Navigation Links
Story ideas from the Journal of Biological Chemistry
Date:1/14/2008

COX-2 inhibitors like Celecoxib have come under scrutiny lately due to adverse cardiovascular side-effects stemming from COX-2 reduction. In both fruit fly and rat models, researchers reveal another adverse effect of Celecoxib; this drug can induce arrhythmia. More interestingly, this effect is independent of the COX-2 enzyme.

Satpal Singh and colleagues tested various Celecoxib doses on the heart rate of Drosophila, a good model for human cardiac pharmacology. To their surprise, administering 3 m Celecoxib (not much higher than the plasma levels in humans taking the drug) reduced heart rate and increased beating irregularities, while 30 m was enough to stop the heart within a minute.

The surprise arises from the fact that Drosophila do not have COX-2 enzymes. Rather, Celecoxib could directly inhibit the potassium channels that help generate the electric current that drives heartbeat.

The researchers could achieve similar heart-stopping results in rat cardiac cells, whereas aspirin, another potent COX-2 inhibitor, had no effect, confirming that another mechanism is at work. The drug also inhibited rat and human potassium channels expressed in a human cell line.

Singh and colleagues point out that since these arrhythmia effects bypass COX-2, it is unclear if other COX-2 inhibitors would yield similar results. They also stress it is too early to speculate on human effects, although their results suggest Drosophila are a valuable tool to investigate other COX-2 drugs.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1

Related biology news :

1. Story ideas from the Journal of Lipid Research
2. The surprising story of Charles Darwin and his homeopathic doctor
3. Story tips from the Department of Energys Oak Ridge National Laboratory, December 2007
4. Story ideas from the Journal of Lipid Research
5. Journal Sleep: Insomniacs are more likely to report a family history of the sleep disorder
6. Nanotechnology and the media: The inside story
7. Rebuilding the evolutionary history of HIV-1 unravels a complex loop
8. Story ideas from the Journal of Biological Chemistry
9. Story tips from the Department of Energys Oak Ridge National Laboratory, October 2007
10. Story ideas from Molecular & Cellular Proteomics
11. Microfossils disclose geologic history of eastern California
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Story ideas from the Journal of Biological Chemistry
(Date:9/22/2014)... overweight, you may be at greater risk for ... and cancer, according to a new study by ... stress can trigger biological responses similar to the ... normal inflammation is an important part of our ... chronic and life-threatening diseases. , In a ...
(Date:9/21/2014)... On the eve of United Nations General Assembly events ... of mothers, newborns and children, Grand Challenges Canada, funded ... in grants for 22 bold ideas to address this ... A program for Bangladeshi mothers working in garment ... thereby improving infant nutrition, reducing absenteeism due to child ...
(Date:9/21/2014)... the University of California, San Diego, have developed a ... control the activity of genes based on sequences of ... its application to human embryonic cells in a paper ... , "All of our cells have the same blueprint, ... John Whitaker, lead author of the report. "Skin cells ...
Breaking Biology News(10 mins):Obesity and stress pack a double hit for health 2Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 2Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 3Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 4Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 5Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 6Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 7Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 8Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 9Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 10Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 11Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 12Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 13Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 14Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 15Program predicts placement of chemical tags that control gene activity 2
... potential for cleaning up contaminated sites by growing plants able ... the plants break certain kinds of pollutants into harmless byproducts ... leaves or release into the air. The problem with plants ... is slow and halts completely when growth stops in winter. ...
... its deadly reputation, the gas carbon monoxide (CO) could ... a result of leading-edge UK research. Chemists at ... of using targeted small doses of CO which could ... transplants and people suffering from high blood pressure. ...
... (ACS) News Service Weekly press package (PressPac) with reports ... Engineering News. With more than 160,000 members, ACS is ... journal, or the American Chemical Society, as the source ... #1 FOR IMMEDIATE RELEASE Faster, more efficient ...
Cached Biology News:Scientists ramp up ability of poplar plants to disarm toxic pollutants 2Scientists ramp up ability of poplar plants to disarm toxic pollutants 3Scientists ramp up ability of poplar plants to disarm toxic pollutants 4Chemistry turns killer gas into potential cure 2American Chemical Society's Weekly PressPac - Oct. 10, 2007 2American Chemical Society's Weekly PressPac - Oct. 10, 2007 3American Chemical Society's Weekly PressPac - Oct. 10, 2007 4American Chemical Society's Weekly PressPac - Oct. 10, 2007 5American Chemical Society's Weekly PressPac - Oct. 10, 2007 6American Chemical Society's Weekly PressPac - Oct. 10, 2007 7American Chemical Society's Weekly PressPac - Oct. 10, 2007 8
(Date:9/22/2014)... Pa. (PRWEB) September 22, 2014 ... rapid diagnostics for the food and beverage industries, ... will be distributed under a non-exclusive agreement by ... and services. , Enartis, an Esseco Group company ... to winemakers in California and other global markets ...
(Date:9/22/2014)... N.J. , Sept. 22, 2014  WIRB-Copernicus ... and ethical review services for clinical research, announced ... (WIRB) has been reaccredited by the Association ... (AAHRPP), which endeavors to improve safeguards for clinical ... Donald A. Deieso , Ph.D., commented, "It ...
(Date:9/22/2014)... BETHESDA, Md. , Sept. 22, 2014  Spherix Incorporated ... fostering and monetization of intellectual property, today announced that the ... patent to the Company in the month of September that ... The issued patent is: USRE45,121 , ... 2014 , Filing date: Dec 27, 2012 ...
(Date:9/20/2014)... USA (PRWEB) September 20, 2014 Entries ... 2015 Prism Awards for Photonics Innovation . The ... the multi-billion dollar optics and photonics industry, and is ... and photonics , and Photonics Media . , ... the versatility of photonics, said SPIE CEO Eugene Arthurs. ...
Breaking Biology Technology:Invisible Sentinel's Test for Wine-Spoilage Microbe to be Distributed by Enartis in Multiple Markets Globally 2Invisible Sentinel's Test for Wine-Spoilage Microbe to be Distributed by Enartis in Multiple Markets Globally 3Western IRB (WIRB) Awarded AAHRPP Reaccreditation 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 3Entry deadline is 10 October for international photonics Prism Awards 2Entry deadline is 10 October for international photonics Prism Awards 3Entry deadline is 10 October for international photonics Prism Awards 4
... YORK, Jan. 15 - The Michael J. Fox,Foundation ... total funding for seven research studies aiming to ... drug makers, to,therapeutically target two genes -- LRRK2 ... only partially understood, role in Parkinson,s disease., ...
... Kan., Jan. 15 The Kansas Bioscience,Authority ... bring together,researchers nationwide to create products that ... diseases to disrupt the national economy or,to ... new Collaborative Biosecurity Research Initiative,(CBRI) are to ...
... Group plc (AIM:,PRG), the international pharmaceutical services ... Senior Director, Clinical Trial Management,specializing in oncology-related ... a leading role in the operations, strategic ... portfolio of oncology,business., Over the past ...
Cached Biology Technology:The Michael J. Fox Foundation Awards $2 Million to Shed Light on Role of LRRK2 and Alpha-Synuclein Genes in Parkinson's Disease 2Collaborative Biosecurity Research Initiative Launched to Target Animal and Public Health Threats Nationally 2Collaborative Biosecurity Research Initiative Launched to Target Animal and Public Health Threats Nationally 3Premier Research Names Patrick Melvin as Senior Director, Clinical Trial Management 2
... the Flp-In System creates isogenic cell ... levels of the protein of interest. ... Figure 3 (click link below). In ... chloramphenicol-acetyl transferase (CAT) was subcloned into ...
... for molecular weight determinations for petroleum-based applications. Multiple solvents can be used, such as water, ... ... ... ...
Fast, sensitive quantitation of total MEK 1/2 concentration....
... and flexibility press-to-seal silicone isolators can be ... researcher. They are available either pre-cut to ... that can be easily trimmed to prepare ... non-cytotoxic and can be used to isolate ...
Biology Products: