Navigation Links
Study: Excessive use of antiviral drugs could aid deadly flu
Date:1/7/2009

COLUMBUS, Ohio Influenza's ability to resist the effects of cheap and popular antiviral agents in Asia and Russia should serve as a cautionary tale about U.S. plans to use the antiviral Tamiflu in the event of widespread avian flu infection in humans, scientists say.

Researchers analyzed almost 700 genome sequences of avian influenza strains to document where and when the virus developed resistance to a class of antiviral drugs called adamantanes and how far resistant strains spread. The analysis suggests that widespread antiviral drug use can accelerate the evolution of drug resistance in viruses, and that resistant strains can emerge and spread rapidly.

The results should serve as a warning to those who consider Tamiflu the next great antiviral medication, the researchers say. Stockpiling Tamiflu has become a standard part of many government, business and health organization plans to prepare for a long-feared pandemic flu outbreak, especially in the event that avian flu mutates enough to infect and be easily transmitted among humans.

"We can't necessarily say what we've seen in adamantanes is predictive of what will happen with Tamiflu. But in the larger dynamic, perhaps it serves as a cautionary tale," said Daniel Janies, senior author of the study and an associate professor of biomedical informatics at Ohio State University.

"Fighting infection is an arms race, and if we're not smart about how we use our arms and understand the evolutionary implications, then we will have ongoing and accelerating problems with drug-resistant microorganisms."

Resistance to adamantanes among strains of seasonal influenza spiked in Asia in 2002, and by 2006 the agents were considered virtually worthless worldwide as a treatment for the flu because more than 90 percent of the strains had developed a resistance to the drugs.

With that knowledge, Janies and colleagues analyzed hundreds of avian flu genomes isolated from
'/>"/>

Contact: Daniel Janies
Daniel.Janies@osumc.edu
614-292-1202
Ohio State University
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Study: diabetic neuropathy costs billions per year in lost work time
2. Study: Fountain of youth for your heart?
3. First-ever study: lack of critical lubricant causes wear in joints
4. Mayo Clinic study: Ossurs collars superior in immobilization and reduction of pressure
5. Study: weight-loss tips differ in African-American, mainstream magazines
6. Smithsonian study: Sediment prediction tools off the mark
7. Mouse study: When it comes to living longer, its better to go hungry than go running
8. Geisinger study: Inflammatory disease causes blindness
9. Stanford study: Bioenergy potential of reviving abandoned agricultural land
10. U-M study: Herceptin targets breast cancer stem cells
11. Study: Future snowmelt in West twice as early as expected; threatens ecosystems and water reserves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Queen in Lewis Carroll,s Through the Looking Glass, ... University of Singapore improved a 35-year-old ecology model ... to millions of years. , The new model, ... the "Red Queen Effect," an evolutionary hypothesis introduced ... suggests that organisms must constantly increase their fitness ...
(Date:7/30/2014)... A deep-sea octopus protected and tended her eggs until ... published July 30, 2014 in the open-access journal ... Aquarium Research Institute and colleagues. , Octopuses typically have ... females protect and take care of their fertilized eggs ... eggs for 1 to 3 months, but little is ...
(Date:7/30/2014)... Chemical Society (ACS) announced today that David L. Kaplan, ... Biomaterials Science & Engineering as editor-in-chief. With the ... new journal will feature high-quality research in the rapidly ... naturally derived materials that interact with living or biological ... reflects the tremendous growth in the field of biomaterials ...
Breaking Biology News(10 mins):Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3Deep-sea octopus has longest-known egg-brooding period 2ACS Biomaterials Science & Engineering: Brand-new journal launches in 2015, names editor 2
... is also available in Chinese on EurekAlert! ... A new laser-beam steering system that aims and focuses bursts ... has been demonstrated by collaborating researchers from Duke University and ... Applied Physics Letters , published by the American Institute of ...
... the RMS Titanic, which is contributing to its deterioration. ... the exterior of ships and underwater metal structures such ... findings in the latest issue of the International ... 8 December, isolated the micro-organisms from a ,rusticle, collected ...
... book, Illinois Birds: A Century of Change, literally took 100 ... Illinois was conducted from 1906-1909. It was repeated from 1956-1958 ... When the 100-year anniversary of that first survey was approaching, ... seized the window of opportunity to do it again and ...
Cached Biology News:Tiny laser light show illuminates quantum computing 2New microscopic life aboard the RMS Titanic 2New book on 100 years of Illinois birds 2New book on 100 years of Illinois birds 3New book on 100 years of Illinois birds 4
(Date:7/30/2014)... , July 30, 2014 Regulus Therapeutics ... company leading the discovery and development of innovative medicines ... results and highlights for the quarter ended June 30, ... financial markets close. Regulus will host ... 2014, at 5:00 pm Eastern Daylight Time to discuss ...
(Date:7/30/2014)... N.Y. and PARIS , ... and Sanofi (EURONEXT: SAN and NYSE: SNY) today announced ... and Drug Administration (FDA) rare pediatric disease priority review ... submission for alirocumab.  The priority review voucher entitles the ... provides for an expedited 6-month review from the filing ...
(Date:7/30/2014)... 2014 W. R. Grace & ... the REVELERIS® Prep purification system , a ... and other researchers to perform both flash and ... , With the REVELERIS® Prep purification system, researchers ... modes with a simple touch of the screen, ...
(Date:7/30/2014)... , July 30, 2014  Decision Resources ... and medical directors in the United ... of biosimilar market penetration will be the level ... (MCOs) and the expected lower cost to patients. ... biosimilars that meet their pricing expectations in order ...
Breaking Biology Technology:Regulus Announces Timing for Second Quarter 2014 Financial Results Webcast and Conference Call 2Regulus Announces Timing for Second Quarter 2014 Financial Results Webcast and Conference Call 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 4Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 5Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 6Grace Launches New REVELERIS® Prep Purification System 2Surveyed U.S. Payers Expect Cost Savings to MCOs and Patients to be the Strongest Drivers of Biosimilar Uptake 2Surveyed U.S. Payers Expect Cost Savings to MCOs and Patients to be the Strongest Drivers of Biosimilar Uptake 3
... March 17 The following was issued,today by the ... president & CEO, Greater Baltimore Committee, 140 company ... WHAT:, The third annual Greater Baltimore Region Bioscience ... 8:00 a.m. / Breakfast & Registration, 8:45 - ...
... 17 Mercury Therapeutics,Inc. (MTI), a company ... targeted drugs, announces that it has retained ... on its strategic and partnering,opportunities, with the ... This appointment follows a significant amount ...
... ST. LOUIS, March 17 (Nasdaq: SIAL ) ... holding its 2008 Annual,Business Review on Wednesday, March 19, ... at 2909 Laclede, St. Louis, Mo. 63103, The ... by 12:30 p.m. CDT,and will also be webcast over ...
Cached Biology Technology:Greater Baltimore Committee to Announce Winners of Third Baltimore Region Bioscience Awards at Ceremonies on March 18 2Mercury Therapeutics, Inc: Marquant Appointed to Advise on Strategic and Partnering Opportunities 2Mercury Therapeutics, Inc: Marquant Appointed to Advise on Strategic and Partnering Opportunities 3
...
... Rabbit Antibody to CRF ... with the ovine CRF sequence ... Cells and fibres are found ... of rat brain in colchicine ...
...
Alexa Fluor 647 anti-mouse Qa-2...
Biology Products: