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Story ideas from the Journal of Lipid Research
Date:8/27/2007

Articles published in the September 2007 issue of the Journal of Lipid Research (Vol. 48, No. 9)

ARTICLE HIGHLIGHTS

  • Renal transplant recipients genetic makeup does not negatively impact fluvastatin use
  • New skin-healing chemicals
  • New anti-inflammatory compound discovered
  • Thematic Review: Understanding how obese fat cells work


* Renal transplant recipients genetic makeup does not negatively impact fluvastatin use

Scientists report that when people with a transplanted kidney take fluvastatin, a drug against cardiovascular disease, their response to the drug is not influenced by their genetic composition.

People who receive a transplanted kidney are at risk of developing potentially fatal premature cardiovascular disease. One way to prevent this from happening is by taking fluvastatin, a drug that significantly reduces myocardial infarction and cardiac death. But patients genetic makeup has been reported to prevent similar cholesterol-lowering drugs, such as pravastatin, from working properly.

To examine potential effects of a genetic makeup on the efficacy of fluvastatin after patients receive a kidney transplant, Hallvard Holdaas and colleagues examined 42 genetic variations previously reported to affect fluvastatin metabolism, cholesterol regulation, cardiovascular disease, and the functioning of a transplanted kidney.

The scientists compared the effects of these genetic variations in 707 renal transplant patients who received fluvastatin and 697 patients who received a placebo and showed that the variations do not increase risks of developing a cardiovascular disease or a kidney disease. Consequently, statin therapy continues to be recommended to patients who received a transplanted kidney, regardless of their genetic makeup, the researchers concluded.

Article:

Contact: Pat Pages
ppages@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

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