Navigation Links
Study finds depletion of alveolar macrophages linked to bacterial super-infections
Date:7/22/2013

A recent study published in the July issue of the Journal of Immunology helps explain why some humans contract bacterial super-infections like pneumonia with influenza. The research was led by Le Bonheur Pediatrician-in-Chief Jon McCullers, MD an infectious disease specialist who is also chair of the Department of Pediatrics for the University of Tennessee Health Science Center and adjunct faculty at St. Jude Children's Research Hospital.

"It's been known that the influenza virus does something to suppress host immune function, which can facilitate development of deadly secondary bacterial pneumonias," said McCullers. "But we haven't known what that was or why it happens."

McCullers' research conducted at his National Institutes of Health-funded laboratory at St. Jude Children's Research Hospital by UTHSC graduate student Hazem Ghoneim, a PhD candidate -- used advanced techniques to differentiate types of alveolar macrophages found in the lungs and airways. Researchers found that of the three types identified, only one is truly capable of fending off secondary bacterial infection. This population of macrophages, labeled the resident alveolar macrophages, is depleted during a flu infection.

"We found that influenza is specifically killing these true alveolar macrophages," said McCullers. "The window of time someone is susceptible to secondary infections corresponds with the time it takes for the other two types of alveolar macrophages to differentiate so they are then able to fight off the infection."

McCullers says his study is a step toward developing strategies for treatment.

"This discovery provides a roadmap for developing immunotherapies that can supplement the natural defenses of our body when they are at their weakest. Influenza and pneumonia are the seventh leading cause of death in the U.S., and we desperately need research such as this to improve our armamentarium," said McCullers.


'/>"/>

Contact: Sara Burnett
sara.burnett@lebonheur.org
901-287-6030
Le Bonheur Children's Hospital
Source:Eurekalert

Page: 1

Related biology news :

1. New study finds nighttime heat waves increasing in Pacific Northwest
2. Study finds missing piece of pediatric cancer puzzle
3. Its not just the heat -- its the ozone: Study highlights hidden dangers
4. LSUHSC researcher awarded NCI grant to study link between chronic inflammation and cancer
5. Healthrageous, United BioSource And Boehringer Ingelheim Launch SMART Digital Diabetes Study
6. Study identifies Deepwater Horizon debris as likely source of Gulf of Mexico oil sheens
7. Carnegie Mellon researchers develop artificial cells to study molecular crowding and gene expression
8. U of T-led study cracks universal RNA code, suggests a new cause for autism
9. Study finds surprising benefits about diary cow inflammation
10. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
11. Journal highlights Arctic sea ice study by UM professor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2015)... GOTHENBURG, Sweden , May 18, 2015 ... touch fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from ... place from June until and including Q3 2015 and the ... Asia . Communicated order values for 2015 hereby amount ... revenues for Q1 2015 of 140 MSEK and a number ...
(Date:5/11/2015)... , May 11, 2015 Curemark LLC, ... the start of a new Phase III double blind, ... its novel formulation, CM-AT, on all children ages 3-8 ... its FDA Phase III double blinded clinical trial for ... low levels of the digestive enzyme chymotrypsin. This new ...
(Date:5/5/2015)... 5, 2015, NXT-ID, Inc. (NASDAQ: NXTD ) ... the growing mobile commerce market, reminds investors and media that ... is presenting  at CARTES SECURE CONNEXIONS AMERICA 2015, held in ... The three-day conference is organized into a series ... is themed Global Fraud: Where is the Trust in ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3
... a good thing better? A gene known as LIS1 is ... developing brain. When an LIS1 gene is missing, brains fail ... brain, are born severely mentally retarded. But new research by ... recently appeared in Nature Genetics, shows that having ...
... newly described fossil whales--a pregnant female and a male ... and provide new insights into how whales made the ... fossils, discovered in Pakistan in 2000 and 2004, are ... the online journal PLoS. "This stunning ...
... Albert Einstein College of Medicine of Yeshiva University have discovered ... causes disease. The study, published in the ... ( PNAS ), may help scientists develop new therapies or ... fungal infections occur most commonly in those with compromised immune ...
Cached Biology News:Weizmann Institute scientists show extra copies of a gene carry extra risk 2Early whales gave birth on land 2Scientists discover how deadly fungus protects itself 2
(Date:5/21/2015)... Veolia’s environmental monitoring technology division, ... distribution agreement with VWR to distribute TECTA™ B16, ... than 160 years of experience, VWR, a leading ... and production facilities, has cultivated a value proposition ... to enable science. Endetec’s TECTA™ B16, combines ...
(Date:5/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/x4b7kw/top_technologies ) ... in HW_Technical Insights" report to their offering. ... trends in the Health and Wellness sector and has ... an impact in the year 2015. The research service ... health and wellness technologies that are anticipated to have ...
(Date:5/20/2015)... Pa. , May 20, 2015  Select ... that the Federal Trade Commission granted early termination ... Antitrust Improvements Act of 1976, as amended, applicable ... MJ Acquisition Corporation, a joint venture that Select ... L.P. As previously announced, MJ Acquisition ...
(Date:5/20/2015)... 20, 2015 Agricultural firm H.J. Baker ... its acquisition of Tiger-Sul. Since the purchase of ... Canada) in May 2005, H.J. Baker has leveraged the ... into a comprehensive portfolio of product offerings and solutions ... Baker and the innovation of Tiger-Sul, transforming the company ...
Breaking Biology Technology:Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Top Technologies in the Health and Wellness Industry 2015 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3
... WILL FOCUS ON COLLECTION, PROCESSING AND STORAGE OF EQUINE ... BONE MARROW AND PLACENTAL TISSUE STEM CELLS, RANCHO ... ), a leading supplier of innovative products and,services that ... its,wholly-owned subsidiary, Vantus, Inc., has signed a formal agreement ...
... Feb. 27 Ocera Therapeutics, a,biopharmaceutical company focused ... to treat a broad range of,gastrointestinal and liver ... joined the company as Chief Medical Officer. Prior ... Chief Medical Officer and Vice,President of Clinical Affairs ...
... Ltd, a specialty,biopharmaceutical company focused on controlling immune ... phase II clinical study with its,anti-allergy technology, ToleroMune. ... cat-dander allergy, and aims to complete the trial ... on the results of a previous double-blind,placebo-controlled phase ...
Cached Biology Technology:ThermoGenesis Subsidiary Vantus Announces Stem Cell Agreement With UC Davis Center For Equine Health 2ThermoGenesis Subsidiary Vantus Announces Stem Cell Agreement With UC Davis Center For Equine Health 3ThermoGenesis Subsidiary Vantus Announces Stem Cell Agreement With UC Davis Center For Equine Health 4ThermoGenesis Subsidiary Vantus Announces Stem Cell Agreement With UC Davis Center For Equine Health 5M. Scott Harris, M.D., Joins Ocera Therapeutics, Inc., as Chief Medical Officer 2Circassia Initiates Phase II Clinical Study With Novel Anti-Allergy Technology 2
... the degradation of single-stranded DNA and RNA ... the nuclease prefers ssDNA over dsDNA by ... degrades double-stranded DNA from both ends (1,2). ... transcript mapping studies (3,4), for flushing staggered ...
Trop-2 Purified Anti-Human clone 162-46, Isotype Mouse IgG 1 , 100 µg Consult technical datasheet for details....
... Enhancer System is used in ... optimize PCR of problematic and/or ... Enhancer Solution with 10X PCRX ... specificity broader magnesium concentration broader ...
... Immunogen: Synthetic peptide derived from the ... Specificity: Specific for the junctophilin-2 ... mouse skeletal muscle homogenates frozen mouse ... blotting Immunohistochemistry(froz) ImmunofluorescenceStorage: Store at -20C ...
Biology Products: