Navigation Links
Study finds possible alternative to bariatric weight loss surgery
Date:4/30/2013

CINCINNATI An experimental procedure successfully tested in obese laboratory rats may provide a less-invasive alternative to bariatric weight-loss surgery, researchers report online in Endocrinology.

Scientists at Cincinnati Children's Hospital Medical Center used a catheter to re-direct the flow of bile from the bile duct into the small intestine, producing the same metabolic and weight-loss benefits as bariatric surgeries such as gastric by-pass. They named the procedure bile diversion, or BD.

"This may lead to novel ways to treat obesity related conditions," said lead investigator, Rohit Kohli, MBBS, MS, a physician and researcher in the Division of Gastroenterology at Cincinnati Children's. "Our results provide compelling evidence that manipulation of bile acids is sufficient to recreate the key effects of bariatric procedures, including gastric bypass, and may be especially beneficial to people with obesity related liver dysfunction."

Bariatric surgery has become an important therapeutic option for morbid obesity and nonalcoholic fatty liver disease. Gastric bypass surgery is associated with sustained weight loss and reduced overall mortality in patients. Still, the invasive procedure which involves altering the gastrointestinal anatomy of patients also comes with medical risks.

Physicians also do not fully understand the biological mechanisms that produce the post-surgical benefits of procedures like gastric bypass. It is theorized that elevated levels of bile acids detected in the blood of patients trigger molecular processes that may help improve metabolism and energy expenditure.

In the current study, Kohli and his collaborators which included researchers at the University of Cincinnati College of Medicine worked from the hypothesis that diverting bile acid in obese rats would recreate the benefits of bariatric surgery.

Male rats with diet-induced obesity received either the bile d
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... years after the Hesperides vessel returned to Spain culminating ... have an increasingly clear picture of how the global ... the input of pollutants from the atmosphere is not ... most remote areas of the planet, and it is ... are presented this week in CSIC Residence for Researchers ...
(Date:9/16/2014)... . CRG researchers ... Journal of Cell Biology describes how Topo 2 ... , At this very moment thousands of our body,s cells ... the body repairs damaged tissues and regenerates others like skin ... "mitosis", during which the cell duplicates its genetic material and ...
(Date:9/16/2014)... Sept. 16, 2014  Cross Match Technologies, a ... announced today the launch of its Verifier ® ... identity of an individual using their secure credentials ... rapidly reads credential documents with embedded biometric data ... the biometric to a live scan of their ...
Breaking Biology News(10 mins):The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 2The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 3Unraveling cell division 2Unraveling cell division 3Cross Match Launches New Identity Management Handheld Solution 2
... ROCKVILLE, Md. -- Several members of the American Society ... or foreign associates of the U.S. National Academy of ... in original research. Three current ASPB members were ... Birchler , Curators Professor of Biological Sciences, University of ...
... Callaghan, a researcher at the Royal Swedish Academy of Sciences, ... and permafrost. "The changes we see are dramatic. ... deviate from the norm when compared with a longer term ... parts of the globe that is warming up fastest today. ...
... and Shinya Yamanaka, MD, PhD, have been elected as members ... in original scientific research. It is one of the highest ... States. They join 70 other scientists who will ... now has 40 current faculty members in the distinguished group. ...
Cached Biology News:A new research report shows effects of climate change in the Arctic are more extensive than expected 2A new research report shows effects of climate change in the Arctic are more extensive than expected 3UCSF scientists honored by National Academy of Sciences 2
(Date:9/15/2014)... Bioptigen announced today the availability of ... optical device metrology and pre-clinical ophthalmic research markets. ... Contact Lens Metrology is designed for non-destructive, non-contact, full ... IOL structures, and donor tissues. The metrology ... in a hydration bath (saline), automated segmentation of anterior ...
(Date:9/15/2014)... AUSTIN, Texas , Sept. 15, 2014 The ... changes in climate, says a new article published by the ... Ahmed , PhD, on climate change and its effects on ... part of an extensive study conducted by Dr. Ahmed in ... China and has implications for the future ...
(Date:9/15/2014)... Maryland , 15 de septiembre de 2014 ... se llevará a cabo del 12 al 18 de octubre. ... (PPTA) y de sus compañías miembro s, la ... la concienciación mundial en torno a la colección de fuentes ... donantes de plasma al salvar y mejorar las vidas ...
(Date:9/14/2014)... variety of ways, including by modifying the protein structure. ... form and perform no or even the "wrong" function: ... diseases such as Alzheimer,s, Parkinson,s or cystic fibrosis. Some ... other molecules of the same type and congregate into ... damage cells and tissues and make people ill. , ...
Breaking Biology Technology:Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology 2Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4La International Plasma Awareness Week será una celebración para los donantes 2La International Plasma Awareness Week será una celebración para los donantes 3Measuring modified protein structures 2Measuring modified protein structures 3
... material that could become essential to efficient, environmentally ... advantage of graphene,s outstanding strength, light weight and ... wells. The Rice University lab of chemist ... Texas-based supplier of drilling fluids and subsidiary of ...
...  Kensey Nash Corporation (Nasdaq: KNSY ) today ... (Nasdaq: SPNC ) that they reached a ... product lines purchased from Kensey Nash in May 2008. ... payable to Kensey Nash.  As previously disclosed, the Company ...
... Sangui enters commercialization phase / Initial order of ... Tamaulipas has issued an initial order of Hemo2Spray, the Sangui ... product Scabremove both registered by the Mexican authorities in September ... the wound spray and Sangui management is positive that an ...
Cached Biology Technology:Functionalized graphene oxide plays part in next-generation oil-well drilling fluids 2Functionalized graphene oxide plays part in next-generation oil-well drilling fluids 3Mexican State of Tamaulipas Starts Training Doctors in Sangui Wound Management 2