Navigation Links
Sweet genes
Date:7/3/2014

Edmonton, July 3, 2014 A research team at the Faculty of Medicine & Dentistry at the University of Alberta have discovered a new way by which metabolism is linked to the regulation of DNA, the basis of our genetic code. The findings may have important implications for the understanding of many common diseases, including cancer.

The DNA wraps around specialized proteins called histones in the cell's nucleus. Normally, histones keep the DNA tightly packaged, preventing the expression of genes and the replication of DNA, which are required for cell growth and division. In order for these critical functions to take place, histones need to be modified with the attachment of an acetyl-group, donated by a critical molecule called acetyl-CoA. This attachment relaxes the DNA, allowing for DNA replication and gene expression. This mechanism is called "epigenetic regulation of DNA" and is important for normal functions (like the growth of an embryo or brain functions) or in common diseases like heart failure or cancer. Until now, how the nucleus generates acetyl-CoA for histone acetylation had remained elusive.

The research team, lead by postdoctoral fellow Gopinath Sutendra and professor Evangelos Michelakis in the Department of Medicine, discovered that an enzyme thought to reside only within mitochondria, called Pyruvate Dehydrogenase Complex (PDC), can actually find its way into the nucleus and do what it is designed to do in the mitochondria: generate acetyl-CoA. When in mitochondria, PDC uses the carbohydrates from our diet to generate acetyl-CoA for energy production. When in the nucleus, PDC can produce acetyl-CoA for histone acetylation.

"Although this jumping of an enzyme from one organelle into another in the cell is not unheard off, our results were quite surprising", Sutendra says. "We wanted to measure acetyl-CoA levels and PDC in the mitochondria because that's where we thought they were. But accidentally we had the nuclei isolated
'/>"/>

Contact: Ross Neitz
rneitz@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related biology news :

1. Sweet sweet straw
2. The sweetest calculator in the world
3. The future of sweet cherry in Australia
4. Childrens preferences for sweeter and saltier tastes are linked to each other
5. Nectar: A sweet reward from plants to attract pollinators
6. UT Austin engineer converts yeast cells into sweet crude biofuel
7. Are sweetpotato weevils differentially attracted to certain colors?
8. The economically valuable sweet-gum trees: Taxonomy and 9 new combinations
9. Targeting cancers sweet tooth
10. The brain cannot be fooled by artificial sweeteners
11. Carbonation alters the minds perception of sweetness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... Canada , April 21, 2015 ... and evolving government policies are boosting access control systems ... According to a recently published report by ... Opportunities, 2020 ", the access control systems market in ... nearly USD1.2 billion by 2020.The access control systems market ...
(Date:4/20/2015)... 2015 Huntington Memorial Hospital is the first ... new miniaturized, wireless monitoring sensor to manage heart failure ... only FDA-approved heart failure monitoring device that has been ... physicians to manage heart failure. The CardioMEMS ... the pulmonary artery (PA) during a non-surgical procedure to ...
(Date:4/20/2015)... The announcement comes as demand ... Management (GRM), Ireland,s foremost records management ... built up an impressive track record of clients within the ... the records management sector in Dubai . ... staffbase and employ a further eight staff members at its ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... Chemical Society (ACS) Weekly PressPac from the Office of ... journals and Chemical & Engineering News ., Please ... as the source for this information.` PressPac Archive: ... New tests: Marijuana damages DNA and may ...
... New Zealand researchers have accelerated research into Multiple Sclerosis ... help to unravel the causes of MS and other ... published today in the prestigious journal Nature Genetics ... remained a mystery. This discovery reveals important new insights ...
... Supply Chain Council -- Global Organization -- Begins in Houston ... and academic member, University of Houston ... College of Technology , ... first permanent Regional Center of Excellence for the U.S. Gulf Region. ...
Cached Biology News:American Chemical Society weekly presspac -- June 10, 2009 2American Chemical Society weekly presspac -- June 10, 2009 3American Chemical Society weekly presspac -- June 10, 2009 4American Chemical Society weekly presspac -- June 10, 2009 5American Chemical Society weekly presspac -- June 10, 2009 6American Chemical Society weekly presspac -- June 10, 2009 7Aussie and Kiwi researchers make double MS genetic discovery 2University of Houston Site of Regional Center of Excellence 2
(Date:4/25/2015)... Join us for a webinar at 12 ... Times using the Transcreener® ADP Assay , Register ... increasingly being incorporated into lead development efforts because longer ... increased therapeutic window and reduced side effects. Though ... such surface plasmon resonance, conjugation of drugs can affect ...
(Date:4/24/2015)... Top student social innovators from the ... universities, including UCSD and SDSU, will pitch their impact ... national and nonprofit companies for an opportunity to win ... Social Innovation Challenge 2015 . , The 2015 Social ... addressing a diverse range of issues including poverty, education, ...
(Date:4/24/2015)... AZ (PRWEB) April 24, 2015 The ... State University (ASU) have entered into an agreement to ... A memorandum of agreement signed by the universities will ... student success and other services particularly, though not exclusively, ... “We have complementary strengths and a similar set of ...
(Date:4/24/2015)... 2015 Leading Regenerative Veterinary Medicine ... allogeneic stem-cell product development program and changes its’ ... corporate strategic direction. , “I am extremely pleased ... cell development program has been kicked into high ... facility and hiring of our new Director of ...
Breaking Biology Technology:BellBrook Labs Webinar: Analyzing Kinase Inhibitor Residence Times using the Transcreener® ADP Assay 25th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 25th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 3South Dakota Mines, Arizona State University Pave Way for Cooperative Research 2Vet-Stem, Inc. Meets New Milestones and Changes Name to VetStem Biopharma 2
... DIEGO , May 11 Biomatrica, ... a solution-centric partnership program established with industry and ... storage and management of nucleic acids.  The Biomatrica ... for the development, testing, validation and use of ...
... May 11 Trans World Alloys (TWA) , one of the ... of their state-of-the-art, 40,000 square foot service center at 249 East Gardena Blvd., ... , (Photo: ... For the past ...
... Rice University researchers report using ultracentrifugation (UCF) to create ... team, led by Rice Professor Junichiro Kono and graduate ... small but significant step toward the dream of an ... quantum nanowire. The other, led by Rice Professor ...
Cached Biology Technology:Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 2Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 3Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 4Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 5Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 6Titanium and Aluminum Distributor, Trans World Alloys Relocates to Its Newly Built, State-of-the-Art Headquarters in Gardena, California 2Nano parfait a treat for scientists 2Nano parfait a treat for scientists 3
... to Protein A and, until recently, no readily ... IgM purification. Standard methods for IgM purification generally ... effective for removing all of the major impurities ... Pierce has developed an easy-to-use affinity matrix ...
... trademark of Merck KGaA. Physical form: Solution in 50% ... mM MgCl 2 , and 20 mM NaCl Preparation ... DNA to acid-soluble oligonucleotides equivalent to a ΔA 260 ... at 37 C (reaction volume 2.625 ml). Assay: ...
... BSA-Free Stabilizer is a bovine protein-free ... It is an aqueous solution that ... MOPS buffer (3-(N-Morpholino) propanesulfonic acid), pH ... combination of 0.02% methylisothiazolone and 0.02% ...
These 96-well 0.2 ml thin-wall PCR plate caps are caps that are used to seal 96-well, 0.2 ml thin-wall PCR plates. Supplied as 300 caps....
Biology Products: