Navigation Links
The genome sequence of Tibetan antelope sheds new light on high-altitude adaptation
Date:5/17/2013

May 17, 2013, Shenzhen, China---- Why Tibetan antelope can live at elevations of 4,000-5,000m on the Qinghai-Tibetan Plateau? In a collaborative research published in Nature Communications, investigators from Qinghai University, BGI, and other institutes provide evidence that some genetic factors may be associated with the species' adaption to harsh highland environments. The data in this work will also provide implications for studying specific genetic mechanisms and the biology of other ruminant species.

The Tibetan antelope (Pantholops hodgsonii) is a native of the high mountain steppes and semi-desert areas of the Tibetan plateau. Interestingly, it is the only member of the genus Pantholops. Tibetan antelope is a medium sized antelope with the unique adaptations to against the harsh high-altitude climate. For non-native mammals such as humans, they may experience life-threatening acute mountain sickness when visiting high-altitude regions.

In this study, researchers suggest that Tibetan antelopes must have evolved exceptional mechanisms to adapt to this extremely inhospitable habitat. Using next-gen sequencing technology, they have decoded the genome of Tibetan antelope and studied the underlying genetic mechanism of high-altitude adaptations.

Through the comparison between Tibetan antelope and other plain-dwelling mammals, researchers found the Tibetan antelope had the signals of adaptive evolution and gene-family expansion in genes associated with energy metabolism and oxygen transmission, indicating that gene categories involved in energy metabolism appear to have an important role for Tibetan antelope via efficiently providing energy in conditions of low partial pressure of oxygen (PO2).

Further research revealed that both the Tibetan antelope and the highland American pika have signals of positive selection for genes involved in DNA repair and the production of ATPase. Considering the exposure
'/>"/>

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

Page: 1 2

Related biology news :

1. The DOE Joint Genome Institute expands capabilities via new partnerships
2. Scientists sequence genome of sacred lotus, which likely holds anti-aging secrets
3. Saving the parrots: Texas A&M team sequences genome of endangered macaw birds
4. Mapping the embryonic epigenome
5. Genome sequencing provides unprecedented insight into causes of pneumococcal disease
6. A new cost-effective genome assembly process
7. Turtle genome analysis sheds light on the development and evolution of turtle-specific body plan
8. CNIO researchers capture the replication of the human genome for the first time
9. Saint Louis University, University of Toronto biologists help decode turtle genome
10. Genome study suggests new strategies for understanding and treating pulmonary fibrosis
11. Coelacanth genome surfaces
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... Researchers from NeuroPhage Pharmaceuticals, Inc. have engineered ... treat most neurodegenerative diseases that are characterized by ... diseases. These molecules are based on what the ... GAIM, which recognizes a characteristic common to many ... misfolded protein. This approach provides NeuroPhage with an ...
(Date:4/22/2014)... developing countries could be monitored from birth to ... a new technique piloted by a London-based university ... be visualised and tracked more quickly, more accurately ... near infra-red spectroscopy (fNIRS), compared to the behavioural ... , Professor Clare Elwell, Professor of Medical ...
(Date:4/21/2014)... HOUSTON, April 21, 2014 Performing brain research that ... advances, University of Houston (UH) junior Khanh (Kate) Nguyen ... science students. A double major in mathematics and physics, ... M. Goldwater Scholarship. , One of the most ... provides funding to sophomore and junior students majoring in ...
Breaking Biology News(10 mins):NeuroPhage discovers GAIM-changing molecules to combat Alzheimer's and related diseases 2NeuroPhage discovers GAIM-changing molecules to combat Alzheimer's and related diseases 3First brain images of African infants enable research into cognitive effects of nutrition 2UH student named Goldwater Scholar, 2 more receive honorable mention 2UH student named Goldwater Scholar, 2 more receive honorable mention 3UH student named Goldwater Scholar, 2 more receive honorable mention 4
... and its consequent lack of access to care appears ... may partly explain the mortality disparity between African-Americans and ... Third AACR Conference on The Science of Cancer Health ... die within four years compared to white patients after ...
... African-American women with breast cancer living in Washington, D.C., ... of insurance type, socioeconomic status and cancer characteristics such ... an associate professor of epidemiology at The George Washington ... the impact of race and socioeconomic status on health ...
... ,Cincinnati, (OH) - The International Rett Syndrome Foundation ... $1.5M in research grants, bringing the 2010 total to ... that moves treatments for Rett syndrome a step closer ... private source of Rett syndrome research funding and with ...
Cached Biology News:Lack of private health insurance impacted cancer survival 2Racial differences in breast cancer treatment persist despite similar economics 2Research becomes a reality for Rett syndrome through new funding 2Research becomes a reality for Rett syndrome through new funding 3Research becomes a reality for Rett syndrome through new funding 4
(Date:1/15/2014)... PA (PRWEB) January 15, 2014 The Pittcon ... publisher of Food Safety Tech , an e-Journal and ... signed an agreement for the second year for the co-location ... Pittcon 2014. The partnership provides that the registration fee to ...
(Date:1/15/2014)... Look inside the new Preferred Solutions® ... lab, from fluid handling to instruments to supplies. Many ... you order. , Preferred Solutions features a full ... L/S® model for precise flow control and dispensing to ...
(Date:1/15/2014)... and SAN JOSE, California , January ... company developing antibody-drug conjugates for cancer, today announced the appointment ... Directors. Dr Reynolds has over 20 years, development experience gained ... at Seattle Genetics. "I am delighted to welcome ...
(Date:1/15/2014)... January 15, 2014 This webinar will ... and clinical safety assessment in biosimilars. , Regulatory frameworks ... biosimilar drug development, however the complex nature of biopharmaceuticals ... safety and efficacy extremely challenging. Based on the specific ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2
... , ROCKVILLE, Md. , Jan. ... today that it has successfully completed a pre-clinical safety and ...  Results from this study are needed to support an Investigational ... protein particle based RSV (RSV-F) vaccine candidate into clinical development. ...
... ... syndicated radio host Dr. Ken Kronhaus to educate about the need for vascular screening in ... carotid arteries for potential causes of stroke, the abdominal aorta for aneurysms, and the legs ... ...
... new antimalarial drugs after discovering the normal function of ... protein, which causes resistance to the front-line drug chloroquine. ... the malarial chloroquine-resistance factor. The study examined transporter ... cell. The genes for these proteins are present in ...
Cached Biology Technology:NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate 2NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate 3NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate 4NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate 5Life Line Screening and Dr. Ken Kronhaus Work Together to Educate People About Vascular Screening 2Life Line Screening and Dr. Ken Kronhaus Work Together to Educate People About Vascular Screening 3Discovery provides new drug targets for malaria cure 2
Animal Origin Free...
IHC Detection Kit (Broad Spectrum AEC)....
...
... Modification Services ,,GenScript offers many ... and antibody fragmentation. Labeling antibodies with ... visualization and quantitation of the target ... preferable to use only the antigen-binding ...
Biology Products: