Navigation Links
Study finds depletion of alveolar macrophages linked to bacterial super-infections
Date:7/22/2013

A recent study published in the July issue of the Journal of Immunology helps explain why some humans contract bacterial super-infections like pneumonia with influenza. The research was led by Le Bonheur Pediatrician-in-Chief Jon McCullers, MD an infectious disease specialist who is also chair of the Department of Pediatrics for the University of Tennessee Health Science Center and adjunct faculty at St. Jude Children's Research Hospital.

"It's been known that the influenza virus does something to suppress host immune function, which can facilitate development of deadly secondary bacterial pneumonias," said McCullers. "But we haven't known what that was or why it happens."

McCullers' research conducted at his National Institutes of Health-funded laboratory at St. Jude Children's Research Hospital by UTHSC graduate student Hazem Ghoneim, a PhD candidate -- used advanced techniques to differentiate types of alveolar macrophages found in the lungs and airways. Researchers found that of the three types identified, only one is truly capable of fending off secondary bacterial infection. This population of macrophages, labeled the resident alveolar macrophages, is depleted during a flu infection.

"We found that influenza is specifically killing these true alveolar macrophages," said McCullers. "The window of time someone is susceptible to secondary infections corresponds with the time it takes for the other two types of alveolar macrophages to differentiate so they are then able to fight off the infection."

McCullers says his study is a step toward developing strategies for treatment.

"This discovery provides a roadmap for developing immunotherapies that can supplement the natural defenses of our body when they are at their weakest. Influenza and pneumonia are the seventh leading cause of death in the U.S., and we desperately need research such as this to improve our armamentarium," said McCullers.


'/>"/>

Contact: Sara Burnett
sara.burnett@lebonheur.org
901-287-6030
Le Bonheur Children's Hospital
Source:Eurekalert

Page: 1

Related biology news :

1. New study finds nighttime heat waves increasing in Pacific Northwest
2. Study finds missing piece of pediatric cancer puzzle
3. Its not just the heat -- its the ozone: Study highlights hidden dangers
4. LSUHSC researcher awarded NCI grant to study link between chronic inflammation and cancer
5. Healthrageous, United BioSource And Boehringer Ingelheim Launch SMART Digital Diabetes Study
6. Study identifies Deepwater Horizon debris as likely source of Gulf of Mexico oil sheens
7. Carnegie Mellon researchers develop artificial cells to study molecular crowding and gene expression
8. U of T-led study cracks universal RNA code, suggests a new cause for autism
9. Study finds surprising benefits about diary cow inflammation
10. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
11. Journal highlights Arctic sea ice study by UM professor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... be cheerful, happy-go-lucky characters, so you might expect that ... , In fact some dogs are distinctly more pessimistic ... , "This research is exciting because it measures ... non-invasively. It offers researchers and dog owners an insight ... said Dr Melissa Starling, from the Faculty of Veterinary ...
(Date:9/18/2014)... are too stressed they are often grouchy, grumpy, nasty, ... (BMI) at EPFL have just highlighted a fundamental synaptic ... the loss of social skills and cognitive impairment. When ... molecule in the brain. This was revealed by a ... Carmen Sandi,s team went to look for answers in ...
(Date:9/17/2014)... and affordable health care to reproductive technologies, the ... the ability of people to identify key issues, ... respectfully, and find the most defensible ways forward. ... support these societal conversations?, The Hastings Center and ... Issues have teamed up to publish a series ...
Breaking Biology News(10 mins):Dogs can be pessimists too 2Dogs can be pessimists too 3How stress tears us apart 2Why bioethics literacy matters 2Why bioethics literacy matters 3
... America (ESA) is proud to announce the winners ... travel grants, which will help entomology students attend ... this November are funded by USDA-NIFA,s Agriculture ... and Nematodes. The grants were created to provide ...
... predicted that tree species will respond to global warming ... a new study of 65 different species in 31 ... Nearly 80 percent of the species aren,t yet ... staying in place -- but speeding up their life ...
... Children,s Hospital Medical Center has developed an antibody that ... hospitalized patients who receive central lines. Margaret Hostetter, ... her team developed the antibody, which prevents Candida ... formation of biofilm in a rat model of catheter-associated ...
Cached Biology News:Entomological Society of America names winners of 2013 student travel grants 2Entomological Society of America names winners of 2013 student travel grants 3Entomological Society of America names winners of 2013 student travel grants 4Entomological Society of America names winners of 2013 student travel grants 5Entomological Society of America names winners of 2013 student travel grants 6Entomological Society of America names winners of 2013 student travel grants 7Entomological Society of America names winners of 2013 student travel grants 8Climate change may speed up forests' life cycles 2
(Date:9/19/2014)...  InterMune, Inc. (Nasdaq: ITMN ) today ... to settle the litigation in the Delaware Court of ... dated as of August 22, 2014, among Roche Holdings, ... term of the Memorandum of Understanding, the Company agreed ... attached exhibit reflecting the amendment to the Company,s Schedule ...
(Date:9/19/2014)... 2014  An entire month is dedicated to one ... Charcot-Marie-Tooth disease (CMT) – a debilitating neuromuscular disease affecting ... atrophy, weakness, and foot and hand deformities. CMT affects ... CMT is a progressive disease, and over time patients ... devices such as leg braces, wheelchairs and scooters to ...
(Date:9/19/2014)... Barnhardt Manufacturing Company has earned the ... Cotton . The USDA Certified Biobased Product Label verifies ... or exceeds levels set by USDA. Biobased products are ... significant part of agricultural, forestry, or marine ingredients. ... be immediately identified as a USDA certified BioPreferred ...
(Date:9/18/2014)... Bipartisan passage this week by the ... stimulate development and commercialization of new technologies and promote ... of SPIE, the international society for optics and ... Innovation (RAMI) Act, now moves to the full Senate ... are optimistic that it will win passage there as ...
Breaking Biology Technology:InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 2InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 4InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 5InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 6InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 7InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 8InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 9InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 10InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 11InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 12InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 13InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 14InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 15InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 16InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 17InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 18InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 19September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3
...  inVentiv Health, Inc., offering best-in-class clinical, commercial and ... it has completed the acquisition of Kforce Clinical ... solutions to pharmaceutical, biotech and medical device companies, ... The transaction closed on March 30, 2012.  ...
... 3, 2012 Health Diagnostic Laboratory, Inc. (HDL, Inc.), ... of Scott Blackwell. Recently named Vice President of Corporate ... values of an advanced laboratory that is growing on ... http://photos.prnewswire.com/prnh/20120403/PH81634 )  "Scott comes to our ...
... N.J., April 3, 2012 Hamamatsu Corporation announces ... distributed through third-party dealers, will now be available ... the company is responsible for the sales, marketing, ... product line for new customers throughout North America. ...
Cached Biology Technology:inVentiv Health Completes Acquisition of Kforce Clinical Research 2inVentiv Health Completes Acquisition of Kforce Clinical Research 3inVentiv Health Completes Acquisition of Kforce Clinical Research 4Health Diagnostic Laboratory Names Scott Blackwell Vice President of Corporate Culture 2Hamamatsu Corporation Announces Exclusive Distribution of Its NanoZoomer Whole-Slide Scanners 2
... binding specificity and signaling of the members ... be modified by alternative splicing--which has important ... you can perform a classical expression profiling ... different alternatively spliced forms of the gene ...
Mouse monoclonal antibody raised against a partial recombinant ST3GAL2. NCBI Entrez Gene ID = ST3GAL2...
... Extraction Kit is manufactured for DNA purification ... byexposure to UV light. The Purification of ... used for DNA-cloning work. The conventional method ... exposure of UV light damages DNA and ...
CleanBox DNA workstation with two 254nm UV lambs & 12-hr timer, 90cm (36-inch)width, single door, 115V (w/crating)...
Biology Products: