Navigation Links
Temp-controlled 'nanopores' may allow detailed blood analysis
Date:3/8/2013

Tiny biomolecular chambers called nanopores that can be selectively heated may help doctors diagnose disease more effectively if recent research by a team at the National Institute of Standards and Technology (NIST), Wheaton College, and Virginia Commonwealth University (VCU) proves effective. Though the findings* may be years away from application in the clinic, they may one day improve doctors' ability to search the bloodstream quickly for indicators of diseasea longstanding goal of medical research.

The team has pioneered work on the use of nanoporestiny chambers that mimic the ion channels in the membranes of cellsfor the detection and identification of a wide range of molecules, including DNA. Ion channels are the gateways by which the cell admits and expels materials like proteins, ions and nucleic acids. The typical ion channel is so small that only one molecule can fit inside at a time.

Previously, team members inserted a nanopore into an artificial cell membrane, which they placed between two electrodes. With this setup, they could drive individual molecules into the nanopore and trap them there for a few milliseconds, enough to explore some of their physical characteristics.

"A single molecule creates a marked change in current that flows through the pore, which allows us to measure the molecule's mass and electrical charge with high accuracy," says Joseph Reiner, a physicist at VCU who previously worked at NIST. "This enables discrimination between different molecules at high resolution. But for real-world medical work, doctors and clinicians will need even more advanced measurement capability."

A goal of the team's work is to differentiate among not just several types of molecules, but among the many thousands of different proteins and other biomarkers in our bloodstream. For example, changes in protein levels can indicate the onset of disease, but with so many similar molecules in the mix, it is important not
'/>"/>

Contact: Chad Boutin
boutin@nist.gov
301-975-4261
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. DNA prefers to dive head first into nanopores
2. Wayne State vision restoration technology receives Notice of Allowance for US patent app
3. Novel storage mechanism allows command, control of memory
4. Universal rules discovered that allow anticipation of critical transitions
5. Artificial atoms allow for magnetic resonance on individual cells
6. New guide will allow electric utilities to develop Green Button Web tools
7. A Spanish breakthrough allows the electroporation of cell cultures for less than 1 Euro
8. Celladon Corporation Receives Notice of Allowance from United States Patent and Trademark Office
9. Small, portable sensors allow users to monitor exposure to pollution on their smart phones
10. Detection, analysis of cell dust may allow diagnosis, monitoring of brain cancer
11. Long menopause allows killer whales to care for adult sons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Temp-controlled 'nanopores' may allow detailed blood analysis
(Date:7/29/2014)... There,s some good news for parents of preterm babies ... that by the time they become teenagers, the brains of ... born at term. , A study conducted by the University,s ... as the preterm child experiences no brain injury in early ... as good as their term-born peers. , However, the results ...
(Date:7/29/2014)... Many different types of cell, including sperm, bacteria ... as flagella. These protrusions, about one-hundredth of a ... move through fluid. Similar, shorter structures called cilia ... where they perform roles such as moving liquids ... are remarkably versatile: they transport mucus and expel ...
(Date:7/28/2014)... of two additional coral communities showing signs of damage from ... the 2010 spill in the Gulf of Mexico. The discovery ... of biology at Penn State University. A paper describing this ... the Gulf of Mexico will be published during the last ... the journal Proceedings of the National Academy of Sciences ...
Breaking Biology News(10 mins):Preterm children's brains can catch up years later 2Microscopic rowing -- without a cox 2Microscopic rowing -- without a cox 3Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2
... CBD COP 9 today, 29th May, a report setting ... conservation of biodiversity" was presented by the report,s author ... by Minister Sigmar Gabriel of Germany and Stavros Dimas ... to promote a better understanding of the true economic ...
... your week-old peach has helped scientists zero in on ... The paradoxical finding gives scientists a better understanding of ... points to a likely target for pesticide development, says ... of Georgia Schools of Medicine and Graduate Studies. ...
... fruits and vegetables per day and drink green or ... according to a first-of-its-kind study by UCLA cancer researchers. ... levels of natural chemicals called flavonoids in their diet ... important finding since more than 90 percent of lung ...
Cached Biology News:The Economics of Ecosystems and Biodiversity- TEEB 2The Economics of Ecosystems and Biodiversity- TEEB 3The Economics of Ecosystems and Biodiversity- TEEB 4The Economics of Ecosystems and Biodiversity- TEEB 5Fruit fly helps identify protein critical to eggshell formation that may be pesticide target 2Fruit fly helps identify protein critical to eggshell formation that may be pesticide target 3Fruits, vegetables and teas may protect smokers from lung cancer, UCLA researchers report 2
(Date:7/29/2014)... PORTLAND, Oregon , July 29, 2014 ... titled, "Global surgical equipment market (types, applications and geography) ... Analysis, Research, Report, Opportunities, Segmentation and Forecast, 2013 - ... expected to reach $12.1 billion by 2020 registering a ... Due to the breakthrough achieved by the electro surgical ...
(Date:7/29/2014)... Philadelphia’s newest entrepreneurial incubation space is ready for ... The Innovation Center @3401 , a collaborative effort of ... to help attract and nurture start-up businesses in the ... , The Innovation Center @3401 (ic@3401), which is ... the new home of DreamIt Ventures and ...
(Date:7/29/2014)... 2014  United Therapeutics Corporation (NASDAQ: ... results for the second quarter ended June 30, ... that our medicines are reaching increasing numbers ... (PAH)," said Martine Rothblatt, Ph.D., United Therapeutics, ... launch this quarter of our extended-release tablet ...
(Date:7/29/2014)... Dr. Jason Wendel – recipient of a Regional Top Doctor ... 10 Plastic Surgeon Specialists for Nashville, TN – has released ... includes a Hydration Booster, Retexturing Night Crème, and Anti-aging C ... younger, more radiant appearance while protecting them from the sun’s ... why at Dr. J. J. Wendel Plastic Surgery, we have ...
Breaking Biology Technology:Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 3Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 2Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 3United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 2United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 3United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 4United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 5United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 6United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 7United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 8United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 9United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 10United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 11United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 12United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 13Dr. J. J. Wendel Launches New Line of Skin Care Products 2
... and Jack Ballantyne, Forensic Biochemistry/Genetics Professor at University of ... join ... GenVault Corporation today,announces that two leading industry experts, ... its Scientific Advisory Board. Dr.,Lai-Goldman is currently the Chief ...
... primer, now in its 3rd edition., ... the third,edition of Building Biotechnology, the definitive ... business courses. This new,edition adds over 100 ... new,and updated figures and tables, and many ...
... -- Record consolidated revenues of $14.9 million -- Record ... $2.3 million - 49% growth ... credit facility - expands capital resources, -- Reported MIS procedure times of 60 minutes and hospital ... days or ...
Cached Biology Technology:GenVault Expands Scientific Advisory Board 2GenVault Expands Scientific Advisory Board 3New Book on the Business of Biotechnology 2AtriCure Reports Record Second Quarter 2008 Financial Results 2AtriCure Reports Record Second Quarter 2008 Financial Results 3AtriCure Reports Record Second Quarter 2008 Financial Results 4AtriCure Reports Record Second Quarter 2008 Financial Results 5AtriCure Reports Record Second Quarter 2008 Financial Results 6AtriCure Reports Record Second Quarter 2008 Financial Results 7AtriCure Reports Record Second Quarter 2008 Financial Results 8
... The ProteoSpin CBED Maxi Kit provides a ... of dilute protein solutions for buffer exchange, and ... samples. The kit is based on spin-column chromatography ... exchanger. Salts such as MgCl 2 , NaCl, ...
Formula variant: With the macro- and micronutrients as described by Lloyd and McCown (1981). Preparation Quantity Equivalency: Formulated to contain 2.3 grams of powder per liter of medium. Physical ...
... separation and fractionation of nucleic-acid ... nuclei from cytosolic proteins A ... greatly facilitating study of low-abundance ... acid binding proteins (e.g., transcription ...
... PEP-126 is an 18 amino acid synthetic peptide whose sequence corresponds ... this peptide is (amino to carboxy terminus): M(1) - A - ... - A - S - P - R - D - ... This peptide may be used for neutralization and control experiments with ...
Biology Products: