Navigation Links
Study: MicroRNA cooperation mutes breast cancer oncogenes
Date:5/7/2013

A University of Colorado Cancer Center study recently published in the journal Cell Death & Disease shows that turning up a few microRNAs a little may offer as much anti-breast-cancer activity as turning up one microRNA a lot and without the unwanted side effects.

It's a bit like the classic thought experiment known as the "tumor problem" formulated by Karl Dunker in 1945 and used frequently in the problem-solving literature: Imagine a person suffers from a malignant tumor in the center of her body. Radiation strong enough to kill the tumor kills any healthy tissue through which it passes. Without operating or killing healthy tissue, how can a doctor use radiation to kill the tumor?

The answer is to target the tumor from many angles many weak rays of radiation pass harmlessly through healthy tissue, but their combined power at the point of the tumor is enough to kill it.

In the present study, CU Cancer Center investigators used "weak" induction of multiple microRNAs that combined from many angles to regulate the known breast cancer oncogenes erbB2/erbB3 (the "tumor") without regulating non-target genes (the "healthy tissue").

"Imagine you have a microRNA that regulates genes A and B. Then you have another microRNA that regulates genes B and C. You amplify each microRNA to a degree that doesn't effect gene A or C, but their combined effect regulates gene B," says Bolin Liu, MD, assistant professor in the Department of Pathology at the University of Colorado School of Medicine.

microRNA is an attractive target in cancer therapy more microRNA can lead to less gene expression, turning down or off the oncogenes that cause cancer. However, to get the desired effect on gene expression frequently requires enhancing microRNA expression 100- or 1,000-fold (or more). And the induced microRNA likely has other genetic targets it will turn down other genes as well as the oncogene, sometimes with unfortunate consequences
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study: Environmental policies matter for growing megacities
2. Study: Widespread test-and-treat HIV policies could increase dangerous drug resistance
3. Study: Probiotics reduce stress-induced intestinal flare-ups
4. Study: Antibiotics are unique assassins
5. International study: Excess dietary salt may drive the development of autoimmune diseases
6. Influenza study: Meet virus new enemy
7. Study: Resveratrol shows promise to protect hearing, cognition
8. Nature Methods study: Using light to control cell clustering
9. Study: Viral reactivation a likely link between stress and heart disease
10. Study: Odd biochemistry yields lethal bacterial protein
11. International study: Where theres smoke or smog, theres climate change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... Aug. 19, 2014 To improve students, chances ... grades, the University of Houston (UH) implemented a ... students at risk for failure. , Through ... Board (THECB), the Department of Biology and Biochemistry ... students taking "General Biology" for non-majors and "Introductory ...
(Date:8/19/2014)... It,s not a monkey. It,s not a lemur. It,s not ... the Philippine tarsier: a tiny, adorable and downright "cool" primate ... that Americans are familiar with," said Rafe Brown, curator-in-charge at ... eyes and ears; an extremely cute, furry body; a long ... expanded fingers and toe tips that look a bit like ...
(Date:8/19/2014)... biomarker strongly associated with basal-like breast cancer, a ... types of chemotherapy. The biomarker, a protein called ... designed to treat this often deadly cancer. , ... Cancer Genome Atlas, molecular biologists Curt M. Horvath ... bioinformatics techniques to detect patterns of gene expression ...
Breaking Biology News(10 mins):University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 2Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 3Biomarker in an aggressive breast cancer is identified 2Biomarker in an aggressive breast cancer is identified 3
... Some soil microorganisms are capable of forging associations with ... these relationships play a highly important ecological and agronomic ... a fungus) thus gives plants a mechanism for improving ... has been in existence for 400 million years and ...
... Oregon State University graduate student working on a ... station on the Tahoe National Forest has photographed ... been confirmed in California since the 1920s. Katie ... on another carnivore called the American marten when ...
... defined biochemical pathway in plants may provide the scientific ... of alternative transportation fuels than currently can be produced, ... materials that determine cell shape and size through a ... geneticist and cellular biologist. By learning more about the ...
Cached Biology News:A common genetic mechanism discovered in nitrogen-fixing plants 2A common genetic mechanism discovered in nitrogen-fixing plants 3Scientists believe photograph depicts wolverine in California 2Newly defined signaling pathway could mean better biofuel sources 2Newly defined signaling pathway could mean better biofuel sources 3Newly defined signaling pathway could mean better biofuel sources 4
(Date:8/20/2014)... , Aug. 20, 2014  PAREXEL International Corporation ... will be presenting at the Baird Healthcare Conference in ... and Chief Financial Officer, will be making a presentation ... EDT on Wednesday, Sept. 3, 2014. A ... the "Investors" section of PAREXEL,s website at www.PAREXEL.com ...
(Date:8/20/2014)... Aug. 20, 2014 /PRNewswire-iReach/ -- A case study ... between the school,s bioengineering department and the Intel® ... Intel® Software Academic Program, UCSD,s research focuses on ... human body.  Photo - ... the work of Dr. Todd P. Coleman ...
(Date:8/20/2014)... 20, 2014 GraphDB™ 6.0 ... including improvements to the enterprise replication cluster, faster ... Lucene, SOLR and Elasticsearch. This release happens to ... performance triplestore – GraphDB™ was formerly known as ... the only mature enterprise resilient RDF triplestore will ...
(Date:8/19/2014)... Research and Markets  has announced the addition of the ... report to their offering. This report analyzes the ... by the following Product Segments: Media, Sera, and Reagents. ... Canada , Japan , Europe ... America . Annual estimates and forecasts are provided for the ...
Breaking Biology Technology:PAREXEL International To Present At Baird Healthcare Conference 2Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2
... reflection, and this one is no different. These last 12 months ... doubt look back on 2005 and pronounce it the year the ... of things, the previous four years were a standing eight count, ... like hell and a lot was lost on bad bets, but ...
... newsletter contains the most-read stories from our Web site in 2005. ... month to over 70,000 last month, many of them sticking around ... to what drew your interest. , ,Let me take a moment ... isnt until March 2 and were more than a third full ...
... care in the United States are enough to make anyone ... seven Americans (15.7 percent) lack health insurance. Thats just short ... federal figures, health spending accounts for 15.3 percent of the ... works out to $5,670 for each American. By 2013, the ...
Cached Biology Technology:2005: the year of the comeback 22005: the year of the comeback 3Health care economics make definition of 'cost' problems difficult 2Health care economics make definition of 'cost' problems difficult 3
The Zymo-Spin PI Fast-Spin column features durable polypropylene construction and is the same column featured in the His-Spin Protein Miniprep. Capacity is 800 l....
LAL Chromogenic Endpoint assay...
...
Catch and Release® v2.0 Reversible Immunoprecipitation System...
Biology Products: