Navigation Links
Story ideas from the Journal of Biological Chemistry
Date:1/14/2008

COX-2 inhibitors like Celecoxib have come under scrutiny lately due to adverse cardiovascular side-effects stemming from COX-2 reduction. In both fruit fly and rat models, researchers reveal another adverse effect of Celecoxib; this drug can induce arrhythmia. More interestingly, this effect is independent of the COX-2 enzyme.

Satpal Singh and colleagues tested various Celecoxib doses on the heart rate of Drosophila, a good model for human cardiac pharmacology. To their surprise, administering 3 m Celecoxib (not much higher than the plasma levels in humans taking the drug) reduced heart rate and increased beating irregularities, while 30 m was enough to stop the heart within a minute.

The surprise arises from the fact that Drosophila do not have COX-2 enzymes. Rather, Celecoxib could directly inhibit the potassium channels that help generate the electric current that drives heartbeat.

The researchers could achieve similar heart-stopping results in rat cardiac cells, whereas aspirin, another potent COX-2 inhibitor, had no effect, confirming that another mechanism is at work. The drug also inhibited rat and human potassium channels expressed in a human cell line.

Singh and colleagues point out that since these arrhythmia effects bypass COX-2, it is unclear if other COX-2 inhibitors would yield similar results. They also stress it is too early to speculate on human effects, although their results suggest Drosophila are a valuable tool to investigate other COX-2 drugs.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1

Related biology news :

1. Story ideas from the Journal of Lipid Research
2. The surprising story of Charles Darwin and his homeopathic doctor
3. Story tips from the Department of Energys Oak Ridge National Laboratory, December 2007
4. Story ideas from the Journal of Lipid Research
5. Journal Sleep: Insomniacs are more likely to report a family history of the sleep disorder
6. Nanotechnology and the media: The inside story
7. Rebuilding the evolutionary history of HIV-1 unravels a complex loop
8. Story ideas from the Journal of Biological Chemistry
9. Story tips from the Department of Energys Oak Ridge National Laboratory, October 2007
10. Story ideas from Molecular & Cellular Proteomics
11. Microfossils disclose geologic history of eastern California
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Story ideas from the Journal of Biological Chemistry
(Date:7/21/2014)... to monitor seals, every movement, researchers have shown for ... to offshore wind farms and pipelines. Those man-made structures ... according to a study published in the Cell Press ... , "I was shocked when I first saw the ... Shoal," an offshore wind farm in the United Kingdom, ...
(Date:7/21/2014)... Want to conserve water and save on your utility ... and published in the current issue of the journal ... List: The Most Effective Actions U.S. Households Can Take ... water use substantially by simple actions such as installing ... consumption. While the suggestions may be familiar, the researchers ...
(Date:7/21/2014)... Dysfunction in dopamine signaling profoundly changes the ... brain,s prefrontal cortex and may be an underlying ... schizophrenia, according to UC Irvine scientists. , This ... that receive this neurotransmitter showed for the first ... of behavioral and physiological functions regulated in the ...
Breaking Biology News(10 mins):Seals forage at offshore wind farms 2Researchers provide guide to household water conservation 2Researchers provide guide to household water conservation 3UCI researchers find epigenetic tie to neuropsychiatric disorders 2
... things that suffer from stress. Trees must deal with stress ... too much water, from scarcity of a needed nutrient, from ... to stress quickly and efficiently is a pressing goal of ... University scientists has identified the molecular mechanism that Populusthe scientific ...
... A recent research study has shown that food ... food due to resource constraints, can lead to greater ... "Prior studies have shown that women living ... health complications," said Craig Gundersen, a University of Illinois ...
... scientists have analysed the temperature and salt levels of the ... evolution of each variable. Their research shows that, since at ... and saltier, and that, since the 1990s, this process has ... layer of the Western Mediterranean increases by 0.002C, and its ...
Cached Biology News:Feeling stressed? So is the poplar 2Food insecurity increases risk of weight gain and complications during pregnancy 2Temperature and salt levels of the Western Mediterranean are on the increase 2
(Date:7/22/2014)... Biofeedback – When a ... diagnosed, selecting medication to best treat it can become ... by using electroencephalography (EEG) can help predict which medicine ... risk of adverse drug events. , The article ... the current issue of the journal Biofeedback offers evidence ...
(Date:7/21/2014)... Hills, IL (PRWEB) July 21, 2014 ... control, and simple programming, the new Cole-Parmer® ... Head is easy to operate for automated ... cycles for hands-free dispensing. The batch count function ... cumulative volume or totalizer tracks amount dispensed across ...
(Date:7/21/2014)... , July 21, 2014  Mike Patterson, ... of $1.6 million in Series Seed B funding ... chemical sensors for the life science, defense, intelligence, ... Capital Partners led the round and was joined ... Angels.  Said Patterson , "This round of ...
(Date:7/20/2014)... July 20, 2014 NSG Precision ... glass optics, and spectrophotometer calibration standards ... NSG has released many products that have transformed ... has been their solid-state calibration standards. , NSG’s ... since their release in 2008. NSG started ...
Breaking Biology Technology:Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 2Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 3New Easy-View Cole-Parmer Digital Gear Pump Drive Makes Performance Monitoring Effortless 2Global Graphene Manufacturing Leader, Graphene Frontiers, Receives Series Seed B Funding To Assure Production Of The Next Generation Of Biological And Chemical Sensor Technology 2How NSG Precision Cells Spectrophotometer Calibration Standards Makes NIR Work Easier 2How NSG Precision Cells Spectrophotometer Calibration Standards Makes NIR Work Easier 3
... May 28 CV Therapeutics,Inc. (Nasdaq: CVTX ... rule 4350, the Company issued new inducement stock ... primarily in connection,with its commercialization efforts in the ... an aggregate 151,800 shares of,common stock and are ...
... May 28 Abt Associates announced that,it has ... Officer.,Small most recently served as Senior Vice President, ... Inc., a $700 million,provider of factory and tool ... Prior to joining Brooks Automation he held the,position ...
... Ohio, May 28 NanoLogix, Inc. (Pink,Sheets: NNLX) ... updates:, NanoLogix personnel will showcase company technology ... Exhibition in Boston, June 1-5 2008. The ASM,meeting ... NanoLogix will be Dr. Sergey Gazenko and CEO ...
Cached Biology Technology:CV Therapeutics Reports Option Grants Under Nasdaq Marketplace Rule 4350 2Abt Associates Names Richard Small Vice President and Chief Financial Officer 2NanoLogix Inc. to Present at The American Society for Microbiology (ASM) General Meeting in Boston; Announces Product Line and Provides Operations Update 2
Anti-Rsk2/MAPKAP Kinase 1b, #0 SK2/MAPKAP K1 beta Smartpool&t 3T3 cell lysate Non-specific Control Pool , #D 1X Universal Buffer...
TNF-R2 (L-20)...
... The PowerEase 500 Power ... mini-gel electrophoresis. It offers extensive ... and four custom methods for ... own preferences. The simple intuitive ...
Eliminate electrical interference from any analog signal, without filtering. Ideal for electrophysiology applications like EKG, EMG, and EEGs. Removes 50/60hz noise and harmonics caused by grounding ...
Biology Products: