Navigation Links
Surprisingly stable long-distance relationships
Date:7/3/2014

Contrary to what was thought, sequences of DNA called enhancers which control a gene's output find their targets long before they are activated during embryonic development, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found. Their study, published online today in Nature, also reveals that, surprisingly, the degree of complexity of enhancers' interactions in the 'simple' fruit fly Drosophila is comparable to what is seen in vertebrates.

"As an embryo develops, there are huge changes in transcription, much of which drives developmental progression: genes are changing from on to off, and off to on but the contacts between enhancers and their target genes remain largely unchanged," says Eileen Furlong from EMBL, who led the work. "Enhancers regulate transcription, so it was really surprising that there are few changes in their interactions at a time when transcription is changing."

To activate a gene, an enhancer has to come into contact with the portion of DNA at the start of the gene its promoter. For enhancers that are located far away from their targets, the cell achieves this by looping the DNA around to bring about that contact. Yad Ghavi-Helm, a postdoctoral fellow in Furlong's lab, found that, in developing fruit fly embryos, these DNA loops are formed, contact is established, and the cell's gene-reading machinery is recruited, hours before the gene is expressed. The results indicate that the whole system is primed in advance, ready to spring to action when needed.

When they looked at all the enhancers that are known in Drosophila and mapped what genes they establish contacts with, the EMBL scientists discovered that these genetic regulators act across long distances in the genome, and in complex ways. Such a prevalence of long-distance action and such complex interactions were previously known to be widespread among vertebrates, but these findings show that
'/>"/>

Contact: Sonia Furtado Neves
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Despite their thick skins, alligators and crocodiles are surprisingly touchy
2. Climate changes effects on temperate rain forests surprisingly complex
3. Computer modeling reveals how surprisingly potent hepatitis C drug works
4. Bats and whales behave in surprisingly similar ways
5. Feral cats avoid urban coyotes, are surprisingly healthy
6. Post-Sandy, Long Island barrier systems appear surprisingly sound
7. Coral reefs in Palau surprisingly resistant to naturally acidified waters
8. Palaus coral reefs surprisingly resistant to ocean acidification
9. Immunosignaturing: An accurate, affordable and stable diagnostic
10. A new breed of stable anti-aromatic compound
11. Treating stable flies in pastures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... and Washington land managers have a new synthesis of ... moist mixed-conifer (MMC) forests in the two states. ... in Eastern Oregon and Washington: A Synthesis of the ... a general technical report published by the U.S. Forest ... to a request from managers for a synthesis of ...
(Date:10/16/2014)... efficiently, they are anything but sustainable: environmental damage ... is becoming increasingly evident. Despite their disadvantages, however, ... regarded as the sole possibility of achieving higher ... Bernhard Schmid, an ecology professor at the University ... agriculture and forestry. After all, a new study ...
(Date:10/16/2014)... Calif. (October 16, 2014) – Post-menopausal women experienced ... on hormone levels or genital bleeding, after 12 ... an investigational fermented soy germ-based nutritional supplement previously ... to a new peer-reviewed pilot study reported in ... (NAMS) annual scientific meeting. , "These data ...
Breaking Biology News(10 mins):New report synthesizes best available science on management of moist mixed-conifer forests 2Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2
... In new research from Saint Louis University, investigators have ... responsible for the series of cellular events that lead to ... found that the brain toxin DOPAL plays a key role ... In earlier research, Saint Louis University investigators found ...
... about how the flea jumps, think again. In 1967, ... to catapult themselves into the air in an elastic ... debate raged about exactly how fleas harness this explosive ... hypotheses, but neither had access to the high speed ...
... 9, 2011 Qqest and M2SYS Technology, a global ... that allows Qqest to offer TimeForce time and attendance ... identification technology at their PC. M2SYS, RightPunch(TM) ... to seamlessly interface with Qqest,s TimeForce time and ...
Cached Biology News:SLU research implicates natural toxin as triggering Parkinson's disease 244-year-old mystery of how fleas jump resolved 244-year-old mystery of how fleas jump resolved 3Qqest Teams Up With M2SYS to Add Biometric Technology at the Desktop to TimeForce Time and Attendance System 2Qqest Teams Up With M2SYS to Add Biometric Technology at the Desktop to TimeForce Time and Attendance System 3
(Date:10/20/2014)... PLAINSBORO, N.J. (PRWEB) October 20, 2014 ... that the Sidney Kimmel Cancer Center at Thomas ... program. , Through the Strategic Alliance Partnership ... and OncLive will collaborate to raise awareness of ... cancer treatment, and other projects. Clinicians and other ...
(Date:10/19/2014)... , Oct. 19, 2014 NextCODE Health, which enables ... genome in real time, today announced the launch of its ... Exchange , at the American Society of Human Genetics (ASHG) ... learn more, sign up and apply for free beta access, ... features and benefits can be viewed here . ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asian Orthopedic ... market in Asia with analysis and forecast of revenue. The ... to grow to around $416.5 million by 2018, at a ... through the TOC of the Asian Orthopedic braces and support ... provided. This also provides a glimpse of the segmentation of ...
(Date:10/18/2014)... October 18, 2014 The report ... Trends and Forecasts to 2019", analyzes the global ... order to understand the industry details such as ... across various geographic regions. , Browse 81 Market ... Slides and in-depth TOC on “1,6-Hexanediol Market by ...
Breaking Biology Technology:Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5
... BEDFORD, Mass. and MADISON, Wis., July 17 ,Hologic, Inc. ... (Nasdaq:,TWTI) ("Third Wave"), today jointly announced the expiration of ... wholly-owned subsidiary Thunder,Tech Corp. (the "Purchaser") for all outstanding ... period expired, as scheduled, at 12:00,midnight, New York City ...
... Will Focus on Strategies to Promote Legislative Pathway for ... ... (Nasdaq:,INSM), a developer of follow-on biologics and biopharmaceuticals for unmet,medical needs, ... Ways and Means Committee from 2001 to 2007, has been,retained by ...
... Ablative Solution to Treat Deep Wrinkles and Significant Photo Damage,- ... Newest Addition Broadens Affirm(TM) Family to Provide Industry,s Most ... Comprehensive Anti-Aging Solution, ... ), a leading developer and manufacturer of a broad array ...
Cached Biology Technology:Hologic, Inc. Accepts Shares of Third Wave Technologies, Inc. in Tender Offer and Commences Subsequent Offering Period 2Hologic, Inc. Accepts Shares of Third Wave Technologies, Inc. in Tender Offer and Commences Subsequent Offering Period 3Hologic, Inc. Accepts Shares of Third Wave Technologies, Inc. in Tender Offer and Commences Subsequent Offering Period 4Hologic, Inc. Accepts Shares of Third Wave Technologies, Inc. in Tender Offer and Commences Subsequent Offering Period 5Insmed Partners With Bill Thomas, Former House Ways and Means Chairman, as Strategic Advisor 2Insmed Partners With Bill Thomas, Former House Ways and Means Chairman, as Strategic Advisor 3Insmed Partners With Bill Thomas, Former House Ways and Means Chairman, as Strategic Advisor 4Cynosure Introduces Affirm CO2(TM) Workstation for Advanced Ablative Therapy 2Cynosure Introduces Affirm CO2(TM) Workstation for Advanced Ablative Therapy 3Cynosure Introduces Affirm CO2(TM) Workstation for Advanced Ablative Therapy 4
... 140kDa GenBank Accession ... amino acids 926-941 (DKKVKPPFIPTIRGRE) of human PRK2. ... Quality Assurance Routinely evaluated by ... Stability 1 year at ...
Replacement Parts for Electrophoresis Apparatus...
Rabbit anti-phospho-EGFr (Tyr992) - Concentrate...
EMBP (FL-222)...
Biology Products: