO (PRWEB) , ... May 29, 2020 , ... ... pharmaceutical, biotech, medical device, diagnostics, and animal health markets, has enabled Cytovale, Inc., ... applying cell mechanics and machine learning, to achieve their first patient in (FPI) ...
(Date:5/28/2020)... BASEL, Switzerland (PRWEB) , ... May 28, 2020 ... ... for biopharmaceutical R&D, today announced the release of Genedata Screener ® 17.0, ... management of screening data from all in-vitro screening assay technologies. Genedata will host ...
(Date:5/26/2020)... ... May 26, 2020 , ... Brilliant , the leading smart ... smart garage door openers, announce a new integration to bring more convenience, simplicity, and ... openers powered by Aladdin Connect® can now be controlled from Brilliant’s in-wall touchscreen control ...
(Date:5/21/2020)... MN (PRWEB) , ... May 19, 2020 , ... Experienced ... help patients get dental implants and bone grafting through PIEZOSURGERY® technology. PIEZOSURGERY ... This is often used to prepare a patient for dental implants, especially when the ...
Breaking Biology Technology: