Navigation Links
Team creates novel vaccine that produces strong immunity against cocaine high
Date:1/4/2011

LA JOLLA, CA January 4, 2011 Researchers from The Scripps Research Institute, Weill Cornell Medical College, and Cornell University have produced a long-lasting anti-cocaine immunity in mice by giving them a unique vaccine that combines bits of the common cold virus with a particle that mimics cocaine.

In their study, published January 4, 2011, in the advanced online edition of Molecular Therapy, the researchers say this novel strategy might be the first to offer cocaine addicts a fairly simple way to break and reverse their habit. The approach could also be useful in treating other addictions, such as to nicotine, heroin, and methamphetamine.

"Our very dramatic data shows that we can protect mice against the effects of cocaine, and we think this approach could be very promising in fighting addiction in humans," says the study's lead investigator, Ronald G. Crystal, chairman and professor of genetic medicine at Weill Cornell Medical College.

"The vaccine suppresses the stimulant effects of the drug," said Scripps Research Professor Kim Janda, a co-author of the paper and a pioneer in the field of developing vaccines against addictive drugs such as cocaine. "Unlike other types of treatment, a vaccine such as this one does not interfere with the neurological targets of the drug, but instead blocks cocaine from ever reaching the brain in the first place."

In the new study, the vaccine effect lasted for at least 13 weeks, the longest time point evaluated in such an approach. Since the vaccine likely will not require multiple expensive infusions, the researchers hope that it can move quickly into human trials.

Clinically, this sort of therapy could be given to people in treatment programs to aid in their recovery. And, like most other types of treatment, it will only be useful for those who want the help.

"This vaccine would be most applicable for addicts who are who are interested in getting off the dr
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Early-stage gene transcription creates access to DNA
2. MIT creates tiny backpacks for cells
3. Florida professor creates endowment for insect scientists
4. Crustacean shell with polyester creates mixed-fiber material for nerve repair
5. NYSCF Fellow lead author on study that creates blood vessel cells from stem cells
6. $15 million stimulus award creates national consortium for revealing scientific resources
7. Antarctica glacier retreat creates new carbon dioxide store
8. Bowman creates graphic translation of climate change data
9. Breeding orchid species creates a new perfume
10. Zapping Titan-like atmosphere with UV rays creates life precursors
11. Exposure to early evening sunlight in spring creates teenage night owls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... emits over a wide part of the electromagnetic spectrum ... built in Lund, Sweden. The MAX IV facility presents ... together its component parts in a storage - ring ... a few hundred metres. Nevertheless, if these various challenges ... experiments that require source brightness and transverse coherence will ...
(Date:10/31/2014)... Ebola one important hurdle has just been cleared – ... of North Carolina at Chapel Hill and colleagues have ... be infected with Ebola and display symptoms similar to ... current issue of Science , will significantly improve ... desperately needed to curb the worldwide public health and ...
(Date:10/31/2014)...  HITLAB SM , a healthcare innovation and ... HITLAB Innovators Summit SM on December 1, ... partner with the Clinton Foundation,s Health Matters Initiative, ... Business School Alumni Club of New ... Operations Research, bringing together leaders in healthcare and ...
Breaking Biology News(10 mins):A new generation of storage -- ring 2Improved mouse model will accelerate research on potential Ebola vaccines, treatments 2HITLAB Announces Inaugural HITLAB Innovators Summit 2HITLAB Announces Inaugural HITLAB Innovators Summit 3
... PHILADELPHIA (December 8, 2013) According to Gertrude Stein, "A ... indicates that might not be the case when it comes ... collaborating institutions have found that as much as 30 percent ... any two individuals. This substantial variation is in turn reflected ...
... items to freezing temperatures may be a viable control option ... new study has found that bed bugs may be less ... article in the Journal of Economic Entomology called ... the authors describe how exposing bed bugs to freezing temperatures ...
... ORLEANS, December 7, 2013) Hematopoietic stem cell transplantation ... drug therapy for blood cancer, has become more accessible ... a result of major advances in transplant strategies and ... during the 55th American Society of Hematology Annual Meeting ...
Cached Biology News:Extensive variability in olfactory receptors influences human odor perception 2International gene therapy trial for 'bubble boy' disease shows promising early results 2International gene therapy trial for 'bubble boy' disease shows promising early results 3International gene therapy trial for 'bubble boy' disease shows promising early results 4International gene therapy trial for 'bubble boy' disease shows promising early results 5International gene therapy trial for 'bubble boy' disease shows promising early results 6International gene therapy trial for 'bubble boy' disease shows promising early results 7
(Date:10/30/2014)... , October 30, 2014 Investor-Edge ... Inc. (NYSE MKT: ONVO), Medivation Inc. (NASDAQ: ... Synthetic Biologics Inc. (NYSE MKT: SYN), and Ironwood Pharmaceuticals ... can be accessed at: http://investor-edge.com/register . ... at 4,549.23, down 0.33%, the Dow Jones Industrial Average ...
(Date:10/30/2014)... 29, 2014 Global polyvinyl chloride (PVC) ... economic crisis during 2008-2009, especially in North America and ... currently is keeping to a growing trend. , The ... utilized in the construction segment. In 2013, the key ... tubing, sheets and rigid film. Moreover, the PVC was ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 On ... Cellular Medicine Showcase in Chicago, leading applied stem ... Surgeon, Dr. Wade McKenna presented talks on New ... Orthopedic Surgical Applications For Stem Cells. , Dr. ... membrane and the properties of AlphaGEMS that include: ...
(Date:10/30/2014)... CA (PRWEB) October 30, 2014 ... today that they have manually curated public data source ... non profit customers. the data is now available ... curates and unifies public and internal data sources for ... and knowledge out of the data that becomes more ...
Breaking Biology Technology:Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 2Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 4Rancho BioSciences Manually Curated TCGA Data Sets Available 2
... , , , , , , ... for nucleic acid amplification. For detailed information about a product , please ... Protector , RNase Inhibitor , , ... , is a new type of RNase ...
... , , , , , , ... size of template , Temperature optimum , Units needed for ... Rnase H activity , Combined RT and DNA Pol. , ... Expand Re- , verse Trans- , ...
... PCR that is as Flexible , as , ... , , , Choose the ... to meet your changing research needs. Central to the LightCycler , ... more than "Just another thermal cycler". It is a completely new integrated , ...
Cached Biology Technology:Product overview 2Product overview 3Product overview 4Product overview 5Product overview 6Product overview 7Properties of Reverse Transcriptases 2The LightCycler is the only System for Quantitative PCR that is as Flexible , as, You are! 2The LightCycler is the only System for Quantitative PCR that is as Flexible , as, You are! 3The LightCycler is the only System for Quantitative PCR that is as Flexible , as, You are! 4
Rat Cardiac Fibroblasts (RCF) (>500,000 cells)...
... Automation Buffer is a concentrated formulation of ... employing capillary action technology, as well as ... collaboration with David Brigati M.D., Department of ... This buffer is recommended for all the ...
...
... users requiring mass detection but not ... TOF Mass spectrometer is ideally suited ... for high performance mass analysis. ... analysis, protein detection, micro-satellite DNA characterization ...
Biology Products: