Navigation Links
Synthetic protein mimics structure, function of metalloprotein in nature
Date:12/10/2009

CHAMPAIGN, Ill. Scientists have designed a synthetic protein that is both a structural model and a functional model of a native protein, nitric-oxide reductase.

The designed protein "provides an excellent model system for studying nitric-oxide reductase, and for creating biocatalysts for biotechnological, environmental and pharmaceutical applications," said University of Illinois chemistry professor Yi Lu, who directed the work.

"Through rational design, we can better understand native proteins, and maybe make one that is more efficient, more stable or more functional," Lu said.

While considerable progress has been made in designing proteins that mimic the structure of native proteins, the goal of reproducing both the structure and the function of native proteins especially metal-containing proteins called metalloproteins has been elusive.

Lu's research group, including lead author Natasha Yeung, and collaborators at the University of Illinois and at Brookhaven National Laboratory, are among the first to design a protein that mimics both the structure and the function of a metalloprotein. The researchers described their work in the journal Nature, published online on Nov. 25.

Nitric-oxide reductase is a key enzyme in the nitrogen cycle that is critical for life. Nitric oxide plays a key role in cell signaling and host-pathogen responses. Therefore, study of nitric-oxide reductase is an important step toward understanding these physiological and pathological processes.

It has been difficult to study nitric-oxide reductase, however, as it is a membrane protein that is not water soluble.

To mimic the structure and function of nitric-oxide reductase, the researchers began with myoglobin, a small muscle protein. Although smaller than nitric-oxide reductase and water soluble, myoglobin can reproduce key features of the native system. Into this scaffold protein the researchers engineered a new iron bind
'/>"/>

Contact: James E. Kloeppel
kloeppel@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert

Page: 1 2

Related biology news :

1. Synthetic biology offers new opportunities for interdisciplinary collaboration
2. New synthetic molecules trigger immune response to HIV and prostate cancer
3. Sun or shade: Pecan leaves photosynthetic light response evaluated
4. Synthetic cells shed biological insights while delivering battery power
5. Understanding a cells split personality aids synthetic circuits
6. Nanotechnology and synthetic biology: What does the American public think?
7. Synthetic Biology Project receives 2 National Science Foundation grants
8. July 9-10 symposium on synthetic biology
9. Synthetic catalyst mimics natures hydrogen economy
10. Synthetic chemical offers solution for crops facing drought
11. Using combinatorial libraries to engineer genetic circuits advances synthetic biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... Huntington Memorial Hospital is the first facility ... miniaturized, wireless monitoring sensor to manage heart failure (HF). ... FDA-approved heart failure monitoring device that has been proven ... to manage heart failure. The CardioMEMS HF ... pulmonary artery (PA) during a non-surgical procedure to directly ...
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/14/2015)... OXFORD, Conn. , April 14, 2015 ... "Company"), a biometric authentication company focused on the growing ... has been nominated for the 2015 New York Design ... The Design100, New York City Design Awards are ... are based on over 2,500 ratings from the marketplace, ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... Amsterdam, 2 November, 2010 - An investigation conducted in the ... Relevance to Humans, Animals and Ecosystems, demonstrates for the first ... is widespread. In the course of the Summer ... was sampled by mothers who had given birth at the ...
... School meal programs play a significant role in ... comprehensive school nutrition services that improve children,s nutritional ... updated joint position paper from the Society for ... the School Nutrition Association (SNA). The updated ...
... NEW YORK, Nov. 2, 2010 The Online Publishers Association ... Effectiveness of the OPA Ad Unit," that found that 90 ... 10 seconds of being on a webpage and users who ... were as emotionally engaged with the advertising as with the ...
Cached Biology News:Exposure of humans to cosmetic UV filters is widespread 2Exposure of humans to cosmetic UV filters is widespread 3Comprehensive nutrition services vital to children's health 2Online Publishers Association Unveils Biometric and Eye Tracking Research to Assess the Effectiveness of New OPA Ad Units 2Online Publishers Association Unveils Biometric and Eye Tracking Research to Assess the Effectiveness of New OPA Ad Units 3
(Date:4/22/2015)... , April 22, 2015  Sangamo BioSciences, Inc. (NASDAQ: ... financial results and accomplishments. For the first ... net loss of $5.3 million, or $0.08 per share, ... $0.12 per share, for the same period in 2014. ... cash equivalents, marketable securities and interest receivable of $226.1 ...
(Date:4/22/2015)... --  MPIRICA Health Inc. , a healthcare quality ... financing from the McQuinn Trust, an early stage, ... employer awareness of MPIRICA.com, delivering easily interpreted, outcomes-based ... hospitals. "As a patient in need ... choosing the hospital and surgeon most likely to ...
(Date:4/22/2015)... 2015 Steep Hill, the industry leader ... it has opened an investment round of $5 ...  The common stock investment round will be offered ... intended to encourage funding of small businesses by ... businesses largely relied on friends and family, venture ...
(Date:4/22/2015)... 22, 2015 Over the ... market witnessed tremendous growth primarily due to ... government support with increased nanotechnology R&D expenditure ... Customization: , http://www.marketsandmarkets.com/requestCustomization.asp?id=65048077 , In ... market is segmented on the basis of ...
Breaking Biology Technology:Sangamo BioSciences Reports First Quarter 2015 Financial Results 2Sangamo BioSciences Reports First Quarter 2015 Financial Results 3Sangamo BioSciences Reports First Quarter 2015 Financial Results 4Sangamo BioSciences Reports First Quarter 2015 Financial Results 5Sangamo BioSciences Reports First Quarter 2015 Financial Results 6Sangamo BioSciences Reports First Quarter 2015 Financial Results 7Sangamo BioSciences Reports First Quarter 2015 Financial Results 8MPIRICA Health Inc. Secures $1.6M to Promote FICO-Like Quality Scores for Surgeries 2Steep Hill Launches $5M Limited Stock Offering 2Steep Hill Launches $5M Limited Stock Offering 3Nanotechnology-based Medical Devices Market to Reach Around $8.5 billion by 2019 - Published by MarketsandMarkets 2Nanotechnology-based Medical Devices Market to Reach Around $8.5 billion by 2019 - Published by MarketsandMarkets 3
... ... Addressing Dynamic Needs of Growing World , ... Wilmington, DE (Vocus) July 9, 2010 -- The world’s population ... than 12 years -- with more than 9 billion people expected on earth before ...
... ... be present at the Process Expo 2010 in Chicago from July 18 ... designing and manufacturing of industrial wastewater treatment systems for the food processing ... technology and that FRC is a major well-known and respected DAF (Dissolved ...
... from microelectronics to power lines because of their ballistic ... those electrons in their tracks? Rice physicist Junichiro ... effect -- the interaction between electrically charged particles and ... nanotubes. While doing so, they came to the ...
Cached Biology Technology:United Nations' World Population Day Calls Attention to Key Global Issues 2United Nations' World Population Day Calls Attention to Key Global Issues 3United Nations' World Population Day Calls Attention to Key Global Issues 4United Nations' World Population Day Calls Attention to Key Global Issues 5FRC Systems International State-of-the-art Industrial Wastewater Treatment Systems 2FRC Systems International State-of-the-art Industrial Wastewater Treatment Systems 3Magnets trump metallics 2
Rabbit polyclonal antibody to NCOA2 [Agarose Immobilized]...
... and low background ,This solution greatly enhances ... higher than obtained with conventional methods. ,Two ... and secondary antibodies, which can suppress the ... , Wide versatility ,It is applicable to ...
Mouse Anti-Human Killer Cell Immunoglobulin-like Receptor, Two Domains, Long Cytoplasmic Tail, 2 (KIR2DL2 (KIR2DL3 Monoclonal Antibody Family: Immunoglobulin Sub-Family: not assigned-Immunogl...
pH-dependent fluorescence; Maximum intensity observed in basic solutions....
Biology Products: