Navigation Links
Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
Date:1/10/2013

The rise of antibiotic-resistant bacteria has initiated a quest for alternatives to conventional antibiotics. One potential alternative is PlyC, a potent enzyme that kills the bacteria that causes strep throat and streptococcal toxic shock syndrome. PlyC operates by locking onto the surface of a bacteria cell and chewing a hole in the cell wall large enough for the bacteria's inner membrane to protrude from the cell, ultimately causing the cell to burst and die.

Research has shown that alternative antimicrobials such as PlyC can effectively kill bacteria. However, fundamental questions remain about how bacteria respond to the holes that these therapeutics make in their cell wall and what size holes bacteria can withstand before breaking apart. Answering those questions could improve the effectiveness of current antibacterial drugs and initiate the development of new ones.

Researchers at the Georgia Institute of Technology and the University of Maryland recently conducted a study to try to answer those questions. The researchers created a biophysical model of the response of a Gram-positive bacterium to the formation of a hole in its cell wall. Then they used experimental measurements to validate the theory, which predicted that a hole in the bacteria cell wall larger than 15 to 24 nanometers in diameter would cause the cell to lyse, or burst. These small holes are approximately one-hundredth the diameter of a typical bacterial cell.

"Our model correctly predicted that the membrane and cell contents of Gram-positive bacteria cells explode out of holes in cell walls that exceed a few dozen nanometers. This critical hole size, validated by experiments, is much larger than the holes Gram-positive bacteria use to transport molecules necessary for their survival, which have been estimated to be less than 7 nanometers in diameter," said Joshua Weitz, an associate professor in the School of Biology at Georgia Tech. Weitz also holds an adju
'/>"/>

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New study identifies significance of co-infection in disease control
2. Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants
3. Major cuts to surging CO2 emissions are needed now, not down the road, study finds
4. International study suggests human genes influence gut microbial composition
5. New study defines the long-sought structure of a protein necessary for cell-cell interaction
6. Bering Sea study finds prey density more important to predators than biomass
7. Big brains are pricey, guppy study shows
8. Hebrew University study finds key mechanism in calcium regulation
9. New study documents the natural relationship between CO2 concentrations and sea level
10. Stowers study hints that stem cells prepare for maturity much earlier than anticipated
11. Birdsong study pecks theory that music is uniquely human
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
(Date:7/13/2015)... SAN JOSE, Calif. , July 13, 2015 ... the leading developer of human interface solutions, today ... second generation touch and display driver integration (TDDI) ... solution is the first to combine Synaptics , ... expertise with proven display driver technology developed in ...
(Date:7/9/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), a leading ... will report financial results for the fourth quarter and ... the close of market. The company will host a ... p.m. PT (5:00 p.m. ET), during which management may ... the live call, analysts and investors should dial 888-455-2260 ...
(Date:7/9/2015)... 2015  Unchained Labs just can,t get enough ... Avid Nano. Avid Nano designs, develops and manufactures ... Also today, Unchained Labs UNcaged the ... use protein sizing system. The pUNk is a ... size, size distribution, aggregation population and molecular weight. ...
Breaking Biology News(10 mins):Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2
... PHILADELPHIA - The University of Pennsylvania,s Laboratory ... entered into a multi-year agreement with specialty chemical ... Scientific Research to launch an international, public-private research ... between academia, government and industry brings together a ...
... Providence, RI Researchers at Rhode Island Hospital have discovered ... injury. The findings shed new light on how the body ... as microvesicles, and offers hope for tissue regeneration. The paper ... Experimental Hematology and is now available online in ...
... mouse colon cancer cells, may help identify patients at ... study by Vanderbilt-Ingram Cancer Center researchers. The findings, ... could help personalize treatments for colon cancer the ... States by identifying patients most likely to benefit ...
Cached Biology News:Penn joins international collaboration in government and academics to research 'soft matter' 2Offering hope for tissue regeneration 2Offering hope for tissue regeneration 3Gene signature may improve colon cancer treatment 2Gene signature may improve colon cancer treatment 3
(Date:7/31/2015)... ... July 31, 2015 , ... Global Resorcinol Market 2015-2019 ... insights on the global resorcinol industry. The report highlights the various growth prospects ... scenarios and analysis of primary and secondary inputs from the existing players of ...
(Date:7/31/2015)... ... July 31, 2015 , ... R-Biopharm is proud to announce ... gluten in foods, has been accepted by AOAC International as Official First Action ... Fermented Cereal-Based Products by R5 Competitive ELISA,” based on a specific monoclonal antibody ...
(Date:7/30/2015)... , July 30, 2015 AACC ... to the 2015 AACC Annual Meeting & Clinical ... from July 26–30. The meeting showcased revolutionary advancements ... the ability of healthcare providers to diagnose patients ... effective medical treatment. As of ...
(Date:7/30/2015)... , ... July 30, 2015 , ... ... appointed Francois Vieillard as Sales & Marketing Director. , With more than ... will be responsible for reinforcing Tronics’ business development activities worldwide. He brings to ...
Breaking Biology Technology:Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 4RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Tronics appoints Francois Vieillard as Sales and Marketing Director 2
... Interleukin Genetics, Inc. (OTC QB: ILIU) announced today that ... Showcase 2011, taking place at the Parc 55 Wyndham ... include a company overview highlighting its business opportunities and ... in the Mission II room.   Company ...
... Jan. 4, 2011 Reportlinker.com announces that a ... catalogue: Emerging Opportunities and ... r Diagnostics Market: US, ... http://www.reportlinker.com/p0357263/The-2011-Cancer-Diagnostics-Market-US-Europe-Japan ...
... , a division of BNA , announces the publication ... of Biotechnology and the Federal Circuit , the only ... body of Federal Circuit precedent in the rapidly developing area ... Biotechnology and the Federal Circuit, Second Edition ...
Cached Biology Technology:Interleukin Genetics, Inc. to Present at Biotech Showcase 2011 2Reportlinker Adds The 2011 Cancer Diagnostics Market: US, Europe, Japan Emerging Opportunities and Business Expansion Strategies 2New Second Edition of Biotechnology and the Federal Circuit Examines the Court's Decisions on Chemical, Biotechnology, and Pharmaceutical Patent Law Cases 2New Second Edition of Biotechnology and the Federal Circuit Examines the Court's Decisions on Chemical, Biotechnology, and Pharmaceutical Patent Law Cases 3New Second Edition of Biotechnology and the Federal Circuit Examines the Court's Decisions on Chemical, Biotechnology, and Pharmaceutical Patent Law Cases 4
... is an easy-to-use siRNA transfection reagent that ... genes in a variety of cell lines. ... an optimized, straightforward protocol. High levels of ... following transfection of 20 to 100 nM ...
... tetramethylrhodamine-conjugated jetSI-ENDO (excitation at 555 ... the powerful siRNA transfection reagent. ... determine the transfection efficiency or ... trafficking of siRNAs. More than ...
... in a Morris Water Maze. Tracks up ... sequence of trials.The Spatial Behavior line is a ... camera, frame grabber, and feature extraction software and ... up to 6 moving animals. Software automatically ...
... systems for cultivation of microorganisms and human ... bio-pharmaceutical products maximum performance and economy for ... cell fermentation 10 L 1,500 L. ... ,*Fully automated control system ,*High-quality components ...
Biology Products: