Navigation Links
Study finds depletion of alveolar macrophages linked to bacterial super-infections
Date:7/22/2013

A recent study published in the July issue of the Journal of Immunology helps explain why some humans contract bacterial super-infections like pneumonia with influenza. The research was led by Le Bonheur Pediatrician-in-Chief Jon McCullers, MD an infectious disease specialist who is also chair of the Department of Pediatrics for the University of Tennessee Health Science Center and adjunct faculty at St. Jude Children's Research Hospital.

"It's been known that the influenza virus does something to suppress host immune function, which can facilitate development of deadly secondary bacterial pneumonias," said McCullers. "But we haven't known what that was or why it happens."

McCullers' research conducted at his National Institutes of Health-funded laboratory at St. Jude Children's Research Hospital by UTHSC graduate student Hazem Ghoneim, a PhD candidate -- used advanced techniques to differentiate types of alveolar macrophages found in the lungs and airways. Researchers found that of the three types identified, only one is truly capable of fending off secondary bacterial infection. This population of macrophages, labeled the resident alveolar macrophages, is depleted during a flu infection.

"We found that influenza is specifically killing these true alveolar macrophages," said McCullers. "The window of time someone is susceptible to secondary infections corresponds with the time it takes for the other two types of alveolar macrophages to differentiate so they are then able to fight off the infection."

McCullers says his study is a step toward developing strategies for treatment.

"This discovery provides a roadmap for developing immunotherapies that can supplement the natural defenses of our body when they are at their weakest. Influenza and pneumonia are the seventh leading cause of death in the U.S., and we desperately need research such as this to improve our armamentarium," said McCullers.


'/>"/>

Contact: Sara Burnett
sara.burnett@lebonheur.org
901-287-6030
Le Bonheur Children's Hospital
Source:Eurekalert

Page: 1

Related biology news :

1. New study finds nighttime heat waves increasing in Pacific Northwest
2. Study finds missing piece of pediatric cancer puzzle
3. Its not just the heat -- its the ozone: Study highlights hidden dangers
4. LSUHSC researcher awarded NCI grant to study link between chronic inflammation and cancer
5. Healthrageous, United BioSource And Boehringer Ingelheim Launch SMART Digital Diabetes Study
6. Study identifies Deepwater Horizon debris as likely source of Gulf of Mexico oil sheens
7. Carnegie Mellon researchers develop artificial cells to study molecular crowding and gene expression
8. U of T-led study cracks universal RNA code, suggests a new cause for autism
9. Study finds surprising benefits about diary cow inflammation
10. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
11. Journal highlights Arctic sea ice study by UM professor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... inhibitor dabrafenib has significant anti-tumour activity in patients ... cancer whose disease has progressed after chemotherapy, according ... 2014 Congress in Madrid, Spain. , "Reports ... generated considerable interest because these mutations may be ... agents," says lead author Dr David Planchard, pulmonary ...
(Date:9/29/2014)... in French . ... of days an expectant mother was deprived of electricity ... of her child, a new study finds., Scientists from ... have detected a distinctive ,signature, in the DNA of ... ice storm. Five months after the event, researchers recruited ...
(Date:9/29/2014)... a previously unknown mechanism by which estrogen prepares ... of estrogen-positive breast cancers, resist cancer drugs. The ... breast cancer therapy and will help doctors predict ... The University of Illinois team reports its findings ... pre-activates the unfolded-protein response (UPR), a pathway that ...
Breaking Biology News(10 mins):Promising results shown with targeted approaches in subsets of non-small cell lung cancer 2Promising results shown with targeted approaches in subsets of non-small cell lung cancer 3Scientists discover a new role for estrogen in the pathology of breast cancer 2
... world over, are hungry for more meat, milk and ... has prompted explosive growth in livestock production and massive ... new textbook, Animal Manure Recycling: Treatment and Management, draws ... to put environmental problems to work and ensure the ...
... Department of Energy is making good on the second phase of ... study led by Dr. Joshua Yuan, Texas A&M AgriLife Research plant ... Yuan, who was granted $1.8 million for Phase I ... potential fuel source., The scientist said his research is moving ahead ...
... a new model for a genetic eye disease, and shows ... monkeys can yield valuable information about the human brain. ... of the Society for Neuroscience and the world,s largest source ... models have long been central in how we understand the ...
Cached Biology News:New textbook tackles the sustainable recycling of manure 2Plant fuel project moves to second phase under US Energy Department grant 2Understanding ourselves by studying the animal kingdom 2
(Date:9/29/2014)... 30, 2014 Each year in ... require medical attention. In the military, burn injury ... to battlefield medical care. More than 800 service ... Burn wounds heal slowly, remain inflamed and often ... physically debilitating and functionally damaging. While developments in ...
(Date:9/29/2014)... Va. , Sept. 29, 2014  Ten ... the fields of cartilage repair, regeneration, allograft reconstruction ... from around the world gathered to discuss the ... Health Institute of Regenerative Medicine symposium, Cartilage ... . Topics included Orthopedic Biosurgery, Minced Juvenile Allograft, ...
(Date:9/29/2014)... global challenges in food security, emerging diseases and ... study published online in Science Express ... University of Arizona College of Agriculture and Life ... team of nine scientists has reviewed progress in ... medicine and environmental management using approaches that consider ...
(Date:9/29/2014)... 2014 According to ... Product (Modifying Enzymes, DNA Polymerase, Acetylase, Methyltransferase, ... Reagents), by Research Area (Developmental Biology, Oncology), ... 2019", published by MarketsandMarkets, provides a detailed ... current market trends, and strategies impacting the ...
Breaking Biology Technology:Faster Healing with Fewer Scars 2World Renowned Experts Discuss Future Of Cartilage Regeneration 2World Renowned Experts Discuss Future Of Cartilage Regeneration 3Evolutionary biology: It's not just for textbooks anymore 2Evolutionary biology: It's not just for textbooks anymore 3Epigenetics Market Worth $783.17 Million by 2019 2Epigenetics Market Worth $783.17 Million by 2019 3Epigenetics Market Worth $783.17 Million by 2019 4
... KYOTO, Japan and MARCY L,ETOILE, France , ... today that they have entered into a partnership to ... microbiology laboratories. bioMerieux will work with Shimadzu and their ... spectrometry technology for optimized integration into the microbiology laboratory ...
... , May 21 Micromet, Inc. (Nasdaq: MITI ... next-generation antibodies for the treatment of cancer, today announced that updates ... at two upcoming medical conferences. , ... Blinatumomab (MT103), the Company,s lead product candidate, will ...
... , BRISBANE, Calif. , May 21 InterMune, Inc. (Nasdaq: ... Medical Officer and Senior Vice President, Clinical Affairs of InterMune, will present at ... May 26 at 3 p.m. EDT . , ... To access a live audio webcast of the presentation, investors ...
Cached Biology Technology:Shimadzu and bioMerieux Enter into Partnership for Mass Spectrometry Applications in Microbiology 2Shimadzu and bioMerieux Enter into Partnership for Mass Spectrometry Applications in Microbiology 3Shimadzu and bioMerieux Enter into Partnership for Mass Spectrometry Applications in Microbiology 4Micromet to Provide Update on BiTE Antibody Development Programs at Upcoming Medical Conferences 2Micromet to Provide Update on BiTE Antibody Development Programs at Upcoming Medical Conferences 3InterMune to Present at 2010 Citi Health Care Conference 2
One-step, microplate or cuvet, colorimetric, linear detection range 0.6 mM to 100 mM. Procedure: 2 min....
One-step, microplate or cuvet, colorimetric, linear detection range 0.9 mg/dL to 200 mg/dL. Procedure: 2 min....
assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and DNA....
One-step, microplate or cuvet, turbidometric, linear detection range 0.096 mg/dL to 11.5 mg/dL. Procedure: 5 min....
Biology Products: