Navigation Links
Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine
Date:7/31/2014

A long-term follow-up study (HPV-023; NCT00518336) shows the sustained efficacy, immunogenicity and safety of GlaxoSmithKline's human papilloma virus (HPV) vaccine Cervarix. Women vaccinated with the HPV-16/18 AS04-adjuvanted vaccine were followed for more than nine years, and vaccine efficacy (VE) against incident infection was 100%. This is the longest follow-up report for a licensed HPV vaccine. Visit https://www.landesbioscience.com/journals/vaccines/article/29532/ for the full paper.

HPV and vaccination

Persistent infection with HPV has been clearly established as the necessary cause of the overwhelming majority of cervical cancer cases. At least 40 different HPV types are known to infect the genital mucosa, of which approximately 15 are associated with cervical cancer. Among these types, HPV-16 and HPV-18 are the most common and responsible for approximately 70% of cervical cancers. Both HPV-16 and HPV-18 are included in the two licensed HPV vaccines (GSK's Cervarix and Merck's Gardasil), which are now widely available and used. Evidence of long-term efficacy against vaccine HPV-types is very important, particularly with respect to maintaining public confidence in mass vaccination programs. HPV vaccines initially were recommended for young girls and women 9-25 years of age who have not been exposed to HPV. Since HPV causes not only cervical cancer but also genital warts and anal cancer, HPV vaccines are also recommended for boys in many countries.

Previous clinical studies

An initial double-blind, randomized, multi-center vaccination study (HPV-001; NCT00689741) was started in 2001, followed for up to 27 months, and then followed by a long-term study of the entire cohort for up to 77 months (6,4 years) post initial vaccination (HPV-007; NCT00120848). HPV-007 was followed by an additional extensive study, HPV-023, resul
'/>"/>

Contact: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UGA study finds theres not always safety in numbers when it comes to extinction risk
2. Sensitive test helps improve vaccine safety
3. NIH funds development of tissue chips to help predict drug safety
4. Jeff Crandall Honored With SAE International Arnold W. Siegel International Transportation Safety Award
5. INTEGRIS Health Puts Patient Safety in the Palm of Your Hand
6. Questions about biosafety? Ask a biosafety expert
7. Climate change impacts to US coasts threaten public health, safety and economy
8. Masked mold toxins in food should be included in safety regulations
9. Additional research must be done to ensure safety of pit latrines, new study says
10. Revolutionary Face Recognition Media Exploitation System Now Available to Enhance Public Safety in Europe
11. RNA-interference pesticides will need special safety testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... in German . ... day in order to reproduce? And why are there two ... the latest issue of the research journal Molecular Human ... Steven Ramm from Bielefeld University Bielefeld has compiled this special ... for a female to copulate with several males in quick ...
(Date:10/17/2014)... in German . ... drugs. When treating overdoses, doctors are often limited to supportive ... there is a combination of drugs involved. So what can ... his grandmother,s pills? ETH professor Jean-Christophe Leroux from the Institute ... answer to this question. "The task was to develop an ...
(Date:10/16/2014)... of Marine Science have received a 3-year, $392,773 ... the streams and wetlands most vulnerable to sea-level ... governments and citizens conserve these important ecosystems. , ... tidal-marsh observations first gathered by VIMS scientists in ... today,s researchers accurately map the slow but inexorable ...
Breaking Biology News(10 mins):Sperm wars 2Emergency aid for overdoses 2Emergency aid for overdoses 3EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3
... one of the less common types of skin cancer but it ... percent). The five-year survival rate for early stage melanoma is ... cancer is detected late or there is recurrence. So a ... the goal is to remove as little tissue as possible while ...
... University of Maryland, in partnership with the University of ... received a $7.9 million federal grant to acquire a ... will help researchers unravel the mysteries of molecules and ... diseases. The grant is among the largest of ...
... Instructor in Medicine, University of Washington, and Associate, Human ... been chosen by the American Society for Microbiology (ASM) ... her outstanding work elucidating the role of neutralizing antibodies ... Health Division, this award recognizes an early career scientist ...
Cached Biology News:Seeing melanoma 2Seeing melanoma 3University of Maryland partnership receives $7.9M from NIH for superconducting research magnet 2University of Maryland partnership receives $7.9M from NIH for superconducting research magnet 3
(Date:10/25/2014)... (PRWEB) October 24, 2014 According ... Market by Data Center Types (Colocation, Enterprise, Telecom), ... Types (Tier 1, Tier 2, Tier 3, Tier ... MarketsandMarkets, defines and segments the Data Center Construction ... and forecasting of revenues. This research report also ...
(Date:10/25/2014)... The Workgroup for Electronic ... authority on the use of health IT to ... appointment of four new co-chairs to the organization’s ... ,     Peter Dumont, Senior Director – ... Leader, Deloitte Consulting LLP ,     Deidre Rodriguez, ...
(Date:10/25/2014)... Today, Nerium International, a leader in scientifically advanced, ... Your Youth” contest, an effort launched to showcase product ... their skin since using Nerium’s product line, but who ... a result of their newfound confidence. , The “Reflect ... International to inspire conversations focused on the personal journey ...
(Date:10/25/2014)... 24, 2014 A new way to ... pitfalls of current skin grafting technologies, it also speeds ... The method, outlined in the October issue of STEM ... deep skin injuries that result from severe burns and ... the skin’s regenerative elements. These wounds heal by contraction, ...
Breaking Biology Technology:Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 2Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 3Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 4WEDI Appoints Four New Security and Privacy Workgroup Co-chairs 2Nerium International™ Inspires Conversation About the Journey of Aging with “Reflect Your Youth” Contest 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3
... This week Jonathan Watson will become the first student to ... engineering dual degree program . , ,Watson, a native of ... UW-Eau Claire and his bachelors degree in engineering from the ... great advantage in preparing for engineering course work because I ...
... and PowerPoint slides online is not enough, faculty and staff ... audio to liven up their course Web pages thanks to ... grant. , ,The services web site, Streaming Media at ... the production of streaming video and audio, comparisons of different ...
... has a new home: Health Sciences Learning Center ... health sciences on the UW-Madison campus. , ,Part of this ... DeLuca , associate dean for research and graduate studies at ... nursing, pharmacy and physical therapy students in one facility. DeLuca ...
Cached Biology Technology:Student to graduate in the Dual Degree Physics and Engineering Program 2University of Wisconsin enriches course web sites with streaming media 2UW Medical School to build Health Sciences Learning Center 2
... Extracts are optimized for maximum packaging efficiencies ... high efficiency extracts (> 109 pfu/g with ... a library containing at least 5 ... extracts are made from a specially designed ...
... 6 delivers enhanced statistics and statistical ... quality improvement managers. As an accepted ... 6 simplifies statistics for novice users ... by experts. It offers a powerful ...
... Mouse anti-Yersinia pestis F1 antigen, Monoclonal ... ELISA: Use at an ... an assay dependent dilution. WB: Use ... molecular weight: 18 kDa. Not tested ...
...
Biology Products: