Navigation Links
Study shows long-term effects of radiation in pediatric cancer patients
Date:8/21/2012

For many pediatric cancer patients, total body irradiation (TBI) is a necessary part of treatment during bone marrow transplant it's a key component of long term survival. But lengthened survival creates the ability to notice long term effects of radiation as these youngest cancer patients age. A University of Colorado Cancer Center study recently published in the journal Pediatric Blood & Cancer details these late effects of radiation.

"These kids basically lie on a table and truly do get radiation from head to toe. There is a little blocking of the lungs, but nothing of, for example, the brain or the kidneys," says Jean Mulcahy-Levy, MD, research fellow at the CU Cancer Center and the paper's first author.

Of 15 patients who received TBI before age 3, many developed endocrine and metabolic problems including testicular malfunction (78 percent), restrictive pulmonary disease due to high levels of blood triglycerides (74 percent), and cataracts (78 percent). Likewise, 90 percent of patients showed abnormally low levels of growth hormone, and 71 percent were considerably under height. Additional late effects of TBI included kidney, liver, skeletal and cardiac malfunction and three of four patients whose IQ had been tested before TBI showed cognitive decline.

"Fifteen doesn't seem like a large number, but because we have such a good pediatric bone marrow transplant program here at Children's Hospital Colorado and radiation therapy program at the CU Cancer Center, we were able to get a large enough cohort of patients to see these overall effects," Mulcahy-Levy says.

The study supports the recommendations of the Children's Oncology Group for long term follow up care for children receiving TBI (survivorshipguidelines.org). Specifically, Mulcahy-Levy hopes that increasing awareness of likely effects will help patients and their doctors screen for, detect, and correct likely effects of TBI.

"It's not so much that yo
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Organic study of live pancreatic tissue yields new opportunities for diabetes research
2. Turmeric spices up virus study
3. Bird louse study shows how evolution sometimes repeats itself
4. Study proves that 1 extinction leads to another
5. NIH backs Rice University study of delay in gene transcription networks
6. Study of fruit fly chromosomes improves understanding of evolution and fertility
7. Selfish DNA in animal mitochondria offers possible tool to study aging
8. UIC study examines exercise and weight loss for older adults with osteoarthritis
9. Eating grapes may help protect heart health in men with metabolic syndrome, new study suggests
10. Carnegie Mellon study shows skin-aging radicals age naturally formed particles in the air
11. New UC Santa Barbara-based project to study contaminants in urban water environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... , April 20, 2015 Huntington Memorial Hospital ... to implant a new miniaturized, wireless monitoring sensor to ... the first and only FDA-approved heart failure monitoring device ... when used by physicians to manage heart failure. ... is implanted in the pulmonary artery (PA) during a ...
(Date:4/20/2015)... , April 20, 2015 The ... Glenbeigh Records Management (GRM), Ireland,s ... Dubai Islamic Bank. Having built up an impressive track record ... a leading player within the records management sector in ... to double is GCC staffbase and employ a further eight ...
(Date:4/17/2015)... 17, 2015 Increasing ... technological advancement to drive biometric systems market in ...   According to a recently released ... &  Opportunities, 2020 ", biometric systems market in ... growth at CAGR of over 22% through 2020. ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... A study that relates global energy use to economic ... , finds strong correlations between these two measures both ... leads the study,s authors to infer that energy use ... increase in energy supply will be required to meet ...
... French . Scientists have discovered direct evidence of ... ammonites, distant relatives of squids, octopuses and cuttlefishes. The discovery ... 65.5 million years ago, at the end of the Cretaceous. ... fossils but until now, there has been no experimental evidence ...
... native perennials instead of corn in the Midwest,s rolling ... University research suggests. Federal mandates and market forces ... biologist Bruce Robertson says, but the environmental consequences of ... are a serious concern. Ethanol in America is ...
Cached Biology News:Study finds energy limits global economic growth 2Ammonites' last meal: New light on past marine food chains 2Ammonites' last meal: New light on past marine food chains 3Biofuel grasslands better for birds than ethanol staple corn, researchers find 2
(Date:4/20/2015)... , April 20, 2015 Stent ... clots from vessels in the brain reduced disability ... by Tudor Jovin, MD, President of the Society ... "This is a giant step forward that ... treatment of stroke patients," said Jovin, who is ...
(Date:4/20/2015)... Columbia and MENLO PARK, ... DelMar Pharmaceuticals, Inc. (OTCQX: DMPI) (DelMar and ... and commercializing proven cancer therapies in new orphan ... the 106th Annual Meeting of the American ... on the potential for its lead product candidate ...
(Date:4/20/2015)... 20, 2015 PMG Research, Inc ... clinical research site: PMG Research of Christie Clinic. Effective ... the clinical research department at Christie Clinic ... to a second region within the United States. This ... enhances PMG’s access to an additional 80,000 patients. For ...
(Date:4/20/2015)... FORT WORTH, Texas , April 20, 2015 /PRNewswire/ ... by orthopedic surgeons for healing bone injuries. The orthobiologics ... of growth opportunities for its stakeholders. The global orthobiologics ... analysis and forecast of revenue. The global orthobiologics market ... projected to reach $7,900.2 million by 2019, at a ...
Breaking Biology Technology:SVIN President Tudor Jovin, MD, Co-Leads Groundbreaking Stroke Study In The New England Journal Of Medicine 2SVIN President Tudor Jovin, MD, Co-Leads Groundbreaking Stroke Study In The New England Journal Of Medicine 3DelMar Pharmaceuticals Presents Promising Preclinical Data on VAL-083's Potential to Treat Temozolomide-Resistant Glioblastoma Multiforme (GBM) 2DelMar Pharmaceuticals Presents Promising Preclinical Data on VAL-083's Potential to Treat Temozolomide-Resistant Glioblastoma Multiforme (GBM) 3DelMar Pharmaceuticals Presents Promising Preclinical Data on VAL-083's Potential to Treat Temozolomide-Resistant Glioblastoma Multiforme (GBM) 4DelMar Pharmaceuticals Presents Promising Preclinical Data on VAL-083's Potential to Treat Temozolomide-Resistant Glioblastoma Multiforme (GBM) 5PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 2PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 3Global Orthobiologics Market is Expected to Reach $7,900.2 Million by 2019, at a CAGR of 6.7% from 2014 to 2019 2Global Orthobiologics Market is Expected to Reach $7,900.2 Million by 2019, at a CAGR of 6.7% from 2014 to 2019 3
... Company now officially following an FDA 510(k) (Pre-Market Notification), Pathway for ... ... Human Appendicitis, CASTLE ROCK, Colo., Nov. 27 AspenBio Pharma,Inc. ... of novel drugs and diagnostics for animals and humans, has,received an ...
... Shamir,Optical Industry Ltd. (Nasdaq: SHMR ) ("Shamir"), a ... ophthalmic lens,market, today announced unaudited financial results for the ... ended September 30, 2007, revenues increased by 28.5%,to $30.9 ... of 2006.,Gross profit for the quarter increased by 25.3% ...
... Masimo receives approval from Ministry of Health, Labor and Welfare ... carbon ... monoxide levels in the blood, IRVINE, Calif., ... Motion and Low Perfusion pulse,oximetry, today announced approval of the ...
Cached Biology Technology:AspenBio Pharma Pursues FDA 510(k) Application Pathway for Appendicitis Blood Test 2AspenBio Pharma Pursues FDA 510(k) Application Pathway for Appendicitis Blood Test 3AspenBio Pharma Pursues FDA 510(k) Application Pathway for Appendicitis Blood Test 4Shamir Optical Industry Ltd. Reports Third Quarter 2007 Results 2Shamir Optical Industry Ltd. Reports Third Quarter 2007 Results 3Shamir Optical Industry Ltd. Reports Third Quarter 2007 Results 4Shamir Optical Industry Ltd. Reports Third Quarter 2007 Results 5Shamir Optical Industry Ltd. Reports Third Quarter 2007 Results 6Shamir Optical Industry Ltd. Reports Third Quarter 2007 Results 7Shamir Optical Industry Ltd. Reports Third Quarter 2007 Results 8Shamir Optical Industry Ltd. Reports Third Quarter 2007 Results 9Shamir Optical Industry Ltd. Reports Third Quarter 2007 Results 10Masimo Corporation Given Approval to Market the Masimo Rad-57 Pulse CO-Oximeter in Japan 2Masimo Corporation Given Approval to Market the Masimo Rad-57 Pulse CO-Oximeter in Japan 3Masimo Corporation Given Approval to Market the Masimo Rad-57 Pulse CO-Oximeter in Japan 4
... Each vial contains 200 g of ... receptor sequence (C-terminal amino acids 380-402; GLTPSAWEASSLRSSRHSGLSHF. ... an antigen for production of Cayman's EP1 ... can be used in conjunction with this ...
Anti-ZFP200 Family: Zinc Finger Peptide Sequence: CGKSFNHKTNLNKHER...
Complete cell culture media with cytokines...
Consists of 4 separate 100mM solutions (ATP,GTP,CTP and UTP pH 7.5) as sodium salts. 98% Pure by HPLC...
Biology Products: