Navigation Links
The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
Date:3/18/2012

Microglia are the first line defence of the brain and are constantly looking for infections to fight off. Overactive microglia can cause uncontrolled inflammation within the brain, which can in turn lead to neuronal damage. New research published in BioMed Central's open access journal Journal of Neuroinflammation shows that, honokiol (HNK) is able to down-regulate the production of pro-inflammatory cytokines and inflammatory enzymes in activated microglia via Klf4, a protein known to regulate DNA.

Scientists from the National Brain Research Centre, Manesar, India, used lipopolysaccharide (LPS), a molecule present on the surface of bacteria, to stimulate an immune response from microglia cells. LPS mimics the effect of a bacterial infection and the microglia cells spring into action, releasing proinflammatory cytokines, such as TNFa.

Activation of microglia also stimulates the production of nitric oxide (NO) and Cox-2, which co-ordinate the immune response, leading to inflammation. However uncontrolled inflammation can lead to neuronal death and permanent brain damage. Microglial inflammation is also observed in several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and multiple sclerosis.

The team led by Dr Anirban Basu found that the inflammatory response was mediated by Klf4, a 'transcription' factor which binds directly to DNA to enhance or impede gene expression. Treating microglia with HNK reduced their activation and HNK treated cells secreted less cytokines in response to LPS. HNK also down regulated the activity of Klf4 (and pNF-kb - another regulator of inflammation).

Dr Basu suggested that HNK down regulates Klf4 which in turn down regulates NO and Cox-2 production. He said, "HNK can easily move across the blood brain barrier and we found that HNK reduced levels of pNF-kb and Klf4 as well as the number of activated microglia in the brains of LPS treated mice."

He continued, "Our work with HNK has found that Klf4 is an important regulator of inflammation. Both HNK and Klf4 may be important not only in regulating inflammation due to infection, but may also have applications in other diseases which affect the brain and nervous system."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central
Source:Eurekalert

Related biology news :

1. Springer and Japanese Society of Biorheology to work together
2. Geraniums could help control devastating Japanese beetle
3. Japanese gourmet mushroom found in Sweden
4. UCLA, Japanese company to collaborate on specialized nano-imaging instrumentation
5. Japanese researchers report on liver transplantation studies using animal and iPS cells
6. Moessbauer group of Mainz University preparing for participation in Japanese moon mission
7. Genome-wide study reveals 3 new susceptibility loci for adult asthma in Japanese population
8. Bulletin of the Atomic Scientists publishes Japanese translation of special Fukushima issue
9. Balance between traditional activities, tourism key to sustaining coastal Alaska communities
10. Traditional Dutch landscape under threat
11. Stroke Belt deaths tied to non-traditional risk factors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2020)... Calif. (PRWEB) , ... May 29, 2020 , ... ... enabler of digital transformation for enterprises globally, has collaborated with EchoNous Inc. to ... FDA. It can measure systolic heart function, which has been clinically tested ...
(Date:5/28/2020)... ... May 27, 2020 , ... Today bioinformatics leader hc1® ... uniquely combines lab testing insights and hc1’s exclusive Local Risk Index in a ... safety of employees returning to the workplace. , “Some of the best ways ...
(Date:5/28/2020)... ... May 28, 2020 , ... Actuate Therapeutics, Inc. ... 1801 Phase 1/2 study (NCT03678883, EudraCT #: 2018-003739-32) will be presented at this ... virtually on May 29th, 2020. Dr. Benedito Carneiro, Brown University’s principal investigator on ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 23, 2020 , ... ... unique lab-made bioresearch materials, today announced the availability of the Delta-G-VSV Pseudotyping System ... University of Tennessee, enables studies of SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness ...
(Date:6/19/2020)... Russia (PRWEB) , ... June 18, 2020 , ... The ... 2018. Its goal is to join forces to radically prolong life and find a ... postpone the aging period. This project was supported by various scientists from all over ...
(Date:6/3/2020)... ... June 03, 2020 , ... Thought ... of biofeedback. In the next installment, Dr. Inna Khazan will discuss the benefits ... to bring their attention to the feelings, thoughts, and emotions they are having ...
(Date:5/28/2020)... ... May 28, 2020 , ... The Security Industry Association ... as the 2020 winners of the Women in Biometrics Awards – a ... , Biometric Update and the SIA Women in Security Forum . ...
Breaking Biology Technology: