Navigation Links
Synthetic collagen from maize has human properties
Date:6/23/2011

Synthetic collagen has a wide range of applications in reconstructive and cosmetic surgery and in the food industry. For proper function in animals a certain number of prolines within the protein need to be hydroxylated. BioMed Central's open access journal BMC Biotechnology reports that for the first time the α1 chain of type 1 collagen has been produced in maize with similar levels of proline hydroxylation to human collagen.

Most collagen used is derived from animals but there are risks associated with this collagen containing infectious agents or being rejected by the body. To avoid this problem several laboratorybased systems have been developed using plants to produce collagen. Plant-derived recombinant proteins should have lower contamination and fewer infectious agents, but these systems are unable to make modifications to the protein essential for proper function in human cells.

Working in collaboration with industrial partners researchers added a gene, which codes for the α1 chain of human CI (hCI α1), to maize along with genes which make human prolyl 4-hydroxylase. This second protein was able to hydroxylate approximately the same percentage of prolines in the recombinant collagen α1 chain, produced in maize, as seen for human collagen made in human cells.

Dr Kan Wang from Iowa State University said, "Producing human collagen in maize seeds is an inexpensive alternative to using animal-derived collagen. The seeds are easy to grow, process, and store. Our transgenic plant system is also able to produce a protein with human-like modifications making it a better choice for a wide range of applications."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Page: 1

Related biology news :

1. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
2. Biological circuits for synthetic biology
3. UC Berkeley launches Synthetic Biology Institute to advance research in biological engineering
4. Open-source software designed to minimize synthetic biology risks
5. Synthetic biology: TUM researchers develop novel kind of fluorescent protein
6. Chicken litter provides organic alternative to synthetic fertilizers
7. Vaccine made with synthetic gene protects against deadly pneumonia
8. Research into synthetic antibodies offers hope for new diagnostics
9. Scripps Research team creates new synthetic compound with HIV-fighting promise
10. Princeton scientists construct synthetic proteins that sustain life
11. Bioethics Commission calls for enhanced federal oversight in new field of synthetic biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
(Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... NJ (PRWEB) , ... October 11, 2017 , ... Personal eye wash is a basic ... one eye at a time. So which eye do you rinse first if a dangerous ... have Plum Duo Eye Wash with its unique dual eye piece. , “Whether ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017  SkylineDx ... London (ICR) and University of Leeds ... to risk-stratify patients with multiple myeloma (MM), in a multi-centric ... The University of Leeds is the ... UK, and ICR will perform the testing services to include ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and ... rebranding initiative announced today. The bold new look is part of a transformation ... moves into a significant growth period. , It will also expand its service offering ...
(Date:10/10/2017)... International research firm Parks Associates announced today that ... TMA 2017 Annual Meeting , October 11 in Scottsdale, ... security market and how smart safety and security products impact the competitive ... Parks Associates: Smart Home Devices: Main ... "The residential security market has experienced continued ...
Breaking Biology Technology: