Navigation Links
TGen and Scottsdale Healthcare launch Phase I 'Thunder God vine' trial for cancer

SCOTTSDALE, Ariz. Sept. 12, 2013 Taking a page from Chinese herbal medicine, Scottsdale Healthcare and the Translational Genomics Research Institute (TGen) today initiated the first-in-human clinical trial for pancreatic cancer patients using a compound derived from a plant known as "Thunder God vine."

The first patient to participate in this clinical trial received treatment today at Scottsdale Healthcare's Virginia G. Piper Cancer Center Clinical Trials, a partnership of Scottsdale Healthcare and TGen.

The Thunder God vine (Tripterygium wilfordii), also known as lei gong teng, is native to China, Japan and Korea. Traditional Chinese medicine has used the vine for more than 2,000 years as a treatment for everything from fever to inflammation and autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis.

A chemical compound called triptolide is among the more than 100 bioactive ingredients derived from the Thunder God vine. Preclinical studies showed a pharmaceutical version of triptolide called Minnelide proved effective against pancreatic cancer cells, according to a study by Dr. Ashok K. Saluja, Professor and Vice-Chair, Department of Surgery, University of Minnesota and Chief Scientific Officer and Co-Founder of Minneamrita Therapeutics LLC, published in the journal Science Translational Medicine.

The U.S. Food and Drug Administration (FDA) recently approved use of the compound Minnelide for a clinical trial of gastrointestinal cancer patients including pancreatic cancer.

"We have known for years about the potential beneficial use of Thunder God vine, but only recently with the advent of Minnelide have we created a form of triptolide that can be easily administered to patients," said Dr. Mohana R. Velagapudi, Chief Executive Officer and Co-Founder of Minneamrita Therapeutics LLC, the trials sponsor. "This clinical trial will hopefully provide the proof of concept so patients beyond the trial can benefit as well."

Noted pancreatic cancer authority Dr. Daniel D. Von Hoff is the principal investigator for the trial opening at Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare. Von Hoff is Chief Scientific Officer for Virginia G. Piper Cancer Center Clinical Trials and TGen's Physician-In-Chief.

"The preclinical results of Minnelide were outstanding," Von Hoff said. "The level of positive preclinical activity gives us hope that this is a new lead for trying to help patients battling pancreatic cancer."

With more than 40 active clinical trials for advanced or rare cancers, Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare, through its partnership with TGen, is one of the leading centers for Phase I oncology trials in the nation. These clinical trials provide clinical care options that did not exist before to Phoenix-area patients as well as patients from all over the country.

"Participants in clinical trials can play a more active role in their own health care, gain access to new research treatments before they are widely available, and help others by contributing to medical research," said Dr. Ramesh Ramanathan, Medical Director for Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare. "The Minnelide trial is another example of how we're bringing added benefit to cancer patients through these first-in-human clinical trials."

Translational Drug Development (TD2), a pharmaceutical development subsidiary of TGen, designed and manages the trial. TD2 worked with Minneamrita Therapeutics LLC to secure regulatory approval for the Phase I trial, which, in addition to the VGPCC Clinical Trials Program, also opened at the University of Minnesota Masonic Cancer Center, where Dr. Edward Greeno, Medical Director of University of Minnesota Physicians Cancer Care, is the principal investigator.

"Minnelide is a remarkable drug and we are happy to have helped bring its potential clinical benefit to patients here first in Scottsdale," said Dr. Stephen Gately, President and Chief Scientific Officer of TD2.


Contact: Steve Yozwiak
The Translational Genomics Research Institute

Related biology news :

1. TGen, Scottsdale Healthcare study shows drug combination extends pancreatic cancer patient survival
2. NIH program explores the use of genomic sequencing in newborn healthcare
3. Notre Dame researchers develop system that uses a big data approach to personalized healthcare
4. Gilde Healthcare III Portfolio Company Definiens Establishes Advisory Board
5. Nurses at forefront of genomics in healthcare
6. Mount Sinai grad student, 25, named to Forbes 30 Under 30 in Science and Healthcare
7. BUSM/VA Boston Healthcare System investigators identify new gene linked to PTSD
8. Pilot Results Move GHX Closer to Delivery of Healthcare Industrys First Implantable Device Supply Chain Solution
9. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
10. BGI, GE Healthcare team up on pioneering stem cell science projects
11. Premier Healthcare Renews Supplier Agreement with Masimo
Post Your Comments:
(Date:11/17/2015)... 2015 Paris from 17 ... Paris from 17 th until 19 ... innovation leader, has invented the first combined scanner in the ... same scanning surface. Until now two different scanners were required: one ... capture both on the same surface. This innovation is ...
(Date:11/17/2015)... 2015  Vigilant Solutions announces today that Mr. ... Directors. --> --> ... the partnership at TPG Capital, one of the largest ... Billion in revenue.  He founded and led TPG,s Operating ... companies, from 1997 to 2013.  In his first role, ...
(Date:11/16/2015)... 16, 2015  Synaptics Inc. (NASDAQ: SYNA ... today announced expansion of its TDDI product portfolio ... controller and display driver integration (TDDI) solutions designed ... new TDDI products add to the previously-announced ... (WQHD resolution), and TD4322 (FHD resolution) solutions. All ...
Breaking Biology News(10 mins):
(Date:12/1/2015)...  Twist Bioscience, a company focused on synthetic DNA, today ... been selected as one of Foreign Policy,s 100 ... blocks of life . Each year, Foreign Policy ... work have changed lives and are shaping the world. ... honor to be recognized among these incredible global leaders," said ...
(Date:12/1/2015)... 2015  The Minnesota High Tech Association (MHTA) has ... Award in the Small and Growing Healthcare award category. ... Minneapolis Convention Center, the Tekne Awards honor ... in developing new technologies that positively impact the lives ... Clostridium difficile infection ( C. diff. ), ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... ... (AFM) announces Park NX10 SICM Module, an add-on scanning ion conductance microscopy module ... power of SICM to an AFM. , Park SICM benefits virtually all materials ...
(Date:12/1/2015)... , Dec. 1, 2015  Symic, a clinical-stage ... the extracellular matrix (ECM), today announced that it has ... advance the company,s pipeline, including its lead candidates SB-030 ... and includes the participation by all existing major investors, ... brings the total capital raised by Symic to over ...
Breaking Biology Technology: