A study presented today at the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases shows that long-term low levels of vitamin D intake are associated with higher 10-year fracture risk in elderly women.
Vitamin D insufficiency in seniors has been shown to contribute to increased risk of osteoporotic fractures. Previous studies have used single vitamin D measurements to investigate effects on bone. However, in elderly women, relatively little is known about the effects of long-term vitamin D insufficiency on bone health.
The study by Swedish researchers used sequential assessment of serum vitamin D to determine if sustained hypovitaminosis D in elderly women leads to increased 10-year fracture incidence.
Study participants at baseline were 1044 Swedish women, all aged 75, with 715 attending at the 5-year follow up. Serum 25-hydroxyvitamin D (25OHD) levels (nmol/l) were classified as low (<50), intermediate (50) and high (>75). Women with values in the same 25OHD category at both samplings were considered to have consistently low, intermediate or high levels. Fracture data was followed for 10 years through X-rays at the radiology department.
The results showed that the incidence of hip fractures within 10 years was significantly lower in those women who were vitamin D sufficient (≥50 nmol/l) at baseline and maintained this level at 5 years. The proportion of women sustaining FRAX fractures was 26.2% and 30% in the group which had consistently high or intermediate 25OHD levels compared to 45.6 % in the group with consistently low levels. The incidence of shoulder, radius and vertebral fractures was not associated with 25OHD status in the study. The majority of fractures occurred between 5 and 10 years after baseline (hip 77%; FRAX 64%) however the time to first fracture (hip and FRAX) did not significantly differ between the three categories of 25OHD using either a single or serial measurem
|Contact: C. Jagait|
International Osteoporosis Foundation