Navigation Links
Stowers study hints that stem cells prepare for maturity much earlier than anticipated
Date:12/27/2012

KANSAS CITY, MOUnlike less versatile muscle or nerve cells, embryonic stem cells are by definition equipped to assume any cellular role. Scientists call this flexibility "pluripotency," meaning that as an organism develops, stem cells must be ready at a moment's notice to activate highly diverse gene expression programs used to turn them into blood, brain, or kidney cells.

Scientists from the lab of Stowers Investigator Ali Shilatifard, Ph.D., report in the December 27, 2012 online issue of Cell that one way cells stay so plastic is by stationing a protein called Ell3 at stretches of DNA known as "enhancers" required to activate a neighboring gene. Their findings suggest that Ell3 parked at the enhancer of a developmentally regulated gene, even one that is silent, primes it for future expression. This finding is significant as many of these same genes are abnormally switched on in cancer.

"We now know that some enhancer misregulation is involved in the pathogenesis of solid and hematological malignances," says Shilatifard. "But a problem in the field has been how to identify inactive or poised enhancer elements. Our discovery that Ell3 interacts with enhancers in ES cells gives us a hand-hold to identify and to study them."

In 2000, Shilatifard identified Ell3 as the third member of the Ell (for "Eleven-nineteen lysine-rich leukemia gene") family of elongation factors, proteins that increase the rate at which genes are expressed. "At the time, we didn't think much of Ell3 because it was highly expressed in testes," says Shilatifard, noting that then people thought that sperm were merely vessels used to carry paternal DNA to an egg and that associated factors would have little relevance to the regulation of future gene expression in the resulting embryo.

But a few years back, a curious Open University graduate student working in the Shilatifard lab, Chengqi Lin, started exploring a potential function for the neglec
'/>"/>

Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Birdsong study pecks theory that music is uniquely human
2. Study turns parasite invasion theory on its head
3. Gout study offers genetic insight into disease of kings
4. Native orchid protection and conservation subject of new AgriLife Research study
5. Cell Transplantation study investigates fate and function of cells transplanted to the CNS
6. Study reports iron oxide nanoparticles effective for labeling human endothelial cells
7. Study looks at gray seal impact on beach water quality
8. Study reveals that animals contribute to seagrass dispersal
9. UC Irvine study of leaping toads reveals muscle-protecting mechanism
10. NTU study finds ways to prevent muscle loss, obesity and diabetes
11. Hass Avocado Board study published in Food & Function journal
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stowers study hints that stem cells prepare for maturity much earlier than anticipated
(Date:6/25/2015)... N.J. , June 25, 2015  TAKE Solutions ... a patent by the United States Patent and Trademark ... Standardization". This process leverages TAKE Solutions, Clinical Accelerators to ... over 50% (when compared to standardization without the accelerators), ... At the heart of ...
(Date:6/24/2015)... 2015 This report provides market analysis of ... years. It contains an analysis of the drivers, challenges, ... impact from the short, medium, and long term perspective ... market, and technology trends that currently, prevail in the ... authorities to efficiently manage the increasing marine traffic and ...
(Date:6/24/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/hhwlfj/huawei_ascend ... "Huawei Ascend Mate 7 Fingerprint Sensor - Reverse ... Huawei,s technological choice for the fingerprint sensor ... and Samsung,s one. The Ascend Mate 7 presents ... a main actor in capacitive sensing human interface ...
Breaking Biology News(10 mins):TAKE Solutions Awarded Patent By USPTO 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2
... Jos Zanchetta, a member of the IOF Board and ... has been named the recipient of the prestigious Pierre ... Osteoporosis Foundation (IOF) in memory of Pierre D. Delmas, ... growth of the Foundation and osteoporosis advocacy worldwide. ...
... the damage caused by a heart attack survived in the ... a mouse model, researchers at The University of Texas MD ... Circulation Research . The study, with researchers at the ... imaging techniques developed by researchers at MD Anderson to track ...
... a 1600 km-wide ash cloud over the Atlantic. The ... visible in stark contrast to white clouds framing this ... emitting steam and ash on 20 March, wreaking havoc ... week caused some flights to be suspended to and ...
Cached Biology News:Transplanted adult stem cells provide lasting help to injured hearts 2Transplanted adult stem cells provide lasting help to injured hearts 3Transplanted adult stem cells provide lasting help to injured hearts 4
(Date:6/29/2015)... 2015 Elsevier , a ... and services, today announced the highlights of its journal ... Journal Citation Reports® (JCR) published by Thomson Reuters, Elsevier ... 2013 to 2014, ahead of the aggregate across other ... in 62 subject categories, up from 61 in 2013. ...
(Date:6/26/2015)... 2015 /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") ... nominees listed in the management information circular dated June ... Annual Meeting of Shareholders, held earlier today, June ... following 5 nominees proposed by management were elected ... the Company,s next Annual Meeting of Shareholders or ...
(Date:6/26/2015)... and MUMBAI, India , June ... NSE: TCS) a leading global IT services, consulting and ... as a Leader in Worldwide Life Sciences R&D Risk-Based ... " IDC MarketScape: Worldwide Life Science R&D Risk-Based Monitoring ... The report evaluated eight leading IT services ...
(Date:6/26/2015)... ... 26, 2015 , ... DNA Genotek, a leading provider of ... (Nasdaq: OSUR) today announced that it has awarded grants to three organizations that ... The company has awarded its OMNIgene®â€¢GUT fecal/stool collection kits and GenoFIND ...
Breaking Biology Technology:Elsevier Announces 2014 Citation Impact Highlights 2Elsevier Announces 2014 Citation Impact Highlights 3iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 2iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 3TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 2TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 3TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 4DNA Genotek Inc. Announces Recipients of Gut Microbiome Grant Program 2DNA Genotek Inc. Announces Recipients of Gut Microbiome Grant Program 3
... Companies will Present at the Largest Marketplace for Emerging ... and CTSI today announced that more than 100 leading ... partners will be showcased in the 4th Annual TechConnect ... R. Brown Convention Center in Houston, Texas. Held ...
... Development and InnovationMOUNTAIN VIEW, Calif., April 22 ... Pharmaceuticals & Biotechnology group assesses a variety of ... in cancer treatment. Physicians, nurses and patients ... reconstitution, home vs. office administration parameters, and barriers ...
... 22 GeneGo, Inc., a leading provider of software ... , today announced that the University of Cardiff has ... researchers will have access to GeneGo,s MetaCore, training and ... their partner relationship with GeneGo to provide a pathway ...
Cached Biology Technology:TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 2TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 3TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 4Frost & Sullivan: Female Cancer Patients More Willing to Use Implantable Infusion Pumps Than Males 2Frost & Sullivan: Female Cancer Patients More Willing to Use Implantable Infusion Pumps Than Males 3Cardiff University Becomes a GeneGo Center of Excellence 2
...
cysteine and glycine-rich protein 2,...
... agent and DNA-topoisomersae II inhibitor (IC50 = 59.2 ... C 29 H 32 O 13 ... Store at: RT ... Soluble to 100 mM ...
HSPBP1 Antibody...
Biology Products: