Navigation Links
The dopamine transporter
Date:7/22/2014

een de novo mutations in the dopamine transporter and Parkinsonism in adults.

The study found that mutations can produce typical effects including debilitating tremors, major loss of motor control, and depression. The study also provides additional support for the idea that dopamine transporter mutations are a risk factor for attention deficit hyperactivity disorder (ADHD).

After identifying the dopamine transporter as the mutated gene linked to Parkinson's, researchers once again turned to the Harel Weinstein Lab due to its long-standing interest and investment in studying the human dopamine transporter.

Sahai's simulations using XSEDE and TACC's Stampede supercomputer supported clinical trials by offering greater insight into how the dopamine transporter is involved in neurological disorders.

"This research is very important to me," Sahai said. "I was able to look at the structure of the dopamine transporter on behalf of experimentalists and understand how irregularities in this protein are harming an actual person, instead of just looking at something isolated on a computer screen."

While there is currently no cure for Parkinson's disease, a deeper understanding of the specific mechanisms behind it will help the seven to ten million people afflicted with the disease.

"Like my work on drug abuse, the end goal is thinking about how we can help people. And it all comes back to drug design," Sahai said.


'/>"/>

Contact: Faith Singer-Villalobos
faith@tacc.utexas.edu
512-232-5771
University of Texas at Austin, Texas Advanced Computing Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Zhichan decoction increases dopaminergic neurons from transplanted NSCs in PD
2. Protective effect of α-synuclein knockdown on dopaminergic neurons
3. Dopamine turns worker ants into warrior queens
4. Dopamine-receptor gene variant linked to human longevity
5. Unlocking the therapeutic potential of SLC13 transporters
6. Cholesterol transporter structure decoded
7. ABC transporters enable leaf beetle larvae to accumulate defensive precursors when feeding
8. How bacteria integrate autotransporters into their outer membrane
9. More food and greener farming with specialised transporters for plants
10. Sodium transporter appears likely target for treating salt-sensitive hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The dopamine transporter
(Date:9/21/2014)... such as mussels and barnacles secrete very sticky proteins ... even underwater. Inspired by these natural adhesives, a team ... be used to repair ships or help heal wounds ... adhesives, the MIT researchers engineered bacteria to produce a ... well as a bacterial protein found in biofilms ...
(Date:9/19/2014)... new resource unveiled today by researchers from several ... Dublin provides both experienced and aspiring researchers with ... and operate robots made from soft, flexible materials. ... laser cutters, and other advances in manufacturing technology, ... field. Using principles drawn from conventional rigid robot ...
(Date:9/19/2014)... the sake of fairness per se but in order ... Frans de Waal, PhD, and Sarah Brosnan, PhD, co-authors ... is defined as a negative reaction to unequal outcomes. ... , Their conclusion comes after the co-authors reviewed more ... it is the evolution of forestalling partner dissatisfaction with ...
Breaking Biology News(10 mins):Engineered proteins stick like glue -- even in water 2Engineered proteins stick like glue -- even in water 3Soft robotics 'toolkit' features everything a robot-maker needs 2Evolution of responses to (un)fairness 2Evolution of responses to (un)fairness 3
... unknown movements of a set of specialized cells, Whitehead ... immune system mounts a successful defense against hostile, ever-changing ... the activity inside structures known as germinal centers (GCs), ... of a foreign virus or bacteria. Within the GCs, ...
... In a study published in Cell Research , ... the genome sequencing and analysis of the endangered Chinese ... published crocodilian genome, providing a good explanation of how ... determination (TSD). The Chinese alligator is a ...
... The Netherlands , August 9, 2013 ... employment market, recruiters and HR specialists need to increase ... Microsoft Dynamics and WCC ELISE for organisations keen to ... Today,s recruiters must grapple with ever-increasing amounts ...
Cached Biology News:Helper cells aptly named in battle with invading pathogens 2Whole-genome sequencing uncovers the mysteries of the endangered Chinese alligator 2Most Efficient Matching in Recruitment With CRMATCH and ELISE 2
(Date:9/18/2014)... BELLINGHAM, Washington, USA (PRWEB) September 18, 2014 ... of Representatives of a bill designed to stimulate development ... high-value jobs is being praised by leaders of ... The bill, the Revitalizing American Manufacturing and Innovation (RAMI) ... vote. The bill’s authors have said they are optimistic ...
(Date:9/18/2014)... 2014 /PRNewswire-iReach/ -- DeepResearchReports.com adds "2014 Deep Research ... and "2014 Deep Research Report on Global and ... database. Photo - http://photos.prnewswire.com/prnh/20140918/147058 ... Global and China Acetic Acid Industry" is a ... China and Global Acetic Acid Market. ...
(Date:9/18/2014)... Ireland , September 18, 2014 ... and Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has ... "Biocompatible Materials - Global Strategic Business ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes ... in US$ Million by the following ...
(Date:9/18/2014)... , Sept. 18, 2014 Research ... "Global and Chinese Stem Cell Industry Report, 2014-2017" ... cells are undifferentiated biological cells that can differentiate into ... more stem cells. Stem cell therapy can be applied ... hematological system disease), nervous system diseases, damage or lesion ...
Breaking Biology Technology:House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3
... 96 temperature,cyclers , Michelle Cayouette Jane ... ,Stratagene Cloning Systems, Inc. , With the introduction of ... 96 temperature cyclers, researchers can begin running oil-free,PCR ... is supplied,with a software upgrade card, which provides more ...
... , Novel method streamlines blood DNA purification for PCR applications , ... , , ... , Stratagene , , ... Using the new DNA Stat blood kit, it is easy , ...
... protein purification and native eukaryotic amino acid ... John Bauer ,Stratagene Cloning Systems, Inc. ... system features rapid and high-yield,production of recombinant ... (LIC) for efficient and directional cloning of ...
Cached Biology Technology:Oil-Free PCR Using the Hot Top Assembly 2Oil-Free PCR Using the Hot Top Assembly 3Oil-Free PCR Using the Hot Top Assembly 4Oil-Free PCR Using the Hot Top Assembly 5Oil-Free PCR Using the Hot Top Assembly 6Oil-Free PCR Using the Hot Top Assembly 7Fast and Easy Isolation of PCR-Ready Genomic DNA from Whole Blood 2Fast and Easy Isolation of PCR-Ready Genomic DNA from Whole Blood 3Fast and Easy Isolation of PCR-Ready Genomic DNA from Whole Blood 4Fast and Easy Isolation of PCR-Ready Genomic DNA from Whole Blood 5New Yeast Cloning System for Producing Proteins with Native Amino Acid,Sequences 2New Yeast Cloning System for Producing Proteins with Native Amino Acid,Sequences 3New Yeast Cloning System for Producing Proteins with Native Amino Acid,Sequences 4New Yeast Cloning System for Producing Proteins with Native Amino Acid,Sequences 5
... Microsphere/Microarray Stabilizer is an aqueous solution that ... non-toxic chemicals in a PBS buffer (phosphate ... This product contains a combination of 0.02% ... StabilCoat Plus Stabilizer provides optimum performance ...
... The mini incubation trays are ... to screen antigens that have ... Each tray has eight 10.5 ... that accommodate strips cut from ...
... Protein Purification Plates are designed for quick ... The 96-well plates feature two 0.25mm holes ... each well. The wells remain liquid-tight during ... during which time the protein diffuses from ...
... 20 Plasma Immunodepletion Kit specifically removes 20 ... plasma or serum in preparation for further ... into the plasma proteome whether you use ... chromatography or go straight to mass spectrometry. ...
Biology Products: