Navigation Links
Study shows long-term effects of radiation in pediatric cancer patients
Date:8/21/2012

For many pediatric cancer patients, total body irradiation (TBI) is a necessary part of treatment during bone marrow transplant it's a key component of long term survival. But lengthened survival creates the ability to notice long term effects of radiation as these youngest cancer patients age. A University of Colorado Cancer Center study recently published in the journal Pediatric Blood & Cancer details these late effects of radiation.

"These kids basically lie on a table and truly do get radiation from head to toe. There is a little blocking of the lungs, but nothing of, for example, the brain or the kidneys," says Jean Mulcahy-Levy, MD, research fellow at the CU Cancer Center and the paper's first author.

Of 15 patients who received TBI before age 3, many developed endocrine and metabolic problems including testicular malfunction (78 percent), restrictive pulmonary disease due to high levels of blood triglycerides (74 percent), and cataracts (78 percent). Likewise, 90 percent of patients showed abnormally low levels of growth hormone, and 71 percent were considerably under height. Additional late effects of TBI included kidney, liver, skeletal and cardiac malfunction and three of four patients whose IQ had been tested before TBI showed cognitive decline.

"Fifteen doesn't seem like a large number, but because we have such a good pediatric bone marrow transplant program here at Children's Hospital Colorado and radiation therapy program at the CU Cancer Center, we were able to get a large enough cohort of patients to see these overall effects," Mulcahy-Levy says.

The study supports the recommendations of the Children's Oncology Group for long term follow up care for children receiving TBI (survivorshipguidelines.org). Specifically, Mulcahy-Levy hopes that increasing awareness of likely effects will help patients and their doctors screen for, detect, and correct likely effects of TBI.

"It's not so much that yo
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

1

GOOD

Page: 1 2

Related biology news :

1. Organic study of live pancreatic tissue yields new opportunities for diabetes research
2. Turmeric spices up virus study
3. Bird louse study shows how evolution sometimes repeats itself
4. Study proves that 1 extinction leads to another
5. NIH backs Rice University study of delay in gene transcription networks
6. Study of fruit fly chromosomes improves understanding of evolution and fertility
7. Selfish DNA in animal mitochondria offers possible tool to study aging
8. UIC study examines exercise and weight loss for older adults with osteoarthritis
9. Eating grapes may help protect heart health in men with metabolic syndrome, new study suggests
10. Carnegie Mellon study shows skin-aging radicals age naturally formed particles in the air
11. New UC Santa Barbara-based project to study contaminants in urban water environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... microbial pathogens are growing increasingly resistant to the conventional ... Wisconsin scientists has synthesized a potent new class of ... infections. , Writing online in the Journal of ... University of Wisconsin-Madison chemistry Professor Helen Blackwell describes agents ... Staphylococcus aureus , a bacterium at the root ...
(Date:5/22/2013)... improve durability in fuel cell powered buses, including ... links between electrode degradation processes and bus membrane ... of electrode degradation stressors in the operating cycle ... The findings of the study, led by SFU ... a long-term study at Burnaby-based Ballard Power Systems ...
(Date:5/22/2013)... Md. (May 22, 2013)The omega 3 fatty acids in ... cardiovascular diseaseso much so that the American Heart Association ... a week, particularly fatty varieties rich in omega 3s. ... a mystery. In a new study, scientists led by ... on this phenomenon by providing evidence that fish oil ...
Breaking Biology News(10 mins):University of Wisconsin chemists find new compounds to curb staph infection 2Tests lead to doubling of fuel cell life 2Fish oil may help the heart beat mental stress 2
... 2009 News reports last week about scuba divers off ... jumbo squid have raised the ire of University of Rhode ... the species who has dived with them several times, he ... is seriously overblown. For years Seibel has heard stories ...
... In a study released online on July 22 in ... Sciences , researchers at Arizona State University and Princeton ... rationally than our multimodal, egg-headed, tool-using, bipedal, opposing-thumbed ... humans being "stupider" than ants. Humans and animals simply ...
... Researchers at the University of Texas Medical Branch at ... while using depot medroxyprogesterone acetate, more commonly known as Depo-Provera ... that all women who use DMPA will gain weight and ... whose weight increased by 5 percent within the first six ...
Cached Biology News:URI researcher sheds light on 'man-eating' squid; finds them timid, nonthreatening 2URI researcher sheds light on 'man-eating' squid; finds them timid, nonthreatening 3Ants more rational than humans 2UTMB study identifies women at risk of gaining excessive weight with injectable birth control 2
(Date:5/23/2013)... , May 24, 2013 Die ... – Bei der englischen Version ... , 91 % der Teilnehmer einer groß angelegten Asthmaumfrage ... % laut GINA [*] -Definition [1] als kontrolliert ... mit Asthma generell einer von vier Denkweisen zugeordnet werden ...
(Date:5/23/2013)... 2013 Can economic incentives such as ... members of the public to increase their donations of ... Hopkins Carey Business School Assistant Professor Mario Macis ... a large body of recent research that supports their ... 2013, issue of Science that the World Health Organization ...
(Date:5/23/2013)... BROWNSBURG, Ind. , May 23, 2013  Rahal ... leader in human cord blood stem cell banking and ... sponsor of the No. 16 Acorn Stairlifts Indy car ... is for the remainder of the IZOD IndyCar 2013 ... Racing (RLL) will work to support awareness of umbilical ...
(Date:5/23/2013)... 23, 2013  Saddleback Memorial Medical Center in ... first hospital on the West Coast to perform a ... option provides women with a state-of-the-art, minimally invasive approach ... Winter , M.D., a highly regarded ... director of minimally invasive surgery at Saddleback Memorial, led ...
Breaking Biology Technology:Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 2Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 3Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 4Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 5Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 6Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 7Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 2Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 3StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 2StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 3Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 3
... Interleukin Genetics, Inc. (OTCQB: ILIU) announced today ... Thursday, November 10 at 4:30 p.m. (EST) to discuss the ... call, dial 877-324-1976 (domestic) or 631-291-4550 (international). The live Webcast ... the Investors section of Interleukin Genetics, Inc.,s Website at ...
... Cumberland Pharmaceuticals Inc. (NASDAQ: CPIX ), ... gastroenterology markets, today announced third quarter 2011 financial results. ... September 30, 2011, net revenue was $13.1 million, up from ... net revenue was driven by an increase in sales of ...
... NEW YORK, Nov. 3, 2011 Reportlinker.com announces ... in its catalogue: Global ... http://www.reportlinker.com/p0619270/Global-Biochip-Markets-Microarrays-and-Lab-on-a-Chip.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=NoCategory INTRODUCTION  ... BCC,s goal for this study ...
Cached Biology Technology:Interleukin Genetics, Inc. Announces Conference Call to Discuss Third Quarter 2011 Results 2Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 2Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 3Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 4Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 5Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 6Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 7Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 8Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 9Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 10Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 11Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 12Global Biochip Markets: Microarrays and Lab-on-a-Chip 2Global Biochip Markets: Microarrays and Lab-on-a-Chip 3Global Biochip Markets: Microarrays and Lab-on-a-Chip 4Global Biochip Markets: Microarrays and Lab-on-a-Chip 5
Immunogen for A300-655A was a phosphorylated synthetic peptide, which represented a portion of human RNA Polymerase II (GeneID 5430) around serine 5 of the C-terminal repeat YSPTSPS....
... Loading Buffer contains a precipitant to ensure that ... tracking dye to allow the user to follow ... ReddyRun™: ABgene ® s proprietary mixture ... same buffer composition used in ReddyRun™ molecular weight ...
human Exodus-2 Research Focus: cytokine/growth factor Storage Temperature: -20C Shipping Temperature: 4C...
... This CLS number is ... created to easily match ... showing no availability yet, ... old Sigma-Aldrich number (Z71,381-3) ...
Biology Products: