Navigation Links
Study identifies possible new acute leukemia marker, treatment target
Date:5/13/2013

COLUMBUS, Ohio A study has identified microRNA-155 as a new independent prognostic marker and treatment target in patients with acute myeloid leukemia that has normal-looking chromosomes under the microscope (that is, cytogenetically normal acute myeloid leukemia, or CN-AML).

The study was led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James). The researchers found that when microRNA-155 (miR-155) is present at abnormally high levels in CN-AML cells, patients are less likely to have a complete remission, and they experience a shorter disease-free period and shorter overall survival. The effect is independent of other known prognostic gene mutations present in the cells.

Published in the Journal of Clinical Oncology with an accompanying editorial and an "Understanding the Pathway" article, the findings suggest that miR-155 plays a pivotal role in CN-AML development, and that it could be a valuable target for the emerging class of drugs designed to inhibit microRNAs, says first author Dr. Guido Marcucci, professor of hematology, a leukemia specialist and associate director for Translational Research at the OSUCCC James. "MiR-155 would be relatively easy to measure at the time of diagnosis," Marcucci says. "We believe it will prove to be a good marker for stratifying patients according to recurrence risk and a good target for emerging compounds designed to inhibit microRNAs."

Principal investigator Dr. Clara D. Bloomfield, Distinguished University Professor and Ohio State University Cancer Scholar and Senior Advisor and William Greenville Pace III Endowed Chair in Cancer Research notes that, "Overall, our findings indicate that miR-155 expression is a strong and independent prognostic marker in CN-AML, and they provide clinical validation of data from preclinical models that support a crucial role of miR-155 in leukemia."

Th
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Women altering menstruation cycles in large numbers, UO study shows
2. Study finds that bacteria organize according to rich-get-richer principle
3. Study finds brain system for emotional self-control
4. Bacteria adapt and evade nanosilvers sting -- new study
5. Clinical Tests Demonstrate Long-Term Effectiveness of Oral Glutathione Supplements - Kyowa Study
6. Study: MicroRNA cooperation mutes breast cancer oncogenes
7. Older US-born Mexican-Americans more physically limited than Mexican-American immigrants: Study
8. Study uncovers mechanism for how grapes reduce heart failure associated with hypertension
9. Study confirms everolimus can overcome trastuzumab resistance in HER-2 positive early breast cancer
10. Study reveals magnitude of variation in gene expression measurements within breast cancers
11. Study opens new prospects for developing new targeted therapies for breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... DUBLIN , Mar. 19, 2015 Research and Markets ... the "Iris Biometrics - Global Strategic Business Report" ... worldwide markets for Iris Biometrics in US$ Thousands. The report ... , Japan , Europe ... East , and Latin America . ...
(Date:3/17/2015)... 17, 2015  MecklerMedia Corporation (OTCQX: MECK) announced ... service robots ever held in New ... May 11-13, 2015 at the Javits Convention Center. ... event include: Acorn Product Development; Axis NJ; c-Link ... Robotics; Littler; NewBotic Corporation; Neya Systems LLC; Reliabotics; ...
(Date:3/12/2015)... 12, 2015 WHEN:Tuesday, March 17, 2015 at ... http://bit.ly/1G7Os0L . SPEAKERS: , Frost & Sullivan Measurement ... http://photos.prnewswire.com/prnh/20150311/181111 Biometric companies must plan ... several different markets and industries. This is especially ... uptrend. Join Frost & Sullivan,s ...
Breaking Biology News(10 mins):Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 2Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 3
... shown to increase the pigment in their skin in response to ... in Nature journal, Scientific Reports , reveals that not only ... DNA damage in their skin just like us, they also accumulate ... Experts in the response of skin to UV radiation at ...
... Washington University researcher will receive $1.3 million over the ... and Digestive and Kidney Diseases (NIDDK) for research that ... possibly informing the development of novel treatments to reverse ... 150 million people worldwide suffer from type 2 diabetes--a ...
... -- According to new research published in The ... does not directly harm the blood vessel cells. Rather, zinc ... circulates in the blood and causes harmful blood vessel cell ... prevent the creation of this compound, but it can protect ...
Cached Biology News:Whales feel the (sun)burn! 2Whales feel the (sun)burn! 3Type 2 diabetes study to examine role amylin plays in disease 2Potential diagnostic marker for zinc status offers insights into the effects of zinc deficiency 2
(Date:3/29/2015)... Texas , March 29, 2015 /PRNewswire/ ... of study data in small cell cervical ... using Caris Molecular Intelligence®, the company,s panomic, ... certain gene mutations which may explain sensitivities ... found that identification of certain biomarkers may ...
(Date:3/27/2015)... 27. März 2015  Peter Walter wurde ... Science für seine bahnbrechende Arbeit ausgewählt, die ... transportiert werden, sowie für die Entschlüsselung der ... auf Stress nutzen, der mit der Ansammlung ... Professor für Biochemie an der University of ...
(Date:3/27/2015)... -- WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... platform company serving the global pharmaceutical, biotechnology, and ... New Drug (IND) application for WuXi MedImmune,s novel ... accepted for review by the China Food and ... 2012, MedImmune, the global biologics research and development ...
(Date:3/26/2015)... SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: SQD; ... including the appointment of auditors, its annual and special ... "Meeting") was adjourned, as previously disclosed on March 25, ... Toronto time). The date of the ... The Meeting will reconvene at the offices of the ...
Breaking Biology Technology:Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer 2Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 4Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3SQI Diagnostics Inc. Announces Adjournment of Meeting 2
... a,drug and diagnostic discovery company, today announced that ... Diagnostics and Genomic,Services Unit and the Therapeutics Unit., ... recent progress in core,programs have laid the foundation ... market. John Jaskowiak has been appointed as Head ...
... 15 As drastic cutbacks at major,pharmaceuticals ... drug teams. Social networks have entered the ... are being scrutinized for,ROI. Product recalls and ... on drug marketers. Yet new marketing opportunities ...
... 15 The Kansas Bioscience,Authority has launched ... nationwide to create products that protect Americans ... disrupt the national economy or,to infect humans., ... Biosecurity Research Initiative,(CBRI) are to support interinstitutional ...
Cached Biology Technology:ExonHit Builds A New Organisation 2ExonHit Builds A New Organisation 3ExonHit Builds A New Organisation 4Beyond DTC: Pharma Industry Faces New Challenges, Competition, Strategies for Market Dominance 2Collaborative Biosecurity Research Initiative Launched to Target Animal and Public Health Threats Nationally 2Collaborative Biosecurity Research Initiative Launched to Target Animal and Public Health Threats Nationally 3
... ,• Eliminates nonspecific products due to ... specificity allows extension through DNA regions which ... Leaves an 'A' overhang ,TEMPase II ... DNA Polymerase that remains inactive at ...
... aqueous solution. Cleaves a-(1-3)- ... carbohydrates and glycoproteins. It is particularly efficient ... the pH must be neutral or above, ... Unit Definition: One unit will ...
This adapter allows the Thermo-Fast® 96 Semi-Skirted (AB-0900 and AB-0990) PCR plates to be used directly in the ABI PRISM® 3100 sequencer without the need for software changes....
... White lyophilized solid. PROTECT FROM LIGHT. PACKAGED ... of γ-secretase. Equipotently inhibits the release of ... 2.6 μM) and Aβ x-42 (ED ... cells stably transfected with the Amyloid Precursor ...
Biology Products: