Navigation Links
Texas Biomed reports faster, more economical method for detecting bioterror threats
Date:11/5/2012

Texas Biomedical Research Institute scientists in San Antonio have developed a faster, less expensive route to screen suitable tests for bioterror threats and accelerate the application of countermeasures.

The new process screens for pairs of affinity reagents molecular magnets that bind to and hold on to their targets, be they toxins, viruses or bacteria. That will enable countermeasures to be selected and utilized much faster than the current practice.

"Using crude extracts from E. coli, the workhorse bacterium of the biotechnology laboratory, the new route bypasses the need for purification and complex equipment, enabling screening to be performed in under an hour," said Andrew Hayhurst, Ph.D., a Texas Biomed virologist.

Normally, he said, such screening requires sophisticated costly equipment to purify and analyze the affinity reagents. Such analysis becomes a huge burden when hundreds of reagents need to be checked and can take weeks to months.

The process funded primarily by Texas Biomed and the San Antonio Area Foundation, and in part by the Defense Threat Reduction Agency and the National Institutes of Health (NIH) was described online in the November 5, 2012 issue of Nature Publishing Group's Scientific Reports.

"We need an inexpensive route to screen libraries of affinity reagents. It had to be simple and self-contained as we eventually needed it to work in the space-suit lab or hot zone," said Hayhurst.

His surprisingly simple scheme allows scientists to make stop-gap tests to any given biological threat in a matter of days, with the screening step completed in an hour. The goal now is to speed up the entire process to work within a single day.

Hayhurst initially developed the pipeline using llama antibodies as the affinity reagents to botulinum neurotoxins, known as the world's most poisonous poisons 100 billion times more toxic than cyanide and handled in a specialized biosafety cabinet at bios
'/>"/>

Contact: Joseph Carey
jcarey@txbiomed.org
210-258-9437
Texas Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. SMU professor Louis Jacobs honored with prestigious award from Texas science teachers
2. EyeLock Inc. Brings High-Tech Iris Biometric Production to Texas
3. Newly discovered letters and translated German ode expand Texas link to infamous Bone Wars
4. Controlling gait of horses may be possible, says key study from Texas A&M
5. BP Biofuels, Texas AgriLife Research sign agreement to advance biofuel feedstock development
6. NSBRI renews space life sciences graduate programs at MIT, Texas A&M
7. University of Texas Medical Branch selected to manage Center for Polar Medical Operations
8. Mining cleanup benefits from Texas A&M expertise
9. Diet of early human relative Australopithecus shows surprises, says Texas A&M researcher
10. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
11. NASA satellite measurements imply Texas wind farm impact on surface temperature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/19/2014)... over the last 30 years contributed only marginally ... that time, according to a new study published ... "Energy access is fundamental to development: it brings ... communication, and health," says IIASA researcher Shonali Pachauri, ... access is widely agreed to be an important ...
(Date:10/18/2014)... patients referred for evaluation of suspected genetic conditions, ... 25 percent, including detection of a number of ... disease, according to a study appearing in ... coincide with the American Society of Human Genetics ... or coding regions of thousands of genes simultaneously ...
(Date:10/17/2014)... Accurate knowledge regarding Ebola is critical and pertinent for ... hazardous global outbreak and epidemic. The Journal, Disaster ... special issue, Ebola Virus and Public Health, to surround ... in this critical societal moment. , On October ... for Clinicians . The primer was prepared by Dr. ...
Breaking Biology News(10 mins):Improved electricity access has little impact on climate change 2Whole-exome sequencing shows potential as diagnostic tool 2
... in Uganda who self-paid for their antiretroviral medications experienced ... or supply logistical disruptions. These treatment interruptions led ... patients. , These findings by a team led by ... Kampala, and UCSF are reported in the April 22, ...
... pediatric specialists at Baylor College of Medicine have discovered a ... that allows drugs to enter cancer cells. , The research ... and Biomolecular Chemistry. , All living cells defend themselves ... form a protective cocoon around the cell's inner machinery and ...
... cells to turnover their contents, something that they do ... and radiation, but it is not known if this ... survive the anti-cancer therapy. However, in a study using ... the University of Pennsylvania have now shown that autophagy ...
Cached Biology News:Resistance to anti-HIV drugs in Uganda developed due to drug supply problems 2Buckyballs used as 'passkey' into cancer cells 2
(Date:10/22/2014)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ICO) ... Oral Amphotericin B program.  The company recently announced ... work involving samples from HIV/AIDS patients exposed to ... clinical studies and regulatory filings to move forward ... approximately $700,000 of funding and technological advice from ...
(Date:10/20/2014)... NEW YORK , Oct. 20, 2014 /PRNewswire/ ... of their experimental ZMapp™ antibody therapeutic to fight ... of how difficult and time-consuming the production of ... healthcare market research publisher said that while some ... cycle of this compound, those with industry knowledge ...
(Date:10/20/2014)... Md. , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... Zola P. Horovitz , Ph.D., from its board of directors ... board in August 2003, and served as its chairman from ... served on the Nominating and Corporate Governance and Audit Committees ... for more than a decade of dedicated service to GenVec, ...
(Date:10/19/2014)... The Latin American hardware encryption display market ... with analysis and forecast of revenue. This market was ... to reach $2,366.8 million by 2018, at a CAGR ... the TOC of the Latin American hardware encryption market ... provided. It also provides a glimpse of the segmentation ...
Breaking Biology Technology:iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Zola P. Horovitz To Retire From GenVec Board 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3
... HEIDELBERG, Germany, September 16 , ... Approach Identifies new,Potential Drug Targets in Wnt Pathway , ... inhibition,stabilizes axin and antagonizes Wnt signalling"** is now available online ... Cellzome,s quantitative chemical proteomics,platform was used to identify a small ...
... , , SAN ... College), a private medical school with more than 1,100 physicians, in ... solution to track, manage and report adverse and near-miss events, as ... Manager (EM) and Claims Manager (CM) modules, part of the SRM ...
... , SAN DIEGO, Sept. 16 Hollis-Eden Pharmaceuticals, ... of a new class of small molecule compounds based on endogenous ... The NASDAQ Stock Market on September 15, 2009. , , ... with Nasdaq Marketplace Rule 4450(a)(5) (the "Minimum Bid Price Rule") because ...
Cached Biology Technology:Cellzome Technology Used to Unravel Novel Regulatory Mechanism in Cancer Signaling Pathway 2The Medical College of Wisconsin Adopts Quantros Event Manager(TM) and Claims Manager(TM) for Comprehensive Malpractice Litigation Management 2Hollis-Eden Pharmaceuticals Receives NASDAQ Notification Related to Minimum Bid Price 2Hollis-Eden Pharmaceuticals Receives NASDAQ Notification Related to Minimum Bid Price 3
The filter 605DF50 for the Molecular Imager FX is a band pass filter for ethidium bromide, SYPRO Red, SYPRO Ruby, Alexa Fluor 532 and 546, and Cy3 dyes when using the 635 nm laser....
The filter 530DF28 for the Molecular Imager FX is a band pass filter for ECL Plus, AttoPhos, SYBR Green, Alexa Fluor 488, FITC, Cy2, and Pro-Q Emerald dyes....
... Sytem is a highly advanced digital ... digital imaging and automation technology that ... analysis, archving/retrieval and colored professional reporting. ... imaging system that aids in performing ...
... single-step staining method for labeling DNA breaks ... The kit contains all the key reagents ... positive and negative control cells for assessing ... for processing individual steps in the assay; ...
Biology Products: