Navigation Links
Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine
Date:7/31/2014

A long-term follow-up study (HPV-023; NCT00518336) shows the sustained efficacy, immunogenicity and safety of GlaxoSmithKline's human papilloma virus (HPV) vaccine Cervarix. Women vaccinated with the HPV-16/18 AS04-adjuvanted vaccine were followed for more than nine years, and vaccine efficacy (VE) against incident infection was 100%. This is the longest follow-up report for a licensed HPV vaccine. Visit https://www.landesbioscience.com/journals/vaccines/article/29532/ for the full paper.

HPV and vaccination

Persistent infection with HPV has been clearly established as the necessary cause of the overwhelming majority of cervical cancer cases. At least 40 different HPV types are known to infect the genital mucosa, of which approximately 15 are associated with cervical cancer. Among these types, HPV-16 and HPV-18 are the most common and responsible for approximately 70% of cervical cancers. Both HPV-16 and HPV-18 are included in the two licensed HPV vaccines (GSK's Cervarix and Merck's Gardasil), which are now widely available and used. Evidence of long-term efficacy against vaccine HPV-types is very important, particularly with respect to maintaining public confidence in mass vaccination programs. HPV vaccines initially were recommended for young girls and women 9-25 years of age who have not been exposed to HPV. Since HPV causes not only cervical cancer but also genital warts and anal cancer, HPV vaccines are also recommended for boys in many countries.

Previous clinical studies

An initial double-blind, randomized, multi-center vaccination study (HPV-001; NCT00689741) was started in 2001, followed for up to 27 months, and then followed by a long-term study of the entire cohort for up to 77 months (6,4 years) post initial vaccination (HPV-007; NCT00120848). HPV-007 was followed by an additional extensive study, HPV-023, resul
'/>"/>

Contact: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UGA study finds theres not always safety in numbers when it comes to extinction risk
2. Sensitive test helps improve vaccine safety
3. NIH funds development of tissue chips to help predict drug safety
4. Jeff Crandall Honored With SAE International Arnold W. Siegel International Transportation Safety Award
5. INTEGRIS Health Puts Patient Safety in the Palm of Your Hand
6. Questions about biosafety? Ask a biosafety expert
7. Climate change impacts to US coasts threaten public health, safety and economy
8. Masked mold toxins in food should be included in safety regulations
9. Additional research must be done to ensure safety of pit latrines, new study says
10. Revolutionary Face Recognition Media Exploitation System Now Available to Enhance Public Safety in Europe
11. RNA-interference pesticides will need special safety testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2015)... 2015   The Sync Project™ today ... measure and harness music to improve health. The ... objective measurements of physiology, enabling the study of ... large populations. It is designed for medical and ... rigorous studies and accelerate the discovery of the ...
(Date:3/10/2015)... OXFORD, Conn. , March 10, 2015 /PRNewswire/ ... NXTDW) ("NXT-ID" or the "Company"), a biometric authentication ... reports the company,s Wocket™ smart wallet has been ... 2015" by Rethink Modern. Rethink Modern ... sharing modern and innovative items for your home and lifestyle that ...
(Date:3/2/2015)... Calif. , March 2, 2015 ... leading developer of human interface solutions, today announced ... that is designed to enable rapid and secure ... ID™ module for gaming is a turnkey solution ... the ability to quickly integrate fingerprint ID solutions ...
Breaking Biology News(10 mins):Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3
... inflammation is a major factor in a wide range of ... fish oil) is known to temper this problem. A new ... The FASEB Journal , helps explain why DHA ... to finding new drugs that will help bring people back ...
... Shenzhen, China The Asian Cancer Research Group (ACRG), ... world,s largest genomics organization, and The University of Hong ... a study of recurrent mutations in hepatocellular carcinoma (HCC), ... international journal Genome Research . The study provides ...
... can have too much of a good thing when it ... to an article published in the July 2013 issue of ... healing can be delayed because the body produces too many ... cells, however, also causes harm by leading to the overproduction ...
Cached Biology News:Harvard and USC scientists show how DHA resolves inflammation 2ACRG and BGI report new evidence for the genetic bases of liver cancer 2Too much of a good thing? Too many 'healing' cells delays wound healing 2
(Date:3/27/2015)... NEW YORK , March 27, 2015  Peter ... in Biomedical Science for his pioneering work on how ... the components of a regulatory mechanism that cells use ... proteins. Dr. Walter is a professor of biochemistry at ... the groundwork for treating a range of human diseases ...
(Date:3/27/2015)... 27, 2015 Governor Andrew M. Cuomo ... for 43North - the world’s largest business idea competition ... prize of $1 million, six $500,000 awards and four ... world to compete for prizes that will turn ideas ... Western New York region. , "Last year's successful ...
(Date:3/26/2015)... 26, 2015 The Market Element LLC, ... strategic alliance with Designing Gig LLC to provide website ... , “Forging this alliance with Designing Gig represents ... can extend a comprehensive, end-to-end, digital solution for our ... execution,” said Chuck Miller, president of The Market Element. ...
(Date:3/26/2015)... , March 26, 2015 PAREXEL ... global clinical research organization , announced ... definitive agreement to acquire all of the ... a leading provider of specialized pharmacovigilance services, ... the collection, detection, assessment, monitoring, and prevention ...
Breaking Biology Technology:German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 2Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 3Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 4Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 5The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4
... to produce methyl ethyl ketone from renewable feedstocks ... Researchers at Genomatica, Inc., a sustainable chemical company, ... ketone (MEK), a commonly used industrial solvent with ... billion. The rapid development breakthrough demonstrates that ...
... Starting with the tiny fruit fly, and then moving into ... Center for Human Genetics (K.U. Leuven) showed that the same ... gene leads to cancer. The scientists think there is a ... with a drug. They report their findings in the reputed ...
... Calif., Feb. 24 Nektar Therapeutics,(Nasdaq: ... the fourth quarter and,year ended December 31, 2008. ... transformational year for Nektar," said Howard W. Robin,President ... our unique polymer,conjugation chemistry platform, we advanced numerous ...
Cached Biology Technology:New Genomatica Chemical Process Targets Ailing Ethanol Assets 2New Genomatica Chemical Process Targets Ailing Ethanol Assets 3New Genomatica Chemical Process Targets Ailing Ethanol Assets 4New Genomatica Chemical Process Targets Ailing Ethanol Assets 5Anti-cancer gene discovered: Perspective for therapy 2Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 2Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 3Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 4Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 5Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 6Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 7Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 8Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 9
... kit contains the basic components required for ... natural and recombinant mouse Dickkopf homolog-1 (Dkk-1) ... kit contains sufficient materials to run ELISAs ... the following conditions are met: The ...
HIV-1 TAT (vN-21)...
Presenilin-1, N-terminus....
Request Info...
Biology Products: