Navigation Links
Study identifies liver gene that regulates cholesterol and fat blood levels
Date:2/7/2013

m genes (Angptl3 and Gpam). Vickers added, "Using a mouse model of dyslipidemia and atherosclerosis, we found hepatic miR-27b and its target genes to be inversely altered, and thus contributing to risk for cardiovascular disease."

The senior author of the study, Dr. Praveen Sethupathy from the University of North Carolina at Chapel Hill School of Medicine, leads an interdisciplinary laboratory that weaves together computational and experimental approaches to understand the role of microRNAs in complex metabolic diseases. "MicroRNAs are thought to impart stability to gene networks, particularly in the face of changes to the environment, such as diet," he says. "MicroRNAs represent promising therapeutic targets for a variety of metabolic diseases, but a lot more work remains to be done in order to fully appreciate how and when they function."

In a related editorial published in this month's issue of Hepatology, Dr. Carlos Fernndez-Hernando from the New York University School of Medicine confirms the emergence of microRNAs in regulating cholesterol and fatty acid metabolism. He writes, "Altogether these data (by Vickers et al.) strongly suggest that miR-27b regulates lipid metabolism, but its role in regulating lipid levels in other cells, such as macrophages and neurons, remains unclear." Dr. Fernndez-Hernando highlights the importance of the new in silico approach used by the researchers to identify microRNAs in regulating genes involved in the same bodily process, suggesting this method could be used to identify microRNAs in controlling genetic networks.


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study shows disease spread in ladybirds with sexually transmitted disease
2. Nitrogen from pollution, natural sources causes growth of toxic algae, study finds
3. Study of a rare disease making people look like a woman but having male genitals under study
4. Study finds potential to match tumors with known cancer drugs
5. Can plants be altruistic? You bet, says new CU-Boulder-led study
6. New study sheds light on link between dairy intake and bone health
7. Medical societies to launch large-scale study on vein filter use
8. Virginia Tech adjunct and colleagues refute a study on racial bias report in NIH awards
9. Researcher uncovers potential cause, biomarker for autism and proposes study to investigate theory
10. New Geology study raises questions about long-held theories of human evolution
11. New study highlights impact of environmental change on older people
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces its biometric payment technology, ... featured in 2015 "I Want That" International CES Special, ... the DIY Network.   DIY,s "I Want ... site of the 2015 International CES for a firsthand ...
(Date:3/19/2015)... March 19, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, announces its biometric payment ... clip that aired this week on Washington DC,s ... In a segment "The Next Great Thing", host ... way to pay, and ,a really big breakthrough in mobile ...
(Date:3/17/2015)... Minn. , March 17, 2015 ... technology company specializing in clinical study management systems, ... be in attendance at ARENA,s Outsourcing in Clinical ... NC.  This event provides an excellent forum for ... easy-to-use, flexible and affordable software-as-a-service (SaaS) eClinical technology ...
Breaking Biology News(10 mins):NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... BERKELEY, CA -- A link between the immune system ... themselves of obsolete or toxic parts may one day ... other deadly infectious diseases. Scientists with the U.S. Department ... have discovered proteins residing in both systems that point ...
... A study in the Sept. 21 on-line edition ... interaction of a critical molecule involved in cell death ... blocking this molecule, called Cyclophilin D (CypD), and development ... for the prevention and treatment of Alzheimer,s disease, according ...
... It seems that our brain can correct speech errors in ... Niels Schiller and Lesya Ganushchak, NWO researchers in Leiden, made ... errors. This research can contribute to improvements in the treatment ... language. Our brain is fairly good at preventing ...
Cached Biology News:Proteomics study yields clues as to how tuberculosis might be thwarting the immune system 2Proteomics study yields clues as to how tuberculosis might be thwarting the immune system 3Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients 2Brain recognizes verbal 'oh dear' wave 2
(Date:3/29/2015)...  Caris Life Sciences® today announced the presentation ... the company,s panomic, comprehensive tumor profiling service, found ... and difficult to treat gynecological cancers may inform ... improve patient outcomes. These studies were presented today ... Gynecologic Oncology (SGO) 2015 Annual Meeting on Women,s ...
(Date:3/29/2015)... Texas , March 29, 2015 /PRNewswire/ ... presentation of important study data showing the ... in 1,599 gynecologic cancer samples. Using Caris ... profiling service, researchers identified expression of programmed ... cancers independent of histology while its ligand ...
(Date:3/27/2015)... March 27, 2015 Earlier this year, ... promotion of hair regrowth in adult men and women ... or Norwood Hamilton classifications of IIa-V and Fitzpatrick Classification ... plagued by products that over-promise and under-deliver, FDA Clearance ... faith and confidence among more than 80 million men ...
(Date:3/27/2015)... , 27. März 2015  Peter ... in Biomedical Science für seine bahnbrechende Arbeit ... zwischen Zellkompartimenten transportiert werden, sowie für die ... zur Reaktion auf Stress nutzen, der mit ... Walter ist Professor für Biochemie an der ...
Breaking Biology Technology:Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 2Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 3Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 4Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 2Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 3Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 4Dr. Robert Leonard Applauds FDA Clearance of Capillus272Pro™ Hair Loss Laser Cap 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 4
... Pa., Sept. 23 Environmental,Tectonics Corporation,s (Amex: ... announced the sale and placement of two BARA-MED(R) ... The,Shoreline Facility was established in Corpus Christi, Texas, ... care medical center in the region. The,facility offers ...
... Premacure to Initiate Phase II Trial for IPLEX(TM) ... UPPSALA, Sweden, Sept. 23 ,Insmed Inc. (Nasdaq CM: ... and Premacure AB, a biopharmaceutical company,dedicated to the ... due to premature birth, today noted the presentation ...
... Vein Recognition Device Helps BayCare Accurately,Identify Patients, ... Patient Privacy, SUNNYVALE, Calif., Sept. 23 ... leading supplier of innovative computer products,including hard ... announced that BayCare Health System, the largest ...
Cached Biology Technology:Environmental Tectonics Corporation Announces a Multiple Sale for Monoplace Hyperbaric Chambers 2Environmental Tectonics Corporation Announces a Multiple Sale for Monoplace Hyperbaric Chambers 3Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blindness in Premature Infants 2Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blindness in Premature Infants 3Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blindness in Premature Infants 4Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blindness in Premature Infants 5Fujitsu PalmSecure and HT Systems' PatientSecure Selected by BayCare Health System to Protect Patient Confidentiality and Prevent Medical Identity Theft 2Fujitsu PalmSecure and HT Systems' PatientSecure Selected by BayCare Health System to Protect Patient Confidentiality and Prevent Medical Identity Theft 3Fujitsu PalmSecure and HT Systems' PatientSecure Selected by BayCare Health System to Protect Patient Confidentiality and Prevent Medical Identity Theft 4Fujitsu PalmSecure and HT Systems' PatientSecure Selected by BayCare Health System to Protect Patient Confidentiality and Prevent Medical Identity Theft 5
... is a new product number, created ... If showing no availability yet, please ... (Z71,487-9) or contact customer service for ... 100 mm, No. of sidearm 4 ...
... pYD1 Yeast Display Vector is specifically designed ... the surface of Saccharomyces cerevisiae. Displayed proteins ... interact with known or putative ligands. pYD1 ... consists of two domains Aga1 and Aga2 ...
Packaging: 6 bottles for 1 l ready-to-use-solution ID clarifier: ready-to-use solution ...
... Polyclonal Antibody against Aph-1a (Aph-1aL,S ... The gamma secretase is a multiprotein ... and Pen-2; all four proteins are ... gamma secretase complex catalyzes cleavage of ...
Biology Products: