Navigation Links
Study: Excessive use of antiviral drugs could aid deadly flu
Date:1/7/2009

COLUMBUS, Ohio Influenza's ability to resist the effects of cheap and popular antiviral agents in Asia and Russia should serve as a cautionary tale about U.S. plans to use the antiviral Tamiflu in the event of widespread avian flu infection in humans, scientists say.

Researchers analyzed almost 700 genome sequences of avian influenza strains to document where and when the virus developed resistance to a class of antiviral drugs called adamantanes and how far resistant strains spread. The analysis suggests that widespread antiviral drug use can accelerate the evolution of drug resistance in viruses, and that resistant strains can emerge and spread rapidly.

The results should serve as a warning to those who consider Tamiflu the next great antiviral medication, the researchers say. Stockpiling Tamiflu has become a standard part of many government, business and health organization plans to prepare for a long-feared pandemic flu outbreak, especially in the event that avian flu mutates enough to infect and be easily transmitted among humans.

"We can't necessarily say what we've seen in adamantanes is predictive of what will happen with Tamiflu. But in the larger dynamic, perhaps it serves as a cautionary tale," said Daniel Janies, senior author of the study and an associate professor of biomedical informatics at Ohio State University.

"Fighting infection is an arms race, and if we're not smart about how we use our arms and understand the evolutionary implications, then we will have ongoing and accelerating problems with drug-resistant microorganisms."

Resistance to adamantanes among strains of seasonal influenza spiked in Asia in 2002, and by 2006 the agents were considered virtually worthless worldwide as a treatment for the flu because more than 90 percent of the strains had developed a resistance to the drugs.

With that knowledge, Janies and colleagues analyzed hundreds of avian flu genomes isolated from
'/>"/>

Contact: Daniel Janies
Daniel.Janies@osumc.edu
614-292-1202
Ohio State University
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Study: diabetic neuropathy costs billions per year in lost work time
2. Study: Fountain of youth for your heart?
3. First-ever study: lack of critical lubricant causes wear in joints
4. Mayo Clinic study: Ossurs collars superior in immobilization and reduction of pressure
5. Study: weight-loss tips differ in African-American, mainstream magazines
6. Smithsonian study: Sediment prediction tools off the mark
7. Mouse study: When it comes to living longer, its better to go hungry than go running
8. Geisinger study: Inflammatory disease causes blindness
9. Stanford study: Bioenergy potential of reviving abandoned agricultural land
10. U-M study: Herceptin targets breast cancer stem cells
11. Study: Future snowmelt in West twice as early as expected; threatens ecosystems and water reserves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... are all sorts of signaling strategies in nature. Peacocks ... satin bowbirds build specialized stick structures, called bowers, and ... bitterling males show off bright nuptial coloration during spawning ... communicate with others. , ... fitness implications for individuals that are either signaling or ...
(Date:4/22/2014)... HOUSTON (April 22, 2014) Biotechnology scientists must ... for new patent and licensing guidelines, according to a ... Policy. , Published in the current issue of the ... on the June 2013 U.S. Supreme Court ruling in ... Genetics that naturally occurring genes are unpatentable. The court ...
(Date:4/22/2014)... orthopedic organizations have presented Beaumont Health System with ... recovery from both athletic and nonathletic injuries. ... awarded a $40,000 grant to fund stem cell-based ... injuries like a ruptured knee anterior cruciate ligament, ... Health, "An anterior cruciate ligament injury is the ...
Breaking Biology News(10 mins):Best practices in communication for the animal world 2Best practices in communication for the animal world 3New patenting guidelines are needed for biotechnology 2New patenting guidelines are needed for biotechnology 3Beaumont awarded grants to study sports-related injury treatment, improve recovery 2
... the puzzles it contains, though, many remain unsolved. We know ... building blocks of each and every cell. But what role ... healthy body, for instance? And what takes place in tumor ... gets out of hand? To get to the bottom ...
... This press release is available in German ... aspect of the human mind. However, how the images and emotions ... heads remains a mystery. Up to now it has not been ... from the Charit hospital in Berlin have now succeeded, for the ...
... With scientific evidence now supporting the age-old wisdom that ... tract infections, people have wondered if there was an ... perhaps in pill form, would be as effective as ... study from researchers at Worcester Polytechnic Institute (WPI) helps ...
Cached Biology News:Cell cultures from a machine 2Scientists measure dream content for the first time 2More power to the cranberry: Study shows juice better than extracts at fighting infections 2
(Date:1/15/2014)... Jan. 15, 2014  Bill Jacobs Automotive, a group of car ... up with the Heartland Blood Center and offering free oil ... drive takes place Saturday, Jan. 18 at the Bill Jacobs ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... Westlake Village, Calif. (PRWEB) January 15, 2014 ... cancer treatment and management through the genomic analysis of ... will offer Therapy Finder™, a web-based cancer decision support ... a reporting option with Cynvenio’s ClearID™ genomic test, Therapy ...
(Date:1/15/2014)... A study has been launched to test ... track could help to tackle the problem of obesity.  This ... GP surgery based in Stowmarket) and academics at University Campus ... Telemetry technology, which is inspired by equipment used to collect ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased ... Life Science organizations who need document translations. Clients will ... their documents in advance with a selection of nearly 50 ... often a critical factor in clinical and scientific fields, and ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2
... Million to ... Chronic Kidney Disease, EL SEGUNDO, Calif., June 26 DaVita ... chronic kidney,disease and failure (CKD), today announced that its third annual ... Beach, Va. DaVita KAT Walks Across America(TM) are a series of,5k ...
... it, soon you might not, researchers at the University ... have demonstrated an approximate cloaking effect created by concentric ... scientists a step closer to a practical solution for ... theoretical exercise," said Harley Johnson, a Cannon Faculty Scholar ...
... white paper titled “Avanta AC™ Advanced Ceramics ... online. This white paper outlines the challenges ... nanometer scale, as well as the advantages ... ceramic nanopowders are critical to a variety ...
Cached Biology Technology:Third Annual DaVita Kidney Disease Awareness Walks to Hit 20 Cities in 2008 2Silicon photonic crystals key to optical cloaking, researchers say 2 SACHEM Launches New Products for High Purity Advanced Ceramic Powders : Avanta AC™ Advanced Ceramics Solutions Offer Unique Advantages over Inorganic Bases in the Manufacture of Advanced Ceramic Nanoparticles 2
... Immunogen: Synthetic peptide derived from the C ... protein This peptide sequence is downstream ... Zymed polyclonal Connexin 36 antibody Cat. No. ... 36. Reactivity: Mouse (positive control: mouse ...
Invitrogen's Calcium Phosphate Transfection Kit provides high-quality reagents to enable the introduction of DNA into tissue culture cells via calcium phosphate co-precipitation....
...
...
Biology Products: