Navigation Links
Study finds possible alternative to bariatric weight loss surgery
Date:4/30/2013

CINCINNATI An experimental procedure successfully tested in obese laboratory rats may provide a less-invasive alternative to bariatric weight-loss surgery, researchers report online in Endocrinology.

Scientists at Cincinnati Children's Hospital Medical Center used a catheter to re-direct the flow of bile from the bile duct into the small intestine, producing the same metabolic and weight-loss benefits as bariatric surgeries such as gastric by-pass. They named the procedure bile diversion, or BD.

"This may lead to novel ways to treat obesity related conditions," said lead investigator, Rohit Kohli, MBBS, MS, a physician and researcher in the Division of Gastroenterology at Cincinnati Children's. "Our results provide compelling evidence that manipulation of bile acids is sufficient to recreate the key effects of bariatric procedures, including gastric bypass, and may be especially beneficial to people with obesity related liver dysfunction."

Bariatric surgery has become an important therapeutic option for morbid obesity and nonalcoholic fatty liver disease. Gastric bypass surgery is associated with sustained weight loss and reduced overall mortality in patients. Still, the invasive procedure which involves altering the gastrointestinal anatomy of patients also comes with medical risks.

Physicians also do not fully understand the biological mechanisms that produce the post-surgical benefits of procedures like gastric bypass. It is theorized that elevated levels of bile acids detected in the blood of patients trigger molecular processes that may help improve metabolism and energy expenditure.

In the current study, Kohli and his collaborators which included researchers at the University of Cincinnati College of Medicine worked from the hypothesis that diverting bile acid in obese rats would recreate the benefits of bariatric surgery.

Male rats with diet-induced obesity received either the bile d
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/24/2015)... , August 24, 2015 The consulting ... ,s largest biometrics manufacturer DERMALOG and its customized solutions and ... African Biometrics Company of the Year Award". DERMALOG is particularly ... .   -Cross reference: Picture is available ... - On Thursday evening, in South ...
(Date:8/20/2015)... CLARA, Calif. , Aug. 20, 2015 /PRNewswire/ ... company focused on improving the user experience and ... and vision technologies, today announced that its ... voice biometric authentication software to be FIDO ... tested TrulySecure for compliance with the FIDO UAF ...
(Date:8/18/2015)... N.J. , Aug. 18, 2015 /PRNewswire/ ... a key contributor to the Submission Content ... by IRISS, a non-profit forum. Dedicated to the ... provides a neutral platform for industry, vendors, ... share information and work towards a standard ...
Breaking Biology News(10 mins):Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3
... The brilliance of butterfly wings has inspired a ... in the fields of security, energy and the environment. ... have just signed a collaborative contract to develop new ... Over the next three years a team of physicists ...
... A chemical culprit responsible for the rapid, mysterious death ... found by collaborating scientists at Rutgers University and the ... may hold unexpected promise in cancer research. The ... in a virus that has been attacking and killing ...
... WEST LAFAYETTE, Ind. - Researchers at Purdue University have ... in spinal cord injuries using nano-spheres that could be ... The synthetic "copolymer micelles" are drug-delivery spheres about 60 ... the diameter of a red blood cell. Researchers ...
Cached Biology News:£3.2m ($5.4 million) research project to capture brilliance of butterfly wings 2Newly discovered fat molecule: An undersea killer with an upside 2Newly discovered fat molecule: An undersea killer with an upside 3Newly discovered fat molecule: An undersea killer with an upside 4Findings show nanomedicine promising for treating spinal cord injuries 2Findings show nanomedicine promising for treating spinal cord injuries 3
(Date:9/1/2015)... , September 2, 2015 ... auf die Forschung und Entwicklung neuartiger Therapien ... chronisch-entzündliche Darmerkrankungen und Reizdarm konzentriert, erhält vom ... dass sein neues Medikament patentiert wird. Das ... Allergien bei Kindern verhindert und Entzündungen vorbeugt.   ...
(Date:9/1/2015)... ... September 02, 2015 , ... Spirax Sarco , the ... its eCommerce site Spirax Sarco Anytime. This platform, offering unique online ordering capabilities, ... your next order? Log on to Spirax Sarco Anytime and within minutes you ...
(Date:9/1/2015)... , Sept. 1, 2015 The American Brain ... (LOI) for its Discovery Research Grant program. LOIs are ... 12:00 noon CDT. Discovery Grants are one-year, ... the potential to change current diagnostic or treatment paradigms ... specifically encourage novel research at its earliest stages, in ...
(Date:9/1/2015)... 1, 2015  ContraVir Pharmaceuticals, Inc. (NASDAQ: CTRV ... commercialization of targeted antiviral therapies, announced today that it ... Annual Global Investment Conference sponsored by H.C. ... at The St. Regis Hotel in New ... Sapirstein , Chief Executive Officer, will provide an overview ...
Breaking Biology Technology:Das Patent von Swecure zur Verhinderung von Allergien bei Kindern wird in den USA zugelassen 2Spirax Sarco Announces New Features to Anytime Platform 2American Brain Tumor Association Seeks Innovative Concepts For Discovery Research Grants 2ContraVir to Present at Rodman & Renshaw 17th Annual Global Investment Conference 2
... BMP,Sunstone Corporation (Nasdaq: BJGP ) ("BMP Sunstone" ... President of BMP Sunstone,Corporation and a member of ... and Chief Operating Officer of BMP Sunstone Corporation,effective ... of BMP Sunstone since April 2008 and,played an ...
... - Company to Request a Hearing -, MONTVALE, ... ) today announced that on June 6, 2008 it ... the,Company that, because it has not regained compliance with ... 4450(a)(5), its securities,are subject to delisting from The NASDAQ ...
... Requires New Clinical Practices ... and Public Health Costs, SAN FRANCISCO and ... Task Force on Epidemiology and Prevention warned,today that ... sleep apnea (OSA) are closely related, and that ...
Cached Biology Technology:BMP Sunstone Corporation Appoints Zhiqiang Han to President and Chief Operating Officer 2BMP Sunstone Corporation Appoints Zhiqiang Han to President and Chief Operating Officer 3Memory Pharmaceuticals Receives Anticipated NASDAQ Staff Determination Letter 2Memory Pharmaceuticals Receives Anticipated NASDAQ Staff Determination Letter 3IDF Urges Healthcare Providers to Address the Relationship Between Type 2 Diabetes and Sleep Apnea 2IDF Urges Healthcare Providers to Address the Relationship Between Type 2 Diabetes and Sleep Apnea 3IDF Urges Healthcare Providers to Address the Relationship Between Type 2 Diabetes and Sleep Apnea 4
Alexa Fluor 647 anti-mouse Qa-2...
... essential for hunting and analyzing the ... as EST sequencing projects, microarrays, functional ... is developed for normalization of cDNA ... for directional cloning. While most normalization ...
... acquision and analysis software for ... applications. Contains powerful stimulus generation ... functions including automated waveform feature ... includes many electrophysiology specific functions ...
normal human fibroblasts Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Biology Products: