Navigation Links
Study offers first explanation of how cells rapidly repair and maintain structure
Date:9/21/2010

SALT LAKE CITYResearchers at Huntsman Cancer Institute (HCI) at the University of Utah have discovered that a protein, zyxin, is necessary for the maintenance and repair of the cell's cytoskeleton, or internal framework, which serves as the muscle and bone of the cell. The research has implications for cancer, as well as other diseases, since alterations in the cytoskeleton are often associated with disease. The research was published in the Sep. 14, 2010, issue of the journal Developmental Cell.

"Just like people, the cells in our bodies are exposed to all kinds of stress," says Mary Beckerle, Ph.D., the study's principal investigator and HCI executive director. "One type of stress, mechanical stress that is derived from application of physical force, is experienced by many organs such as the lung, which stretches with each breath, the heart, which is physically challenged with each beat, and the uterus, which undergoes intense contractions during labor and childbirth. We were interested in how living cells respond to such stress. In this study, we showed that mechanical stress can damage the cytoskeleton but that cells have special machinery that rapidly recognizes the damage and repairs it."

Mark Smith, Ph.D., one of the HCI researchers involved in the study explains that, "When a cell's environment changes and stress is applied, cytoskeletal bundles, called actin stress fibers, can literally begin to tear, but then are rapidly repaired. This process begins within seconds and allows the cell to retain its structure. We showed that a protein called zyxin is required for the maintenance and repair of the actin cytoskeleton." Zyxin expression is down-regulated in certain cancers and future experiments will explore whether loss of this cytoskeletal repair pathway in tumor cells is responsible for the disruption of the cytoskeleton that is common in cancer cells.

The researchers studied the process by imaging live cells that expressed fluorescently tagged cytoskeletal proteins. This allowed them to observe the mechanism whereby actin stress fibers maintain homeostasis, or balance. The repair mechanism was directly triggered by force and served to relieve mechanical stress on actin stress fibers, which in turn provided a system for rapid response to force changes in the extracellular environment.


'/>"/>

Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

Related biology news :

1. Gene-environmental interactions and MS progression is focus of new study
2. Manganese in drinking water: Study suggests adverse effects on childrens intellectual abilities
3. Women with diabetes having more C-sections and fetal complications: study
4. Study finds possible persistence switch for tuberculosis
5. New study finds milk drinkers may have a healthy weight advantage
6. Rice study examines how bacteria acquire immunity
7. USF receives NIH grant to study implications of maternal infection as cause of autism
8. Last strongholds for tigers identified in new study
9. VCU study: Team uncovers possible risk gene for schizophrenia
10. LiXEdrom: Innovative measuring chamber for X-ray study of liquid jets
11. OU study on genetics in fruit flies leads to new method for understanding brain function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2016)... --  Unisys Corporation (NYSE: UIS ) today announced ... testing its biometric identity solution at the Otay Mesa border ... identify certain non-U.S. citizens leaving the country. ... determine the efficiency and accuracy of using biometric technologies in ... until May 2016. --> the United States ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® ... and enrollment solutions, today announced the addition of ... Altus multi-factor authentication platform. New contextual ... managers to step-up security where it,s needed most ... Washington, DC . --> ...
(Date:3/3/2016)...  2016FLEX, organized by FlexTech, a SEMI Strategic ... flexible, hybrid and printed electronics. More than 650 ... gathered for short courses, technical session, exhibits, and ... Flex Conference celebrates its 15 th anniversary ... and universities contributing to the adoption of flexible ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... LONDON , May 3, 2016 ... Report Assessing Developers and Producers of Those Competitor Biologics  ... Guide to Companies, Activities and Prospects ,  ... drug companies? And what are their sales potentials? ... There you see results, trends, opportunities and revenue forecasting. ...
(Date:5/3/2016)... ... 2016 , ... According to world renowned prostate cancer surgeon, Dr. David ... had two main treatment options: surgery or radiation. Based on a patient’s goals, disease ... has enabled doctors to administer higher doses of radiation to prostate cancer ...
(Date:5/2/2016)... , May 2, 2016 Q ... its technology partner Mannin Research Inc. will be attending ... which takes place from May 1-5, 2016 in ... be meeting with its vendors and research partners. The ... development goals and other collaborative opportunities for the MAN-01 ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... StarNet Communications ... today announced the addition of three Secure Remote Desktop modules to its flagship X-Win32 ... desktops from Linux and Unix servers to the user’s PC over encrypted SSH. , ...
Breaking Biology Technology: