Navigation Links
Study finds new vulnerability in malaria parasite
Date:11/27/2013

imidazopyrazines by evolving parasite cell lines that were resistant against the drugs and then analyzing the parasites' genomes for the changes responsible for conferring resistance. Those genetic changes pointed to the gene that encodes PI4K.

The CUMC team, led by David Fidock, PhD, professor of microbiology & immunology and medical sciences (in medicine), used novel genetic tools to confirm that PI4K was being directly targeted by the imidazopyrazines.

Then, using cellular imaging, the CUMC team found that imidazopyrazines interfere with the function of PI4K on the parasite Golgi (the organelle that packages proteins for delivery to other cellular destinations). "We think that disrupting the function of PI4K at the Golgi stops the parasite from making new membranes around its daughter cells, thereby preventing the organism from reproducing," said Dr. Lee.

Because PI4K is also found in humans, Dr. Winzeler said, the next challenge is to develop a drug that retains selectivity between the parasite and human versions of the enzyme. "As we now know the identity of this protein and hope to soon solve its structure, this task should be much easier," she said.


'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Study finds the forgotten ape threatened by human activity and forest loss
2. Large study shows pollution impact on coral reefs -- and offers solution
3. CSI-type study identifies snakehead
4. Study examines potential evolutionary role of sexual regret in human survival and reproduction
5. Gene-silencing study finds new targets for Parkinsons disease
6. New genomic study provides a glimpse of how whales could adapt to ocean
7. Study finds gene network associated with alcohol dependence
8. A study on cell migration provides insights into the movement of cancer cells
9. UT Dallas study: Initial success for new tinnitus treatment
10. Connections in the brains of young children strengthen during sleep, CU-Boulder study finds
11. Women prescribed combination HRT should use caution when taking apigenin supplement, MU study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study finds new vulnerability in malaria parasite
(Date:2/13/2015)... , Feb. 13, 2015 ACT Genomics ... that aims to transform cancer genomic information into ... the company has raised US$ 8 million in the ... in Taipei, Taiwan , ACT ... ACTOnco™. With the aim to implement next generation ...
(Date:2/11/2015)... 2015 According to ... Market by Product (Cards and Readers, Biometrics, Controllers, Management ... Industrial, Healthcare, Education) and By Geography - Global Forecast and Analysis ... Access Control Market is expected to reach ... CAGR of 10.6% between 2014 and 2020. ...
(Date:2/5/2015)... PARK, North Carolina , 5. Februar ... 35. Jahr als spezialisiertes Logistikunternehmen und hat ... als einzige klinische Logistikfirma (Clinical Logistics Organization ... Kernbotschaft der neuen Kampagne lautet First ... Lieferungen. Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
Breaking Biology News(10 mins):ACT Genomics Raises $8 Million in its First Private Funding Round 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3
... AURORA, Colo. (Dec. 9, 2013) A new study shows ... concussions than those closer to sea-level, a phenomenon attributed to ... tightly in the skull. "This is the first time ... Comstock, PhD, associate professor of epidemiology at the Colorado School ...
... Liver (EASL) today publishes their revised Clinical Practice Guidelines ... (HCV) (1). The EASL guidelines, which supersede the ... physicians and other healthcare providers optimise their management of ... estimated that approximately 160 million individuals, i.e. 2.35% of ...
... of tumours in over one per cent of all cancer ... has been broadly linked to cancer development. The team ... activated that increases tumour growth. Drugs that inhibit the biological ... in development thus highlighting a potential new targeted therapy for ...
Cached Biology News:Study shows first link between altitude and concussion 2EASL publishes revised clinical practice guidelines to optimise the management of hepatitis C virus 2EASL publishes revised clinical practice guidelines to optimise the management of hepatitis C virus 3Gene promotes 1 in 100 of tumors 2
(Date:2/27/2015)... (PRWEB) February 27, 2015 FamilyFarms Group ... General Manager of State Line Farms, received the 2015 ... a producer, under the age of 35, who has ... is an honor to win the Tomorrow's Top Producer ... who won the Top Producer Award and learning from ...
(Date:2/27/2015)... , Feb. 27, 2015  Steep Hill, the industry ... and internationally, intends to open a full service medical ... Mexico , bringing advanced scientific tools and methodology ... Steep Hill is currently the only laboratory licensed ... potency and contaminant testing in order to meet the ...
(Date:2/26/2015)... Feb. 26, 2015 S&P Capital IQ (MHFI) ... Report coverage on MabVax Therapeutics Holdings Inc . ... clinical stage biotechnology company focused on the development of ... in the treatment of cancer. MabVax has discovered a ... protective immune responses generated by patients who have been ...
(Date:2/26/2015)... MOUNTAIN VIEW, Calif. , Feb. 26, 2015 /PRNewswire/ ... appointment of Kate Black as Privacy Officer ... international, federal, and state privacy laws as well as ... and regulatory team, she will be responsible for reviewing, ... for customers in the U.S. and abroad. She joined ...
Breaking Biology Technology:Matt Sims Receives the 2015 Tomorrow’s Top Producer Horizon Award 2Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 2S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 523andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2
... ARLINGTON, Va., July 13 The Generic Pharmaceutical Association ... Kathleen Jaeger on the Senate HELP Committee,s vote on biogenerics legislation. ... disappointed that the Committee action could result in patients having little ... in the House to ensure that a true balance is achieved ...
... 13, 2009) Whitehead Institute scientists have developed a ... target diseases that until now have stymied drug developers, ... yeast to synthesize and screen the molecules, cutting target ... weeks. The current drug discovery process ...
... ERT (Nasdaq: ERES ), a leading provider of ... medical device, and related industries, announced today that it will release ... 2009 after the market closes. After the release, the Company will ... , For the conference call, interested ...
Cached Biology Technology:GPhA Calls Senate HELP Committee Action Disappointing for Countless Patients 2New method may accelerate drug discovery for difficult diseases like Parkinson's 2New method may accelerate drug discovery for difficult diseases like Parkinson's 3New method may accelerate drug discovery for difficult diseases like Parkinson's 4ERT to Announce 2009 Second Quarter Results on July 30, 2009 2
... glycerol stocks contained in standard 96-well microtiter ... with approximately 5,000 clones per plate. After ... well, the corresponding subplate is screened with ... positive well(s). Cells from a positive well ...
... designed for flexibility and routine operation. With ... lens, true hyperbolic quadrupole and high-speed simultaneous ... range of sample types and applications. New ... standard Agilents unique ShieldTorch System, which enables ...
... is a fully automated microplate luminescence ... widest possible range of applications based ... assays luciferase, -galactosidase, gene activities with ... Luminescent Immunoassays Cell-based assays ...
... depleted sera are specifically depleted of a ... the depleted protein, the alternative and classical ... therefore ideal for the detection and quantitation ... have been used to assess complement activation ...
Biology Products: