Navigation Links
Stowers study hints that stem cells prepare for maturity much earlier than anticipated
Date:12/27/2012

KANSAS CITY, MOUnlike less versatile muscle or nerve cells, embryonic stem cells are by definition equipped to assume any cellular role. Scientists call this flexibility "pluripotency," meaning that as an organism develops, stem cells must be ready at a moment's notice to activate highly diverse gene expression programs used to turn them into blood, brain, or kidney cells.

Scientists from the lab of Stowers Investigator Ali Shilatifard, Ph.D., report in the December 27, 2012 online issue of Cell that one way cells stay so plastic is by stationing a protein called Ell3 at stretches of DNA known as "enhancers" required to activate a neighboring gene. Their findings suggest that Ell3 parked at the enhancer of a developmentally regulated gene, even one that is silent, primes it for future expression. This finding is significant as many of these same genes are abnormally switched on in cancer.

"We now know that some enhancer misregulation is involved in the pathogenesis of solid and hematological malignances," says Shilatifard. "But a problem in the field has been how to identify inactive or poised enhancer elements. Our discovery that Ell3 interacts with enhancers in ES cells gives us a hand-hold to identify and to study them."

In 2000, Shilatifard identified Ell3 as the third member of the Ell (for "Eleven-nineteen lysine-rich leukemia gene") family of elongation factors, proteins that increase the rate at which genes are expressed. "At the time, we didn't think much of Ell3 because it was highly expressed in testes," says Shilatifard, noting that then people thought that sperm were merely vessels used to carry paternal DNA to an egg and that associated factors would have little relevance to the regulation of future gene expression in the resulting embryo.

But a few years back, a curious Open University graduate student working in the Shilatifard lab, Chengqi Lin, started exploring a potential function for the neglec
'/>"/>

Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Birdsong study pecks theory that music is uniquely human
2. Study turns parasite invasion theory on its head
3. Gout study offers genetic insight into disease of kings
4. Native orchid protection and conservation subject of new AgriLife Research study
5. Cell Transplantation study investigates fate and function of cells transplanted to the CNS
6. Study reports iron oxide nanoparticles effective for labeling human endothelial cells
7. Study looks at gray seal impact on beach water quality
8. Study reveals that animals contribute to seagrass dispersal
9. UC Irvine study of leaping toads reveals muscle-protecting mechanism
10. NTU study finds ways to prevent muscle loss, obesity and diabetes
11. Hass Avocado Board study published in Food & Function journal
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stowers study hints that stem cells prepare for maturity much earlier than anticipated
(Date:11/15/2014)... 13, 2014  While we may still be a few ... in "Star Trek" to gain instant access to all that ... with smartphones and tablets for monitoring and measuring our health ... This may seem a tad Orwellian to some, but a ... of these technological opportunities into their healthcare regime. ...
(Date:11/10/2014)... pods began appearing on U.S. store shelves in early ... ever since. The small packets can be tossed into ... a liquid or powder. The convenience, though, has come ... from researchers at Nationwide Children,s Hospital found that from ... of 17,230 children younger than 6 years of age ...
(Date:11/7/2014)... , November 6, 2014 Leading Biometric ... better mobile security revolutionizing online transactions.  Companies in focus today ... Ltd. (NYSE: BABA ), Google Inc. (NASDAQ: ... eBay Inc. (NASDAQ: EBAY ) and MasterCard Inc. ... and NXTDW), a biometric authentication company focused on the ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Study finds laundry detergent pods, serious poisoning risk for children 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
... insights on the differences in cardiovascular pathophysiology between women ... a globally recognized expert in gender specific medicine, and ... address at the 98th Annual American Medical Women,s Association ... 2013. "I will introduce unique nervous systems differences ...
... large number of individuals. It is observed at all scales, ... shoals of fish, flocks of birds and animal herds. Now ... Ireland, have uncovered new collective properties of swarm dynamics in ... this could be used to control swarms of animals, robots, ...
... grave in London, containing more than a dozen skeletons ... The victims are thought to have died during the ... they excavate the site. The Plague is ... lungs and is highly contagious, leading to mass outbreaks ...
Cached Biology News:
(Date:11/18/2014)... (PRWEB) November 18, 2014 Alanda ... and Transparency Reporting solutions, announced today that a ... using its Consummate Provider™ solution in both the ... a Global, SaaS based, Data Quality remediation portal, ... their third party Providers improve their ability to ...
(Date:11/18/2014)... 2014 Array Architects is proud of ... to the nation's hospitals and health systems. It is ... dedicating their careers to the advancement of both the ... her respective field, Laura Silvoy has been chosen to ... Winter Simulation Conference. , Laura will present her ...
(Date:11/18/2014)... -- Novira Therapeutics, Inc., a privately held biopharmaceutical company developing ... virus (HBV) infection, today announced that Brian F. ... Board (SAB).  "We are thrilled to ... Schade , Chief Executive Officer of Novira.  "Brian brings ... invaluable to Novira as our lead core inhibitor program, ...
(Date:11/16/2014)... November 16, 2014 James Hill and ... Filtered Fume Hoods, 3 Years Later” scheduled for Thursday, ... of 2011, Butler University surprised many in the lab ... their organic chemistry and general chemistry teaching laboratories at ... to building age and substantial growth within the chemistry ...
Breaking Biology Technology:Alanda Software Completes Successful Implementation of Global Data Quality & Vendor Management Solution for Top Tier Global Biopharmaceutical Company 2Array Healthcare Simulation Expert Slated to Speak at Winter Simulation Conference 2Novira Therapeutics Announces Appointment of Brian F. Daniels, M.D., to its Scientific Advisory Board 2Novira Therapeutics Announces Appointment of Brian F. Daniels, M.D., to its Scientific Advisory Board 3Don't miss the I2SL High-Tech Talks Webinar Series Presenting: Butler University's Renovation With Filtered Fume Hoods, 3 Years Later 2Don't miss the I2SL High-Tech Talks Webinar Series Presenting: Butler University's Renovation With Filtered Fume Hoods, 3 Years Later 3
... 28 /PRNewswire-FirstCall/ - Oncothyreon Inc. (the,"Company") (Nasdaq: ... development of innovative therapeutic products for the treatment ... clinical development plans,and corporate objectives for 2008. Oncothyreon ... molecules with the potential to,improve the lives and ...
... PARIS, January 28 Sanofi-aventis announced,today that ... approved for marketing in Japan by the ... prevention of venous thromboembolism (VTE) in patients,undergoing ... as total hip,replacement, total knee replacement and ...
... Calif., Jan. 25 Onyx,Pharmaceuticals, Inc. (Nasdaq: ... the Wachovia Healthcare Conference on Wednesday, January 30, ... a live webcast of the,presentation at:, ... log on 15 minutes early in order to,register ...
Cached Biology Technology:Oncothyreon highlights corporate and clinical objectives for 2008 2Oncothyreon highlights corporate and clinical objectives for 2008 3Oncothyreon highlights corporate and clinical objectives for 2008 4Oncothyreon highlights corporate and clinical objectives for 2008 5Clexane(R)/Lovenox(R) Approved in Japan 2Clexane(R)/Lovenox(R) Approved in Japan 3Clexane(R)/Lovenox(R) Approved in Japan 4Clexane(R)/Lovenox(R) Approved in Japan 5
Recombinant Rat Fas Ligand/TNFSF6...
Request Info...
FGF Receptor 1 Antibody...
... Anti-Na + /K + ATPase ... : NM_001001586 Immunogen : Purified Na ... membrane fractions of rabbit kidney outer medulla ... containing 0.05% sodium azide Quality Assurance: routinely ...
Biology Products: