Navigation Links
The dopamine transporter
Date:7/22/2014

een de novo mutations in the dopamine transporter and Parkinsonism in adults.

The study found that mutations can produce typical effects including debilitating tremors, major loss of motor control, and depression. The study also provides additional support for the idea that dopamine transporter mutations are a risk factor for attention deficit hyperactivity disorder (ADHD).

After identifying the dopamine transporter as the mutated gene linked to Parkinson's, researchers once again turned to the Harel Weinstein Lab due to its long-standing interest and investment in studying the human dopamine transporter.

Sahai's simulations using XSEDE and TACC's Stampede supercomputer supported clinical trials by offering greater insight into how the dopamine transporter is involved in neurological disorders.

"This research is very important to me," Sahai said. "I was able to look at the structure of the dopamine transporter on behalf of experimentalists and understand how irregularities in this protein are harming an actual person, instead of just looking at something isolated on a computer screen."

While there is currently no cure for Parkinson's disease, a deeper understanding of the specific mechanisms behind it will help the seven to ten million people afflicted with the disease.

"Like my work on drug abuse, the end goal is thinking about how we can help people. And it all comes back to drug design," Sahai said.


'/>"/>

Contact: Faith Singer-Villalobos
faith@tacc.utexas.edu
512-232-5771
University of Texas at Austin, Texas Advanced Computing Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Zhichan decoction increases dopaminergic neurons from transplanted NSCs in PD
2. Protective effect of α-synuclein knockdown on dopaminergic neurons
3. Dopamine turns worker ants into warrior queens
4. Dopamine-receptor gene variant linked to human longevity
5. Unlocking the therapeutic potential of SLC13 transporters
6. Cholesterol transporter structure decoded
7. ABC transporters enable leaf beetle larvae to accumulate defensive precursors when feeding
8. How bacteria integrate autotransporters into their outer membrane
9. More food and greener farming with specialised transporters for plants
10. Sodium transporter appears likely target for treating salt-sensitive hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The dopamine transporter
(Date:10/29/2014)... their types and numbers of bugs and bacteria ... the difference between a closed case and an ... a more than $866,000 U.S. Department of Justice ... changing populations. The microbial communities may provide crucial ... race, socioeconomic relations and more, said Eric Benbow, ...
(Date:10/29/2014)... as ,facultative, form part—together with other cells—of tissues and ... from the others. However, they have a very special ... cells again. This phenomenon is something that happens in ... tissue growth, thus allowing the regeneration of the organ ... the underlying mechanism that allows these cells to retain ...
(Date:10/29/2014)... October 27, 2014 — Cambridge, MA and Hebei, China ... the complete, high quality sequencing of the Jujube genome. ... Rhamnaceae family, and the Jujube genome is particularly difficult ... other complicating factors. It is the first time that ... sequenced. This study has been recently published in ...
Breaking Biology News(10 mins):MSU partners with Detroit to investigate death scenes 2A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2BGI Tech and Hebei Agricultural University complete the genome sequencing of the jujube tree 2
... [Brown University] In India most people who are HIV ... cheap and available. It would therefore meet international standards of ... to test every person in the billion-plus population every five ... PLoS One . The findings are based on ...
... meet June 16-19, 2013 at the Best Western Ramkota Rapid ... as the Entomological Society of America,s North Central Branch holds ... , Forests pests, such as the mountain pine ... pests such as the western corn rootworm, the soybean aphid, ...
... genome consortium, consisted of scientists from China Agricultural University, ... the genome sequencing and analysis of the duck ( ... A viruses, which caused a new epidemic in China ... and provides an invaluable resource for unraveling the interactive ...
Cached Biology News:Cost-effective: Universal HIV testing in India 2Cost-effective: Universal HIV testing in India 3Cost-effective: Universal HIV testing in India 4The duck genome provides new insight into fighting bird flu 2
(Date:10/27/2014)... October 27, 2014 The report ... Intelligent Traffic Management, Communication, Monitoring), and by Display ... to 2019” segments the global market into various ... It also identifies the drivers and restraints for ... challenges. , Browse 75 market tables and 37 ...
(Date:10/27/2014)... Pa. , Oct. 27, 2014 ... Foundation of America (CCFA) announced today the launch ... , an educational campaign designed to ... diseases (IBD) on the paired role of nutrition ... To view the multimedia assets associated with this ...
(Date:10/26/2014)... (PRWEB) October 26, 2014 The ... Routers, ADC, Network Security Equipment, WAN Optimization Appliances]: ... and segments the data center networking market into ... of revenues. The report also identifies the factors ... opportunities impacting it along with the future roadmaps. ...
(Date:10/25/2014)... 25, 2014 The report “Adipic ... by Geography - Global Trends & Forecast to ... respect to market drivers, opportunities, and trends in ... and 27 figures spread through 217 slides and ... Trends & Forecast to 2019”., http://www.marketsandmarkets.com/Market-Reports/adipic-acid-269.html , ...
Breaking Biology Technology:Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 2Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 3Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 4
... March 5 AcroMetrix, a global leader ... and serological,diagnostics, announced today that it has ... for the development and supply of molecular ... AcroMetrix provides In Vitro Diagnostic manufacturers and ...
... NeoStem, Inc. (Amex: NBS ),which is pioneering ... cells for future medical need, today announced that,Denis Rodgerson, ... The University of Nevada Las Vegas campus this evening. ... of adult stem,cell collection centers into Las Vegas, the ...
... industry insiders respectively serve, pressing industry needs to ... ... WASHINGTON, March 5 Logos Press announces two new ... education. These new books respectively serve,pressing needs to empower ...
Cached Biology Technology:AcroMetrix Signs Development and Supply Agreement With Beckman Coulter Inc. for Molecular Quality Control Standards 2NeoStem's Denis Rodgerson, Ph.D. to Lecture on Stem Cells and Regenerative Medicine at University of Nevada Las Vegas Campus 2NeoStem's Denis Rodgerson, Ph.D. to Lecture on Stem Cells and Regenerative Medicine at University of Nevada Las Vegas Campus 3New Books on Best Practices in Biotechnology Business Development and Biotechnology Education 2