Navigation Links
T-cadherin affects blood vessel growth in breast cancer, hormone from fat cells may play a role
Date:4/4/2008

Researchers at the Burnham Institute for Medical Research (Burnham) may have found a new option for targeted breast cancer therapy by showing the link between a certain protein and the formation and development of blood vessels that feed breast tumors. Like mortar between bricks in a wall, T-cadherin is a protein that helps cells stick together and collectively form tissues. Cancer cells that loosen their adhesive tissue bonds stop producing T-cadherin, and in tumors, only the blood vessels that supply oxygen and nutrients express this protein. Now, Barbara Ranscht, Ph.D., and Robert Oshima, Ph.D., at Burnham have led a team that developed the first living model to study this proteins effect on tumor angiogenesis by creating a strain of mice that develops spontaneous mammary gland tumors in the absence of T-cadherin. Their results appeared March 1 in Cancer Research.

Evidence of T-cadherins role in vascularization has been somewhat controversial, explains Dr. Ranscht, senior author of the study, which includes Drs. Lionel Hebbard and Michle Garlatti from the Burnham Institute as equally contributing first authors and Drs. Robert Cardiff and Lawrence Young as collaborators from the University of California, Davis. But our knockout model clearly shows that T-cadherin plays a role in promoting tumor vascularization, with implications for tumor growth and animal survival.

The tumor model developed in Dr. Ranschts laboratory shows that loss of T-cadherin slows down tumor growth and improves survival compared to controls where T-cadherin is present: The absence of T-cadherin delays tumor growth by an average of 10 days, decreases tumor size, and apoptosis markers, indicators of cell suicide, are six times higher. The tumor-bearing knockouts live an average of 18.5 days longer than their wild-type counterparts, which translates into approximately 18 months of human life span.

The normal models in the study developed solid adenocarcino
'/>"/>

Contact: Andrea Moser
amoser@burnham.org
858-646-3146
Burnham Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study finds pitching mound height affects throwing motion, injury risk
2. Gene dose affects tumor growth
3. Restless legs syndrome affects nearly 2 percent of US/UK children
4. Gender, coupled with diabetes, affects vascular disease development
5. Umbilical cord blood cell therapy may reduce signs and symptoms of Alzheimers disease
6. Umbilical cord blood cell therapy in an animal model of Alzheimers disease
7. Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice
8. Diabetes makes it hard for blood vessels to relax
9. Weill Cornell team discovers how brains own tPA helps regulate blood flow to neurons
10. High blood pressure in older adults traced to genes effects in blood vessels
11. Eltrombopag effective for hepatitis C patients with low blood-platelet counts
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
T-cadherin affects blood vessel growth in breast cancer, hormone from fat cells may play a role
(Date:9/16/2014)... Proteins are responsible for practically all vital functions ... reactions, forward signals, transport particular substances and control ... that proteins do not function independently of each ... you examine the protein networks, you find many ... Falter-Braun from TUM,s Chair of Plant Systems Biology. ...
(Date:9/16/2014)... , Sept. 16, 2014  Cross Match ... management solutions, announced today the launch of its ... authenticate the identity of an individual using their ... Verifier Sentry rapidly reads credential documents with embedded ... by matching the biometric to a live scan ...
(Date:9/16/2014)... season of bounty. Fungi of dizzying variety erupt from ... search of elusive but delectable wild mushrooms. Part of ... hunt, and their mysterious not-quite-meat, not-quite-vegetable qualities that belie ... you are eating known to science? , The Fungi ... some estimates range up to 10 million species, only ...
Breaking Biology News(10 mins):Good networkers make prime targets 2Cross Match Launches New Identity Management Handheld Solution 2What's for dinner? Rapidly identifying undescribed species in a commercial fungi packet 2What's for dinner? Rapidly identifying undescribed species in a commercial fungi packet 3
... Slugs are every gardener,s enemy: They can destroy overnight, ... don,t like all plants in the same way they ... posed by the botanist and founder of Chemical Ecology, Ernst ... More than a hundred years later chemists from Friedrich-Schiller-University Jena ...
... hands and arms through innovative robotic and virtual reality-based video ... Sergei Adamovich, a biomedical engineer. Thanks to a ... Adamovich is developing better ways to rehabilitate people who have ... Preliminary laboratory results appear promising: ...
... 2010) Acidity is increasing in some regions of the ... ocean, where it is now recognized that increased levels of ... more acidic. These more acidic conditions in key parts of ... to new research published in the journal Estuaries and ...
Cached Biology News:Self-defense strategies of moss 2NJIT engineer helps stroke patients regain motor functions in hands, arms 2Changing Chesapeake Bay acidity impacting oyster shell growth 2Changing Chesapeake Bay acidity impacting oyster shell growth 3
(Date:9/16/2014)... phones to cars and flashlights, batteries play an ... companies constantly are seeking ways to improve battery ... using a water-based solution, researchers at the University ... efficient nuclear battery that could be used for ... in automobiles and also in complicated applications such ...
(Date:9/16/2014)... September 16, 2014 BlueInGreen® ... most efficient method for delivering dissolved gases into ... Inc. as a manufacturer’s representative firm to ... dissolution products for municipal water and wastewater applications ... , H2Flow was founded in 1992 and serves ...
(Date:9/16/2014)... MILLBROOK, N.Y. , Sept. 16, 2014  Donald Fresne, ... the appointment of Stephan Vagner , PhD to its ... the University of Toulouse, France , performed ... Germany , and at Inserm, the French institute of ... Inserm and works both at the Curie Institute, Orsay, ...
(Date:9/16/2014)...  The Council for Entrepreneurial Development (CED), the ... country, today released a mid-year update to its ... It showed that in the first half of ... in the technology, life science, advanced manufacturing and ... variety of sources. Significant investment in technology companies and ...
Breaking Biology Technology:BlueInGreen® Expands into Canada – Signs Representative Agreement with H2Flow Equipment Inc. 2New Appointment to the Scientific Advisory Committee at Egenix, Inc. 2CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 2CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 3CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 4
... KNSY ) is scheduled to participate in a ... at the 2007 RBC Capital Markets,Healthcare Conference., Douglas ... panel,discussion on Thursday, December 13th at 8:00 a.m. ET ... York. The conference is by invitation only,however individuals can ...
... Promoting Advanced Technology,Industries Careers, HARRISBURG, Pa., ... from the Harrisburg area will continue learning ... special collaboration,between several local schools and the ... by the Harrisburg University of Science and,Technology, ...
... Dendreon Corporation (Nasdaq:,DNDN) today announced that the Company ... senior vice president of clinical affairs and chief ... a decade of oncology,drug development and patient treatment ... to the filing of the company,s Biologics License,Application ...
Cached Biology Technology:Capital Area Biotechnology Partnership Receives $160,000 State Investment 2Dendreon Promotes Dr. Mark Frohlich to Senior Vice President of Clinical Affairs and Chief Medical Officer 2Dendreon Promotes Dr. Mark Frohlich to Senior Vice President of Clinical Affairs and Chief Medical Officer 3
... a new technology for sensitive detection ... amounts of DNA (5). This process ... modify the DNA, followed by PCR ... distinguish methylated from unmethylated DNA. The ...
... m7G(5')ppp(5')G (Cap Analog) is used for the ... in vitro transcription reactions. Substitution of cap ... GTP in an in vitro transcription reaction ... structure into a large fraction of the ...
... The iEMS Incubator/Shaker HT ... Thus, the iEMS Incubator/Shaker HT ... as DNA hybridization and primer ... is available as a one-cabinet ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. -...
Biology Products: