Navigation Links
The dopamine transporter
Date:7/22/2014

To further understand the effects of drug abuse, Sahai and other researchers in the Harel Weinstein Lab at Cornell are delving into drug interactions on a molecular level.

Using supercomputer resources, she is able to observe the binding of dopamine and various drugs to a 3D model of the dopamine transporter on a molecular level. According to Sahai, the work requires very long simulations in terms of microseconds and seconds to understand how drugs interact with the transporters.

Through the Extreme Science and Engineering Discovery Environment (XSEDE), a virtual cyberinfrastructure that provides researchers access to computing resources, Sahai performs these simulations on Stampede, the world's 7th fastest supercomputer, at the Texas Advanced Computing Center (TACC).

"XSEDE-allocated resources are fundamental to helping us understand of how drugs work. There's no way we could perform these simulations on the machines we have in house. Through TACC as an XSEDE service provider, we can also expect an exponential increase in computational results, and good customer service and feedback."

Ultimately, Sahai's research will contribute to an existing body of work that is attempting to develop a cocaine binding inhibitor without suppressing the dopamine transporter.

"If we can understand how drugs bind to the dopamine transporter, then we can better understand drug abuse and add information on what's really important in designing therapeutic strategies to combat addiction," Sahai said.

A Common Link in the Research

While Sahai is still working to understand drug abuse, her simulations of the dopamine transporter have contributed to published research on Parkinson's disease and other neurological disorders.

In a collaborative study with the University of Copenhagen, Copenhagen University Hospital, and other research groups in the U.S. and Europe, researchers revealed the first known link betw
'/>"/>

Contact: Faith Singer-Villalobos
faith@tacc.utexas.edu
512-232-5771
University of Texas at Austin, Texas Advanced Computing Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Zhichan decoction increases dopaminergic neurons from transplanted NSCs in PD
2. Protective effect of α-synuclein knockdown on dopaminergic neurons
3. Dopamine turns worker ants into warrior queens
4. Dopamine-receptor gene variant linked to human longevity
5. Unlocking the therapeutic potential of SLC13 transporters
6. Cholesterol transporter structure decoded
7. ABC transporters enable leaf beetle larvae to accumulate defensive precursors when feeding
8. How bacteria integrate autotransporters into their outer membrane
9. More food and greener farming with specialised transporters for plants
10. Sodium transporter appears likely target for treating salt-sensitive hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The dopamine transporter
(Date:4/27/2015)... FORT LAUDERDALE, Fla. , Apr. 27, 2015 /PRNewswire/ ... provider of access control and security systems is pleased ... joined the company as a consultant and member of ... Bedore is widely known as a thought leader ... Socrates Distance Learning Technology Group, and has published studies ...
(Date:4/14/2015)... April 14, 2015  HYPR Corp. today announced ... ® ) Alliance tm , an industry consortium ... commit to share technology and collaborate to deliver ... interoperable, more secure and private, and easier to ... verification that protects sensitive user information and eliminates ...
(Date:4/9/2015)... JOSE, Calif. , April 9, 2015 ... human interface solutions, announced today that it will report ... on Thursday, April 23, 2015, after the close of ... for analysts and investors at 2:00 p.m. PT (5:00 ...   To participate on the live call, ...
Breaking Biology News(10 mins):Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Synaptics to Report Third Quarter Results on April 23 2
... Stanford University is subjecting chunks of rock to hellish conditions ... climate change. By exposing a handful of ... critical new data about the large-scale underground storage of carbon ... warming. "About 60 percent of the world,s ...
... with children embrace religious traditions for social and personal ... University at Buffalo -- The State University of New ... some atheist scientists want their children to know about ... about their own religious preferences. "Our research shows ...
... a key to weight loss a no-brainer. But now, ... couch potato, stretched out in front of the TV, can ... on the pounds. Such inactivity actually encourages the body ... Gefen of TAU,s Department of Biomedical Engineering. Along with his ...
Cached Biology News:AGU meeting: Stanford scientists subject rocks to hellish conditions to combat global warming 2AGU meeting: Stanford scientists subject rocks to hellish conditions to combat global warming 3AGU meeting: Stanford scientists subject rocks to hellish conditions to combat global warming 4Some atheist scientists with children embrace religious traditions, according to new Rice research 2'Just chill?' Relaxing can make you fatter 2
(Date:5/21/2015)... (PRWEB) May 21, 2015 Patent Offering, ... method for diagnostic or therapeutic imaging within a body ... uses an endoscope having a low cost, single-use disposable ... filing date was October 18, 2013 and the patent ... technology enables the physician to customize the lighting and ...
(Date:5/21/2015)... , May 20, 2015 Research and ... the addition of the "2015 Global Survey ... their offering. The primary goal of ... flow cytometry instruments and reagents. Key information the ... the selection of flow cytometers, predominantly used applications ...
(Date:5/21/2015)... King of Prussia, PA (PRWEB) May 21, 2015 ... that Julia O’Neill has joined the firm as senior ... more than 30 years of experience in the management ... the vaccines, biologics, pharmaceutical and chemical industries. , “We’re ... enhance our longstanding capabilities in data analytics,” said Dr. ...
(Date:5/20/2015)... 20, 2015 This year has been ... lawns. US Patented Pearl’s Premium Ultra Low Maintenance ... the country that are coming out of record bad ... number of major global concerns related to water, health, ... – the alternative to the standard, water-wasting, chemical-treated standard ...
Breaking Biology Technology:IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3Global Survey on Flow Cytometry Adoption Trends 2015 2Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Breakthrough 4th Generation Low Maintenance Lawn Seed Offers Solution to California Drought 2
... of discovery and safety services to, meet ... development community, BOSTON and CLEVELAND, Aug. 6 ... cell lines and,services for drug-discovery and development applications, ... lines available to researchers,through a new Web site: ...
... ... alternatives, WALTHAM, Mass., ... that the Company is focusing its,day-to-day operations exclusively on obtaining financing ... cash,resources, the Company,s employees were released from employment, except,for Shawn Cain, ...
... 5 Replidyne, Inc.,(Nasdaq: RDYN ) today announced its ... 30, 2008., Replidyne reported a net loss of $18.7 ... loss per basic and diluted common share of $0.69,per share, ... basic,common share or $1.65 per common share on a fully ...
Cached Biology Technology:ChanTest Launches New Business to Provide Validated Ion Channel Expressing Cell Lines to the Research Community 2ChanTest Launches New Business to Provide Validated Ion Channel Expressing Cell Lines to the Research Community 3Arbios Announces It Has Suspended Operations 2Arbios Announces It Has Suspended Operations 3Arbios Announces It Has Suspended Operations 4Arbios Announces It Has Suspended Operations 5Replidyne Announces Second Quarter 2008 Results From Operations 2Replidyne Announces Second Quarter 2008 Results From Operations 3Replidyne Announces Second Quarter 2008 Results From Operations 4Replidyne Announces Second Quarter 2008 Results From Operations 5Replidyne Announces Second Quarter 2008 Results From Operations 6Replidyne Announces Second Quarter 2008 Results From Operations 7
Request Info...
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed. Free windows version for academic use....
... Services are uniquely positioned to ... current competitive environment. Invitrogens experts ... express, purify, and characterize proteins ... Studies, Activity Assays, X-ray Crystallography, ...
... Standard Tray (3 per pack), 1. ... and blot processing.Automated staining of Coomassie ... and nucleic acid analysis.Prepares blots for ... detection.Programmable control of protocol, solution, volume, ...
Biology Products: