Navigation Links
Study: Probiotics reduce stress-induced intestinal flare-ups
Date:3/14/2013

ANN ARBOR, Mich. For those with irritable bowel syndrome who wonder if stress aggravates their intestinal disorder, a new University of Michigan Health System study shows it's not all in their head.

Researchers revealed that while stress does not cause IBS, it does alter brain-gut interactions and induces the intestinal inflammation that often leads to severe or chronic belly pain, loss of appetite and diarrhea.

Stress has a way of suppressing an important component called an inflammasome which is needed to maintain normal gut microbiota, but probiotics reversed the effect in animal models, according to findings published online ahead of print in Gastroenterology.

"The effect of stress could be protected with probiotics which reversed the inhibition of the inflammasome," says senior study author and gastroenterologist John Y. Kao, M.D., associate professor of internal medicine at the University of Michigan. "This study reveals an important mechanism for explaining why treating IBS patients with probiotics makes sense."

Probiotics are live bacteria that help grow the gut-dwelling "good" bacteria that keep pathogens in check, aid digestion and nutrient absorption and contribute to immune function.

U-M researchers including Chung Owyang, M.D., chief of the U-M Division of Gastroenterology, Gary Huffnagle, Ph.D., professor of pulmonary and critical care, and infectious disease expert Vincent Young, M.D., Ph.D., were able to identify the way stress significantly altered the composition of gut bacteria and the role of probiotics.

Maintaining healthy microbiota requires action by nucleotide-binding oligomerization domain protein-like receptors, pyrin-domain containing (NLRP)-6 inflammasomes. But when stressed, mice produced corticotropin-releasing hormone (CRH) that prevented inflammasomes from doing their job.

Inhibiting inflammosomes alters the composition of the gut, leading to intestin
'/>"/>

Contact: Shantell M. Kirkendoll
smkirk@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Study: Antibiotics are unique assassins
2. International study: Excess dietary salt may drive the development of autoimmune diseases
3. Influenza study: Meet virus new enemy
4. Study: Resveratrol shows promise to protect hearing, cognition
5. Nature Methods study: Using light to control cell clustering
6. Study: Viral reactivation a likely link between stress and heart disease
7. Study: Odd biochemistry yields lethal bacterial protein
8. International study: Where theres smoke or smog, theres climate change
9. UT study: Students who are more physically fit perform better academically
10. New study: Many flame retardants in house dust -- unsafe levels
11. Study: DNA barcoding can ID natural health products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... An increasing number of U.S. children are experiencing ... to research presented at Digestive Disease Week (DDW). ... at the Cleveland Clinic Children,s Hospital found that ... breath compared to their lean counterparts. The pattern ... can be correlated to potential complications associated with ...
(Date:5/17/2013)... white noise of the South, but the night belongs to ... hangs heavy from the humidity and the sounds of wildlife. ... of frogs, toads and salamanders, is the center of amphibian ... are the auditorium for their symphonic choruses, the scientists of ... ARMI, have front-row seats. , Amphibians, which rely ...
(Date:5/17/2013)... will celebrate the science and technology of the ... during the inaugural Atlanta Science Festival, March 22-29, ... museums, corporations, K-12 schools and universities, the festival ... children and adults at venues across the city. ... The annual Atlanta Science Festival is a collaboration ...
Breaking Biology News(10 mins):New research identifies risks, interventions for children's GI health 2New research identifies risks, interventions for children's GI health 3Front-row seats to climate change 2Front-row seats to climate change 3Front-row seats to climate change 4First Atlanta Science Festival set for 2014 2
... around the world are breathing a sigh of ... of being harvested for their natural disease-fighting substances. ... which lives symbiotically inside the sea squirt, actually ... day be used in cancer treatment. , Despite ...
... of Iowa Biological Sciences Professor Daniel F. Eberl and his ... deafness in fruit flies that may shed light on deafness ... the Usher 1B Syndrome in Humans, Lead to Deafness in ... of the journal Current Biology. , Eberl says their recent ...
... be fused with large, protein-based drugs such as granulocyte ... that is capable of surviving the journey through the ... into the bloodstream to be used by the body, ... School of Pharmacy. , This technology may allow for ...
Cached Biology News:UI researcher studies deafness in fruit flies, humans 2Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs 2Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs 3
(Date:5/21/2013)... New York , May 21, 2013 ... by Transparency Market Research ( http://www.transparencymarketresearch.com ) "Biochip Products ... Research, IVD Tests) - U.S. Industry Analysis, Size, Share, Growth, ... 2.4 billion in 2011 and is expected to grow ... to reach an estimated value of USD 4.7 billion ...
(Date:5/21/2013)... Norristown, PA (PRWEB) May 21, 2013 ... company, today announced that Dr. Charles Signorino, the Company’s ... on April 1, 2013 after 32 years of service. ... Adolfo Gomez, Emerson’s current President, has been named as ... recognized luminary in the pharmaceutical industry, having made a ...
(Date:5/21/2013)... BALTIMORE , May 21, 2013  Personal ... will use its proprietary methodologies and expertise in ... novel kinase targets in collaboration with Blueprint Medicines. ... aimed at identifying genomic alterations in tumors, and ... selective kinase inhibitors for a genetically defined patient ...
(Date:5/21/2013)... NANONEX CORPORATION, a pioneer and leading company ... successful delivery and installation of a new nanoimprint ... major Japanese manufacturing company. , ... lithography tool that has the ability to process ... types. Based on Nanonex inventions and proprietary technologies, ...
Breaking Biology Technology:The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 2The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 3The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 4The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 5Emerson Resources Announces CEO Retirement and Appointment of Successor 2Emerson Resources Announces CEO Retirement and Appointment of Successor 3Personal Genome Diagnostics And Blueprint Medicines Form Collaboration to Identify Novel Kinase Targets 2Personal Genome Diagnostics And Blueprint Medicines Form Collaboration to Identify Novel Kinase Targets 3Nanonex Announces the Shipment and Installation of an Innovative Nanoimprint Lithography System for Fully Automated Manufacturing 2
... , , SAO PAULO , Feb. ... to postpone a decision to reduce Brazil,s ,ethanol import duty from ... to be announced, but not for its impact to take effect once ... it describes as little more than a "bureaucratic" delay. , ...
... , SAN FRANCISCO , ... a leader in Integrated Voice Response (IVR)/Integrated Web Response (IWR) ... allows users to design and deploy clinical trial Integrated Response ... of clinical trials. This time and cost savings stems from ...
... ... nematodes as the Divergence and National Corn Growers Association continues collaboration. , ... (PRWEB) February 9, 2010 -- ... Research (SBIR) grants totaling $500,000, along with renewed funding from the National Corn Growers ...
Cached Biology Technology:Brazilian Sugarcane Industry Association Stresses Need for Brazil's Government to Announce Ethanol Import Tariff Cut as Soon as Possible 2Brazilian Sugarcane Industry Association Stresses Need for Brazil's Government to Announce Ethanol Import Tariff Cut as Soon as Possible 3endpoint Saves Money and Time for Medical Research Teams Through PULSE 2endpoint Saves Money and Time for Medical Research Teams Through PULSE 3New Funding Validates Importance of Divergence's Work on Nematodes 2New Funding Validates Importance of Divergence's Work on Nematodes 3
... catalyzes the formation of phosphodiester bonds in ... with 3' hydroxyl and 5' phosphate termini. ... ligation which can be performed in 5 ... substrates for this enzyme. A T4 ...
Bovine Renal Artery Smooth Muscle Cells (BRASMC) (>500,000 cells)...
... BioControl is a major step forward ... liquid handling system - with one ... cone modules. All five single channel ... fit one handle. The lightweight handle ...
Sulfadimethoxine (CH-2027)...
Biology Products: