Navigation Links
Study details paired risk factors in preeclampsia
Date:9/10/2013

PROVIDENCE, R.I. [Brown University] Although preeclampsia occurs in about 3 percent of pregnancies, it's still unforeseen in many cases. A report of new research, now in press at the Journal of Reproductive Immunology, documents how two distinct risk factors combine to affect the odds that a first-time mother could develop the sometimes life-threatening pregnancy complication. The findings suggest there could be new ways to plan pregnancy with improved awareness and management of the risk.

For years evidence has mounted that preeclampsia may have its origin in the mother's immune response to pregnancy. For that reason, researchers have been studying the potential role of two risk factors: the level of similarity between the mother and father or mother and fetus in a set of five human leukocyte antigen (HLA) genes related to immune system compatibility; and the degree of vaginal exposure the mother has had to the father's semen before becoming pregnant.

The new study, first published online in August, measured both of those risk factors in detail and in combination in 118 women who developed preeclampsia and in 106 similar women who did not. The data set came from SOPHIA, the Study of Pregnancy Hypertension in Iowa maintained by the University of Iowa.

The study's main finding is that women who have had relatively little prior vaginal exposure to the father's semen and who had a high-level of matching of the class I group of three HLA genes had 4.5 times greater odds of developing preeclampsia than women with greater exposure and less gene matching. The analysis accounted for other risk factors, such as Body Mass Index.

"When you have both low seminal fluid exposure and high sharing [of Class I HLA genes], you are at highest risk," said study lead and corresponding author Elizabeth Triche, assistant professor of epidemiology in Brown University's School of Public Health.

The increased odds appear to confirm pr
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. African-American study identifies 4 genetic variants associated with blood pressure
2. Therapy slows onset and progression of Lou Gehrigs disease, study finds
3. Cytos Biotechnology Presents Additional Results From Phase 2a Study of CYT003 for the Treatment of Allergic Asthma
4. LSUHSC researchers develop new system to better study behavior, cell function
5. 400-year study finds Northeast forests resilient, changing
6. UCSF receives $4.5M to study value of gene sequencing in newborns
7. First study to investigate the human genome in multiple sclerosis
8. Red cedar tree study shows that Clean Air Act is reducing pollution, improving forests
9. Penn study: Shutting off neurons helps bullied mice overcome symptoms of depression
10. Type 2 diabetes study to examine role amylin plays in disease
11. Cell study offers more diabetic patients chance of transplant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... OXFORD, England , November 4, 2014 ... expansion and vertical market growth   Fuel3D ... it has closed a funding round totaling $6.4 million (£4 ... (£1.6 million) funding secured earlier this year and paves the ... product in 2015. The funding round was led ...
(Date:11/4/2014)... , Nov. 4, 2014   Neurotechnology , ... announced that the latest version of its fingerprint ... Ongoing MINEX evaluation organized by NIST. ... algorithms using the INCITS 378 fingerprint standard template ... in public tenders in the United ...
(Date:11/3/2014)... published in this month,s Proceedings of the ... a recently discovered communication molecule of the body,s immune ... to limit inflammation and the current study reports its ... ability of the immune system to recognize and target ... effect on the immune system now allows us to ...
Breaking Biology News(10 mins):Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3PNAS: From HIV to cancer, IL-37 regulates immune system 2
... about 95 per cent of life was wiped out in ... at the University of Calgary believe they have discovered evidence ... producing ash clouds that had broad impact on global oceans. ... the latest Permian extinction," says Dr. Steve Grasby, adjunct professor ...
... Research is trying to determine whether Alzheimer,s disease might ... new study suggests those efforts could be improved by ... status of elderly people at risk for dementia. ... surveys, asks people to remember what they have eaten. ...
... BUFFALO, N.Y. -- An innovative, educational computing platform developed ... the cloud (remote, high-capacity, scalable servers) is helping UB ... new level. Soon, high-school and middle-school students will benefit ... by UB faculty members with a $250,000 National Science ...
Cached Biology News:Researchers find smoking gun of world's biggest extinction 2Study of nutrition, Alzheimer's links hampered by research approach 2With cloud computing, the mathematics of evolution may get easier to learn 2With cloud computing, the mathematics of evolution may get easier to learn 3With cloud computing, the mathematics of evolution may get easier to learn 4
(Date:11/26/2014)... (PRWEB) November 26, 2014 The report ... defines and segments the concerned market for revenue forecasts ... at a CAGR of 51.9% from 2013 to 2018. ... reach a value of $1,415.6 million by 2018. , ... Automation Report TOC for information about the market segmentation ...
(Date:11/26/2014)... and PHILADELPHIA , Nov. ... most demanding and unforgiving environments. Human exploration of space ... performance to ensure mission safety and success, and prevent ... performance for mission success, little is known about how ... of cognition are primarily affected. Now, Penn ...
(Date:11/26/2014)... (PRWEB) November 25, 2014 Whitehouse ... officially joined the Morris County (New Jersey) Chamber ... is a leading business organization in the North ... to further engage some key clients in the ... in the geographic area. Membership enables Whitehouse Laboratories ...
(Date:11/26/2014)... Global biostimulants market is expected to ... estimated CAGR of 12.5%. In order to cater ... least ecological impacts, farmers are looking to adopt ... yield more effectively & efficiently. Biostimulants are consequently ... return on investments. , Leading companies in the ...
Breaking Biology Technology:Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 2Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 3Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 4Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 4
... of Gene Expression (SAGE) is a sequence-based approach to the ... a powerful tool, one of the more comprehensive methods available ... to a profile of the expressed genes. 1 SAGE ... genes expressed in a specimen. The ability to count many ...
... , Overview , ... valuable tool in verifying and improving peptide synthesis. Matrix Assisted Laser Desorption ... rapid, easy to use and requires relatively little maintenance. This work shows ... peptide synthesis. This work was first presented by A. Falick, G. Tarr ...
... Purpose , ... monitoring of protease inhibitor (PI) and non-nucleoside reverse transcriptase inhibitor ... importance of assessing inter-individual and intra-individual metabolism variability. To be ... used to monitor these drugs is fast and easy to ...
Cached Biology Technology:Serial Analysis of Gene Expression Using ABI PRISM DNA Sequencers and BigDye Terminators 2Serial Analysis of Gene Expression Using ABI PRISM DNA Sequencers and BigDye Terminators 3Serial Analysis of Gene Expression Using ABI PRISM DNA Sequencers and BigDye Terminators 4Serial Analysis of Gene Expression Using ABI PRISM DNA Sequencers and BigDye Terminators 5Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS 2Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS 3A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors) 2A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors) 3A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors) 4
One-step, microplate or cuvet, colorimetric, linear detection range 8 mg/dL to 300 mg/dL. Procedure: 5 min....
dynactin 4, mRNA (cDNA clone MGC:3248 IMAGE:3505855), complete cds...
MOUSE ANTI HUMAN NPM...
RABBIT ANTI HUMAN CHYMOTRYPSIN...
Biology Products: