Navigation Links
Team creates novel vaccine that produces strong immunity against cocaine high
Date:1/4/2011

heroin, or puff of crackproduced the greatest feeling they had ever experienced. Many will also tell you that they too often spent their money, health, family, friends, and lives to try to get that feeling back.

"Unfortunately, there is no methadone for cocaine," said Janda. "Immunotherapy, however, might provide the added boost to keep a person from a major relapse, as after immunization a slip will not produce a drug effect."

Building on Previous Work

The Janda laboratory and the laboratory of George Koob, chair of the Committee on The Neurobiology of Addictive Disorders at Scripps Research, have , however, been working for more than a decade trying to find new approaches for combating addictive drugs of abuse such as cocaine.

In previous work, Janda and his synthetic team had developed several alternative formulations of anti-cocaine vaccines, which also acted by stimulating an active immune response against the drug in the bloodstream. However, a drawback of these prior vaccines as a lack of ready transferability to clinical trials.

In the new study, the team took advantage of a cocaine-hapten-scaffold (a cocaine-antigen that would elicit cocaine-producing antibodies) that Janda developed in the early 90s, this time chemically modifying it so that it could be attached to components of the adenovirus, a common cold virus. In this way, the human immune system was alerted to an infectious agent (the virus), but also learned to "see" the cocaine as an intruder. In this approach, the researchers used only the parts of the adenovirus that elicited an immune response, discarding those that produce sickness.

To test the effect of the vaccine, the researchers then injected billions of these viral concoctions into laboratory mice and found a strong immune response was generated against the vaccine. When put in test tubes, these antibodies gobbled up cocaine.

The scientists then tested the vaccine's effect o
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Early-stage gene transcription creates access to DNA
2. MIT creates tiny backpacks for cells
3. Florida professor creates endowment for insect scientists
4. Crustacean shell with polyester creates mixed-fiber material for nerve repair
5. NYSCF Fellow lead author on study that creates blood vessel cells from stem cells
6. $15 million stimulus award creates national consortium for revealing scientific resources
7. Antarctica glacier retreat creates new carbon dioxide store
8. Bowman creates graphic translation of climate change data
9. Breeding orchid species creates a new perfume
10. Zapping Titan-like atmosphere with UV rays creates life precursors
11. Exposure to early evening sunlight in spring creates teenage night owls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... published research study examining only marketing directed at ... food restaurants has found that the majority of ... to such marketing tactics. , Authored by Arizona ... the study is the first to examine the ... exterior of fast food restaurants and its relationship ...
(Date:11/3/2014)... , Nov. 3, 2014 Research and Markets ... "Cell Therapy - Technologies, Markets and Companies" to their ... therapy technologies and methods, which have already started to play ... cell transplantation is replacing the old fashioned bone marrow transplants. ... therapy is bound to become a part of medical practice. ...
(Date:11/2/2014)... issue of Physics World , James Dacey explores ... of death" to take their innovations from the lab ... gruelling challenge facing all start-up companies as they move ... because of two main factors: physics-based inventions are usually ... turn out to be a lot more complicated than ...
Breaking Biology News(10 mins):Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3The 'valley of death' facing physics start-ups 2
... Los Baos, Philippines A small insect that has devastated ... over the past few yearscausing the loss of thousands of ... productionis the focus of a critical and timely conference this ... major type of rice pest that can destroy one-fifth of ...
... and Texas A & M University have discovered a ... specific tissues in animals. In studies to determine ... group previously identified a region of a smooth muscle ... of any plasmid carrying this sequence uniquely in cultured ...
... to Consultancy in Automotive, IRVINE, Calif., June 20 ... auto industry executive who has worked with,Jaguar, Audi, Volkswagen, ... The,position will be based in Irvine, Calif., and will ... responsible for managing existing,client relationships as well as developing ...
Cached Biology News:Research required urgently to control planthopper pests 2Research required urgently to control planthopper pests 3New paradigm for cell-specific gene delivery 2Len Hunt Joins Gallup Consulting Group 2
(Date:11/21/2014)... 20, 2014 The report, ... Oligos, Enzymes, Cloning kits), Technology (Bioinformatics, Nanotechnology, ... Pharmaceuticals, Biomaterials, Bioremediation) - Global Forecast to ... drivers, threats, opportunities, and challenges. , Browse ... spread through 185 pages and in-depth TOC ...
(Date:11/21/2014)... 2014 2014 Deep Research Report ... in-depth research report on the transformer market. The ... application, and industry chain structure as well as ... analysis, including China’s domestic market as well as ... situation analysis. The report also covers information on ...
(Date:11/18/2014)... Calif. , Nov. 18, 2014 Cord ... platinum sponsor of the 10th Annual World Stem Cell Summit, ... medicine stakeholders. The 2014 World Stem Cell Summit will be ... San Antonio, Texas . The ... and development of lifesaving cures and therapies, convening the most ...
(Date:11/18/2014)... NJ (PRWEB) November 18, 2014 ... Quality and Transparency Reporting solutions, announced today that ... live using its Consummate Provider™ solution in both ... is a Global, SaaS based, Data Quality remediation ... and their third party Providers improve their ability ...
Breaking Biology Technology:Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 2International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 3Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3Alanda Software Completes Successful Implementation of Global Data Quality & Vendor Management Solution for Top Tier Global Biopharmaceutical Company 2
... March 14 Kendle (Nasdaq: KNDL ), ... Senior Vice President and Chief Financial Officer Karl,"Buzz" ... Eleventh,Annual Global Healthcare Conference. The conference will be ... Florida, March 18-20, 2008. Kendle,s,presentation is scheduled for ...
... Diagnostics,Incorporated (NYSE: DGX ), the nation,s leading ... it is scheduled to speak,at the Cowen and ... March 18, 2008, at the Marriott Copley Place, ... begin at,8:45 a.m. Eastern Time., The presentation ...
... March 14 Creighton University,law, science, medical and ... it takes to convert scientific research into new ... a competitive application and,interview process -- are enrolled ... time on Feb. 13. A three-year, $536,000 National ...
Cached Biology Technology:Kendle to Present at the Lehman Brothers Eleventh Annual Global Healthcare Conference 2Quest Diagnostics to Speak at Cowen and Company 28th Annual Health Care Conference 2NSF Funds New Entrepreneurship Program 2
Request Info...
SHEEP ANTI BOVINE BETA-LACTOGLOBULIN A...
Rabbit polyclonal to Somatostatin 28 ( Abpromise for all tested applications). entrezGeneID: 6750 SwissProtID: P61278...
... is an essential component of the COP9 ... various cellular and developmental processes. The CSN ... ubiquitin (Ubl) conjugation pathway by mediating the ... E3 ligase complexes. The complex is also ...
Biology Products: