Navigation Links
Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
Date:1/10/2013

nct appointment in the School of Physics at Georgia Tech.

The study was published online on Jan. 9, 2013 in the Journal of the Royal Society Interface. The work was supported by the James S. McDonnell Foundation and the Burroughs Wellcome Fund.

Common Gram-positive bacteria that infect humans include Streptococcus, which causes strep throat; Staphylococcus, which causes impetigo; and Clostridium, which causes botulism and tetanus. Gram-negative bacteria include Escherichia, which causes urinary tract infections; Vibrio, which causes cholera; and Neisseria, which causes gonorrhea.

Gram-positive bacteria differ from Gram-negative bacteria in the structure of their cell walls. The cell wall constitutes the outer layer of Gram-positive bacteria, whereas the cell wall lies between the inner and outer membrane of Gram-negative bacteria and is therefore protected from direct exposure to the environment.

Georgia Tech biology graduate student Gabriel Mitchell, Georgia Tech physics professor Kurt Wiesenfeld and Weitz developed a biophysical theory of the response of a Gram-positive bacterium to the formation of a hole in its cell wall. The model detailed the effect of pressure, bending and stretching forces on the changing configuration of the cell membrane due to a hole. The force associated with bending and stretching pulls the membrane inward, while the pressure from the inside of the cell pushes the membrane outward through the hole.

"We found that bending forces act to keep the membrane together and push it back inside, but a sufficiently large hole enables the bending forces to be overpowered by the internal pressure forces and the membrane begins to escape out and the cell contents follow," said Weitz.

The balance between the bending and pressure forces led to the model prediction that holes 15 to 24 nanometers in diameter or larger would cause a bacteria cell to
'/>"/>

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New study identifies significance of co-infection in disease control
2. Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants
3. Major cuts to surging CO2 emissions are needed now, not down the road, study finds
4. International study suggests human genes influence gut microbial composition
5. New study defines the long-sought structure of a protein necessary for cell-cell interaction
6. Bering Sea study finds prey density more important to predators than biomass
7. Big brains are pricey, guppy study shows
8. Hebrew University study finds key mechanism in calcium regulation
9. New study documents the natural relationship between CO2 concentrations and sea level
10. Stowers study hints that stem cells prepare for maturity much earlier than anticipated
11. Birdsong study pecks theory that music is uniquely human
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
(Date:9/1/2014)... 50 years ago, electron microscopy revealed the presence of ... and disappear. But scientists still don,t know what they ... proteins are believed to be crucial to the life ... approach to disease treatment., In the Journal of ... to investigators from various backgrounds, from biophysics to cell ...
(Date:8/31/2014)... of Warwick have discovered that ,good, cholesterol is turned ... methylglyoxal - MG, was found to damage ,good, HDL ... the body. , Low levels of HDL, High ... increased levels of MG being common in the elderly ... Supported by funding from the British Heart Foundation (BHF) ...
(Date:8/31/2014)... is developing drugs that are highly effective against a ... patient. Such properties are directly related to the 3D ... have a shape that is perfectly complementary to a ... specificity. Publishing in Nature Chemistry , EPFL scientists ... the 3D structure of bioactive peptides and enhance their ...
Breaking Biology News(10 mins):Scientists call for investigation of mysterious cloud-like collections in cells 2Sugar substance 'kills' good HDL cholesterol, new research finds 2A new synthetic amino acid for an emerging class of drugs 2A new synthetic amino acid for an emerging class of drugs 3
... director of Syracuse Biomaterials Institute (SBI) and Milton and ... Syracuse University,s L.C. Smith College of Engineering and Computer ... functionally graded materials (FGMs) to shape memory polymers (SMPs). ... switch between two shapes, from a fixed (temporary) shape ...
... SPRING HARBOR, N.Y. (Jan. 5, 2011) Auxin is a ... aspects of plant development and physiology. A new book, ... overview of auxin and its many roles in plant biology. ... plant research," write the editors, Mark Estelle, Dolf Weijers, Karin Ljung, ...
... Treating fractures in children requires special knowledge of ... and adolescent patients is less often caused by technical ... in this age group. Using the example of treating ... Marburg-Gieen University Medical Center, and Lucas Wessel, University Medical ...
Cached Biology News:Syracuse University team develops functionally graded shape memory polymers 2
(Date:8/28/2014)... Best Sanitizers, Inc., the first company ... sanitizer, asks food processors and food handling professionals to ... they’re currently using to Best Sanitizers’ Alpet® E3 ... to fighting cross-contamination and the spread of pathogens in ... are key criteria that make a hand sanitizer most ...
(Date:8/28/2014)... The ability for organizations to attract ... allow individuals to perform at the highest of levels, ... looking to compete in this post–recession era. The ... as the sector increasingly focuses on the importance of ... have real results on the organization's development and the ...
(Date:8/28/2014)... Exciting new work by a Florida State University ... that can take your temperature, emit white light, and ... the molecule looks like a butterfly. , Biwu Ma, ... Engineering in the FAMU-FSU College of Engineering, created the ... has continued to discover that his creation has many ...
(Date:8/28/2014)... CA (PRWEB) August 28, 2014 ... is offering a promotion for Eppendorf Safe ... customers to purchase the highest quality tubes at ... are ideal for customers doing chemical, medical, pharmaceutical, ... technicians who are not regularly able to afford ...
Breaking Biology Technology:Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3
... CITY, China, Feb. 11 /PRNewswire-Asia-FirstCall/ -- ... CBPO) (,China Biologic, or the,Company,), one ... in the,People,s Republic of China (,PRC,), ... subsidiary, Shandong Taibang Biological Products Co.,Ltd. ...
... -- Tianyin,Pharmaceutical, Co., Inc., (NYSE: TPI ), ... based in Chengdu, China, today,announced that management will hold ... at 8:45 a.m. EST on Wednesday, February 18, 2009.,Financial ... the market,closes. , Interested parties ...
... China, Feb. 11 /PRNewswire-Asia-FirstCall/ -- China Pharma,Holdings, Inc. ... and markets specialty pharmaceutical products in China,announced today ... the generic,version of the leading hypertension drug Candesartan. ... for this product are anticipated to require,approximately 18 ...
Cached Biology Technology:China Biologic Products Receives High-Technology Enterprise Certification to Qualify for Preferential Income Tax Rate 2China Biologic Products Receives High-Technology Enterprise Certification to Qualify for Preferential Income Tax Rate 3Tianyin Pharmaceutical Co., Inc. to Host Fiscal Year 2009 Second Quarter Earnings Conference Call on Wednesday, February 18, 2009 at 8:45 a.m. EST 2China Pharma Holdings, Inc. Announces Clinical Trials Already Underway for Candesartan 2China Pharma Holdings, Inc. Announces Clinical Trials Already Underway for Candesartan 3
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... Library Panels were designed for full-length gene ... PCRs to identify the desired cDNA clone. ... a 96-well "Master Plate," where each well ... identified the positive well(s) by gel electrophoresis ...
... is an affordable, compact benchtop imager ... providing a broad array of automated ... high-resolution images with high-performance laser autofocus, ... and emission filter changers, and a ...
... Contents include: Microarray hybridization chamber ... chamber top, clamp, thumbscrew) Microarray chamber user ... and are intended to be cleaned and ... with Agilents Catalog Oligo Microarray kits and ...
Biology Products: