Navigation Links
Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
Date:1/10/2013

The rise of antibiotic-resistant bacteria has initiated a quest for alternatives to conventional antibiotics. One potential alternative is PlyC, a potent enzyme that kills the bacteria that causes strep throat and streptococcal toxic shock syndrome. PlyC operates by locking onto the surface of a bacteria cell and chewing a hole in the cell wall large enough for the bacteria's inner membrane to protrude from the cell, ultimately causing the cell to burst and die.

Research has shown that alternative antimicrobials such as PlyC can effectively kill bacteria. However, fundamental questions remain about how bacteria respond to the holes that these therapeutics make in their cell wall and what size holes bacteria can withstand before breaking apart. Answering those questions could improve the effectiveness of current antibacterial drugs and initiate the development of new ones.

Researchers at the Georgia Institute of Technology and the University of Maryland recently conducted a study to try to answer those questions. The researchers created a biophysical model of the response of a Gram-positive bacterium to the formation of a hole in its cell wall. Then they used experimental measurements to validate the theory, which predicted that a hole in the bacteria cell wall larger than 15 to 24 nanometers in diameter would cause the cell to lyse, or burst. These small holes are approximately one-hundredth the diameter of a typical bacterial cell.

"Our model correctly predicted that the membrane and cell contents of Gram-positive bacteria cells explode out of holes in cell walls that exceed a few dozen nanometers. This critical hole size, validated by experiments, is much larger than the holes Gram-positive bacteria use to transport molecules necessary for their survival, which have been estimated to be less than 7 nanometers in diameter," said Joshua Weitz, an associate professor in the School of Biology at Georgia Tech. Weitz also holds an adju
'/>"/>

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New study identifies significance of co-infection in disease control
2. Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants
3. Major cuts to surging CO2 emissions are needed now, not down the road, study finds
4. International study suggests human genes influence gut microbial composition
5. New study defines the long-sought structure of a protein necessary for cell-cell interaction
6. Bering Sea study finds prey density more important to predators than biomass
7. Big brains are pricey, guppy study shows
8. Hebrew University study finds key mechanism in calcium regulation
9. New study documents the natural relationship between CO2 concentrations and sea level
10. Stowers study hints that stem cells prepare for maturity much earlier than anticipated
11. Birdsong study pecks theory that music is uniquely human
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
(Date:8/28/2014)... The support of peer groups and clinicians ... programs, according to recent University of Georgia research. ... the Athens-Clarke County area determined that role models ... of mothers of infants. , "Mothers who received ... at breastfeeding," said study co-author Alex Anderson, an ...
(Date:8/28/2014)... Aug. 28, 2014  Privacy Advocate and Senior Staff ... Lynch , joins the lineup of biometric and mobile ... Biometrics UnPlugged Executive Summit in Tampa, Florida ... Previously announced speakers include Steven Rahman, Director, Technology and Strategy ... at Experian. The theme of this year,s event is ...
(Date:8/28/2014)... (Maximizing Access to Research Careers) Program has announced ... of Sports Medicine,s Conference on Integrative Physiology of ... These awards are meant to promote the ... underrepresented groups into the mainstream of the basic ... young scientists at the American College of Sports ...
Breaking Biology News(10 mins):Breastfeeding study shows need for effective peer counseling programs 2Biometrics UnPlugged Welcomes the Electronic Frontier Foundation's Jennifer Lynch to the Mobility at the Crossroads of Commerce and Privacy Summit 2
... study has pinpointed a natural ingredient of human blood ... human AIDS, from infecting immune cells and multiplying. The ... of HIV to full-blown AIDS and—because it works in ... the development of another class of drugs in the ...
... of the tumor-suppressor gene Rb2/p130 has demonstrated the ability ... developed into an anti-cancer therapeutic, according to researchers at ... Medicine. , The researchers reported their findings, "A small ... inhibition of cdk2 activity, cell cycle arrest and tumor ...
... special cocoa made to retain naturally occurring compounds called ... brain function and chart the course for future research ... decline and dementia, according to a panel of scientists ... the American Association for the Advancement of Science (AAAS). ...
Cached Biology News:Discovery of an HIV inhibitor in human blood points to new drug class 2Discovery of an HIV inhibitor in human blood points to new drug class 3Small molecule dervived from Rb2/p130 could act as cancer therapeutic 2Flavanols in cocoa may offer benefits to the brain 2Flavanols in cocoa may offer benefits to the brain 3
(Date:8/28/2014)... (PRWEB) August 28, 2014 Sterlitech is ... polymeric membranes to its stable of products . ... molecular weight cut-offs and include membrane filters with surface ... increase in customer demand for our membrane process testing ... variety of flat sheet membranes,” explains Sterlitech President Mark ...
(Date:8/28/2014)... Woodstock, Vt. (PRWEB) August 28, 2014 ... microbiology testing around the world is available from ... industrial diagnostics companies. “ Industrial Microbiology Market Review, ... the Industrial Market ” (IMMR—4) tracks and compares ... in in North America, Europe and Asia, and ...
(Date:8/28/2014)... NY (PRWEB) August 28, 2014 Whitehouse ... its long term partnership with PTI Inspection Systems ... clients with state of the art leak testing method ... the art instruments currently available. As part of this ... High Voltage Leak Detection Instrument developed and ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 In ... through Lawrence Livermore National Security LLC ... develop and deliver a state-of-the-art laser system for ... (ELI Beamlines), under construction in the Czech Republic. ... the laser system, called the " High repetition-rate ...
Breaking Biology Technology:Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3
... Arbios Systems, Inc.,(OTC Bulletin Board: ABOS) today announced ... the European Union to pursue CE Marking,the SEPET(TM) ... British,Standards Institute (BSI), one of the leading notified ... effort to obtain a CE Mark for SEPET, ...
... diaDexus, Inc.,today announced the appointment of Fisher HealthCare ... Test for the Hitachi, Hitachi,Roche P-Modular and Olympus chemistry ... was recently cleared by the U.S.,Food & Drug Administration ... chemistry analyzers., The PLAC Test is the only ...
... LA JOLLA, Calif., April 15 DermTech, ... detection of,melanoma and other diseases, will present data ... non-invasive assay that distinguishes melanoma,from benign moles. The ... of Melanoma in Suspicious Pigmented Nevi", shows that ...
Cached Biology Technology:Arbios Commences Process to Seek European Marketing Approval for SEPET(TM) 2Arbios Commences Process to Seek European Marketing Approval for SEPET(TM) 3Arbios Commences Process to Seek European Marketing Approval for SEPET(TM) 4diaDexus Selects Fisher HealthCare to Sell New Automated PLAC(R) Test 2diaDexus Selects Fisher HealthCare to Sell New Automated PLAC(R) Test 3DermTech Study on Melanoma Molecular Diagnostic to Be Presented at AACR 2
Assay Diluent, 10 L...
Assay Diluent Trial Pack, 4 x 100 mL...
HRP Monoclonal-Goat Diluent - 5X Concentrate, 25 mL...
SpectroQuest single beam 1.8nm UV/Vis spectrophotometer; stand-alone unit...
Biology Products: