Navigation Links
Study identifies possible new acute leukemia marker, treatment target
Date:5/13/2013

COLUMBUS, Ohio A study has identified microRNA-155 as a new independent prognostic marker and treatment target in patients with acute myeloid leukemia that has normal-looking chromosomes under the microscope (that is, cytogenetically normal acute myeloid leukemia, or CN-AML).

The study was led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James). The researchers found that when microRNA-155 (miR-155) is present at abnormally high levels in CN-AML cells, patients are less likely to have a complete remission, and they experience a shorter disease-free period and shorter overall survival. The effect is independent of other known prognostic gene mutations present in the cells.

Published in the Journal of Clinical Oncology with an accompanying editorial and an "Understanding the Pathway" article, the findings suggest that miR-155 plays a pivotal role in CN-AML development, and that it could be a valuable target for the emerging class of drugs designed to inhibit microRNAs, says first author Dr. Guido Marcucci, professor of hematology, a leukemia specialist and associate director for Translational Research at the OSUCCC James. "MiR-155 would be relatively easy to measure at the time of diagnosis," Marcucci says. "We believe it will prove to be a good marker for stratifying patients according to recurrence risk and a good target for emerging compounds designed to inhibit microRNAs."

Principal investigator Dr. Clara D. Bloomfield, Distinguished University Professor and Ohio State University Cancer Scholar and Senior Advisor and William Greenville Pace III Endowed Chair in Cancer Research notes that, "Overall, our findings indicate that miR-155 expression is a strong and independent prognostic marker in CN-AML, and they provide clinical validation of data from preclinical models that support a crucial role of miR-155 in leukemia."

Th
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Women altering menstruation cycles in large numbers, UO study shows
2. Study finds that bacteria organize according to rich-get-richer principle
3. Study finds brain system for emotional self-control
4. Bacteria adapt and evade nanosilvers sting -- new study
5. Clinical Tests Demonstrate Long-Term Effectiveness of Oral Glutathione Supplements - Kyowa Study
6. Study: MicroRNA cooperation mutes breast cancer oncogenes
7. Older US-born Mexican-Americans more physically limited than Mexican-American immigrants: Study
8. Study uncovers mechanism for how grapes reduce heart failure associated with hypertension
9. Study confirms everolimus can overcome trastuzumab resistance in HER-2 positive early breast cancer
10. Study reveals magnitude of variation in gene expression measurements within breast cancers
11. Study opens new prospects for developing new targeted therapies for breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2015)... , August 26, 2015 ... Four, and Five Factor), Application (Travel & Immigration, Government, ... - Global Forecast to 2020", published by MarketsandMarkets, Multi-Factor ... by 2020, growing at a CAGR of 17.7% between ... and 82 F igures spread through 169 ...
(Date:8/20/2015)... 20, 2015   Sensory, Inc ., a ... user experience and security of consumer electronics through ... that its TrulySecure™ is the first ... be FIDO Certified™. The FIDO (Fast ... the FIDO UAF (Universal Authentication Framework) 1.0 specifications, ...
(Date:8/17/2015)... OXFORD, Conn. , Aug. 17, 2015  NXT-ID, ... a biometric authentication company focused on the growing mobile ... announces its new sales campaign for Q4 2015. The ... winning marketing team consisting of Amplitude Marketing Group ( ... Amplitude Marketing Group is a leader in retail driven ...
Breaking Biology News(10 mins):Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3
... sensitive new genetic test can now detect a crippling disease ... to Virginia and north to Canada. Although it does not ... red tide, the disease can have a significant impact on ... harvests and commercial aquaculture operations. , QPX - for quahog ...
... future of the tropics unfolds, scientists must explain the ... increase and environmental changesAs human populations and their impacts ... many different ways. Forests are being cleared, burned, ... they are also being altered in insidious ways by ...
... me sad when an article that should have picture doesn't ... student's group in the iGEM competition , check it out! ... 'camera'. , Using Petri dishes full of genetically engineered ... of Texas at Austin and UCSF successfully created the first-ever ...
Cached Biology News:New genetic test can detect clam disease 2Scientists must offer solutions for conserving tropical forests in a rapidly changing world 2Student scientists create living bacterial photographs 2Student scientists create living bacterial photographs 3
(Date:9/2/2015)... BioLight Life Sciences Investments ... a firm that invests in, manages and commercializes ... today that presentations highlighting its IOPtiMate™ system for ... the Ophthalmology Futures European Forum and the XXXIII ... Refractive Surgeons ("ESCRS"), both taking place in the ...
(Date:9/2/2015)... ... ... Temarry Recycling's new $100,000 waste to energy capital project ... to contribute to the sustainability of our natural resources. , Waste to Energy ... operating at their Mexico facility, Recicladora Temarry, for the last 7 years. While ...
(Date:9/1/2015)... 2015 The American Brain Tumor Association (ABTA) ... Discovery Research Grant program. LOIs are due no later ... Discovery Grants are one-year, $50,000 grants that ... change current diagnostic or treatment paradigms for adults and ... research at its earliest stages, in the hopes that ...
(Date:9/1/2015)... ... September 01, 2015 , ... AxioMx Inc. ... the National Institutes of Health (NIH) has awarded the company a Phase I ... NIH’s National Institute of Diabetes and Digestive and Kidney Diseases. AxioMx will use ...
Breaking Biology Technology:Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 2Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 3Temarry Recycling’s New $100,000 Waste to Energy Renovation 2American Brain Tumor Association Seeks Innovative Concepts For Discovery Research Grants 2AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 2AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 3
... Corp. (Nasdaq: KOOL ), a leading supplier of ... cells, said today that the FDA has agreed with its ... AXP disposable bagsets that it announced in November.At that time, ... result of any safety issues; the field action was a ...
... Va., Feb. 26 Insmed Inc. (Nasdaq: ... it will host a conference call on Wednesday, March ... results for the fourth quarter and year-end 2008. ... before the market opens on March 11th.To participate in ...
... launched its revolutionary Trusted LASIK Surgeons directory service and ... a resource for consumers seeking to improve their vision ... improve their chances of attaining 20-20 vision. What ... unique screening process ensuring that only those who are ...
Cached Biology Technology:ThermoGenesis Says FDA Concurs with Plan for Previously Announced AXP(TM) Bagset Recall 2ThermoGenesis Says FDA Concurs with Plan for Previously Announced AXP(TM) Bagset Recall 3Insmed to Host Fourth Quarter and Full-Year 2008 Conference Call 2Rick Fraunfelder, M.D. of the Casey Vision Correction Center in Portland, Oregon, Joins Elite Group of Surgeons Listed at Trusted LASIK Surgeons 2Rick Fraunfelder, M.D. of the Casey Vision Correction Center in Portland, Oregon, Joins Elite Group of Surgeons Listed at Trusted LASIK Surgeons 3Rick Fraunfelder, M.D. of the Casey Vision Correction Center in Portland, Oregon, Joins Elite Group of Surgeons Listed at Trusted LASIK Surgeons 4Rick Fraunfelder, M.D. of the Casey Vision Correction Center in Portland, Oregon, Joins Elite Group of Surgeons Listed at Trusted LASIK Surgeons 5Rick Fraunfelder, M.D. of the Casey Vision Correction Center in Portland, Oregon, Joins Elite Group of Surgeons Listed at Trusted LASIK Surgeons 6Rick Fraunfelder, M.D. of the Casey Vision Correction Center in Portland, Oregon, Joins Elite Group of Surgeons Listed at Trusted LASIK Surgeons 7Rick Fraunfelder, M.D. of the Casey Vision Correction Center in Portland, Oregon, Joins Elite Group of Surgeons Listed at Trusted LASIK Surgeons 8
... Specificity: This antibody recognizes ... not cross-react with other related ... antibody with murine IRF7 protein ... analysis of the 293T cells ...
Rabbit anti-phospho-EGFr (Tyr992) - Concentrate...
Contains L-glutamine...
... biosynthesized by the 11(R)-LOs of the ... fresh water hydra, H. vulgaris. The ... oocyte maturation and tentacle regeneration, respectively, ... produced when aspirin-treated recombinant COX-2 is ...
Biology Products: