Navigation Links
Study maps human metabolism in health and disease
Date:3/3/2013

Scientists have produced an instruction manual for the human genome that provides a framework to better understand the relationship between an individual's genetic make-up and their lifestyle.

The international team of researchers say their study published in Nature Biotechnology provides the best model yet to explain why individuals react differently to environmental factors such as diet or medication.

"This research is the second important stage of our understanding of the human genome," said study author Professor Pedro Mendes, from The University of Manchester's School of Computer Science. "If the sequencing of the human genome provided us with a list of the biological parts then our study explains how these parts operate within different individuals.

"The results provide a framework that will lead to a better understanding of how an individual's lifestyle, such as diet, or a particular drug they may require is likely to affect them according to their specific genetic characteristics. The model takes us an important step closer to what is termed 'personalised medicine', where treatments are tailored according to the patient's genetic information."

The research, which involved scientists from Manchester, Cambridge, Edinburgh, Reykjavik, San Diego, Berlin and others, mapped 65 different human cell types and half of the 2,600 enzymes that are known drug targets in order to produce the network model.

Co-author Douglas Kell, Chief Executive of Biotechnology and Biological Sciences Research Council (BBSRC) and Professor of Bioanalytical Science at the Manchester Institute of Biotechnology, said: "To understand the behaviour of a system one must have a model of it. By converting our biological knowledge into a mathematical model format, this work provides a freely accessible tool that will offer an in-depth understanding of human metabolism and its key role in many major human diseases.

"This study offers the most complete model of the human metabolic network available to date to help analyse and test predictions about the physiological and biochemical properties of human cells."

Dr Nicolas Le Novre, from the Babraham Institute in Cambridge (UK), said: "This is a model that links the smallest molecular scale to the full cellular level. It contains more than 8,000 molecular species and 7,000 chemical reactions no single researcher could have built this alone. Having large collaborations like these, using open standards and data-sharing resources, is crucial for systems biology."


'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-771-788-1563
University of Manchester
Source:Eurekalert

Related biology news :

1. Volcanic aerosols, not pollutants, tamped down recent Earth warming, says CU-Boulder study
2. Study provides insights into plant evolution
3. New study reveals how sensitive US East Coast regions may be to ocean acidification
4. CETS offers new method to help simplify the study of brain pathologies
5. New study could explain why some people get zits and others dont
6. Global tipping point not backed by science: Study
7. Study led by NUS researchers proves the existence of 3 overstretched DNA structures
8. Wayne State study shows airborne dust in urban areas impacts lead levels in children
9. Georgia Physicians Study Published in The Journal of Urology
10. New study shows continued decline in the last remaining stronghold for leatherback sea turtles
11. Study finds maize in diets of people in coastal Peru dates to 5,000 years ago
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... TURKU, Finland , June 9, 2016 ... French National Police deploy Teleste,s video security solution to ensure ... France during the major tournament ... and data communications systems and services, announced today that its ... Police Prefecture to back up public safety across ...
(Date:6/2/2016)... June 2, 2016 The Department of ... awarded the 44 million US Dollar project, for the ... Plates including Personalization, Enrolment, and IT Infrastructure , ... the production and implementation of Identity Management Solutions. Numerous renowned ... Decatur was selected for the most ...
(Date:6/1/2016)... NEW YORK , June 1, 2016 ... Biometric Technology in Election Administration and Criminal Identification to ... According to a recently released TechSci Research report, " ... Sector, By Region, Competition Forecast and Opportunities, 2011 - ... $ 24.8 billion by 2021, on account of growing ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... On Wednesday, June 22, 2016, the ... the Dow Jones Industrial Average edged 0.27% lower to finish ... 0.17%. Stock-Callers.com has initiated coverage on the following equities: Infinity ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... ). Learn more about these stocks by accessing their free ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® Inc. (RCA), ... free webinar on Performing Quality Investigations: Getting to Root Cause. ... no charge. , Incomplete investigations are still a major concern to the Regulatory ...
(Date:6/23/2016)...  Amgen (NASDAQ: AMGN ) today announced ... life sciences incubator to accelerate the development of new ... at QB3@953 was created to help high-potential life science ... early stage organizations - access to laboratory infrastructure. ... two "Amgen Golden Ticket" awards, providing each winner with ...
(Date:6/22/2016)... , June 22, 2016 Cell Applications, ... allow them to produce up to one billion ... lot within one week. These high-quality, consistent stem ... preparing cells and spend more time doing meaningful, ... a proprietary, high-volume manufacturing process that produces affordable, ...
Breaking Biology Technology: