Navigation Links
The compound in the Mediterranean diet that makes cancer cells 'mortal'
Date:5/20/2013

ells. We think this can have great value clinically as a potential cancer-prevention strategy."

Doseff oversaw this work with co-lead author Erich Grotewold, professor of molecular genetics and director of Ohio State's Center for Applied Plant Sciences (CAPS). The two collaborate on studying the genomics of apigenin and other flavonoids, a family of plant compounds that are believed to prevent disease.

The research appears this week in the online early edition of the journal Proceedings of the National Academy of Sciences.

Though finding that apigenin can influence cancer cell behavior was an important outcome of the work, Grotewold and Doseff point to their new biomedical research technique as a transformative contribution to nutraceutical research.

They likened the technique to "fishing" for the human proteins in cells that interact with small molecules available in the diet.

"You can imagine all the potentially affected proteins as tiny fishes in a big bowl. We introduce this molecule to the bowl and effectively lure only the truly affected proteins based on structural characteristics that form an attraction," Doseff said. "We know this is a real partnership because we can see that the proteins and apigenin bind to each other."

Through additional experimentation, the team established that apigenin had relationships with proteins that have three specific functions. Among the most important was a protein called hnRNPA2.

This protein influences the activity of messenger RNA, or mRNA, which contains the instructions needed to produce a specific protein. The production of mRNA results from the splicing, or modification, of RNA that occurs as part of gene activation. The nature of the splice ultimately influences which protein instructions the mRNA contains.

Doseff noted that abnormal splicing is the culprit in an estimated 80 percent of all cancers. In cancer cells, two types of splicing
'/>"/>

Contact: Pam Frost Gorder
Gorder.1@osu.edu
614-292-9475
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists map all possible drug-like chemical compounds
2. Compound stimulates tumor-fighting protein in cancer therapy
3. Beers bitter compounds could help brew new medicines
4. New compound overcomes drug-resistant Staph infection in mice
5. Promising compound restores memory loss and reverses symptoms of Alzheimers
6. A new breed of stable anti-aromatic compound
7. Compound in grapes, red wine could be key to fighting prostate cancer
8. Scientists identify insect-repelling compounds in Jatropha
9. Purple corn compound may aid in developing future treatments for Type 2 diabetes, kidney disease
10. Screening technique uncovers 5 new plant activator compounds
11. Mushroom-derived compound lengthens survival in dogs with cancer, Penn Vet study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... geologist Juliane Mller the Fram Strait is a key region ... this passage between Greenland and Svalbard warm Atlantic water flows ... west side cold Arctic water masses and sea ice push ... A considerable portion of the Atlantic water cools here on ... The circulation of the water caused in this manner drives ...
(Date:8/21/2014)... designed by an international standards process, will be available ... an invited review published in the OnlineFirst version of ... the official journal of the American Society for Parenteral ... reduce the occurrence of misconnection that can be harmful ... are used to join medical devices, components, and accessories ...
(Date:8/21/2014)... in severe abdominal pain, vomiting and systemic inflammation. Every ... with the disease resulting in 1000 deaths. There is ... fluid and nutritional support. , Dr Jason Bruce, ... research, said "The major causes of pancreatitis include bile ... combined with a high fat diet. In fact, the ...
Breaking Biology News(10 mins):Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3New feeding tube connectors will improve patient safety 2Insulin offers new hope for the treatment of acute pancreatitis 2
... Spanish . Making DNA sequences being passed through ... point that they take on the form of diminutive spaghetti. This ... of the lines of research in which CIC microGUNE is working, ... are shortly to apply for a patent. The technique basically consists ...
... New York / Heidelberg, 6 April 2011 The ... pads of many insects, lizards and spiders give them the ... James Bullock and Walter Federle from the University of Cambridge ... away these adhesive hairs from surfaces are what allows beetles ...
... used to rehabilitate the arms and hands of people who ... the University of Southampton. In a paper to be ... and Technology (IET) Assisted Living Conference, Dr Geoff Merrett, a ... and evaluation of three technologies which could help people who ...
Cached Biology News:DNA stretching -- A new technique being carried out at CIC microGUNE to detect illnesses 2Nature helps to solve a sticky problem 2Scientists develop new technology for stroke rehabilitation 2
(Date:8/22/2014)... Research and Markets has announced the addition ... Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - ... The global molecular biology enzymes market was ... to grow at a CAGR of 13.74% to reach ... reagents find applications in a large number of fields ...
(Date:8/22/2014)... August 22, 2014 The identification ... organisms can be accelerated by exome sequencing. Built ... technologies, the custom SeqCap EZ Developer system has ... Mr. Watson will additionally present how he achieved ... available human and mouse exome kits. With over ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 DNA vaccine ... progress in its development of JRC-LAMP-vax, an innovative and ... pollen. Phase IC studies began this month in Hawaii, ... hay fever. , The Japanese red cedar releases pollen ... in Japan. Mountain Cedar pollen wreaks similar havoc in ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 ... Fertilizer Industryā€¯ is a professional and in-depth ... The report provides basic Seaweed Fertilizer information, ... industry chain structure as well as industry ... analysis, including domestic market as well as ...
Breaking Biology Technology:Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 3Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3
... Sequence Analysis Problem -, - Exhibit to Spotlight ... MISSION VIEJO, Calif., Sept. 26 Supporting ... genomic search,technology, SLIM Search, Inc. announces it is ... Next Generation,Sequencing Conference. The conference will review new ...
... Phil Coggins to Continue as President and CSO, ... Osprey,Pharmaceuticals, Ltd., a privately held biotechnology company developing,first-in-class ... today the appointment of Jack M. Anthony to ... the position of,CEO will continue as President and ...
... September 26 XTL,Biopharmaceuticals Ltd. (NASDAQ: XTLB ... September 24, 2007, the Company received a NASDAQ ... with the minimum,$10 million shareholders, equity requirement for ... forth in Marketplace Rule 4450(a)(3), and that,its ADRs ...
Cached Biology Technology:SLIM Search, Inc. Sponsors Next Generation Sequencing Conference for the Biomedical Market 2SLIM Search, Inc. Sponsors Next Generation Sequencing Conference for the Biomedical Market 3SLIM Search, Inc. Sponsors Next Generation Sequencing Conference for the Biomedical Market 4Osprey Pharmaceuticals Names Jack M. Anthony as CEO 2Osprey Pharmaceuticals Names Jack M. Anthony as CEO 3XTL to Appeal NASDAQ Staff Determination; XTL May Transfer its ADR Listing to the NASDAQ Capital Market 2XTL to Appeal NASDAQ Staff Determination; XTL May Transfer its ADR Listing to the NASDAQ Capital Market 3
GM130 Immunogen: Recombinant purified rat GM130 Family / Subclass 1: Signal Transduction Storage: 4 C...
NATIVE RAT OSTEOCALCIN...
... Specifications(L x W x H): 17 ... 5/16"18.7 lbsCapacity: 12 slidesTime: Programmable 0 - ... denaturation and hybridization steps 40 user programmable ... and Fixed temperature) Rapid temperature ramp-up from ...
Defender against cell death 1...
Biology Products: