Navigation Links
The compound in the Mediterranean diet that makes cancer cells 'mortal'
Date:5/20/2013

ells. We think this can have great value clinically as a potential cancer-prevention strategy."

Doseff oversaw this work with co-lead author Erich Grotewold, professor of molecular genetics and director of Ohio State's Center for Applied Plant Sciences (CAPS). The two collaborate on studying the genomics of apigenin and other flavonoids, a family of plant compounds that are believed to prevent disease.

The research appears this week in the online early edition of the journal Proceedings of the National Academy of Sciences.

Though finding that apigenin can influence cancer cell behavior was an important outcome of the work, Grotewold and Doseff point to their new biomedical research technique as a transformative contribution to nutraceutical research.

They likened the technique to "fishing" for the human proteins in cells that interact with small molecules available in the diet.

"You can imagine all the potentially affected proteins as tiny fishes in a big bowl. We introduce this molecule to the bowl and effectively lure only the truly affected proteins based on structural characteristics that form an attraction," Doseff said. "We know this is a real partnership because we can see that the proteins and apigenin bind to each other."

Through additional experimentation, the team established that apigenin had relationships with proteins that have three specific functions. Among the most important was a protein called hnRNPA2.

This protein influences the activity of messenger RNA, or mRNA, which contains the instructions needed to produce a specific protein. The production of mRNA results from the splicing, or modification, of RNA that occurs as part of gene activation. The nature of the splice ultimately influences which protein instructions the mRNA contains.

Doseff noted that abnormal splicing is the culprit in an estimated 80 percent of all cancers. In cancer cells, two types of splicing
'/>"/>

Contact: Pam Frost Gorder
Gorder.1@osu.edu
614-292-9475
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists map all possible drug-like chemical compounds
2. Compound stimulates tumor-fighting protein in cancer therapy
3. Beers bitter compounds could help brew new medicines
4. New compound overcomes drug-resistant Staph infection in mice
5. Promising compound restores memory loss and reverses symptoms of Alzheimers
6. A new breed of stable anti-aromatic compound
7. Compound in grapes, red wine could be key to fighting prostate cancer
8. Scientists identify insect-repelling compounds in Jatropha
9. Purple corn compound may aid in developing future treatments for Type 2 diabetes, kidney disease
10. Screening technique uncovers 5 new plant activator compounds
11. Mushroom-derived compound lengthens survival in dogs with cancer, Penn Vet study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2015)... 19, 2015 Research ... addition of the  "Genetic Testing Market Outlook ... http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent report, Genetic Testing ... of the current and future genetic testing ... their working principles and types are covered ...
(Date:5/14/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/5whpxg/fingerprint ... Sensors Market in Smart Mobile Devices " report ... 2014 was a watershed year for fingerprint sensors in ... Pay,. Apple gave fingerprint sensors a raison d,etre in ... sensors are a must-have feature in flagship smartphones. ...
(Date:5/11/2015)... 11, 2015  Synaptics Incorporated (NASDAQ: SYNA ... today announced the appointment of Wajid Ali ... Officer, reporting to Rick Bergman , President ... Financial Officer, Kathleen Bayless , who announced ... Mr. Ali brings extensive financial management expertise to ...
Breaking Biology News(10 mins):Global Genetic Testing Market Outlook 2018 2Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... Spring Harbor Laboratory will host the inaugural conference ... project to create a virtual center in cyberspace ... conference, titled "Bringing Plant and Computing Scientists Together ... for April 7-9, 2008, will take the first ...
... DALLAS April 4, 2008 Researchers at UT ... method to screen small synthetic molecules and pull out ... less expensively than current methods. In one screen ... new technique quickly singled out five promising candidates that ...
... tablets, might not be that beneficial for the majority ... access journal Genome Biology. Although this trace element is ... we have lost some of the need for selenium, ... plasma, when our evolutionary ancestors left the oceans and ...
Cached Biology News:iPlant Kickoff Conference at CSHL begins tackling plant biology's grand challenges 2iPlant Kickoff Conference at CSHL begins tackling plant biology's grand challenges 3Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find 2Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find 3Supplements are not nutritious 2
(Date:5/29/2015)... Delcath Systems, Inc. (NASDAQ: DCTH ... focused on oncology with an emphasis on the ... that results of a large, European single-center experience ... hepatic metastases with the Delcath Hepatic CHEMOSAT ® ... abstract at the American Society of Clinical Oncology ...
(Date:5/29/2015)... , May 28, 2015 Research and ... of Jain PharmaBiotech,s new report "Cytogenetics - ... This report deals with cytogenetics in ... mainly to describe the chromosome structure and identify ... molecular biology, it is also referred to as ...
(Date:5/29/2015)... Translation is frequently listed as one of the ways ... in a way that is right for a company, translation ... or service offering. , Here are some of the ... a company's bottom line: , 1.    Attract bigger audience. , With ... use, why not offer it globally? Nelson Mandela once said: ...
(Date:5/28/2015)... , May 28, 2015 ... ) has announced the addition of ... - Technologies, Markets and Companies"  to ... ,This report describes and evaluates animal ... medicine and pharmaceuticals as well as ...
Breaking Biology Technology:Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 2Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 3Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 4Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 5Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 2Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 3Three Ways Translation Can Help Businesses Grow 2Global Animal Biotechnology Report 2015 - Technologies, Markets and Companies Analysis to 2024 2Global Animal Biotechnology Report 2015 - Technologies, Markets and Companies Analysis to 2024 3
... Avigen,s decision to return capital to stockholders through ... 27 Biotechnology Value Fund, L.P. ("BVF"), today ... AVGN ) voted overwhelmingly to remove the existing ... with BVF,s nominees. The vote took place earlier ...
... 19% Increase In Total Revenue To $5.6 Million; 34% ... -- International Isotopes Inc. (OTC Bulletin Board: ... December 31, 2008. Total Revenue . ... $4,690,588 in 2007, which represents an increase of $911,885 ...
... Bavarian,Nordic published the company,s Annual Report 2008. The report ... Bavarian Nordic,s revenue for the ... tax of DKK 183 million, which was in line ... cash and cash equivalents stood,at DKK 796 million. For ...
Cached Biology Technology:Biotechnology Value Fund, L.P. Announces Overwhelming Support to Remove the Board of Directors of Avigen, Inc. at Special Meeting of Stockholders 2International Isotopes Inc. Announces Year End Financial Results 2International Isotopes Inc. Announces Year End Financial Results 3International Isotopes Inc. Announces Year End Financial Results 4Bavarian Nordic Publishes its Annual Results 2008 2Bavarian Nordic Publishes its Annual Results 2008 3Bavarian Nordic Publishes its Annual Results 2008 4Bavarian Nordic Publishes its Annual Results 2008 5Bavarian Nordic Publishes its Annual Results 2008 6Bavarian Nordic Publishes its Annual Results 2008 7
... clear polystyrene with frosted labeling surfaces, ... cell counting. 100% integrity tested. Linkage: ... product number, created to easily match ... availability yet, please order under the ...
... The Corning CellBIND surface is produced by ... more hydrophilic surface giving more consistent, even ... CellBIND enhances cell attachment and growth uunder ... medium. • CellBIND may provide a more ...
... The Bio-Plex suspension array system, 100-240 ... analysis of up to 100 proteins and ... array is composed of up to 100 ... be conjugated with a unique reactant (enzyme ...
...
Biology Products: