Navigation Links
Study shows new treatment strategy effective for certain lung cancers
Date:3/10/2011

New Orleans, LA LSU oncologist Vince D. Cataldo, MD, is the lead author of a review article reporting two chemotherapy drugs now indicated for second and third-line therapy in patients with advanced non-small-cell lung cancer are remarkably effective in treating a certain subset of these patients. Dr. Cataldo, a Clinical Assistant Professor of Medicine at LSU Health Sciences Center New Orleans School of Medicine, practicing at LSU's Earl K. Long Medical Center and Hematology-Oncology Clinic in Baton Rouge, and his colleagues say these drugs should be considered as a first-line treatment in people who are known to carry an Epidermal Growth Factor Receptor (EGFR) mutation. The paper is published in the March 10, 2011 issue of the New England Journal of Medicine.

The drugs, Erlotinib and Gefitinib, which are in a class of highly-specific small molecule tyrosine kinase inhibitors, work by blocking the activation of EGFR which is involved in cell survival and growth, as well as the development of a nourishing blood supply and metastasis.

"Targeting the genetic mutation contributing to the development of the cancer, this class of drugs produced a response rate that exceeded 70% in these patients," notes Dr. Cataldo.

The drugs, taken by mouth, also had fewer side effects. Unlike traditional cytotoxic agents, Erlotinib and Gefitinib do not typically cause myelosuppression, neuropathy, alopecia, or severe nausea.

Lung cancer, the leading cause of cancer-related death worldwide, accounted for an estimated 157,300 deaths in the United States in 2010. Approximately 85 to 90% of all cases of lung cancer are nonsmall-cell lung cancer (NSCLC) which is also associated with smoking. Advanced-stage NSCLC is currently considered an incurable disease for which standard chemotherapy provides marginal improvement in overall survival at the expense of substantial morbidity and mortality. Furthermore, less than 30% of patients with meta
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study finds usage of, recommendations for supplements common within various physician specialties
2. Study provides explanation for connection between low birth weight and obesity later in life
3. New UF study shows some sharks follow mental map to navigate seas
4. Study shows how plants sort and eliminate genes over millennia
5. MBARI and Monterey Bay National Marine Sanctuary to study effects of shipping containers lost at sea
6. Rensselaer professor utilizing New York state grant to study adult stem cells
7. Study analyzes role of PARP enzyme in eukaryotes
8. Fossil bird study describes ripple effect of extinction in animal kingdom
9. University of Missouri researcher study provides insight into how corn makes hormones
10. Rainwater harvest study finds roofing material affects water quality
11. A study reveals the keys to the locomotion of snails
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Wis. No matter how many times it,s ... social, communicating creatures. , But by using ... organisms radically alter their behavior to suit their ... of them are present, and act accordingly. , ... millions, it may change from innocuous to pathogenic, ...
(Date:9/18/2014)... turned its newborn screening program into a model other states ... the first-ever Newborn Screening Quality Award from the March of ... M.P.H., Arizona,s Department of Health Services director, with the award ... policy of full transparency for the length of time it ... lab for analysis, and set a target of having 95 ...
(Date:9/18/2014)... global cycles of carbon and nitrogen comprise all ... and environmental systems have caused imbalances and perturbations ... gases (GHGs). Increased GHGs result in climate changes ... ecosystems, oceans and the atmosphere. Understanding these feedback ... branch of environmental science during the past three ...
Breaking Biology News(10 mins):Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 3Greenhouse gas research enters a new era 2
... from the University of Southern Denmark have identified how a ... in a cell,s membrane. Such holes cause high blood pressure, ... medication for high blood pressure. High blood pressure can ... a specific mutated protein. Now the researchers at University of ...
... suffer from the consequences of maternal drug exposure during pregnancy, ... used substances. This motivated the study, published in the ... to decipher the molecular basis of how the major psychoactive ... brain development of the unborn foetus. The study ...
... have engineered an efficient and environmentally friendly catalyst for ... extensively in modern industry to manufacture fertilizer and refine ... element, it is generally not found as the pure ... (H2O) or to carbon in methane (CH4), the primary ...
Cached Biology News:Punctured cell membranes lead to high blood pressure 2Cannabis during pregnancy endangers fetal brain development 2Engineers teach old chemical new tricks to make cleaner fuels, fertilizers 2Engineers teach old chemical new tricks to make cleaner fuels, fertilizers 3Engineers teach old chemical new tricks to make cleaner fuels, fertilizers 4
(Date:9/18/2014)... About POCT POCT, ... clinical laboratory. It helps in making fast clinical ... medication. POCT is gaining popularity due to the ... as diabetes, heart disease, and obesity. It is ... to minimize errors during the diagnosis of patients. ...
(Date:9/18/2014)... Ireland , September 18, 2014 ... and Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has ... "Biocompatible Materials - Global Strategic Business ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes ... in US$ Million by the following ...
(Date:9/18/2014)... 18, 2014 Research and Markets ... "Global N-acetylcysteine Industry Report 2014" report to ... Industry Report 2014 is a professional and in-depth ... N-acetylcysteine industry. The report provides a ... applications and industry chain structure. The N-acetylcysteine market ...
(Date:9/18/2014)...  U.S. biotech company Kultevat has strengthened ... technology developed by the Donald Danforth Plant Science ... for applications in production of natural rubber in ... developed under the direction of Roger Beachy , ... of the Danforth Plant Science Center, and is used ...
Breaking Biology Technology:POCT Market in China 2014-2018 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global N-acetylcysteine Industry Report 2014 2Kultevat obtains license of gene switch technology 2
... a provider of single-molecule DNA analysis technology, announced Thursday it ... of brain tumor, known as oligodendroglioma. OpGen, based in Madison, ... and professor of genetics and chemistry at the University of ... , ,Optical mapping, invented by Schwartz, will enable researchers to ...
... investors, and media is a leading indicator, the technology market is ... when he said DEMO 2004 felt "like a bit of the ... were repeated by dozens of attendees who talked to or emailed ... this industry unlike any we've felt in the past 36 months. ...
... to offshore outsourcing as an issue du jour. I ... (an election year at that for America) due to ... future of the U.S. Prominent voices along every point ... Democratic presidential nomination to the Bush Administration and a ...
Cached Biology Technology:OpGen joins UW, Henry Ford Heath in Improving Brain Tumor Treatment 2The Tech Market is Looking Up 2The Tech Market is Looking Up 3The Tech Market is Looking Up 4The Great Offshore Outsourcing Debate 2
... AP Conjugate Stabilizer is an aqueous ... protein and other non-toxic stabilizing chemicals ... pH 5.5 6.5. This ... methylisothiazolone and 0.02% bromonitrodioxane as a ...
... binding is a problem in your ... immobilized NeutrAvidin products as superior alternatives ... a modified avidin derivative that combines ... biotin-binding protein with exceptionally low nonspecific ...
Cells are grown to a specified density and induced, when necessary. Protein expression samples are collected at 3 growth points and analyzed by SDS-PAGE/Coomassie....
... generated hybridomas against a large variety ... you are provided with personalized project ... lines developed by Covance remain exclusive ... hybridoma development project has four phases: ...
Biology Products: