Navigation Links
Study examines effects of genetic variants for infants with neonatal abstinence syndrome
Date:4/30/2013

Among infants with neonatal abstinence syndrome (NAS; caused by in utero opioid exposure), variants in certain genes were associated with a shorter length of hospital stay and less need for treatment, preliminary findings that may provide insight into the mechanisms underlying NAS, according to a study in the May 1 issue of JAMA, a theme issue on child health.

Jonathan M. Davis, M.D., of The Floating Hospital for Children at Tufts Medical Center, Boston, presented the findings of the study at a JAMA media briefing.

"In the past decade, there has been a significant increase in opioid use during pregnancy, estimated to affect 5.6 per 1,000 births," according to background information in the article. Neonatal abstinence syndrome is a disorder composed of a constellation of signs and symptoms involving dysfunction of the nervous system, gastrointestinal tract, and respiratory system because of in utero drug exposure or iatrogenic (due to therapy) withdrawal after maternal use of drugs for pain control during pregnancy. "The incidence of NAS has tripled in the past decade, affecting 60 percent to 80 percent of infants born to mothers receiving methadone or buprenorphine. Although clinical factors, including maternal smoking, psychiatric medications, and breastfeeding, can affect the incidence and severity of NAS, to our knowledge contributing genetic factors influencing NAS have not been previously identified."

Variations in the genes OPRM1, ABCB1, and COMT are associated with risk for opioid addiction in adults. Dr. Davis and colleagues conducted a study to determine whether genomic variations in these genes are associated with length of hospital stay (LOS) and the need for treatment of NAS. The study was conducted at 5 tertiary care centers and community hospitals in Massachusetts and Maine between July 2011 and July 2012. DNA samples were genotyped for single-nucleotide polymorphisms (SNPs), and NAS outcomes were correlat
'/>"/>

Contact: Julie Jette
jjette@tuftsmedicalcenter.org
617-636-3265
The JAMA Network Journals
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Houston engineering professor awarded grant to study melanoma treatment
2. Monoclonal Antibody with Xencors High ADCC Fc Technology Enters Phase 2 Study in B-cell Acute Lymphoblastic Leukemia
3. BUSM study reveals novel mechanism by which UVA contributes to photoaging of skin
4. Study led by NUS scientists reveals escalating cost of forest conservation
5. Rescue me: New study finds animals do recover from neglect
6. Genome study suggests new strategies for understanding and treating pulmonary fibrosis
7. Hop, skip or jump? Study says no to all of the above
8. Federal Government Organization achieves cleaner and faster Clinical Study Data using Tablet PCs from TabletKiosk
9. Half of Tamiflu prescriptions went unused during 2009 H1N1 swine flu pandemic, UK sewage study
10. CU-Boulder study looks at microbial differences between parents, kids and dogs
11. TGen-led study discovers dramatic changes in bacteria following male circumcision
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/st5b3m/saudi_arabia ) has ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Arabia Biomedical Sensors market is estimated at $0.23 billion ... period 2014-2020 The near future will bring ... of each individual. These sensors can be set to ...
(Date:8/25/2015)... LAKE CITY and BELLEVUE, Wash. ... global leader in advanced robotic systems, announced today it ... robotic unmanned ground vehicle (UGV), at the National Tactical ... City.  The Guardian S is the ... the culmination of years of research and in-field trials ...
(Date:8/20/2015)... Calif. , Aug. 20, 2015 ... on consumers that are active and healthy. However, ... in the hospital environment to help improve diagnostic ... a video from the Wearable Technologies Conference ... discussed new applications for wearables in healthcare.    ...
Breaking Biology News(10 mins):Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3
... A team of scientists from The Scripps Research ... the deadliest antibiotic-resistant bacteria. The compound could one day ... highly resistant bacterial infections. The results were published ... of the American Chemical Society . "[These results] ...
... AURORA, Colo. (Aug. 24, 2011) A scientist investigating why ... coordination has found that key eye reflexes are substantially altered. ... researcher Alberto Costa, MD, Ph.D., could lead to new tools ... at improving quality of life for those with this genetic ...
... The delivery system for an important class of proteins ... mere three components, according to a new study. ... percent of the membrane proteins in a cell, are known ... membrane after construction. New research from the University of Chicago ...
Cached Biology News:Scientists reengineer antibiotic to overcome dangerous antibiotic-resistant bacteria 2Scientists reengineer antibiotic to overcome dangerous antibiotic-resistant bacteria 3Scientists reengineer antibiotic to overcome dangerous antibiotic-resistant bacteria 4Researcher finds altered cerebella in those with Down syndrome 2Three-part handoff delivers proteins to membrane surface 2Three-part handoff delivers proteins to membrane surface 3
(Date:9/2/2015)... , Sep. 02, 2015 ... ) has announced the addition of Jain ... Markets and Companies" to their offering. ... several technologies besides fluorescence in situ hybridization ... FISH. Molecular cytogenetics includes application of nanobiotechnology, ...
(Date:9/2/2015)... Australian prostate cancer technology company Minomic International ... recognising ,outstanding, science that uses its patented antibody. ... novel prostate cancer diagnostic test known as MiCheck® next ... out the peer-reviewed Australian Museum Eureka Science Prize for ... This prize is awarded for ground breaking research that ...
(Date:9/2/2015)... Israel , September 2, 2015 ... the intent of the National Institute of Allergy and Infectious ... (NIH) within the Department of Health and Human Services (HHS), ... in the United States in the ... universal flu vaccine candidate, Multimeric-001 (M-001), as a primer vaccine, ...
(Date:9/2/2015)... ... September 02, 2015 , ... Temarry Recycling's new ... waste to energy process and continue to contribute to the sustainability of our ... Waste to Energy process has been operating at their Mexico facility, Recicladora Temarry, ...
Breaking Biology Technology:Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 2Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 3Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 2BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 3Temarry Recycling’s New $100,000 Waste to Energy Renovation 2
... Inc., (TSX:,ARI), a biotechnology company discovering and developing ... five abstracts have been,selected for presentation at the ... from April 12-16, 2008 in San Diego, California.,The ... findings,about its CD44, TROP-2, CD59, and CD9 antibody ...
... Time to Brazil ... and ... of the Sanofi-aventis Group, announced today that six,million doses of Stamaril(TM)(1) ... the yellow fever epidemic in Latin,America., Brazil received four million ...
... - $2 M to ProMetic over the next 12 months - $30 M ... ... in-licensed ProMetic,s yield improving technology, - Incorporation of ProMetic,s prion reduction technology ... manufacturing process, ...
Cached Biology Technology:ARIUS announces five abstracts selected for presentation at 2008 AACR Annual Meeting 2ARIUS announces five abstracts selected for presentation at 2008 AACR Annual Meeting 3Sanofi Pasteur Mounts Emergency Response to Yellow Fever Epidemic in Latin America 2Sanofi Pasteur Mounts Emergency Response to Yellow Fever Epidemic in Latin America 3ProMetic announces signature of definitive license agreement with Kedrion for two hyperimmune products 2ProMetic announces signature of definitive license agreement with Kedrion for two hyperimmune products 3ProMetic announces signature of definitive license agreement with Kedrion for two hyperimmune products 4
Request Info...
... is formulated specifically for Alkaline Phosphatase conjugates. ... of activity for both the enzyme and ... dilution. This product has been chemically ... customer a longer shelf life, resistance to ...
... binding is a problem in your ... immobilized NeutrAvidin products as superior alternatives ... a modified avidin derivative that combines ... biotin-binding protein with exceptionally low nonspecific ...
... 4000 workstation is the simplest, easiest-to-use system ... automated liquid handling capabilities,into their labs, or ... support routine applications on a separate instrument. ... automation even when you have thousands ...
Biology Products: