Navigation Links
Sweet! Glycocongugates are more than the sum of their sugars
Date:8/25/2014

There's a certain type of biomolecule built like a nano-Christmas tree. Called a glycoconjugate, it's many branches are bedecked with sugary ornaments.

It's those ornaments that get all the glory. That's because, according to conventional wisdom, the glycoconjugate's lowly "tree" basically holds the sugars in place as they do the important work of reacting with other molecules.

Now a chemist at Michigan Technological University has discovered that the tree itselfcalled the scaffoldis a good deal more than a simple prop.

"We had always thought that all the biological function resides in the sugar," said Tarun Dam, principal investigator of the Mechanistic Glycobiology Lab at Michigan Tech. "People didn't appreciate that the scaffolds were active."

The discovery opens up new avenues for research, in particular the development of more and better pharmaceuticals. Glycoconjugates are found naturally in the body, but they are also an important class of drugs that includes anything from cancer treatments to vaccines.

To determine if the scaffold had a role to play in biological reactions, Dam and his team built and tested two types of glycoconjugate molecules. They had the same sugars and virtually identical shapes but were comprised of different scaffolds, one made of protein, the other a synthetic. The scientists then tested how the different glycoconjugates reacted with biomolecules called lectins. Lectins play an important role in numerous biological processes and are a target for many glycoconjugate drugs.

If the scaffolds had been inert, the reactions would have been identical. However, the sugars on the protein scaffold reacted with the lectins differently.

"If the scaffolds are different, they can cause my drug to work one way and your drug to work another way, even though they have similar epitopes [sugars]," Dam said. "Tweaking the scaffold can change the drug's function."


'/>"/>

Contact: Marcia Goodrich
mtunews@mtu.edu
906-487-2343
Michigan Technological University
Source:Eurekalert  

Page: 1

Related biology news :

1. 2 servings of salmon a week is healthy for pregnant women and their babies
2. Study finds peoples niceness may reside in their genes
3. Lizard moms may prepare their babies for a stressful world
4. Deterring signals: Tobacco plants advertise their defensive readiness to attacking leafhoppers
5. Vampire jumping spiders identify victims by their antennae
6. New Tool Helps Drug Developers Optimize Their Research and Target Development for Better Results and a Stronger Competitive Edge
7. Parasitic plants steal genes from their hosts
8. Cougars are re-populating their historical range, new study confirms
9. Research: Many programs to help diabetics manage their health do work
10. Better looking birds have more help at home with their chicks
11. The old primates club: Even male monkeys ride their fathers coattails to success
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sweet! Glycocongugates are more than the sum of their sugars
(Date:7/9/2015)... 2015 Research and ... the "Biometrics for Banking; Market & Technology ... to their offering. The adoption for ... growth and the forecast is that by 2020 ... companies involved in delivering biometric systems to the ...
(Date:7/8/2015)... NEW YORK , July 8, 2015 /PRNewswire/ ... today announced BD & Guidepoint Mentor, a ... access to Guidepoint,s expert network services. ... cutting-edge technologies to improve healthcare delivery and outcomes and, ... each start-up entrepreneur will be able to directly engage ...
(Date:7/7/2015)... 2015  Based on its recent analysis of ... Credence ID, LLC with the 2015 Asia-Pacific ... Year Award. Credence ID has developed a low-cost, ... of offering enrollment and identification solutions to the ... was formed by experts from the mobile biometrics ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5
... start-ups Straw Fuels and AdFerTech have won prizes ... supported by the EU,s main climate innovation initiative, ... the Climate-KIC Early Stage Entrepreneurs Prize, which will ... of Climate-KIC,s pan-European start-up Acceleration Programme. Straw Fuels, ...
... Colo., USA GSA Bulletin postings ... as seen in the Pyrenees; facies architecture in ... Permian Maroon Formation; preglacial fluvial gorges and valleys; ... Africa; Ediacaran fossils from Mistaken Point, Newfoundland; geologic ...
... Increasing block-rate water budgets are an innovative type of ... sizes are based on household characteristics, environmental conditions, and ... what constitutes "efficient" water use given those characteristics and ... relatively low for the most essential uses of water ...
Cached Biology News:Liquor converter, BBQ logs win €20K prizes at UK innovation showcase 2Mistaken point, Sanctuary of Zeus, catastrophic outburst floods, shocked sand grains 2Mistaken point, Sanctuary of Zeus, catastrophic outburst floods, shocked sand grains 3Mistaken point, Sanctuary of Zeus, catastrophic outburst floods, shocked sand grains 4Mistaken point, Sanctuary of Zeus, catastrophic outburst floods, shocked sand grains 5Mistaken point, Sanctuary of Zeus, catastrophic outburst floods, shocked sand grains 6Mistaken point, Sanctuary of Zeus, catastrophic outburst floods, shocked sand grains 7Mistaken point, Sanctuary of Zeus, catastrophic outburst floods, shocked sand grains 8Mistaken point, Sanctuary of Zeus, catastrophic outburst floods, shocked sand grains 9Mistaken point, Sanctuary of Zeus, catastrophic outburst floods, shocked sand grains 10An innovative approach to promote water use efficiency 2An innovative approach to promote water use efficiency 3
(Date:7/30/2015)... 30, 2015 Ascendis Pharma A/S (Nasdaq: ... its innovative TransCon technology to address significant unmet ... a six-month Phase 2 study to evaluate the ... in 53 treatment-naïve, pre-pubertal children with growth hormone ... pleased with the top-line results from our Phase ...
(Date:7/30/2015)... ... ... its 2015 growth plan and as a follow up to the recently announced expansion of ... pleased to announce that it has begun construction on a new Microbiological Laboratory. The new ... dedicated to basic USP 51, USP 61, and USP 62 testing specific to raw materials. ...
(Date:7/29/2015)... Sanofi, un leader mondial ... pour le premier semestre 2015. Le Directeur Général ... Visionner l,interview vidéo et lire la transcription ... Au sommaire de l,interview :  - ... - Diabète - Praluent ...
(Date:7/29/2015)... (Q2 2015: +14% CER / 20% of sales) led the regional performance in ... , as well as solid contributions from Korea, India ... Middle East / Africa (Q2 2015: ... , Turkey and the United Kingdom ... excluding U.S. HPV sales, on demand across all customer classes. The top seven ...
Breaking Biology Technology:Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2QIAGEN Reports Results for Second Quarter and First Half of 2015 2QIAGEN Reports Results for Second Quarter and First Half of 2015 3QIAGEN Reports Results for Second Quarter and First Half of 2015 4QIAGEN Reports Results for Second Quarter and First Half of 2015 5QIAGEN Reports Results for Second Quarter and First Half of 2015 6QIAGEN Reports Results for Second Quarter and First Half of 2015 7QIAGEN Reports Results for Second Quarter and First Half of 2015 8QIAGEN Reports Results for Second Quarter and First Half of 2015 9QIAGEN Reports Results for Second Quarter and First Half of 2015 10
... , ... (DIA) and the US Food and Drug Administration (USFDA) will host Assessing Benefits and Risks ... , ... 2009 -- The Drug Information Association (DIA) and the US Food and Drug ...
... ... Products announced a financial support partnership with several key vendors to ... collective effort with a dedicated "Pink" section on their website, ... will be available. Spectrum will also donate $1 per order ...
... Inc. (OTC Bulletin Board: BTEL) announced results for the fiscal ... or $0.33 per diluted share, on revenues of $12,640,000. ... diluted share on revenues of $11,495,000 in fiscal year 2008. ... of $174,000 or $0.06 per diluted share, on revenues of ...
Cached Biology Technology:Global Regulators to Discuss Benefit-Risk Approaches of Medicinal Products at DIA Workshop 2Global Regulators to Discuss Benefit-Risk Approaches of Medicinal Products at DIA Workshop 3Spectrum Announces Support Partnership for Breast Cancer Research During Breast Cancer Awareness Month 2Spectrum Announces Support Partnership for Breast Cancer Research During Breast Cancer Awareness Month 3Biotel Announces Fourth Quarter and Year End Results 2
Umbilical cord blood eosinophils, For immunohistochemistry (IHC)...
Human peripheral blood PBMCs, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Umbilical cord blood mononuclear cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood MNCs and T Cells...
Umbilical cord blood basophils, For immunohistochemistry (IHC)...
Biology Products: