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Technique finds gene regulatory sites without knowledge of regulators
Date:11/19/2009

oss-validation tests representing hundreds of modules in the mouse genome and in the fruit fly genome. In addition, seven predictions were experimentally validated through genetic techniques, demonstrating the effectiveness of the approach for mammalian and insect genomes.

Sinha and colleagues are currently working on thermodynamics-based models for potential use in predicting cis-regulatory modules in different species.

"By describing the underlying chemistry in terms of molecules, DNA sequences and binding energies, it may be possible to use knowledge about gene regulation in one species to make predictions about gene regulation in corresponding systems in very diverse species," Sinha said.


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Contact: James E. Kloeppel
kloeppel@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert

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