Navigation Links
Study fingers chickens, quail, in spread of H7N9 influenza virus

Among the copious species of poultry in China, quail and chickens are the likely sources of infection of H7N9 influenza virus to humans, according to a paper published ahead of print in the Journal of Virology.

"Knowing the likely poultry species lets us target our interventions better to prevent human infections," says corresponding author David Suarez, of the United States Department of Agriculture.

The H7N9 avian influenza virus was first reported in humans in March 2013 in China. Since then over 375 human cases have been confirmed and over 100 have died. Only 1 case has been reported outside of China: A woman from Guangdong Province who was traveling in Malaysia and is presumed to have contracted the virus in China. According to the World Health Organization, most known human infections have resulted from direct or indirect contact with poultry.

Suarez' laboratory originally became concerned about H7N9 after sequences from several isolates were made available in public databases, early in the outbreak. "We quickly recognized that the virus from this outbreak was unusual, and represented a real human and veterinary risk," he says. Most of the genes had come from a poultry virus that had existed in china for many years, and two genes probably came from a wild bird isolate, he says.

"We felt a major knowledge gap in the outbreak was that we didn't know which poultry species was maintaining the virus and exposing people," says Suarez. "With this information, better decisions can be made to control and hopefully eradicate the virus."

In the study, Suarez and his collaborators first infected seven species of poultry with a human isolate of the Chinese H7N9 virus. The virus replicated well in quail and chickens, and the former quickly infected their cage-mates, says Suarez.

The virus replicated less well in other poultry species, and did not transmit efficiently. Pigeons were notably resistant to becoming infected. In additional experiments, quail transmitted virus efficiently, while pekin ducks and pigeons did not.

None of the poultry species became sick when infected with H7N9, making detection of the virus that much more difficult in the birds, says Suarez. "This work supports the need for better surveillance in animal species for avian influenza," says Suarez.

"The silent carriage also creates a conflict between poultry producers, who want to preserve their flocks, versus the public health goals of eradicating the virus," says Suarez.

"This work supports the field epidemiology studies that had identified live poultry markets as the likely source of the outbreak," says Suarez. "The Chinese correctly closed the live bird markets where they had human infections, and that reduced the number of cases for a while. However, their efforts did not eradicate the virus and it has returned for a second wave."

Contact: Jim Sliwa
American Society for Microbiology

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
(Date:4/26/2016)... April 27, 2016 Research ... Multi-modal Biometrics Market 2016-2020"  report to their offering.  ... The analysts forecast the global multimodal ... 15.49% during the period 2016-2020.  Multimodal ... sectors such as the healthcare, BFSI, transportation, automotive, ...
(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ON , June 27, 2016 /PRNewswire/ - BIOREM Inc. ... has been advised by its major shareholders, Clean Technology ... United States based venture capital ... shares of Biorem (on a fully diluted, as converted ... the disposition of their entire equity holdings in Biorem ...
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former ... of the University of North Carolina Kenan-Flagler Business School effective June ... UNC Kenan-Flagler, with a focus on the school’s international efforts, leading classes and ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of ... the Cary 5000 and the 6000i models are higher end machines that use the ... of the spectrophotometer’s light beam from the bottom of the cuvette holder. , ...
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
Breaking Biology Technology: