Navigation Links
Study highlights possible new approach to prostate cancer treatment
Date:8/1/2013

CINCINNATI -- A study in the Journal of Biological Chemistry identifies a new therapeutic approach to treat prostate cancer.

Conducted at Cincinnati Children's Hospital Medical Center, the research shows that expression of the FoxM1 protein is essential for prostate cancer to develop in mouse models. The study appears in the journal's Aug. 2 edition.

The study also shows that depletion of FoxM1 in prostate epithelial cells inhibits tumor cell proliferation, the process by which new blood vessels are formed, and metastasis -- the spread of cancer to other organs of the body.

"It is possible that FoxM1 is important for both cancer initiation and cancer progression," says Tanya Kalin, MD, PhD, a physician-scientist in the division of Pulmonary Biology at Cincinnati Children's and senior author of the study. "Our findings provide the foundation for the development of new therapeutic approaches based on inhibition of FoxM1."

FoxM1 is known to be involved in most solid tumor cancers. Kalin's lab published a study in 2006 showing that increased levels of FoxM1 were associated with the development and progression of prostate cancer in mice. Although the current study focuses primarily on prostate cancer, the findings could also help researchers better understand the pathogenesis of pediatric disease.

In this new study, Kalin and colleagues at Cincinnati Children's studied a novel mouse model of prostate cancer. In this model, loss of FoxM1 decreased tumor growth and metastasis. Without this model, over-expression of FoxM1, either alone or in combination with inhibition of a tumor suppressor known as p19ARF caused a robust proliferation of epithelial cells. This proliferation of cells was not enough to induce progression from proliferation to actual prostate cancer, but it caused small prostate epithelial tubes to shrink.


'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1

Related biology news :

1. Breath analysis reliably indicates presence, level of infection in mice, UCI study finds
2. Southerners are less trusting, but trust is a factor in environmental cooperation, study shows
3. Study investigates extraordinary trout with tolerance to heavily polluted water
4. Extinct ancient ape did not walk like a human, study shows
5. Study explains Pacific equatorial cold water region
6. Study finds depletion of alveolar macrophages linked to bacterial super-infections
7. New study finds nighttime heat waves increasing in Pacific Northwest
8. Study finds missing piece of pediatric cancer puzzle
9. Its not just the heat -- its the ozone: Study highlights hidden dangers
10. LSUHSC researcher awarded NCI grant to study link between chronic inflammation and cancer
11. Healthrageous, United BioSource And Boehringer Ingelheim Launch SMART Digital Diabetes Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) ... Global Strategic Business Report" report to their offering. ... in US$ Thousands. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific ... Latin America . Annual estimates and ...
(Date:3/17/2015)... 17, 2015 Emotient, the leader in ... announced general availability of Emotient Analytics , ... analysis of facial expressions. The system analyzes videos ... products and services. It delivers audience response metrics ... - as derived from facial evidence of emotional ...
(Date:3/12/2015)... March 12, 2015 The mascots of the ... Hospital, part of Wake Forest Baptist Medical Center. They ... the 2015 ACC Men,s Basketball Tournament. Young patients enjoyed ... and getting their autographs. Brenner Children,s Hospital ... is the only children,s hospital in northwest ...
Breaking Biology News(10 mins):Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4
... no good evidence supporting a harmful effect of exercise on ... according to a review of studies published in this month,s ... is an extremely popular leisure-time activity in many countries throughout ... the modern lifestyle. It is widely promoted in as being ...
... SVOX, the leading provider of,embedded speech solutions ... Group of Siemens AG, according to SVOX CEO ... of Siemens AG developed,over 25 years, including the ... patent families. The majority of the Professional,Speech Processing ...
... Ill. -- Most people know that too much sodium from ... that people trying to lower their blood pressure should also ... to sodium. Researchers found that the ratio of sodium-to-potassium ... disease than sodium or potassium alone. "There isn,t ...
Cached Biology News:SVOX Acquires Speech Processing Unit of Siemens AG, Expands Into Speech Recognition and Speech Dialog 2Cutting salt isn't the only way to reduce blood pressure 2
(Date:3/29/2015)... , March 29, 2015  Caris ... study data in small cell cervical cancer ... Caris Molecular Intelligence®, the company,s panomic, comprehensive ... gene mutations which may explain sensitivities and ... that identification of certain biomarkers may guide ...
(Date:3/29/2015)... 2015 As a symbol of its ... our pharmaceutical manufacturing clients, Whitehouse Laboratories is excited to ... Berkenstock Race Team for the 2015 race season. Success ... but a strong sense of precision and attention to ... success in the quality control testing laboratory. Sponsorship of ...
(Date:3/27/2015)... March 27, 2015 The consumption of ... of the recession and high prices in 2008. However, ... recovered and keeps on gaining momentum now. , To ... at more than 100,000 thousand tonnes. No considerable growth ... the global capacity rocketed during 2012-2013, registering 11% growth ...
(Date:3/27/2015)... 27, 2015  Neogen Corporation (NASDAQ: NEOG ) ... prearranged trading plan in accordance with Securities and Exchange ... CEO of Neogen Corporation, is a minority owner of ... stock. Herbert does not have control of ... filing is only for a portion of the shares ...
Breaking Biology Technology:Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer 2Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer 3Whitehouse Laboratories Reaffirms Commitment to Speedy Results – Renews Sponsorship of Berkenstock Racing Team 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 3Neogen CEO adopts 10b5-1 Trading Plan 2
... Valkee ( http://valkee.com ), the inventor of the world,s ... of Oulu present two clinical trials at the 11th ... Budapest on November 9 th -11 th . In ... supplement of the International Journal of Psychiatry in Clinical ...
... 7, 2011 IDEXX Laboratories, Inc. (NASDAQ: ... acquired the research and diagnostic laboratory (RADIL) business ... University of Missouri for $43 million in cash. ... and diagnostic testing services to bioresearch customers. ...
... Halozyme Therapeutics, Inc. (NASDAQ: ... targeting the extracellular matrix for the diabetes, ... results for the third quarter of 2011 and discussed ... "The past few months highlight the progress ...
Cached Biology Technology:Bright Light into the Ear Canal Treats Seasonal Depression Effectively in Two Clinical Trials Presented by Valkee and University of Oulu 2Bright Light into the Ear Canal Treats Seasonal Depression Effectively in Two Clinical Trials Presented by Valkee and University of Oulu 3IDEXX Laboratories Acquires the RADIL Reference Laboratory from the University of Missouri 2IDEXX Laboratories Acquires the RADIL Reference Laboratory from the University of Missouri 3IDEXX Laboratories Acquires the RADIL Reference Laboratory from the University of Missouri 4Halozyme Therapeutics Reports Third Quarter 2011 Financial Results 2Halozyme Therapeutics Reports Third Quarter 2011 Financial Results 3Halozyme Therapeutics Reports Third Quarter 2011 Financial Results 4Halozyme Therapeutics Reports Third Quarter 2011 Financial Results 5Halozyme Therapeutics Reports Third Quarter 2011 Financial Results 6Halozyme Therapeutics Reports Third Quarter 2011 Financial Results 7
... Compound(s) tested through 63 ... assays spanning a broad ... panel includes many non ... several non-selective assays. ...
...
... The Genome Sequencer 20 System revolutionizes ... massively parallel fashion. The Genome Sequencer ... accessories Reagents and consumables for library ... for mapping and de novo assembly ...
... to the maintenance of appropriate levels ... important and diverse as those involved ... stress response, antigen presentation, modulation of ... cell cycle regulation, transcription, and signalling ...
Biology Products: