Navigation Links
Team creates novel vaccine that produces strong immunity against cocaine high
Date:1/4/2011

heroin, or puff of crackproduced the greatest feeling they had ever experienced. Many will also tell you that they too often spent their money, health, family, friends, and lives to try to get that feeling back.

"Unfortunately, there is no methadone for cocaine," said Janda. "Immunotherapy, however, might provide the added boost to keep a person from a major relapse, as after immunization a slip will not produce a drug effect."

Building on Previous Work

The Janda laboratory and the laboratory of George Koob, chair of the Committee on The Neurobiology of Addictive Disorders at Scripps Research, have , however, been working for more than a decade trying to find new approaches for combating addictive drugs of abuse such as cocaine.

In previous work, Janda and his synthetic team had developed several alternative formulations of anti-cocaine vaccines, which also acted by stimulating an active immune response against the drug in the bloodstream. However, a drawback of these prior vaccines as a lack of ready transferability to clinical trials.

In the new study, the team took advantage of a cocaine-hapten-scaffold (a cocaine-antigen that would elicit cocaine-producing antibodies) that Janda developed in the early 90s, this time chemically modifying it so that it could be attached to components of the adenovirus, a common cold virus. In this way, the human immune system was alerted to an infectious agent (the virus), but also learned to "see" the cocaine as an intruder. In this approach, the researchers used only the parts of the adenovirus that elicited an immune response, discarding those that produce sickness.

To test the effect of the vaccine, the researchers then injected billions of these viral concoctions into laboratory mice and found a strong immune response was generated against the vaccine. When put in test tubes, these antibodies gobbled up cocaine.

The scientists then tested the vaccine's effect o
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Early-stage gene transcription creates access to DNA
2. MIT creates tiny backpacks for cells
3. Florida professor creates endowment for insect scientists
4. Crustacean shell with polyester creates mixed-fiber material for nerve repair
5. NYSCF Fellow lead author on study that creates blood vessel cells from stem cells
6. $15 million stimulus award creates national consortium for revealing scientific resources
7. Antarctica glacier retreat creates new carbon dioxide store
8. Bowman creates graphic translation of climate change data
9. Breeding orchid species creates a new perfume
10. Zapping Titan-like atmosphere with UV rays creates life precursors
11. Exposure to early evening sunlight in spring creates teenage night owls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/25/2015)... Ark. , Feb. 25, 2015  ABC ... and billing in the Health and Fitness Industry, ... well as to MYiCLUBonline.  The latest upgrade includes ... the inclusion of cardless check-in via Identity One ... the first time through interactive displays at the ...
(Date:2/19/2015)... Feb .19, 2015 Research and Markets ... of the "Military Electro-Optical / Infrared Systems ... by Platform - Forecast to 2020" report ... electro-optical/infrared systems market is expected to reach $16.35 ... 7.71%. This report segments the military ...
(Date:2/11/2015)... 2015 According to ... Market by Product (Cards and Readers, Biometrics, Controllers, Management ... Industrial, Healthcare, Education) and By Geography - Global Forecast and Analysis ... Access Control Market is expected to reach ... CAGR of 10.6% between 2014 and 2020. ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4
... 2008 -- With reducing carbon emissions on the national agenda, ... and policy issues on how carbon sinks or carbon sequestration ... Carbon sequestration is the process through which carbon dioxide (CO ... and crops through photosynthesis, and stored as carbon in biomass ...
... tomography to Google searches, higher mathematics and computation are ... The University of Pennsylvania,s new graduate program in ... symposium to spotlight the frontiers of research and provide ... Talks will be given by international leaders in subjects ...
... restoration projects to protect storm buffeted infrastructure along the ... that provides "false hope" and prevents endangered communities from ... Western Carolina University (WCU). As hurricanes have ... has been filled with the words of politicians, policy ...
Cached Biology News:Carbon sinks: Issues, markets, policy 2Wetlands restoration not a panacea for Louisiana coast 2Wetlands restoration not a panacea for Louisiana coast 3
(Date:3/6/2015)... 2015 Health eCareers, the only online single-source ... this week announced the launch of ENA Job ... The ENA Job Center provides a powerful venue ... find job openings and for employers to reach the ... in the field. Job seekers now ...
(Date:3/6/2015)... , March 6, 2015  Attorney Advertising-- Bronstein, ... on behalf of purchasers of the securities of ... OREX -News).  Such investors are ... his investor relations coordinator Eitan Kimelman ... The investigation concerns whether Orexigen and certain of ...
(Date:3/6/2015)... VA (PRWEB) March 06, 2015 Anton ... sodium hydroxide concentration by utilizing laboratory refractometers. Sodium ... is used in producing a variety of products including ... base is a staple of the chemical industry; its ... petroleum – and nearly everything in between. NaOH ...
(Date:3/5/2015)... ARLINGTON, Va. , March 5, 2015   ... selected as semi-finalists in the HX360 Innovation Challenge ... eighty-three entries, will compete to be chosen as one ... a panel of senior health system executives and venture ... The HX360 Innovation Challenge takes place at the 2015 ...
Breaking Biology Technology:Health eCareers Announces Online Career Center for the Emergency Nurses Association 2Health eCareers Announces Online Career Center for the Emergency Nurses Association 3SHAREHOLDER ALERT: Bronstein, Gewirtz & Grossman, LLC Announces Investigation of Orexigen Therapeutics, Inc. 2HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 2HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 3HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 4
... Italy, November 10 Health-Robotics today,announced that ... Automation since,1971, has selected Health Robotics, CytoCare(TM) ... by TOSHO,s engineering and management,teams, and by ... process included multiple visits to Health Robotics, ...
... Delivery Technology and own Pipeline ... ... 10 Critical,Pharmaceuticals, the speciality pharmaceuticals company, today announced,that it ... on the company,s success in developing its unique,CriticalMix delivery technology ...
... and research group Plasma & Materials Processing (PMP) of ... awarded the Leverhulme Technology Transfer Award 2008. They receive ... for the research group) for their successful transfer of ... Hoex,s Ph.D. research was rewarded with the SolarWorld Junior ...
Cached Biology Technology:Health Robotics Announces Strategic Partnership in Japan for its CytoCare(TM) Robot with TOSHO Inc. 2Health Robotics Announces Strategic Partnership in Japan for its CytoCare(TM) Robot with TOSHO Inc. 3Health Robotics Announces Strategic Partnership in Japan for its CytoCare(TM) Robot with TOSHO Inc. 4Critical Pharmaceuticals Raise GBP650K 2Critical Pharmaceuticals Raise GBP650K 3TU/e awarded for knowledge transfer to solar energy industry 2
... by a modification of the procedure ... Bioeng., 11 , 1055 ... yield an A 260 of ... (1 cm light path). Physical Form: ...
... White solid.. PACKAGED UNDER INERT GAS. ... reaction is "driven" to completion. A protective agent ... found in many other preparations. Blocks the lethal ... by titration. Contaminants: Heavy metals: ≤1 ...
... Basically, most ``special`` dye stains ... a few other non-routine) stains are ... of a paraffin block, staining, coverslipping ... Stain (for senile plaques) ,Bodian`s Stain ...
... pombe Whole Genome ChIP-on-chip Microarray is ... yeast (S. pombe) DNA binding proteins ... Agilent DNA microarrays. This set delivers ... with greater true binding events and ...
Biology Products: