Navigation Links
Study identifies liver gene that regulates cholesterol and fat blood levels
Date:2/7/2013

m genes (Angptl3 and Gpam). Vickers added, "Using a mouse model of dyslipidemia and atherosclerosis, we found hepatic miR-27b and its target genes to be inversely altered, and thus contributing to risk for cardiovascular disease."

The senior author of the study, Dr. Praveen Sethupathy from the University of North Carolina at Chapel Hill School of Medicine, leads an interdisciplinary laboratory that weaves together computational and experimental approaches to understand the role of microRNAs in complex metabolic diseases. "MicroRNAs are thought to impart stability to gene networks, particularly in the face of changes to the environment, such as diet," he says. "MicroRNAs represent promising therapeutic targets for a variety of metabolic diseases, but a lot more work remains to be done in order to fully appreciate how and when they function."

In a related editorial published in this month's issue of Hepatology, Dr. Carlos Fernndez-Hernando from the New York University School of Medicine confirms the emergence of microRNAs in regulating cholesterol and fatty acid metabolism. He writes, "Altogether these data (by Vickers et al.) strongly suggest that miR-27b regulates lipid metabolism, but its role in regulating lipid levels in other cells, such as macrophages and neurons, remains unclear." Dr. Fernndez-Hernando highlights the importance of the new in silico approach used by the researchers to identify microRNAs in regulating genes involved in the same bodily process, suggesting this method could be used to identify microRNAs in controlling genetic networks.


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study shows disease spread in ladybirds with sexually transmitted disease
2. Nitrogen from pollution, natural sources causes growth of toxic algae, study finds
3. Study of a rare disease making people look like a woman but having male genitals under study
4. Study finds potential to match tumors with known cancer drugs
5. Can plants be altruistic? You bet, says new CU-Boulder-led study
6. New study sheds light on link between dairy intake and bone health
7. Medical societies to launch large-scale study on vein filter use
8. Virginia Tech adjunct and colleagues refute a study on racial bias report in NIH awards
9. Researcher uncovers potential cause, biomarker for autism and proposes study to investigate theory
10. New Geology study raises questions about long-held theories of human evolution
11. New study highlights impact of environmental change on older people
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... fast and accurate tool to diagnose tuberculosis in ... developed test (TAM-TB assay) is the first reliable ... The test features excellent specificity, a similar sensitivity ... a blood test. The promising findings are a ... children, particularly in tuberculosis-endemic regions. , The study ...
(Date:8/31/2014)... busy attacking us, germs go after each other. But ... for the infected microbes: Sometimes viruses actually carry helpful ... its diet or better attack its own hosts. , ... system would robotically destroy anything it recognized as invading ... now revealed that one variety of the bacterial immune ...
(Date:8/31/2014)... diagnosis has changed very little. After taking a blood sample ... glass slide, stains it with a special dye, and looks ... disease. This approach gives an accurate count of how many ... disease severity but is not ideal because there is ... Singapore-MIT Alliance for Research and Technology (SMART) has now come ...
Breaking Biology News(10 mins):New tuberculosis blood test in children is reliable and highly specific 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 3A new way to diagnose malaria 2A new way to diagnose malaria 3
... perennial wheat to be grown on any significant basis in ... Texas Agricultural Experiment Station plant pathologist., From wheat producers ... is finding a groundswell of interest as he begins planting ... wheat study., Rush obtained his initial perennial wheat seed ...
... Barbara, Calif.) -- By peering deep into evolutionary history, ... discovered the origins of photosensitivity in animals. ... the scientific journal PLoS ONE. The scientists studied the ... animals that have existed for hundreds of millions of ...
... convene for two days in Germany, Oct. 18-19, to ... foster better economic and social conditions in Africa through ... pledged in the declarations of the Gleneagles and Heiligendamm ... development. About 70 experts from nine African nations, ...
Cached Biology News:A wheat for all seasons -- and reasons 2A wheat for all seasons -- and reasons 3UCSB researchers discover the dawn of animal vision 2Improving science, technology in Africa is aim as G-8, African, UN experts convene in Berlin 2Improving science, technology in Africa is aim as G-8, African, UN experts convene in Berlin 3
(Date:8/28/2014)... research platform uses a laser to measure ... stress and heating, an approach likely to ... and batteries., This new technique, called nanomechanical ... and the surface stress of microscale structures ... the merits of surface-stress influence on mechanical ...
(Date:8/28/2014)... 2014  Next month, executives from clinical trial marketing firm ... beginning with Patient-Centered Clinical Trials 2014 , to be ... , September 4-5. Patient recruitment experts Bonnie A. ... will share insights on the benefits of employing an ... – from media to mobile apps – can be used ...
(Date:8/28/2014)... Fla. Exciting new work by a Florida State ... system that can take your temperature, emit white light, ... And, the molecule looks like a butterfly. , Biwu ... Biomedical Engineering in the FAMU-FSU College of Engineering, created ... but has continued to discover that his creation has ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 PrimeSource ... construction materials, selected SoundConnect to support ... cloud based audio and web conferencing platform GlobalMeet ... support PrimeSource’s employees’ needs. SoundConnect delivers award ... , PrimeSource Building Products will be utilizing ...
Breaking Biology Technology:New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2
... Florida in mid-October. Late in the month, Florida Governor Jeb ... negotiations to create and pass a bill creating a $369 ... for the Scripts Research Institute to focus on biotechnology research ... an example of a state that successfully attracted a private ...
... university, an emerging biotech industry, a well educated work force ... has a $3.2 billion budget deficit and a per capita ... below the national average in citizens with a 4-year degree, ... states. The current state of our economy presents a complex ...
... took huge strides last week. In fact, the technology ... mortals might use in everyday communications. , ,What's driving ... executive board rooms to the stuff of ordinary communications? ... the availability of low-cost, high-quality desktop video cameras; and ...
Cached Biology Technology:Florida: Investing Heavily in Biotechnology - Governor uses state funds to attract large biotech companies 2Florida: Investing Heavily in Biotechnology - Governor uses state funds to attract large biotech companies 3Florida: Investing Heavily in Biotechnology - Governor uses state funds to attract large biotech companies 4WARF Collaboration a Win-Win for Wisconsin 2WARF Collaboration a Win-Win for Wisconsin 3Video Conferencing for the Masses 2Video Conferencing for the Masses 3
Mouse monoclonal antibody raised against a partial recombinant STAU2. NCBI Entrez Gene ID = STAU2...
...
Mouse polyclonal antibody to NR2F2 - nuclear receptor subfamily 2, group F, member 2...
... provides optimized blocking and wash solutions ... Ready-to-use wash solutions have been validated ... Slides for Microarrays (Product Code S ... 1L • Microarray Post Hybridization Wash ...
Biology Products: