Navigation Links
Study highlights possible new approach to prostate cancer treatment
Date:8/1/2013

CINCINNATI -- A study in the Journal of Biological Chemistry identifies a new therapeutic approach to treat prostate cancer.

Conducted at Cincinnati Children's Hospital Medical Center, the research shows that expression of the FoxM1 protein is essential for prostate cancer to develop in mouse models. The study appears in the journal's Aug. 2 edition.

The study also shows that depletion of FoxM1 in prostate epithelial cells inhibits tumor cell proliferation, the process by which new blood vessels are formed, and metastasis -- the spread of cancer to other organs of the body.

"It is possible that FoxM1 is important for both cancer initiation and cancer progression," says Tanya Kalin, MD, PhD, a physician-scientist in the division of Pulmonary Biology at Cincinnati Children's and senior author of the study. "Our findings provide the foundation for the development of new therapeutic approaches based on inhibition of FoxM1."

FoxM1 is known to be involved in most solid tumor cancers. Kalin's lab published a study in 2006 showing that increased levels of FoxM1 were associated with the development and progression of prostate cancer in mice. Although the current study focuses primarily on prostate cancer, the findings could also help researchers better understand the pathogenesis of pediatric disease.

In this new study, Kalin and colleagues at Cincinnati Children's studied a novel mouse model of prostate cancer. In this model, loss of FoxM1 decreased tumor growth and metastasis. Without this model, over-expression of FoxM1, either alone or in combination with inhibition of a tumor suppressor known as p19ARF caused a robust proliferation of epithelial cells. This proliferation of cells was not enough to induce progression from proliferation to actual prostate cancer, but it caused small prostate epithelial tubes to shrink.


'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1

Related biology news :

1. Breath analysis reliably indicates presence, level of infection in mice, UCI study finds
2. Southerners are less trusting, but trust is a factor in environmental cooperation, study shows
3. Study investigates extraordinary trout with tolerance to heavily polluted water
4. Extinct ancient ape did not walk like a human, study shows
5. Study explains Pacific equatorial cold water region
6. Study finds depletion of alveolar macrophages linked to bacterial super-infections
7. New study finds nighttime heat waves increasing in Pacific Northwest
8. Study finds missing piece of pediatric cancer puzzle
9. Its not just the heat -- its the ozone: Study highlights hidden dangers
10. LSUHSC researcher awarded NCI grant to study link between chronic inflammation and cancer
11. Healthrageous, United BioSource And Boehringer Ingelheim Launch SMART Digital Diabetes Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Conn. , July 24, 2014 NXT-ID, Inc., ... m-commerce market, announces its next generation smart wallet, Wocket™, was recently ... Anita Finley interviewed Gino Pereira , ... over thirty minutes. Mr. Gino ... bulky wallets full of credit cards and walks host ...
(Date:7/23/2014)... twins has found that early reading skill might positively ... Child Development , was conducted by researchers at ... "Since reading is an ability that can be improved, ... Stuart J. Ritchie, research fellow in psychology at the ... of reading problems might aid not only the growth ...
(Date:7/23/2014)... about the crow and the pitcher, a thirsty bird happens ... drink from it, he finds the water level out of ... the bird drops pebbles into it one at a ... to drink his fill. , Highlighting the value of ingenuity, ... effective than brute force. It also characterizes crows as pretty ...
Breaking Biology News(10 mins):Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 2Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 3Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 4Stronger early reading skills predict higher intelligence later 2Smarter than a first-grader? 2Smarter than a first-grader? 3Smarter than a first-grader? 4
... SUNNYVALE, California, September 29, 2010 ... ... ... keyed by longUrl, so we need to grab the first one. for (var r in data.results) { ...
... This release is also available in Chinese on ... 2010) -- The second law of thermodynamics is a big ... existential crunch. The tendency of a closed systems to become ... a popular, if not depressing, "things fall apart" sort-of-law that ...
... COLD SPRING HARBOR, N.Y. (Sept. 28, 2010) -- A ... in Gene Regulation , reviews our understanding of two RNA ... was both information store and biocatalyst; and the contemporary RNA ... host of other RNAs operate. "[T]he plasticity ...
Cached Biology News:HCL Technologies Launches AeroPASS Airport Security Solution 2HCL Technologies Launches AeroPASS Airport Security Solution 3HCL Technologies Launches AeroPASS Airport Security Solution 4HCL Technologies Launches AeroPASS Airport Security Solution 5HCL Technologies Launches AeroPASS Airport Security Solution 6HCL Technologies Launches AeroPASS Airport Security Solution 7HCL Technologies Launches AeroPASS Airport Security Solution 8HCL Technologies Launches AeroPASS Airport Security Solution 9Tiny generators turn waste heat into power 2New book reviews ancient and modern worlds of RNA 2
(Date:7/24/2014)... Texas (PRWEB) July 24, 2014 ... Potassium Sulphate Industry” is a professional and in-depth ... report introduces Potassium Sulphate basic information, including ... and industry overview. This research covers the international ... as global industry analysis covering macroeconomic environment & ...
(Date:7/24/2014)... Draper University, a top program ... announce that for 6 weeks this summer, 39 ... on the Draper University campus in the heart ... focused on entrepreneurship, building real-world skills, and “learning ... its sixth cohort, continues to refresh its curriculum ...
(Date:7/23/2014)... , July 24, 2014 Lyfebulb, ... Pharmaceuticals Inc. (OTCQX and NASDAQ OMX First North ... or "the Company"), announced a collaboration to increase ... last night at an event attended by more ... parties. Lyfebulb is a health and wellness company ...
(Date:7/23/2014)... the Helmholtz-Zentrum Dresden-Rossendorf (HZDR), the Vienna University of ... succeeded in embedding nearly perfect semiconductor crystals into ... producing hybrid nanowires, very fast and multi-functional processing ... in the future. The research results will be ... , Nano-optoelectronics are considered the cornerstone of future ...
Breaking Biology Technology:Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 2Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 4Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 5A crystal wedding in the nanocosmos 2
... LANSING, Mich., Oct. 15 Forbes Magazine has,named Neogen ... of the 200 Best,Small Companies in America for the ... years., "Conventional wisdom would have investors flee small-cap ... safer bets, the thinking,goes. Maybe not right now with ...
... /PRNewswire/ - Norgen Biotek Corp., an innovative,Canadian biotechnology ... acids and protein purification, today announced the,launch of ... acids from,environmental samples, the Soil DNA Isolation Kit ... ideal for environmental microbiological,studies, and provide high quality, ...
... is promoting its new PadLock Set Saver product at ... Lake City,UT, at The Salt Palace, October 15-17, 2008., ... promoting,its new PadLock Set Saver at the ANCC National ... IV administration set storage,solution, PadLock provides a secure seal ...
Cached Biology Technology:Neogen Honored by Forbes; Two Brokerage Firms Initiate Coverage 2High-quality DNA/RNA from Microorganisms in Environmental Samples 2Baxa Corporation Features PadLock(R) Set Saver at the ANCC National Magnet Conference(TM) 2
Presenilin 2 Immunogen: Synthetic peptide corresponding to residues 31-47 of human Presenilin 2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Monoclonal Anti-Gα o purified immunoglobulin buffered aqueous solution Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide. partially purified bovine brain Gα O ...
Potassium Channel kv3.2...
... 2, Neuronal (GLYT2). The antiserum has been ... nervous system. The staining pattern obtained with ... in situ hybridization with probes to GLYT2 ... for glycinergic neurons. Preabsorption of the antiserum ...
Biology Products: