Navigation Links
Swimming upstream: Molecular approaches to better understand male infertility
Date:8/24/2010

iosis, which is tightly regulated by molecular processes within the cell. The question is, what are the epigenetic players involved in that process?

To begin to answer that question Berger, Govin, and their colleagues developed a way to systematically mutate portions of two proteins, histone H3 and histone H4, looking for defects in spore formation.

DNA in a cell is not like a free-floating tangle of yarn; it is tightly wrapped around protein spindles. Those spindles are built of histone proteins, and chemical changes to these spool proteins can either loosen or tighten their interaction with DNA, affecting, among other things, gene expression. Berger and her team used their mutants more than 100 were tested -- to identify novel histone modifications key to gamete formation.

According to Berger and Govin's analysis, sites on both histone H3 and H4 turned out be important. One critical modification site the team picked up is threonine-11 on histone H3 (H3T11), the phosphorylation of which is required to complete meiosis. The researchers also found a trio of lysines on histone H4, whose acetylation enables efficient compaction of chromosomal DNA into mature spores. The team demonstrated that these modifications also occur during mouse sperm formation and identified some candidates for the proteins that both "read" and "write" those modifications, as well.

Berger said the study is noteworthy on several levels. First, it establishes a screening method to identify epigenetic changes during sperm or egg formation, a process Govin is already applying to other histone proteins. Second, it proves that yeast spore formation closely models the mechanisms of mammalian sperm formation, a key advance given the complexity of mammalian genetics and the technical hurdles inherent in running a genetic screen in mice. Finally, assuming these epigenetic marks are also present and serve similar functions in humans, the study identifies potential b
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Biosensors reveal how single bacterium gets the message to split into a swimming and a stay-put cell
2. New molecular signaling cascade increases glucose uptake
3. AACR hosts molecular diagnostics conference in Denver, Colo.
4. American Society for Biochemistry and Molecular Biology honors 11 outstanding scientists
5. WPI research shows how cranberry juice fights bacteria at the molecular level
6. Molecular biology provides clues to health benefits of olive oil
7. NSF grant will develop new online hub for biochemistry, molecular biology educators
8. Elsevier announces the winner of the Ahmed Zewail prize in molecular sciences
9. Molecular discovery suggests new strategy to fight cancer drug resistance
10. Genetics Society of America to host 2010 Yeast Genetics & Molecular Biology Meeting
11. Molecular methods are not sufficient in systematics and evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... C-Labs LLC, a leading provider of remote ... today announced the appointment of John Traynor ... strategic advisor to the firm, Mr. Traynor will now ... based out of the C-Labs office in ... Muench , Chief Executive Officer. Photo - ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock ... authentication solutions, and MorphoTrust USA (Safran), ... services, today announced a strategic partnership to offer ... motor vehicle administration (MVA), airport screening and financial ... identity-related solutions, MorphoTrust serves consumers through a nationwide ...
(Date:11/7/2014)... Researchers led by Dr. Debra Auguste, associate professor, ... at The City College of New York, have ... treatment for one of the most aggressive forms ... (TNBCs) have a high mortality rate owing to ... effective therapeutic options. However, Professor Auguste,s team, discovered ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... MADISON, WI, SEPTEMBER 2, 2008 Varying the rate of ... intuitive sense, as farmers have long observed differences in ... The availability of spatial yield information from combines equipped ... improved management. So, optimizing inputs to match ...
... biomarkers for the detection of diseases including cancer and ... Cell Research . The findings pave the way ... are a class of naturally occurring small non-coding RNAs ... reporting individual miRNAs as diagnostic biomarkers of specific cancers ...
... University nanophotonics pioneer Naomi Halas has won one of ... the University of Pennsylvania,s Nano/Bio Interface Center (NBIC). ... the innovative synthesis of nanostructures. She will accept the ... ceremonies Oct. 29 in Philadelphia. Halas is the ...
Cached Biology News:A little nitrogen can go a long way 2A little nitrogen can go a long way 3
(Date:11/24/2014)... 24, 2014 Five American winners ... Al Maktoum Awards for Medical Sciences", in its 8 ... Arab Emirates , on 15 December 2014. ... The Carter Center which won the Hamdan Award ... in numerous programs that aim to improve health and ...
(Date:11/24/2014)... , Nov. 24, 2014 VolitionRx Limited ... tests for cancer and other conditions, today announced that data ... the Science for Business BioWin Day 2014, being held November ... data come from VolitionRx,s lung cancer pilot study, the samples ... Centre Hospitalier Universitaire (CHU) de Liege in Belgium ...
(Date:11/24/2014)... 2014   Veracyte, Inc. (Nasdaq: VCYT ... and chief executive officer, will present in a fireside chat ... Conference on Tuesday, December 2, 2014 at 12:30 p.m. ET ... live audio webcast and subsequent replay may be accessed by ... the website at least 15 minutes prior to the live ...
(Date:11/24/2014)... Continental Clinical Solutions, LLC (Continental) ... trials at its mid-Atlantic late-phase research facility, located ... with the idea of closing patient disparities in ... medical advances," said Continental's CEO, Saleh Stevens ... immortal cell line of Henrietta Lacks, dubious ethical ...
Breaking Biology Technology:Five US Winners Among Recipients of Hamdan Medical Awards 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6Veracyte to Present at the Piper Jaffray 26th Annual Healthcare Conference 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3
... 21, 2011 MDOUTLOOK®, the global oncology intelligence initiative ... Annual Quick Poll research launched immediately following this month,s ... (ASCO) in Chicago. These Quick Polls expand on previous ... annual meetings, as well as similar efforts after the ...
... 21, 2011 Waife & Associates, Inc. (W&A), change ... is adding the consulting practice of Mark Di Ianni, ... Di Ianni has been a senior executive in the ... and/or managing a series of successful companies. In recent ...
... ROCKVILLE, Md., June 21, 2011 For successful ... needs to be aligned from concept through the ... (RAPS)webinar, participants will learn why Regulatory and Marketing ... product claims and promote the product for both ...
Cached Biology Technology:MDOUTLOOK® 4th Annual Quick Polls From ASCO 2011: Report on Clinical Impact of New Developments in Cancer Therapeutics 2MDOUTLOOK® 4th Annual Quick Polls From ASCO 2011: Report on Clinical Impact of New Developments in Cancer Therapeutics 3Waife & Associates, Inc. Adds Mark Di Ianni as Principal Consultant 2How-To RAPS Webinar June 30: Regulatory and Marketing Symbiosis from Concept to Launch 2
UltraMount is formulated for coverslipping sections stained with alcohol soluble chromogens, such as Fast-Red or AEC. No heating is required prior to use. Coverslips may be removed by soaking in wate...
AM100 is an aqueous-based, permanent mounting media designed for use with alkaline phosphatase and immunoperoxidase stained tissue sections....
...
... Fixation Buffer, used in conjunction with ... can be used to fix and ... staining of cytokines and other cytoplasmic ... been specially formulated for reducing non-specific ...
Biology Products: