Navigation Links
Team creates novel vaccine that produces strong immunity against cocaine high
Date:1/4/2011

heroin, or puff of crackproduced the greatest feeling they had ever experienced. Many will also tell you that they too often spent their money, health, family, friends, and lives to try to get that feeling back.

"Unfortunately, there is no methadone for cocaine," said Janda. "Immunotherapy, however, might provide the added boost to keep a person from a major relapse, as after immunization a slip will not produce a drug effect."

Building on Previous Work

The Janda laboratory and the laboratory of George Koob, chair of the Committee on The Neurobiology of Addictive Disorders at Scripps Research, have , however, been working for more than a decade trying to find new approaches for combating addictive drugs of abuse such as cocaine.

In previous work, Janda and his synthetic team had developed several alternative formulations of anti-cocaine vaccines, which also acted by stimulating an active immune response against the drug in the bloodstream. However, a drawback of these prior vaccines as a lack of ready transferability to clinical trials.

In the new study, the team took advantage of a cocaine-hapten-scaffold (a cocaine-antigen that would elicit cocaine-producing antibodies) that Janda developed in the early 90s, this time chemically modifying it so that it could be attached to components of the adenovirus, a common cold virus. In this way, the human immune system was alerted to an infectious agent (the virus), but also learned to "see" the cocaine as an intruder. In this approach, the researchers used only the parts of the adenovirus that elicited an immune response, discarding those that produce sickness.

To test the effect of the vaccine, the researchers then injected billions of these viral concoctions into laboratory mice and found a strong immune response was generated against the vaccine. When put in test tubes, these antibodies gobbled up cocaine.

The scientists then tested the vaccine's effect o
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Early-stage gene transcription creates access to DNA
2. MIT creates tiny backpacks for cells
3. Florida professor creates endowment for insect scientists
4. Crustacean shell with polyester creates mixed-fiber material for nerve repair
5. NYSCF Fellow lead author on study that creates blood vessel cells from stem cells
6. $15 million stimulus award creates national consortium for revealing scientific resources
7. Antarctica glacier retreat creates new carbon dioxide store
8. Bowman creates graphic translation of climate change data
9. Breeding orchid species creates a new perfume
10. Zapping Titan-like atmosphere with UV rays creates life precursors
11. Exposure to early evening sunlight in spring creates teenage night owls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... this false-color image from the Terra satellite show the different ... wildfires in Eastern Russia. The burn scars show up ... The wildfires have broken across the remote parts of Eastern ... image from the MODIS instrument, it is still possible ... Two recent image features noted below show the devastating number ...
(Date:7/25/2014)... and disrupted brain development is an essential part ... largely unknown. However, thanks to funding from the ... University (GW) researcher Anthony-Samuel LaMantia, Ph.D. may be ... to these key questions in the field of ... and physiology at the GW School of Medicine ...
(Date:7/25/2014)... 25 countries and 35 states will attend the ... Society of America (GSA) next week at the ... feature close to 500 presentations (including 70 talks) ... expression and regulation, functional genomics, chemical biology and ... variety of diseases. , Of special note ...
Breaking Biology News(10 mins):GW researcher receives grant to answer the how and why of autism during development 2Yeast meeting to showcase latest breakthroughs in genetics and molecular biology 2
... State Universitys computational mathematical sciences program in ... will power a new set of undergraduate ... $1 million grant from the National Science ... in computational mathematical sciences, will initially offer ...
... the Neural Basis of Cognition (CNBC), a joint project ... have for the first time described a mechanism called ... the fly allowing stimuli to be more keenly sensed. ... the January 2008 issue of Nature Neuroscience, and available ...
... simulations provide the first concrete molecular explanation of how ... into two daughter cells at the end of each ... Cell biologists at Yale and physicists at Columbia ... a cell assembles the contractile ring, the short-lived force-producing ...
Cached Biology News:Computational mathematical sciences receives NSF grant for undergraduate research 2Computational mathematical sciences receives NSF grant for undergraduate research 3Neuronal circuits able to rewire on the fly to sharpen senses 2How molecular muscles help cells divide 2
(Date:7/28/2014)... TORONTO , July 28, 2014 /PRNewswire/ -   ... latest group of companies to join its growing portfolio ... hallmarks of Toronto,s JOLT accelerator, ... startups on the roster. Since its ... that have successfully raised  $7.5M of financing. Now at ...
(Date:7/28/2014)... July 28, 2014 Appistry, Inc. ... that bring the power of genomics to next-generation medicine, ... Appistry Pipeline Challenge . , Two Appistry staff ... the National Center for Genome Resources, and Mr. Neil ... Clinics of Kansas City. Rounding out the panel are ...
(Date:7/28/2014)... , July 28, 2014 Research and Markets ... Size Analysis Market 2014-2018" report to their offering. ... size analysis is a technique used to determine the size ... liquid. It is crucial to analyze the size of particles ... particle size analysis is performed to determine the behavior and ...
(Date:7/25/2014)... in each person,s digestive tract. Scientists believe that some ... harmful infections, but their role in human health is ... the role of these bacteria, a team of researchers ... fluctuations in the bacterial populations of two research subjects ... July 25 issue of the journal Genome Biology ...
Breaking Biology Technology:JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 2JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 3Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2Global Particle Size Analysis Market 2014-2018 2Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3
... as an early warning system for potential ecological ... at Stockholm University and the University of East ... and food production are of fundamental importance for ... sudden changes in ecosystems caused by various pressures ...
... Receives Positive Committee Recommendation in European UnionSAN MATEO, Calif., ... ), a biopharmaceutical company focused on developing and commercializing ... a conference call on Friday, March 20, 2009 at ... quarter and year-end 2008 results and the European Medicines ...
... Indicated for Peripheral Neuropathic Pain in Non-Diabetic AdultsConference ... SAN MATEO, Calif., March 19 NeurogesX, ... company focused on developing and commercializing novel pain ... Agency,s (EMEA) Committee for Medicinal Products for Human ...
Cached Biology Technology:Internet can warn of ecological changes 2Internet can warn of ecological changes 3NeurogesX to Hold Conference Call to Discuss Fourth Quarter and Year-End 2008 Financial Results and European Regulatory Update 2NeurogesX to Hold Conference Call to Discuss Fourth Quarter and Year-End 2008 Financial Results and European Regulatory Update 3NeurogesX to Hold Conference Call to Discuss Fourth Quarter and Year-End 2008 Financial Results and European Regulatory Update 4NeurogesX' Qutenza(TM) (NGX-4010) Receives Positive Committee Recommendation in European Union 2NeurogesX' Qutenza(TM) (NGX-4010) Receives Positive Committee Recommendation in European Union 3NeurogesX' Qutenza(TM) (NGX-4010) Receives Positive Committee Recommendation in European Union 4NeurogesX' Qutenza(TM) (NGX-4010) Receives Positive Committee Recommendation in European Union 5NeurogesX' Qutenza(TM) (NGX-4010) Receives Positive Committee Recommendation in European Union 6
... HRP Conjugation Kits are based on ... that are consistent and reproducible. This ... conjugate your protein or antibody, including ... buffer. Activated HRP is supplied ...
... Acridinium NHS ester can be ... nucleic acids. The covalently bound ... chemiluminescence in the presence of ... proteins can be used as ...
... designed to hold up to 6 strain chambers ... easy to use design ensures that cells grow ... stretching or compression. This unit allows you to ... to produce 64 unique strain settings. The instrument ...
... a novel procedure for the uniform amplification ... genome DNA from small samples. This method ... and highly reproducible amplification and labeling procedure ... REPLI-g Mini Kit module (QIAGEN) and a ...
Biology Products: