Navigation Links
Study finds possible alternative to bariatric weight loss surgery
Date:4/30/2013

CINCINNATI An experimental procedure successfully tested in obese laboratory rats may provide a less-invasive alternative to bariatric weight-loss surgery, researchers report online in Endocrinology.

Scientists at Cincinnati Children's Hospital Medical Center used a catheter to re-direct the flow of bile from the bile duct into the small intestine, producing the same metabolic and weight-loss benefits as bariatric surgeries such as gastric by-pass. They named the procedure bile diversion, or BD.

"This may lead to novel ways to treat obesity related conditions," said lead investigator, Rohit Kohli, MBBS, MS, a physician and researcher in the Division of Gastroenterology at Cincinnati Children's. "Our results provide compelling evidence that manipulation of bile acids is sufficient to recreate the key effects of bariatric procedures, including gastric bypass, and may be especially beneficial to people with obesity related liver dysfunction."

Bariatric surgery has become an important therapeutic option for morbid obesity and nonalcoholic fatty liver disease. Gastric bypass surgery is associated with sustained weight loss and reduced overall mortality in patients. Still, the invasive procedure which involves altering the gastrointestinal anatomy of patients also comes with medical risks.

Physicians also do not fully understand the biological mechanisms that produce the post-surgical benefits of procedures like gastric bypass. It is theorized that elevated levels of bile acids detected in the blood of patients trigger molecular processes that may help improve metabolism and energy expenditure.

In the current study, Kohli and his collaborators which included researchers at the University of Cincinnati College of Medicine worked from the hypothesis that diverting bile acid in obese rats would recreate the benefits of bariatric surgery.

Male rats with diet-induced obesity received either the bile diversion procedure or a sham surgery in which the bile duct was dissected. A third group of animals did not undergo surgery and were also used as an experimental control group. Researchers then compared the metabolic effects of bile diversion, sham surgery and no surgery for five weeks as rats in all three groups were fed high-fat diets.

Rats undergoing bile diversion had elevated levels of bile acids in their blood and exhibited increased weight loss, reduced fat mass, improved glucose tolerance and reduced liver fat. These characteristics were not observed in the sham or "no surgery" groups.

Kohli said the researchers will use their findings to further explore how bile diversion and increased bile acids in the blood drive molecular signaling pathways leading to metabolic improvement and weight loss. While emphasizing that extensive additional research is still required, Kohli added an eventual goal is to develop therapeutic agents that can produce the same benefits as bariatric surgery without patients having to go through surgical procedures that alter intestinal anatomy.


'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted to ... of 2015 The gross margin was 49% (27) ... operating margin was 40% (-13) Earnings per share rose ... was SEK 249.9 M (21.2) , Outlook   ... The operating margin for 2016 is estimated to exceed ...
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers use ... 6000i models are higher end machines that use the more unconventional z-dimension of 20mm. ... from the bottom of the cuvette holder. , FireflySci has developed several Agilent ...
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... and Mold) microbial test has received AOAC Research Institute approval 061601. , “This ... introduced last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. ...
(Date:6/23/2016)... ... 2016 , ... Supplyframe, the Industry Network for electronics hardware ... . Located in Pasadena, Calif., the Design Lab’s mission is to bring together ... built and brought to market. , The Design Lab is Supplyframe’s physical representation ...
Breaking Biology Technology: