Navigation Links
Study fingers chickens, quail, in spread of H7N9 influenza virus
Date:3/18/2014

Among the copious species of poultry in China, quail and chickens are the likely sources of infection of H7N9 influenza virus to humans, according to a paper published ahead of print in the Journal of Virology.

"Knowing the likely poultry species lets us target our interventions better to prevent human infections," says corresponding author David Suarez, of the United States Department of Agriculture.

The H7N9 avian influenza virus was first reported in humans in March 2013 in China. Since then over 375 human cases have been confirmed and over 100 have died. Only 1 case has been reported outside of China: A woman from Guangdong Province who was traveling in Malaysia and is presumed to have contracted the virus in China. According to the World Health Organization, most known human infections have resulted from direct or indirect contact with poultry.

Suarez' laboratory originally became concerned about H7N9 after sequences from several isolates were made available in public databases, early in the outbreak. "We quickly recognized that the virus from this outbreak was unusual, and represented a real human and veterinary risk," he says. Most of the genes had come from a poultry virus that had existed in china for many years, and two genes probably came from a wild bird isolate, he says.

"We felt a major knowledge gap in the outbreak was that we didn't know which poultry species was maintaining the virus and exposing people," says Suarez. "With this information, better decisions can be made to control and hopefully eradicate the virus."

In the study, Suarez and his collaborators first infected seven species of poultry with a human isolate of the Chinese H7N9 virus. The virus replicated well in quail and chickens, and the former quickly infected their cage-mates, says Suarez.

The virus replicated less well in other poultry species, and did not transmit efficiently. Pigeons were notably resistant to becoming infected. In additional experiments, quail transmitted virus efficiently, while pekin ducks and pigeons did not.

None of the poultry species became sick when infected with H7N9, making detection of the virus that much more difficult in the birds, says Suarez. "This work supports the need for better surveillance in animal species for avian influenza," says Suarez.

"The silent carriage also creates a conflict between poultry producers, who want to preserve their flocks, versus the public health goals of eradicating the virus," says Suarez.

"This work supports the field epidemiology studies that had identified live poultry markets as the likely source of the outbreak," says Suarez. "The Chinese correctly closed the live bird markets where they had human infections, and that reduced the number of cases for a while. However, their efforts did not eradicate the virus and it has returned for a second wave."


'/>"/>
Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... 2016   The Weather Company , an IBM Business ... industry-first capability in which consumers will be able to interact ... questions via voice or text and receive relevant information about ... Marketers have long sought an advertising solution that can ... personal, relevant and valuable; and can scale across millions of ...
(Date:5/16/2016)... May 16, 2016   EyeLock LLC , a ... the opening of an IoT Center of Excellence in ... expand the development of embedded iris biometric applications. ... of convenience and security with unmatched biometric accuracy, making ... aside from DNA. EyeLock,s platform uses video technology to ...
(Date:4/28/2016)... GOTHENBURG, Sweden , April 28, 2016 ... 1,491.2 M (139.9), up 966% compared with the first quarter of ... Operating profit totaled SEK 589.1 M (loss: 18.8) and the operating ... SEK 7.12 (loss: 0.32) Cash flow from operations was ... , The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Cancer experts from ... believe could be a new and helpful biomarker for malignant pleural mesothelioma. Surviving ... to read it now. , Biomarkers are components in the blood, tissue ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly ... technologies, services and solutions to the healthcare market. The company's primary focus is ... manufacturing, sales and marketing strategies that are necessary to help companies efficiently bring ...
(Date:6/27/2016)... PHILADELPHIA , June 27, 2016  Liquid ... today announced the funding of a Sponsored Research ... study circulating tumor cells (CTCs) from cancer patients.  ... changes in CTC levels correlate with clinical outcomes ... therapies. These data will then be employed to ...
(Date:6/24/2016)... on a range of subjects including policies, debt and investment ... Speaking at a lecture to the Canadian Economics ... the country,s inflation target, which is set by both the ... "In certain areas there needs to be frequent ... not sit down and address strategy together?" He ...
Breaking Biology Technology: