Navigation Links
Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
Date:1/10/2013

The rise of antibiotic-resistant bacteria has initiated a quest for alternatives to conventional antibiotics. One potential alternative is PlyC, a potent enzyme that kills the bacteria that causes strep throat and streptococcal toxic shock syndrome. PlyC operates by locking onto the surface of a bacteria cell and chewing a hole in the cell wall large enough for the bacteria's inner membrane to protrude from the cell, ultimately causing the cell to burst and die.

Research has shown that alternative antimicrobials such as PlyC can effectively kill bacteria. However, fundamental questions remain about how bacteria respond to the holes that these therapeutics make in their cell wall and what size holes bacteria can withstand before breaking apart. Answering those questions could improve the effectiveness of current antibacterial drugs and initiate the development of new ones.

Researchers at the Georgia Institute of Technology and the University of Maryland recently conducted a study to try to answer those questions. The researchers created a biophysical model of the response of a Gram-positive bacterium to the formation of a hole in its cell wall. Then they used experimental measurements to validate the theory, which predicted that a hole in the bacteria cell wall larger than 15 to 24 nanometers in diameter would cause the cell to lyse, or burst. These small holes are approximately one-hundredth the diameter of a typical bacterial cell.

"Our model correctly predicted that the membrane and cell contents of Gram-positive bacteria cells explode out of holes in cell walls that exceed a few dozen nanometers. This critical hole size, validated by experiments, is much larger than the holes Gram-positive bacteria use to transport molecules necessary for their survival, which have been estimated to be less than 7 nanometers in diameter," said Joshua Weitz, an associate professor in the School of Biology at Georgia Tech. Weitz also holds an adju
'/>"/>

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New study identifies significance of co-infection in disease control
2. Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants
3. Major cuts to surging CO2 emissions are needed now, not down the road, study finds
4. International study suggests human genes influence gut microbial composition
5. New study defines the long-sought structure of a protein necessary for cell-cell interaction
6. Bering Sea study finds prey density more important to predators than biomass
7. Big brains are pricey, guppy study shows
8. Hebrew University study finds key mechanism in calcium regulation
9. New study documents the natural relationship between CO2 concentrations and sea level
10. Stowers study hints that stem cells prepare for maturity much earlier than anticipated
11. Birdsong study pecks theory that music is uniquely human
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
(Date:7/22/2014)... of planthopper known as Conosimus, which now includes six ... the southern part of the Iberian Peninsula in the ... in the open-access Journal of Insect Science ... Conosimus baenai , has been named after Manuel Baena, ... of Iberian Hemiptera. , Conosimus baenai differs ...
(Date:7/21/2014)... a professor of entomology and cooperating faculty ... the University of California, Riverside, has been awarded the ... of Chemical Ecology ( ISCE ). , Awarded first ... the society,s highest honor. It is awarded annually to ... the study of chemicals that mediate interactions between living ...
(Date:7/21/2014)... to monitor seals, every movement, researchers have shown for ... to offshore wind farms and pipelines. Those man-made structures ... according to a study published in the Cell Press ... , "I was shocked when I first saw the ... Shoal," an offshore wind farm in the United Kingdom, ...
Breaking Biology News(10 mins):UC Riverside entomologist receives international honor for chemical ecology contributions 2Seals forage at offshore wind farms 2
... the egg genome? Researchers have answered a similarly vexing ... of long stretches of repeated DNA in the human genome ... published online by Nature Genetics on October 7, ... the human genome that are partly responsible for both disease ...
... CITY, Utah - Mario R. Capecchi, Ph.D., distinguished professor ... Utahs Eccles Institute of Human Genetics and a Howard ... Prize in Physiology or Medicine. The announcement was ... Karolinska Institute, in Stockholm, Sweden. The prize recognizes Capecchis ...
... of Cincinnati (UC) radiologists have developed a new ... eases diagnosis of venous diseases. Multi-detector computed ... three-dimensional images of arteries, the vessels which carry ... blood throughout the body. Veins, smaller vessels that ...
Cached Biology News:Which came first, the chicken genome or the egg genome? 2Which came first, the chicken genome or the egg genome? 3Gene-targeting pioneer Mario Capecchi shares 2007 Nobel Prize in Medicine 2Gene-targeting pioneer Mario Capecchi shares 2007 Nobel Prize in Medicine 3New thoracic imaging approach can pinpoint underlying venous problems 2
(Date:7/22/2014)... 22, 2014 Hussey Copper , a ... antimicrobial copper announces Pullman Regional Hospital,s conversion of ... antimicrobial solid touch surface, at a nominal cost.  This ... E-coli and other bacteria within 2 hours of exposure 1 ... bacteria and infectious diseases in its facilities. ...
(Date:7/22/2014)... 22, 2014  United Therapeutics Corporation (NASDAQ: ... release its second quarter 2014 financial results before ... United Therapeutics will host a half-hour teleconference ... Eastern Time.  The teleconference is accessible by dialing ... of the teleconference will be available for one ...
(Date:7/22/2014)... 2014 Dr. Williams says, “Bush has ... recognized that the greatest health care system in the ... needlessly deadly while trying to serve the public. Unfortunately, ... to transform an enormous system that none of them ... his continuing series of Open Letters ( http://is.gd/wdU2CM ) ...
(Date:7/21/2014)... yield so far is small, but chemists at the ... substitution process to make a precursor to transparent thin ... energy devices. , A paper describing the approach is ... of the journal Inorganic Chemistry , which draws ... nuclear chemistry fields. The paper was chosen by the ...
Breaking Biology Technology:Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Dr. Ira Williams Asks What’s Wrong With Jonathan Bush’s Book, Where Does It Hurt? 2Oregon chemists eye improved thin films with metal substitution 2
... , ... goBalto.com introduces a new project management tool - "Projects" - to help ... management tools can be awkward and cumbersome. goBalto Projects takes on project management ... time and money. , ...
... , PHOENIX and SAN CARLOS, Calif., Oct. 10 ... data today from its Phase 2 clinical trial of ... (AAPM) 20th Annual Clinical Meeting in Phoenix, Arizona. ... stage investigational product candidate in clinical development for the ...
... of Toronto have developed a new "lab-on-a-chip" technique that analyses ... at risk of breast cancer much more quickly than ever ... metabolites the products of metabolized estrogen in breast ... patients compared to healthy women, and is therefore believed to ...
Cached Biology Technology:goBalto Introduces Web-based Solution to Manage Drug-development Collaborations 2Topline Results from Phase 2 Clinical Trial of Oral NKTR-118 Presented at 20th American Academy of Pain Management Annual Clinical Meeting (AAPM) in Phoenix 2Topline Results from Phase 2 Clinical Trial of Oral NKTR-118 Presented at 20th American Academy of Pain Management Annual Clinical Meeting (AAPM) in Phoenix 3Topline Results from Phase 2 Clinical Trial of Oral NKTR-118 Presented at 20th American Academy of Pain Management Annual Clinical Meeting (AAPM) in Phoenix 4New lab-on-a-chip technique developed at U of T 2
DNase I (Deoxyribonuclease I) digests single- and double-stranded DNA to oligodeoxyribonucleotides. Ribonuclease activity has been reduced to non-detectable levels....
... coli containing a clone of the human Topoisomerase ... II alters the topological state of nucleic acids ... transient break which generates a separate DNA helix ... DNA passage mechanism, the enzyme can relax negatively ...
RNase-Free DNase 50 l...
supplied with 10x reaction buffer...
Biology Products: