Navigation Links
Sweet genes
Date:7/3/2014

Edmonton, July 3, 2014 A research team at the Faculty of Medicine & Dentistry at the University of Alberta have discovered a new way by which metabolism is linked to the regulation of DNA, the basis of our genetic code. The findings may have important implications for the understanding of many common diseases, including cancer.

The DNA wraps around specialized proteins called histones in the cell's nucleus. Normally, histones keep the DNA tightly packaged, preventing the expression of genes and the replication of DNA, which are required for cell growth and division. In order for these critical functions to take place, histones need to be modified with the attachment of an acetyl-group, donated by a critical molecule called acetyl-CoA. This attachment relaxes the DNA, allowing for DNA replication and gene expression. This mechanism is called "epigenetic regulation of DNA" and is important for normal functions (like the growth of an embryo or brain functions) or in common diseases like heart failure or cancer. Until now, how the nucleus generates acetyl-CoA for histone acetylation had remained elusive.

The research team, lead by postdoctoral fellow Gopinath Sutendra and professor Evangelos Michelakis in the Department of Medicine, discovered that an enzyme thought to reside only within mitochondria, called Pyruvate Dehydrogenase Complex (PDC), can actually find its way into the nucleus and do what it is designed to do in the mitochondria: generate acetyl-CoA. When in mitochondria, PDC uses the carbohydrates from our diet to generate acetyl-CoA for energy production. When in the nucleus, PDC can produce acetyl-CoA for histone acetylation.

"Although this jumping of an enzyme from one organelle into another in the cell is not unheard off, our results were quite surprising", Sutendra says. "We wanted to measure acetyl-CoA levels and PDC in the mitochondria because that's where we thought they were. But accidentally we had the nuclei isolated
'/>"/>

Contact: Ross Neitz
rneitz@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related biology news :

1. Sweet sweet straw
2. The sweetest calculator in the world
3. The future of sweet cherry in Australia
4. Childrens preferences for sweeter and saltier tastes are linked to each other
5. Nectar: A sweet reward from plants to attract pollinators
6. UT Austin engineer converts yeast cells into sweet crude biofuel
7. Are sweetpotato weevils differentially attracted to certain colors?
8. The economically valuable sweet-gum trees: Taxonomy and 9 new combinations
9. Targeting cancers sweet tooth
10. The brain cannot be fooled by artificial sweeteners
11. Carbonation alters the minds perception of sweetness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2015)... /CNW Telbec/ - handyem Inc. and FlowMetric Diagnostics ... of handyem,s HPC-150 portable flow cytometer within FlowMetric ... unprecedented model of mobile laboratory platform is presented ... Pennsylvania Convention Center, ... to 18 th 2015.  By virtue of ...
(Date:6/15/2015)... , June 15, 2015 A ... from Telstra reveals the majority of US consumers using mobile ... via biometrics, such as fingerprint and voiceprint, instead of having ... According to Telstra,s " Mobile Identity   -   ... report, with smartphones now the primary channel used by ...
(Date:6/9/2015)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, will be providing demonstrations of its ... Drug Information Association (DIA) Annual Meeting in ... will include previews of many exciting new enhancements that ... iMedNet 2015 Feature 1 Release. ...
Breaking Biology News(10 mins):handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4MedNet To Provide Sneak Peeks Of Its iMedNet "2015 Feature 1 Release" At The DIA Annual Meeting 2MedNet To Provide Sneak Peeks Of Its iMedNet "2015 Feature 1 Release" At The DIA Annual Meeting 3
... Kentucky plant pathologists recently discovered a metabolite that plays a ... humans and one-celled microorganisms to fend off a wide range ... systemic immunity. This mode of resistance has been known for ... that resistance have remained a mystery. The findings of ...
... How exactly bacterial pathogens cause diseases in plants ... to solve this problem. Now Wenbo Ma ... California, Riverside, has performed research on the soybean plant ... understanding of plant-pathogen interactions, a rapidly developing area among ...
... by researchers at the San Diego Supercomputer Center at ... to study evolutionary relationships among large populations of living ... to understand how to operate large, complex computer systems. ... (Cyberinfrastructure for Phylogenetic RESearch) Gateway, is an ...
Cached Biology News:Kentucky researchers find a key to plant disease resistance 2How do plants fight disease? 2How do plants fight disease? 3SDSC's CIPRES Gateway provides window to the past -- and fast 2SDSC's CIPRES Gateway provides window to the past -- and fast 3
(Date:7/6/2015)... ... July 06, 2015 , ... Discovery ... diagnostic tests are key drivers of the global molecular diagnostics market. BCC Research ... the introduction of new companion diagnostic tests will increase demand for inexpensive and ...
(Date:7/6/2015)... , July 6, 2015  Viveve Medical, Inc. ("Viveve") (OTCQB: VIVMF), ... Patricia Scheller , Viveve,s Chief Executive Officer, and Scott ... VirtualInvestorConferences.com on July 9, 2015. , , , ... , , , TIME:     , , , ... , , , http://tinyurl.com/viveve   , ...
(Date:7/6/2015)... July 6, 2015 ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") ... agreement with Novella Clinical (Novella), to conduct ... with newly diagnosed glioblastoma. Novella is a full-service, global ... small to mid-sized oncology companies. The ICT-107 phase 3 ... US, Europe and ...
(Date:7/3/2015)... ... July 03, 2015 , ... ... in applications such as animal waste reduction, bioremediation, wastewater treatment, aquaculture and ... settings, announced today that it will be showcasing, ManureMagicâ„¢, its industry-leading product ...
Breaking Biology Technology:Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 2Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 3Viveve to Webcast Live at VirtualInvestorConferences.com 2Viveve to Webcast Live at VirtualInvestorConferences.com 3ImmunoCellular Therapeutics Establishes Agreement with Novella Clinical to Conduct ICT-107 Phase 3 Registration Trial in Glioblastoma 2DryLet to Highlight Benefits of Patented ManureMagicâ„¢ at North American Manure Expo in Chambersburg, PA July 14-15, 2015 2
... Midwest at places like the Maytag plant in Galesburg, Ill., which ... many experts giving opinions about why these jobs are disappearing. ... cheaper wages and most stop there with their strategic analysis. That ... so focused on the bottom line. Its a safe bet for ...
... and technology industries are a major strength of the ... economic health of the state. These industries reflect ... healthcare technologies and devices. Concentration of this knowledge ... products and services in the device and technology arena. ...
... market research on an ongoing basis is the most ... for many companies, the benefits of conducting marketing research ... to be at odds: , ,Marketing research can ... costly. , ,The traditional solution to this quagmire is ...
Cached Biology Technology:Spend Money to Make Money and Dump Obsolete Tech Strategies 2Spend Money to Make Money and Dump Obsolete Tech Strategies 3Spend Money to Make Money and Dump Obsolete Tech Strategies 4Talking Bout My Generation: The Evolution of Online Marketing Research 2Talking Bout My Generation: The Evolution of Online Marketing Research 3
IMAGEQUANT 100 IQTL, 1 EA. Category: ImageQuant CCD Imagers....
ImageQuant 100 UV, 1 EA. Category: ImageQuant CCD Imagers....
The FlowTACS Apoptosis Detection Kit is designed specifically for in situdetection of apoptotic...
...
Biology Products: