Navigation Links
Synthetic derivatives of THC may weaken HIV-1 infection to enhance antiviral therapies
Date:4/30/2013

A new use for compounds related in composition to the active ingredient in marijuana may be on the horizon: a new research report published in the Journal of Leukocyte Biology shows that compounds that stimulate the cannabinoid type 2 (CB2) receptor in white blood cells, specifically macrophages, appear to weaken HIV-1 infection. The CB2 receptor is the molecular link through which the pharmaceutical properties of cannabis are manifested. Diminishing HIV-1 infection in this manner might make current anti-viral therapies more effective and provide some protection against certain HIV-1 complications.

"The synthetic compounds we used in our study may show promise in helping the body fight HIV-1 infection,'" said Yuri Persidsky, M.D., Ph.D., a researcher involved in the work from the Department of Pathology and Laboratory Medicine at Temple University School of Medicine in Philadelphia, PA. "As compounds like these are improved further and made widely available, we will continue to explore their potential to fight other viral diseases that are notoriously difficult to treat."

To make this discovery, scientists used a cell culture model to infect human macrophages with HIV-1 and added synthetic compounds similar to the active ingredient in marijuana to activate the CB2 receptor. At different times during the infection, samples from the culture were taken to see if the replication of the HIV virus was decreased. The researchers observed diminished HIV growth and a possible protective effect from some HIV-1 complications.

"HIV/AIDS has posed one of the most significant health challenges in modern medicine," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Recent high profile vaccine failures mean that all options need to be on the table to prevent or treat this devastating infection. Research on the role of cannabinoid type 2 receptors and viral inf
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Predictability: The brass ring for synthetic biology
2. Synthetic molecule first electricity-making catalyst to use iron to split hydrogen gas
3. Synthetic Biologics to Present at the 2013 BIO CEO & Investor Conference
4. Developing microbial cell factories by employing synthetic small regulatory RNAs
5. Oscillating gel gives synthetic materials the ability to speak
6. Synthetic and biological nanoparticles combined to produce new metamaterials
7. New report finds increase in media coverage of synthetic biology
8. Synthetic fuel could eliminate US need for crude oil
9. Microchoreography: Researchers use synthetic molecule to guide cellular dance
10. Nottingham part of £20m investment for UK synthetic biology
11. Synthetic biofilter wins through to the top Sweet 16 in Boston
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... of The Proceedings of the National ... 29, raises a number of startling questions about a ... take for granted. At the end of the last ... shifted from hunting animals and gathering fruits and tubers ... straightforward and yet the more scientists learn, the more ...
(Date:4/16/2014)... TALLAHASSEE, Fla. Florida State University researchers have identified ... deterioration of bone density and muscle mass with obesity. ... heavier you were the better your bones would be ... Ilich-Ernst, the Hazel Stiebeling Professor of Nutrition at Florida ...
(Date:4/16/2014)... Kennedy,s disease, spinal and bulbar muscular atrophy (SBMA) is a ... and atrophy. Researchers have long considered it to be essentially ... the spinal cord and brainstem that control muscle movement. , ... 2014 online issue of Neuron , a team of ...
Breaking Biology News(10 mins):Genetic study tackles mystery of slow plant domestications 2Genetic study tackles mystery of slow plant domestications 3Genetic study tackles mystery of slow plant domestications 4Researchers: Obesity can amplify bone and muscle loss 2Mutant protein in muscle linked to neuromuscular disorder 2
... A new study by researchers at NYU School of Medicine ... cells, causing mutations that can lead to melanoma. ... skin to protect it from the ultraviolet rays of the ... cells because they are unable to repair themselves as efficiently. ...
... been hearing about ESA,s most recently launched mission, CryoSat-2. ... in excellent health with scientists very encouraged by the ... Duncan Wingham, Lead Investigator for the CryoSat mission, stated, ... in-orbit specifications, the ground segment software is fine, the ...
... A new study from researchers in Ottawa and Toronto ... cell may be able to help treat sepsis, a deadly ... body. The study, published in the American Journal of ... can triple survival rates in an experimental model of sepsis. ...
Cached Biology News:UVA radiation damages DNA in human melanocyte skin cells and can lead to melanoma 2CryoSat-2 exceeding expectations 2Stem-cell therapy may provide new approach to fight infection 2
(Date:1/15/2014)... IL (PRWEB) January 15, 2014 Look ... find hard-working items for the lab, from fluid handling ... Guaranteed-in-Stock (GIS)—ready to ship when you order. , ... Peristaltic Pumps , from the L/S® model for precise ...
(Date:1/15/2014)... This webinar will focus on EMA and ... in biosimilars. , Regulatory frameworks are evolving many countries ... the complex nature of biopharmaceuticals makes the demonstration of ... challenging. Based on the specific aspects of biosimilar drug ...
(Date:1/15/2014)... January 15, 2014 The Microcompetition with Foreign ... disease. One of these latent viruses is the Epstein Barr ... (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease that ... study found that RA patients have high concentrations of EBV ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of ... of tinnitus. Patients listen to sound therapy that is ... of weeks to months, their tinnitus volume decreases. , AudioNotch ... Music and Notched White Noise. Now, AudioNotch is pleased to ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3
... ATLANTA, Dec. 11 WellCentive ( http://www.wellcentive.com ),today ... information technology (HIT),solutions designed to efficiently, securely and ... care providers. WellCentive Gateway allows,providers, such as ... variety of,outside HIT systems. WellCentive Connect is ...
... Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM ) today announced that ... passed away on Wednesday. Dr. Waltz had been a director ... the time of his death, Dr. Waltz served on Peregrine,s Audit ... , "The sudden loss of our business colleague ...
... - SCRIP Awards Recognises the Best and Brightest in ... - Glenmark is the Only Indian Company to ... The best and brightest of ... London at the 2008 SCRIP Awards hosted,by the leading UK broadcaster ...
Cached Biology Technology:WellCentive Launches New Health Information Exchange Platforms 2WellCentive Launches New Health Information Exchange Platforms 3Peregrine Pharmaceuticals Mourns Loss of Chairman Thomas A. Waltz 2SCRIP, the Leading Pharmaceutical Magazine in the World Crowns Glenmark as the "Best Pharma Company in the World - SME" and the "Best Company in Emerging Markets" at the SCRIP Awards 2008 in London 2
cysteine and glycine-rich protein 2,...
BKBeta2 potassium channel Antigen: Fusion protein amino acids 1-41 (N-terminus) and 218-235 (C-terminus) of mouse BKBeta2 Accession Number: Q9CZM9...
Anti-CD74 Monoclonal Antibody Description: 200 l Research Focus: cell surface antigens Storage: 4C Shipping Temperature: 4C...
Gap junction protein, beta 2, 26kDa (connexin 26) Antigen: Peptide...
Biology Products: