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Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine
Date:7/31/2014

levels, as measured by ELISA and PBNA. High and sustained levels of IgG antibodies were observed, reaching a plateau approximately 18 months after the first vaccine dose and remaining stable thereafter. Compared with levels following natural infection, IgG levels in the vaccine group were 10.8-fold and 10.0-fold higher for HPV-16 and HPV-18, respectively.

Confidence in mass vaccination programs

To date, these data represent the longest follow-up reported for a licensed HPV vaccine. There were no safety concerns. The study authors led by Dr Paulo S Naud from the Federal University of Rio Grande do Sul (Porto Alegre, Rio Grande do Sul, Brazil) conclude that these results should provide confidence in the duration of protection offered by HPV mass vaccination programs existing in a number of countries around the world.

Dr Ronald Ellis, Editor-in-Chief of HV&I, comments: "HPV vaccine has been distinctive in having achieved 100% protective efficacy in licensure trials and showing excellent persistence of protective immunity. The data in this article show persistence of protection for about one decade, which should give adolescents and young adults an increased level of confidence in taking this vaccine and being protected against the development of cervical and other cancers."


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Contact: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Source:Eurekalert

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