Navigation Links
Study identifies liver gene that regulates cholesterol and fat blood levels
Date:2/7/2013

Researchers have identified a microRNA liver gene, miR-27b, which regulates lipid (cholesterol or fat) levels in the blood. This regulator gene controls multiple genes involved in dyslipidemiaabnormal blood cholesterol levels that can contribute to heart disease. Study details published in the February issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD), describe a new in silico approach to identify the significance of microRNAs in regulating disease-related gene pathways.

The Human Genome Project (HGP) was completed in April, 2003 and the world had a map of the 3 billion DNA letters making up the human genome. One of the HGP leaders was Dr. Francis Collins, currently NIH Director and contributor to the present study. "The HGP provided the basic instruction book for human biology," explains Dr. Collins. "Further genomic studies, such as the investigation of microRNAs, have built upon the efforts of the HGP to explain how the genome carries out its functions, and helps identify genes involved in the development of disease."

For the present study, lead author Dr. Kasey Vickers from the NIH/NHLBI Lipoprotein Metabolism Section (presently at Vanderbilt University School of Medicine) and colleagues performed high-throughput small RNA sequencing of mouse liver and detected roughly 150 microRNAs. The team used a novel in silico approach to identify microRNA regulatory hub genes involved in lipid metabolism. In human and mouse livers miR-27b was determined to be the strongest hub with 27 predicted targets.

"We found liver miR-27b levels to be sensitive to high triglycerides (hyperlipidemia) in the blood and liver," said Dr. Vickers. The team reported a nearly 3-fold increase in miR-27b levels in the liver of mice on a high-fat diet, with 42% of calories from fat. In human liver tissue cells, researchers determined that miR-27b regulates mRNA and protein expression of key lipid-metabolis
'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study shows disease spread in ladybirds with sexually transmitted disease
2. Nitrogen from pollution, natural sources causes growth of toxic algae, study finds
3. Study of a rare disease making people look like a woman but having male genitals under study
4. Study finds potential to match tumors with known cancer drugs
5. Can plants be altruistic? You bet, says new CU-Boulder-led study
6. New study sheds light on link between dairy intake and bone health
7. Medical societies to launch large-scale study on vein filter use
8. Virginia Tech adjunct and colleagues refute a study on racial bias report in NIH awards
9. Researcher uncovers potential cause, biomarker for autism and proposes study to investigate theory
10. New Geology study raises questions about long-held theories of human evolution
11. New study highlights impact of environmental change on older people
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... SAN DIEGO , Jan. 26, 2015   Epic ... treatment of cancer, today announced that Murali Prahalad , ... Personalized Medicine World Conference (PMWC) 2015: Silicon Valley, ... Mountain View, Calif. on January 26-28, ... entitled, "CTCs Come of Age as Biomarkers." Last year, Epic ...
(Date:2/5/2015)... NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, announces ... CEO Conference on January 29 th at 10:30 ... CEO of NXT-ID will present and host a live ... wallet and its full suite of biometric technologies. Investors ...
(Date:1/22/2015)... 22, 2015 Research and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) ... Global Market Overview" report to their offering. , ... ensure that an individual is who she/he is claiming to ... of a person,s unique physical characteristics, such as fingerprint, hand ...
Breaking Biology News(10 mins):Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3
... On September 11, firefighters, police officers and ambulance ... Trade Center complex. They battled to save people from ... and evacuated as many people as they could in ... making their jobs even harder was the problem of ...
... Over the course of a lifetime, the heart pumps ... the order to do this, the muscle fibers of the ... by Dr. Wolfgang Rottbauer, vice chair of the Department of ... A. Katus), has discovered a protein that is responsible for ...
... prescribed by traditional healers in Brazil to treat a range of ... Now for the first time, researchers at Newcastle University have been ... crenata otherwise known as Brazilian mint. , Testing this ... Graciela Rocha was able to show that when prepared as a ...
Cached Biology News:Magic box for mission impossible 2Magic box for mission impossible 3New genetic cause of cardiac failure discovered 2Got a pain? -- Have a cup of Brazilian mint 2
(Date:2/26/2015)... (PRWEB) February 26, 2015 RURO, Inc., ... released FreezerPro® version 6.2 – the latest update to ... reputation is that of a quick and easy method ... With the latest version, RURO engineering has enhanced the ... to move large amounts of sample records. , ...
(Date:2/26/2015)... ANGELES , Feb. 26, 2015 Tauriga ... life sciences company with interests in the natural wellness ... technology, announced today that its products will be featured ... Roth Capital Partners, 27 th Annual Growth Stock ... Carlton, located at 1 Ritz Carlton Drive, ...
(Date:2/26/2015)... February 26, 2015 On Wednesday, February ... building a nationwide Clostridium difficile (C. diff) awareness movement, ... burden study by the Centers for Disease Control & ... almost half a million infections among Americans in a ... homes. , The study also estimates that 29,000 ...
(Date:2/25/2015)... , Feb. 25, 2015 Today, BioMed Realty ... realignment, including a number of promotions and additions to ... company,s strategy to increase shareholder returns through strategic investments ... health care industry and the innovation sector. ... Kent Griffin is leaving his role as President ...
Breaking Biology Technology:RURO Releases FreezerPro® version 6.2 2SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 2SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 3SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 4Peggy Lillis Foundation Lauds CDC's New, More Comprehensive Study on the Burden of C. difficile Infections in the United States 2Peggy Lillis Foundation Lauds CDC's New, More Comprehensive Study on the Burden of C. difficile Infections in the United States 3Peggy Lillis Foundation Lauds CDC's New, More Comprehensive Study on the Burden of C. difficile Infections in the United States 4BioMed Realty Announces Realignment To Leverage Depth Of Life Science Real Estate Expertise And Increase Shareholder Value 2BioMed Realty Announces Realignment To Leverage Depth Of Life Science Real Estate Expertise And Increase Shareholder Value 3BioMed Realty Announces Realignment To Leverage Depth Of Life Science Real Estate Expertise And Increase Shareholder Value 4
... the first time, Eli Lilly and Company (NYSE: ... grassroots projects across the globe and have their donations matched ... impact of each employee,s charitable contribution. Lilly ... across the world a customized Lilly Global Giving website, where ...
... in the journal Nature Physics , the academics, ... of Manchester in 2004, have revealed more about its ... world are already looking at ways to build devices ... the research from the creators of the material promises ...
... SAN MATEO, Calif., July 22, 2011 NeurogesX, Inc. ... on developing novel pain management therapies, today announced that ... purchase agreement in connection with a private placement to ... standard closing conditions, is expected to receive approximately $20 ...
Cached Biology Technology:Lilly Global Giving Puts Power of Philanthropy in Employees' Hands 2Lilly Global Giving Puts Power of Philanthropy in Employees' Hands 3Lilly Global Giving Puts Power of Philanthropy in Employees' Hands 4Graphene's 'quantum leap' takes electronics a step closer 2NeurogesX, Inc. Announces $20 Million Private Placement 2NeurogesX, Inc. Announces $20 Million Private Placement 3NeurogesX, Inc. Announces $20 Million Private Placement 4
... Preparation contains a unique β-agarose digesting enzyme ... of intact DNA and RNA from low ... in TAE, TBE, MOPS, or phosphate buffers. ... the TAE, TBE, MOPS, and phosphate electrophoresis ...
... high PCR specificity *High PCR specificity ... enzyme with unique QIAGEN PCR Buffer ... provided by the stringent built-in hot ... Master Mix and simple reaction setup ...
Recombinant Cat Interferon Alpha Activity: 2.7 x 10 7 u/mg...
... Thermo Labsystems' Wellwash AC ... twin-strip microplate washer available, and ... sensors for wash, waste and ... shaker and automatic rinsing and ...
Biology Products: