Navigation Links
Study finds possible alternative to bariatric weight loss surgery
Date:4/30/2013

CINCINNATI An experimental procedure successfully tested in obese laboratory rats may provide a less-invasive alternative to bariatric weight-loss surgery, researchers report online in Endocrinology.

Scientists at Cincinnati Children's Hospital Medical Center used a catheter to re-direct the flow of bile from the bile duct into the small intestine, producing the same metabolic and weight-loss benefits as bariatric surgeries such as gastric by-pass. They named the procedure bile diversion, or BD.

"This may lead to novel ways to treat obesity related conditions," said lead investigator, Rohit Kohli, MBBS, MS, a physician and researcher in the Division of Gastroenterology at Cincinnati Children's. "Our results provide compelling evidence that manipulation of bile acids is sufficient to recreate the key effects of bariatric procedures, including gastric bypass, and may be especially beneficial to people with obesity related liver dysfunction."

Bariatric surgery has become an important therapeutic option for morbid obesity and nonalcoholic fatty liver disease. Gastric bypass surgery is associated with sustained weight loss and reduced overall mortality in patients. Still, the invasive procedure which involves altering the gastrointestinal anatomy of patients also comes with medical risks.

Physicians also do not fully understand the biological mechanisms that produce the post-surgical benefits of procedures like gastric bypass. It is theorized that elevated levels of bile acids detected in the blood of patients trigger molecular processes that may help improve metabolism and energy expenditure.

In the current study, Kohli and his collaborators which included researchers at the University of Cincinnati College of Medicine worked from the hypothesis that diverting bile acid in obese rats would recreate the benefits of bariatric surgery.

Male rats with diet-induced obesity received either the bile d
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... , June 30, 2015 Genisphere ... as CEO to help further develop Genisphere,s therapeutics capabilities ... partnering experience, having spent much of the last 25 ... Amgen, Baxter Bioscience, and Johnson & Johnson. Tom started ... Technology and Biotech Corporate Finance. He graduated from Dartmouth ...
(Date:6/25/2015)... According to a new ... Area), Technology, Material (Optical Prism, Piezoelectric, Capacitive & ... Others) & Geography - Global Forecast to 2014 ... is expected to reach $14,500.07 Million by 2020, ... Browse 76 market Tables and 109 Figures spread ...
(Date:6/24/2015)... YORK , June 24, 2015 The ... rate. The major drivers for the market include growth ... number of new drug launches. Over the years, the ... increased. Between 2001 and 2010, the FDA approved 225 ... according to WIPO, Europe accounted ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4
... APRIL 2010 -- Improvements in aerial survey methods have led ... according to a paper published Arctic , the journal ... Previous estimates of narwhals were based on surface counts ... placed populations between 20,000 and 30,000. New estimates increase ...
... PITTSBURGHAn international study based at the University of ... that can biodegrade carbon nanotubesthe superstrong materials found in ... the potentially damaging health effects of being exposed to ... Nature Nanotechnology . The results could open ...
... New research is shedding light on the preferred habitat of ... overlooked species in Arctic marine food webs. Squid, along ... role as prey in Arctic waters for species such as ... Gardiner, a PhD candidate in the Biological Sciences Department of ...
Cached Biology News:New survey techniques improve narwhal population estimates 2Pitt-led study identifies human enzyme that breaks down potentially toxic nanomaterials 2Pitt-led study identifies human enzyme that breaks down potentially toxic nanomaterials 3Habitat of elusive Northern squid documented by researcher 2
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... Costello served ... levee system to protect the Orange County, Texas area from future storm surge ... design team in determining several potential levee alignment alternatives for providing protection, Costello also ...
(Date:7/29/2015)... ... July 29, 2015 , ... Nearly everyone has heard ... Yet few people realize that a rich source of these cells is teeth—baby teeth ... teeth that need to be pulled to make room for braces. These potent ...
(Date:7/28/2015)... ... 2015 , ... The new Xsample 530 sample changer for vials can be used ... viscosities – from less than 12,000 mPas (internal air) up to 36,000 (external air) – ... catches the eye about Xsample 530 is its removable magazine, which is easily lifted off ...
(Date:7/28/2015)... Mass. , July 28, 2015 ... measuring cell metabolism, is the provider of XF ... across all disease research areas. As the links ... exploration into cell metabolism is escalating rapidly.   ... published by the Nature Publishing Group (NPG) featuring ...
Breaking Biology Technology:Preventing Storm Surge Flooding in Houston 2Advanced Oral and Maxillofacial Surgery (AOMS) in Elmhurst, IL Partners with Provia Labs to make Store-A-Tooth™ Dental Stem Cell Banking Available to their Patients 2New Moves in Automatic Sample Handling: Introducing Xsample 530 2XF Technology Used to Demonstrate Feasibility of Stem Cell Regenerative Technique 2XF Technology Used to Demonstrate Feasibility of Stem Cell Regenerative Technique 3
... strategy-driven biotech and pharmaceutical product development company, announced today ...  The new office space, located at 7361 Calhoun Place, ... RRD,s business footprint to 13,000 sq ft. ... RRD has achieved in the last year," said Scott ...
... Sept. 9 WaferGen Biosystems, Inc. (OTC Bulletin Board: ... genomic analysis systems, today announced that its corporate presentation ... Annual Global Healthcare Conference, Tuesday, September 14, 2010, beginning ... accessed at www.wafergen.com , and will be available ...
... CANTON, Ohio, Sept. 8 Public ... us. From our workplaces to our homes and everywhere in ... at constant risk. Every year more and more people are ... Centers for Disease Control and Prevention, approximately 15 to 60 ...
Cached Biology Technology:RRD Announces Move to New Corporate Headquarters 2WaferGen Corporate Presentation to be Webcast at Rodman and Renshaw's 12th Annual Healthcare Conference 2SpectraSan 24 Holds First Public Health and Safety Symposium in Ohio 2SpectraSan 24 Holds First Public Health and Safety Symposium in Ohio 3
... shakers have the durability to ... 3-high, and the uniformity and ... shake" applications. Heavily built ... our stackers are designed for ...
... with any of UVP's Doc-It systems. When ... 1D Analysis software onto your existing computer. ... functions and enhancement tools. Doc-It 1D Analysis ... algorithms for quick and accurate electrophoresis analysis., ...
CQCS kit for first KR 4i , (first unit)....
... Multidrop Combi is a new generation dispenser combining ... with the proven performance of the existing Multidrop ... large volume area starting from 500 nl up ... range. ,It is optimized for multiple ...
Biology Products: