Navigation Links
Study begins to reveal clues to the cause and progression of sepsis
Date:8/13/2007

PITTSBURGH, Aug. 13 Not all patients with sepsis mount the same immune response, even when they look the same clinically, according to findings from the first large-scale natural history study of sepsis. The results, published by University of Pittsburgh School of Medicine researchers in the August 13/27 issue of the Archives of Internal Medicine, indicate that past interpretations of how the immune system responds to infection interpretations on which many experimental treatments were based were incorrect.

This year, nearly 1 million Americans will develop sepsis, a result of the bodys inflammatory response to an infection, which can lead to organ failure and death. More than 30 percent will die, making sepsis the 10th leading cause of death. While incidence rates of sepsis have been steadily increasing over the years, little is known about the condition. Past investigational treatments have been based on data from small studies, and most of these therapies have failed.

Researchers at the University of Pittsburgh believe that these treatments failed, at least in part, because of insufficient data to fully understand the complexity and variability of the inflammatory response to sepsis. To gain a better understanding into the mechanisms behind the condition, the researchers conducted the Genetic and Inflammatory Markers of Sepsis study (GenIMS), which collected extensive clinical and laboratory data geared to help analyze the risks of a person developing sepsis and dying. Data were collected from 2,320 subjects who came to hospital emergency rooms at 28 sites nationwide.

With sepsis, were dealing with one of the deadliest diseases, yet we know so little about the condition. The situation is similar to what this country experienced over 50 years ago with heart disease and stroke we knew that too many people were dying of cardiovascular disease, but we didnt know enough about the disease to effectively treat and prevent it, s
'/>"/>

Contact: Jocelyn Uhl Duffy
UhlJH@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bioartificial kidney under study at MCG
2. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
3. W.M. Keck Foundation funds study of friendly microbes
4. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
5. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
6. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
7. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
8. Study Links Ebola Outbreaks To Animal Carcasses
9. Genome-wide mouse study yields link to human leukemia
10. Breakthrough Microarray-based Technology for the Study of Cancer
11. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... computer science and engineering professor with an expertise in ... Science Foundation grant worth more than $600,000 to develop ... fly., Heng Huang, an associate professor, will lead the ... Arlington Computer Science and Engineering department. Scientists are compiling ... large number of genes involved in fruit fly development ...
(Date:7/22/2014)... 2014) New research from the Monell Center reveals ... can increase airway inflammation in asthmatics for at least ... that expectations can play in health-related outcomes. , "Asthmatics ... expect that an odor is harmful, our bodies react ... lead author Cristina Jan, PhD, a Monell physiologist. "Both ...
(Date:7/22/2014)... not be good for the average steak, but it ... prepare to survive Alaska,s winter cold. , "Alaska wood ... a steak does in your freezer and the frog ... shape than the steak," said Don Larson, University of ... recent paper demonstrating that freeze tolerance in Alaska wood ...
Breaking Biology News(10 mins):UT Arlington big data team wins $600,000 NSF grant to build gene expression database 2In asthma, it's not just what you smell, but what you think you smell 2In asthma, it's not just what you smell, but what you think you smell 3Alaska frogs reach record lows in extreme temperature survival 2Alaska frogs reach record lows in extreme temperature survival 3
... Laval’s Faculty of Medicine have discovered that a ... a pathological reaction in skin cells. Guillaume Morissette, ... about the mode of action of this substance—called ... of Dermatology. , DMAE (2-dimethylaminoethanol) is used in ...
... 15 percent of couples of childbearing age struggle with the ... hope with Cornell researchers' identification of a mutation in a ... the first time that a dominant mutation that leads specifically ... say they can now look for similar mutations in the ...
... made a breakthrough by detecting the electrical equivalent of ... a step closer to both seeing the ‘heartbeat?of a ... , To stay alive, individual biological cells must ... membranes. This flow produces an electrical current that could, ...
Cached Biology News:Anti-wrinkle compound causes pathological reaction in skin cells 2Researchers find gene mutation that causes infertility in male mice 2A new study of living cells could revolutionize the way we test drugs 2
(Date:7/22/2014)... og SHENZHEN , Kina, ... Co., LTD, (BGI Tech), et datterselskab af BGI, ... en ny human whole exome-sekvenseringstjeneste baseret på Complete ... højt anset i branchen for at levere patenterede ... af alle typer varianter, blev købt af BGI ...
(Date:7/22/2014)... , July 22, 2014 Hussey Copper ... MD-Cu 29 antimicrobial copper announces Pullman Regional Hospital,s ... first EPA-registered antimicrobial solid touch surface, at a nominal ... of MRSA, E-coli and other bacteria within 2 hours of ... protecting against bacteria and infectious diseases in its facilities. ...
(Date:7/22/2014)... Quorum Review IRB, the industry leader in central ... called Quick Step™ . The offering went live on ... industry’s need for seamless study start-up with a large volume ... planning 50 or more North American investigator sites, as well ... count of 80 or more. Qualifying studies may also enroll ...
(Date:7/22/2014)... Biofeedback – When a behavioral problem ... medication to best treat it can become a matter ... electroencephalography (EEG) can help predict which medicine will offer ... adverse drug events. , The article “Medication Prediction ... issue of the journal Biofeedback offers evidence that quantitative ...
Breaking Biology Technology:BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 2Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 3Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 2Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 3
... , , LAKE MARY, Fla., ... Inc. (NasdaqCM: NGBF) today announced that on August 26, 2009, ... staff indicating that, based on the Company,s stockholders equity as ... the quarter ended June 30, 2009, the Company is no ...
... , BALTIMORE, Md., Aug. 27 Champions Biotechnology, ... development of advanced preclinical platforms and tumor specific data to ... results for the fiscal year ended April 30, 2009. Full ... Company,s Form 10-K available at www.championsbiotechnology.com. , , ...
... , , MURRIETA, Calif., Aug. ... announce the expansion of its US operations. Copan Diagnostics, Inc. ... plastic transfer pipet and additional medical device manufacturing operations to ... addition of blow molding machinery and filling and packing equipment ...
Cached Biology Technology:New Generation Biofuels Receives NASDAQ Notice of Noncompliance with Continued Listing Requirements 2Champions Biotechnology Reports Fiscal 2009 Full-Year Financial Results 2Champions Biotechnology Reports Fiscal 2009 Full-Year Financial Results 3Champions Biotechnology Reports Fiscal 2009 Full-Year Financial Results 4Champions Biotechnology Reports Fiscal 2009 Full-Year Financial Results 5Copan Announces Multimillion Expansion for US Pipet Manufacturing Operations 2
... stain has bright fluorescence when bound to dsDNA ... for detecting dsDNA in gels using laser scanners ... nucleic acid stain has also found uses ... bandshift assays. A 500 µL unit size (S-7563) ...
... cross-linking techniques are defined by the author ... Wong. This valuable hardcover guide includes hundreds ... application references. More than 300 pages detail ... conjugate preparation from selection and design ...
... protein separation by two-dimensional electrophoresis (2D-PAGE), ... package from Bio-Rad and protein identification ... to meet customers requirements regarding experimental ... format of the results permanent contact ...
... reagents for immune complex disruption (ICD) of ... using a combination of low pH and ... transferred to microplate wells which are coated ... to HIV-1 p24. The immobilized monoclonal antibody ...
Biology Products: