Navigation Links
Superbugs may have a soft spot, after all
Date:2/26/2013

The overuse of antibiotics has created strains of bacteria resistant to medication, making the diseases they cause difficult to treat, or even deadly. But now a research team at the University of Rochester has identified a weakness in at least one superbug that scientists may be able to medically exploit.

Biologists Gloria Culver at Rochester and Keith Connolly, now at Harvard University, thought one key to stopping the bacteria may lie with proteins, so they studied the mechanism behind the development of bacterial ribosomesthe cell's protein-manufacturing machine.

"We targeted the ribosomes in our research because cells and organisms can't live if they don't make proteins, and they can't make proteins if their ribosomes aren't functioning properly." said Culver.

Culver and Connolly specifically worked with cultures of E. coli, a bacteria commonly found in the intestines. While E. coli is usually harmless, some strains are resistant to antibiotics and can cause serious food poisoning.

They discovered that two proteins already present in E. coli cellsRbfA and KsgAneed to be in balance with each other in order for ribosomes to function. If those proteins are present in the wrong concentrations, the ribosomes will not mature properly and will be unable to produce proteins, leading to the death of the cells. Their findings are being published this week in the journal Molecular Microbiology.

Culver said with the discovery that KsgA and RbfA.must be balanced for the cells to function properly, the next goal is to determine an effective way to disrupt that balance.

Crucially, RbfA does not exist in humans. "That may make it possible," Culver said," to kill E. coli without having a harmful effect on people."

Eric Brown, a professor of biochemistry and biomedical sciences at McMaster University in Hamilton, Ont., calls their work creative and scholarly. "Ribosome assemb
'/>"/>

Contact: Peter Iglinski
peter.iglinski@rochester.edu
585-273-4726
University of Rochester
Source:Eurekalert

Page: 1 2

Related biology news :

1. Hunt for superbugs in Australian animals
2. Hydrogen peroxide vapor enhances hospital disinfection of superbugs
3. 1 year after Fukushima
4. AGU: Venice hasnt stopped sinking after all
5. Black flies may have a purpose after all
6. Estrogen hormone reveals protective ability after traumatic brain injury
7. Obstructive sleep apneas damage evident after 1 month
8. Scientists read the ash from the Icelandic volcano 2 years after its eruption
9. Microbial communities shifted dramatically after Deepwater Horizon spill
10. Regenerated cells may restore vision after corneal dysfunction
11. Cinega de Santa Clara unchanged after pilot run of Yuma Desalting Plant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 2014 Research and Markets ... of the "The Global Watermarking and ... http://photos.prnewswire.com/prnh/20130307/600769 ... of the global digital media watermarking and ... monitor piracy by securely and invisibly embedding ...
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... the "Micro Market Monitor: North America Perimeter Security ... http://photos.prnewswire.com/prnh/20130307/600769 The North ... a CAGR of 3.6% from 2014 to 2019. Although ... market, Canada is expected to ...
(Date:12/17/2014)... , Dec. 15, 2014 Research and Markets ... addition of the "Samsung Galaxy S5 - ... report to their offering. ... totally different sensing technology than the iPhone 5S, ... sensor in its product. The Galaxy ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... promising alternative for the reconstitution of lost ... complications associated with traditional transplants. Tissue engineers ... by using engineered tissue substitutes that can ... into the host tissue. The traditional tissue-engineering ...
... After disappearing from Ontario due to over hunting in ... province thanks to the efforts of the Ontario elk ... success, published in the March issue of Restoration Ecology, ... various Ontario sites between 1998 and 2001. , "The ...
... to rivals with a visual display "shout" to get their ... lizards signal ownership of their territory by sitting up on ... extending a colorful throat pouch. They can spot a rival ... postdoctoral researcher at UC Davis who is working with Judy ...
Cached Biology News:
(Date:12/19/2014)... Dec. 18, 2014  Decision Resources Group finds that ... market will grow moderately through 2023 as the aging ... awareness of dental biomaterials all spur procedure volumes. Growth ... China and India ... procedures within reach for a larger proportion of the ...
(Date:12/19/2014)... , Dec. 18, 2014   ISN ... & Safety Performance Indicators publication series. With ... of activity reported in 2013 within its online contractor ... and safety key performance indicator (KPI) statistics. ... Clients, U.S. publication is available in two ...
(Date:12/17/2014)... NY (PRWEB) December 16, 2014 The ... changes since 2013, which is why IBISWorld updated its ... industry continues to benefit from an intensified focus on ... proposal for new emission standards for power plants and ... operators. According to IBISWorld Industry Analyst Sarah Kahn, “a ...
(Date:12/17/2014)... Bellingham, Washington, USA (PRWEB) December 16, 2014 ... Kirstin Baum, manager at Philipps- Universität Marburg’s Department ... optics and photonics, in the newly released ... 2015-2016. “And never be too shy to ask ... STEM (science, technology, engineering, and mathematics) occupations ranging ...
Breaking Biology Technology:Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3
... GeneLink Biosciences, Inc. (OTCBB: GNLK), a leading consumer ... the stock of its wholly owned direct-selling subsidiary ... (OTCBB: WELL), another public company operating in the ... and Capsalus executed definitive agreements for the sale ...
... DIEGO, Feb. 16, 2012 /PRNewswire-iReach/ -- FirstMark ... the multiple biomarker cardiovascular blood test PREvent. These clinical ... predict near term (2-3 years) risk of myocardial infarction ... or significant CAD. The clinical study and final data ...
... announced today the publication of key results relating to ... for high-value G-protein-coupled receptor (GPCR) targets in Science ... a Lipid G Protein-Coupled Receptor," was co-authored by Receptos ... and Raymond Stevens, Ph.D. Drs. Rosen and Stevens are ...
Cached Biology Technology:GeneLink Biosciences Completes Sale of GeneWize Life Sciences 2FirstMark's Landmark Clinical Study Successfully Completed that Fulfills the Unmet Need to Access the Risk of Near Term MI 2Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science 2Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science 3Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5...
...
RayBio L Series 507: RayBio Label-based Antibody Array I (1 glass slide with 2 subarrays) Class: Antibody Array Products Product Group: Antibody Array...
Rat CXCL7/Thymus Chemokine-1 DuoSet Economy Pack, 45 Plate...
Biology Products: