Navigation Links
The dietary supplement genistein can undermine breast cancer treatment
Date:9/23/2008

CHAMPAIGN, Ill. Women taking aromatase inhibitors to treat breast cancer or prevent its recurrence should think twice before also taking a soy-based dietary supplement, researchers report.

Genistein, a soy isoflavone that mimics the effects of estrogen in the body, can negate the effectiveness of aromatase inhibitors, which are designed to reduce the levels of estrogens that can promote tumor growth in some types of breast cancer.

The new study, which included researchers from the University of Illinois, Virginia Polytechnic and State University and the National Center for Toxicological Research, appears in the journal Carcinogenesis.

Aromatase inhibitors are a mainstay of breast cancer treatment in post-menopausal women. These drugs work by interfering with the enzyme aromatase, which catalyzes a crucial step in converting precursor molecules to estradiol, the main estrogen in the body.

About two-thirds of all cases of breast cancer diagnosed in the U.S. are estrogen dependent or estrogen sensitive, which means that the tumors grow more rapidly in the presence of estrogen.

Most women diagnosed with breast cancer are post-menopausal, so their ovaries are no longer producing normal levels of estrogen. Other tissues, however, produce a steroid hormone, androstenedione (AD), which with the help of aromatases is converted to testosterone and estrogens. The estrogens produced from AD can stimulate the growth of some types of breast cancer tumors.

The researchers conducted several trials in a mouse model of estrogen-dependent post-menopausal breast cancer. First, they gave the mice AD, which was converted to estrogen and created a high estrogen environment.

This helped the researchers determine the maximum growth rate of the breast cancer tumors.

Next, they added Letrozole, an aromatase inhibitor widely prescribed to post-menopausal women with estrogen-dependent breast cancer. Th
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Researchers uncover details about how dietary restriction slows down aging
2. Market testing of dietary supplements and drugs underscores value of USPs public health programs
3. Changing the global dietary environment
4. Dietary calcium could possibly prevent the spread of breast cancer to bone
5. UF scientists reveal how dietary restriction cleans cells
6. L-1 Identity Solutions to Hold Supplemental Second Quarter 2008 Financial Results Q&A Conference Call at 2:00p.m. (ET) Today
7. Researchers identify cancer preventive properties in common vitamin supplement
8. A nutritional supplement could improve the clinical situation of ICU patients
9. People with diabetes may have all natural citrus supplement
10. Wellmune WGP supplementation alleviates
11. Pediatricians alerted to the developmental nature of underage drinking in special journal supplement
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The dietary supplement genistein can undermine breast cancer treatment
(Date:4/18/2014)... of researchers led by a University of California, Riverside ... $7.5 million Department of Defense grant to uncover fundamental ... for the predictable design of light-weight, tough and strong ... from plants and animals, including the mantis shrimp, toucan ... have constructed over millions of years and coming up ...
(Date:4/17/2014)... April 17, 2014The development of stem cell therapies to ... to characterize stem cell populations based on cell surface ... a new marker that is highly expressed in a ... blood, which they describe in an article in ... Ann Liebert, Inc., publishers. The article is available free ...
(Date:4/17/2014)... hundred births, Down syndrome - or trisomy 21 - ... It results from a chromosomal abnormality where cells of ... (1% of the human genome). A study conducted by ... Genetic Medicine and Development at the University of Geneva ... shed light on how the extra chromosome 21 upsets ...
Breaking Biology News(10 mins):Mantis shrimp, toucan and trilobite, oh my 2Mantis shrimp, toucan and trilobite, oh my 3Trisomy 21: How an extra little chromosome throws the entire genome off balance 2Trisomy 21: How an extra little chromosome throws the entire genome off balance 3
... medicine, when a depressed person visits a psychiatrist for treatment ... that they will respond to the medication they are prescribed. ... response in individual patients. It would be very ... predict the likelihood that individual patients would respond to specific ...
... from cells of the embryonic nervous system. The ... range from spontaneous regression to fatal outcomes. Highly ... and overcoming the resistance mechanisms of highly aggressive ... effective treatments. Scientists from the department ...
... unchanged over the past 60 years, a physicist is trying ... different theory of its origin that traces cancer back to ... In this month,s special issue of ... Davies, principal investigator at Arizona State University,s Center for Convergence ...
Cached Biology News:A calculator to estimate the likelihood of antidepressant response 2Neuroblastoma: Autophagy protects from chemotherapy 2Cancer is a result of a default cellular 'safe mode,' physicist proposes 2
(Date:1/15/2014)... 15, 2014 Two champions of science, ... sponsorship of an annual competition for middle and high ... to, innovative STEM study. The competition presents students with ... of Engineering Aptitude, Mathematics, and Sciences is a ...
(Date:1/15/2014)... January 15, 2014 DTS Language Services, ... Online Web Portal for Life Science organizations who need document ... the subject matter of their documents in advance with a ... reduce time-to-delivery of translations, often a critical factor in clinical ...
(Date:1/15/2014)... CA (PRWEB) January 15, 2014 ... research solutions, today announced that Lupin Limited, one of ... Freeslate’s CM Protégé PharmD System for high ... Mumbai, India, is focused on a wide range of ...
(Date:1/15/2014)... , Jan. 15, 2014 TaiGen Biotechnology Company, ... exclusive agreement with R-Pharm, a leading Russian pharmaceutical company, ... the Russian Federation , ... Independent States (CIS). Nemonoxacin is a novel antibiotic for the ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5DTS Improves Efficiency for Life Science Document Translations 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... April 23, 2012 Ahram Biosystems, Inc., a leading innovator ... Palm PCR F1-12, the economy model of its innovative portable ... PCR system, delivering PCR amplification with high speed and sensitivity ... PCR F1-12 system provides three " Standard Fast" speed ...
... 2012  The American Telemedicine Association is pleased to host ... 1 in San Jose, California ( www.ata2012.com ).  ATA ... covering all aspects of telemedicine, telehealth, mHealth and remote ... telemedicine, or you,re a seasoned professional, ATA 2012 provides ...
... a pair of information-carrying molecules: DNA and RNA. These ... they display hereditymeaning they can encode and pass on ... processes of Darwinian evolution. A long-debated question ... molecules other than DNA and RNA. John ...
Cached Biology Technology:Ahram Biosystems Announces Launch of the New Economy Model F1-12 of Its Palm PCR Series 2Free Expo-Hall Passes for ATA 2012 2Strange cousins: Molecular alternatives to DNA, RNA offer new insight into life's origins 2Strange cousins: Molecular alternatives to DNA, RNA offer new insight into life's origins 3Strange cousins: Molecular alternatives to DNA, RNA offer new insight into life's origins 4
BAI-1 (T-20)...
MOUSE ANTI HUMAN CYTOKERATIN 1-8...
GOAT ANTI HUMAN PSA (ISOFORM 1)...
... ZMD.437. Immunogen: Synthetic peptide derived from ... and rat ZO-1. Specificity: Specific for ... protein. Reactivity: Human Dog Rat Mouse ... cells frozen mouse liver heart blood vessel ...
Biology Products: