Navigation Links
The host makes all the difference
Date:3/26/2009

"Where there are many scientific works dealing solely with the flu virus, we have investigated how the host reacts to an infection," says Klaus Schughart, head of the Experimental Mouse Genetics research group. In infection experiments the researchers have now discovered that an excessive immune response is responsible for the fatal outcome of the disease in mice. This overreaction has genetic roots. The findings have now been published in the scientific magazine PLoS One.

For their investigations the researchers injected seven different inbred mouse strains with the same quantity of type Influenza A flu viruses. All of the animals within one mouse strain are genetically identical, like identical twins. However, one strain differs from another just like different individuals in the human population. To their surprise, the researchers were able to identify strong differences in the progression of the influenza between the seven strains. In five of the strains the illness was mild: the animals lost weight, recovering completely after seven to eight days. However, in two of the mouse strains the animals lost weight rapidly and died after just a few days.

The researchers looked for reasons for these differences: they investigated how the immune system of the animals responds to the virus. "The mice die from their own immune defences, which are actually supposed to protect them against the virus. The immune system produces too many messengers, which have a strong activating effect on the immune cells. These cells then kill tissue cells in the lungs that are infected with the virus," says Schughart. At the same time, these overactive cells also destroy healthy lung tissue. In mice that died the researchers also found one hundred times more viruses than in animals that survived. "It appears that the animals have specific receptors on their cells that make them more receptive to a severe viral infection." Flu infections in humans could take a
'/>"/>

Contact: Dr. Bastian Dornbach
bastian.dornbach@helmholtz-hzi.de
49-053-161-811-407
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. The egg makes sure that sperm dont get too old
2. Tobacco makes medicine
3. Liking sweets makes sense for kids
4. Oh baby, interventional radiology makes childbirth safer
5. Red wine vs. white? It makes no difference when it comes to breast-cancer risk
6. Mount Sinai Hospital researcher makes stem cell breakthrough
7. Peptides-on-demand: McGill researchers radical new green chemistry makes the impossible possible
8. Rett Syndrome Research Trust advisor makes significant discovery
9. Tree lizard’s quick release escape system makes jumpers turn somersaults
10. Biophysical Reviews makes debut in 2009
11. Our unconscious brain makes the best decisions possible
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- ... it has agreed to a partnership with Gabriel ... fastest growing Certified Nursing Assistant ... Health Institute  an exclusive member of Binary,s LiveScan ... Binary Biometrics will improve its service capabilities ...
(Date:8/21/2014)... In a finding that has implications for life in ... in the solar system, LSU Associate Professor of Biological ... National Science Foundation, or NSF, this week published a ... lake that lies 800 meters (2600 feet) beneath the ... microbial ecosystems.", Given that more than 400 subglacial lakes ...
(Date:8/21/2014)... Oct. 18-22, 2014 , WHERE: , San ... Diego, CA 92101 , WHAT: , Invited ... the latest research in human genetics. Examples of ... abstracts on rare genetic variants in health and ... for sun sensitivity (Saturday, Oct. 18, 5:30-7:30 pm) ...
Breaking Biology News(10 mins):LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4American Society of Human Genetics 2014 Annual Meeting 2
... STATE COLLEGE, Pa., Feb. 22, 2011 IntegenX Inc. ... forensics software will power the data analysis feature of ... identification. The incorporated software will enable the integrated system ... compatible with human identification database search systems. ...
... the most common congenital defects in humans it ... routine antenatal sonography is a kidney abnormality known ... from the kidney to the bladder is impeded. By ... at the Hospital for Sick Children, Toronto, have identified ...
... D.C. --- The choices an individual makes about environmental ... a person,s social network. Michigan State University scientists are ... to better communicate sustainability science. "Instead of trying ... more effective by using the structure of social networks ...
Cached Biology News:SoftGenetics to Supply Forensic Analysis Software for IntegenX's Automated DNA Identity Profiling System 2SoftGenetics to Supply Forensic Analysis Software for IntegenX's Automated DNA Identity Profiling System 3Sustainability solutions need the power of networks 2
(Date:8/22/2014)... are intensively investigated for application as catalysts, ... and components in photonics and molecular electronics. ... for understanding physical and chemical properties, has ... USA, have demonstrated that high-resolution electron microscopy ... structure in which all gold atoms are ...
(Date:8/22/2014)... Aug. 22, 2014 Research and Markets ... and China Gel Permeation Chromatography (GPC) Industry Report 2014" ... Global and China Gel Permeation Chromatography (GPC) Industry Report ... state of the global gel permeation chromatography industry with ... provides a basic overview of the industry including definitions, ...
(Date:8/22/2014)... Los Angeles (PRWEB) August 22, 2014 ... for age-defying products, is in the spotlight again. ... night cream and its NeriumFirmTM Body Contouring Cream ... presented by Backstage Creations during the 66th Primetime ... the patented NAE-8® extract, third-party clinical trials show ...
(Date:8/21/2014)... N.Y. , Aug. 21, 2014  BioSpecifics ... biopharmaceutical company developing first in class collagenase-based products ... or CCH) in the U.S. and XIAPEX ® ... significant results from a randomized, double-blind Phase 2a ... cellulite, or edematous fibrosclerotic panniculopathy. The results showed ...
Breaking Biology Technology:A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2Global and China Gel Permeation Chromatography (GPC) Industry Report 2014 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5
... , Dr. Karl-Heinz Esser, multiBIND biotec GmbH, ... GmbH and, , ... , , ... technology demonstrate,that even small amounts of free DNA molecules,are sufficient to cause infections, ...
... Key words: Xanthochromia, Cerebrospinal fluid (CSF), Subarachnoid haemorrhage, Haemoglobin, ... , Introduction: ... the yellow discoloration indicating the presence of bilirubin in the ... in vivo subarachnoid haemorrhage from a traumatic lumbar ...
... , Minimum Analytical Instrument Requirement: , Adept HPLC System 1, isocratic , ... Typical Method: , Column: Nucleosil SB, ... 4.0 ,F low Rate: 0.8 mL/minute , Detector: UV at 210nm , ... Peak Identification ,1. L-Glutamine ,2. Pyrrolidone carboxylic acid ,3. Glutamic acid, ...
Cached Biology Technology:New Insights Into DNA Decontamination 2New Insights Into DNA Decontamination 3New Insights Into DNA Decontamination 4New Insights Into DNA Decontamination 5XANTHOCHROMIA IN CEREBROSPINAL FLUID 2XANTHOCHROMIA IN CEREBROSPINAL FLUID 3XANTHOCHROMIA IN CEREBROSPINAL FLUID 4
12(S)-HETE-d8 is used as an internal standard for the quantification of 12(S)-HETE by stable isotope dilution mass spectrometry....
...
... kits are designed to rapidly and ... using our patented APA Technology. APAgene ... an extraordinarily competitive price. All necessary ... The Locator Kit can be used ...
... designed to deparaffinize and perform Heat Induced ... tissue sections mounted on glass microscope slides. ... at the high temperature used in HIER ... the paraffin by detergent. Formaldehyde fixation impairs ...
Biology Products: