Navigation Links
Stowers study hints that stem cells prepare for maturity much earlier than anticipated
Date:12/27/2012

ted gene by initiating a global search for regions occupied by Ell3 in the genome of mouse embryonic stem cells. His search in collaboration with a bioinformatician in the Shilatifard lab, Alexander S. Garruss, revealed that Ell3 sits on more than 5,000 enhancers, including many that regulate genes governing stem cell maturation into spinal cord, kidney, and blood cells.

"What was interesting was that Ell3 marked enhancers that are active and inactive, as well as enhancers that are known as "poised," says Lin, referring to a transition state from inactive to active. "That indicated that Ell3's major function might be to prime activation of genes that are just about to be expressed during development."

The fact that silent genes can be "primed" for expression was no surprise: researchers knew that the enzymatic machine that copies DNA into the RNA blueprint for proteinsa protein called Pol IIoften pauses at the start of a gene, presumably revving its engine in preparation to jump across the genetic start gate in response to a developmental signal. However, Shilatifard and colleagues showed several years ago that paused Pol II is not a prerequisite for rapid transcriptional induction.

The surprise came when researchers used a molecular trick to deplete mouse ES cells of Ell3 and then did a "genomic" survey. They found that paused Pol II vanished from the start sites of many genes in Ell3-deficient cells. This means that not only does Ell3 preferentially mark stem enhancers, but also that its presence there is necessary to keep an idling Pol II ready for action.

Most of the current study defines how, when the developmental time is right, enhancer-bound Ell3 cooperates with components of a big-boss elongation factor called the Super Elongation Complex to release Pol II from the start gate, allowing the expression of genes required for stem cell differentiation. Critical among those findings is their observation that mouse stem cell
'/>"/>

Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Birdsong study pecks theory that music is uniquely human
2. Study turns parasite invasion theory on its head
3. Gout study offers genetic insight into disease of kings
4. Native orchid protection and conservation subject of new AgriLife Research study
5. Cell Transplantation study investigates fate and function of cells transplanted to the CNS
6. Study reports iron oxide nanoparticles effective for labeling human endothelial cells
7. Study looks at gray seal impact on beach water quality
8. Study reveals that animals contribute to seagrass dispersal
9. UC Irvine study of leaping toads reveals muscle-protecting mechanism
10. NTU study finds ways to prevent muscle loss, obesity and diabetes
11. Hass Avocado Board study published in Food & Function journal
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stowers study hints that stem cells prepare for maturity much earlier than anticipated
(Date:11/7/2014)... 2014 Leading Biometric companies aim to ... revolutionizing online transactions.  Companies in focus today are: NXT-ID, Inc. ... BABA ), Google Inc. (NASDAQ: GOOG ), ... EBAY ) and MasterCard Inc. (NYSE: MA) ... a biometric authentication company focused on the growing mobile commerce ...
(Date:11/6/2014)... because of metastasis, yet progress in preventing and ... "It,s been particularly challenging to design drugs that ... in systems biology at Harvard Medical School. ... they,ve already metastasized." , Gujral and colleagues have ... researchers better understand how metastasis begins. Their findings ...
(Date:11/6/2014)... Baltimore, MD, November 6, 2014 - Insilico Medicine, ... in aging and age related diseases announced a ... medicine of cancer, Champions Oncology, Inc (OTC: CSBR). ... genomics for personalized medicine, but Champions Oncology,s TumorGraft ... can validate the chemotherapy regimen experimentally generating vast ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6Migration negation 2Migration negation 3Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... compounds that stimulate stem cell growth in the brain, ... people affected by Parkinson's disease, strokes, multiple sclerosis, and ... appear in the September 2006 issue of The FASEB ... be responsible for causing key brain cells, neurons, to ...
... gene linked to both depression and bipolar disorder has been ... , The collaboration, led by Professor Hugh Gurling at UCL ... looked at bipolar cases in families living in the UK ... people with bipolar disorder. The results of the genetic searches, ...
... contraceptive is "five to ten years" away. But are we getting ... week marked the announcement of one hot new lead and one ... in Italy and at the Population Council in New York have ... Medicine, Oct. 29). By injecting the compound as an attachment to ...
Cached Biology News:New gene linked to bipolar disorder 2Male contraception: One door opens, another closes 2Male contraception: One door opens, another closes 3
(Date:11/24/2014)... 2014   Veracyte, Inc. (Nasdaq: VCYT ... and chief executive officer, will present in a fireside chat ... Conference on Tuesday, December 2, 2014 at 12:30 p.m. ET ... live audio webcast and subsequent replay may be accessed by ... the website at least 15 minutes prior to the live ...
(Date:11/24/2014)... Md. , Nov. 24, 2014  Spherix ... development company committed to the fostering and monetization ... Spherix v. VTech Telecommunications Ltd.,  Case No. 3:13-cv-03494-M ... Case No. 3:13-cv-03496-M, both in the United States ... Texas . On ...
(Date:11/22/2014)... Prominent academics, leaders of the ... December 3rd at Genetic Rx, a networking conference ... take place at the Joseph B. Martin Conference ... the present and future of genetic medicines—including siRNA, ... editing—as well as the treatment of patients with ...
(Date:11/22/2014)... MI (PRWEB) November 22, 2014 ... to simulate the proper management of life-like respiratory ... test lung devices . Grand Rapids-based, Michigan Instruments ... to donate two of the respiratory simulation units ... $15,000 each. Grand Valley and Muskegon Community College ...
Breaking Biology Technology:Veracyte to Present at the Piper Jaffray 26th Annual Healthcare Conference 2Markman Hearing Held as Scheduled in VTech and Uniden Cases 2Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3
... A new post-hoc sub-analysis of an important set of ... as the "core clinical cohort" population – showed that ... with a 26 percent relative risk reduction in the ... stroke, compared to treatment with clopidogrel (8.3 percent vs. ...
... National Institute of Standards and Technology (NIST), George ... made nano-sized sensors that detect volatile organic compoundsharmful ... productsthat offer several advantages over today,s commercial gas ... to detect one or several compounds over a ...
... automatic and portable detector that takes just fifteen minutes ... is being developed by US researchers. The technology amplifies ... reveal the presence of just 40 microscopic cells of ... known as anthrax, is a potentially lethal microbe that ...
Cached Biology Technology:Effient® (Prasugrel) Showed Significant 26 Percent Reduction in Cardiovascular Events Over Clopidogrel in New Core Clinical Cohort Population Sub-Analysis of the TRITON-TIMI 38 Pivotal Study 2Effient® (Prasugrel) Showed Significant 26 Percent Reduction in Cardiovascular Events Over Clopidogrel in New Core Clinical Cohort Population Sub-Analysis of the TRITON-TIMI 38 Pivotal Study 3Effient® (Prasugrel) Showed Significant 26 Percent Reduction in Cardiovascular Events Over Clopidogrel in New Core Clinical Cohort Population Sub-Analysis of the TRITON-TIMI 38 Pivotal Study 4Effient® (Prasugrel) Showed Significant 26 Percent Reduction in Cardiovascular Events Over Clopidogrel in New Core Clinical Cohort Population Sub-Analysis of the TRITON-TIMI 38 Pivotal Study 5Effient® (Prasugrel) Showed Significant 26 Percent Reduction in Cardiovascular Events Over Clopidogrel in New Core Clinical Cohort Population Sub-Analysis of the TRITON-TIMI 38 Pivotal Study 6Effient® (Prasugrel) Showed Significant 26 Percent Reduction in Cardiovascular Events Over Clopidogrel in New Core Clinical Cohort Population Sub-Analysis of the TRITON-TIMI 38 Pivotal Study 7Effient® (Prasugrel) Showed Significant 26 Percent Reduction in Cardiovascular Events Over Clopidogrel in New Core Clinical Cohort Population Sub-Analysis of the TRITON-TIMI 38 Pivotal Study 8Nanowire-based sensors offer improved detection of volatile organic compounds 2Nano detector for deadly anthrax 2
... assays on four slides. The new ArraySlide ... 96 (6mm x 7mm) individual printing surfaces ... screening analysis studies. Unlike other systems, this ... the presence of contaminating adhesives. The chamber ...
... Ease of Use : GeneTraffic is built ... for biological research. GeneTraffic provides visual and ... your data prior to analysis. , ... your projects using the MIAME (Minimum Information ...
... siTrio siRNA --- a cocktail of ... gene of interestis our most popular product. ... than 75% knockdown of your target gene ... siRNA for transfection and confirmation of optimal ...
... kit #27295 has improved stability and convenience from ... not only has overcome this problem but also ... have changed the formulation of HRP conjugated antibody ... By this change, the stability of the conjugate ...
Biology Products: